LOCUS       NM_001107508            1082 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kallikrein related-peptidase 12 (Klk12), mRNA.
ACCESSION   NM_001107508 XM_001080413 XM_008759351 XM_218644
VERSION     NM_001107508.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Guillon-Munos,A., Oikonomopoulou,K., Michel,N., Smith,C.R.,
            Petit-Courty,A., Canepa,S., Reverdiau,P., Heuze-Vourc'h,N.,
            Diamandis,E.P. and Courty,Y.
  TITLE     Kallikrein-related peptidase 12 hydrolyzes matricellular proteins
            of the CCN family and modifies interactions of CCN1 and CCN5 with
            growth factors
  JOURNAL   J Biol Chem 286 (29), 25505-25518 (2011)
   PUBMED   21628462
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Shinmura,K., Tao,H., Yamada,H., Kataoka,H., Sanjar,R., Wang,J.,
            Yoshimura,K. and Sugimura,H.
  TITLE     Splice-site genetic polymorphism of the human kallikrein 12 (KLK12)
            gene correlates with no substantial expression of KLK12 protein
            having serine protease activity
  JOURNAL   Hum Mutat 24 (3), 273-274 (2004)
   PUBMED   15300858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jan 4, 2023 this sequence version replaced
            XM_008759351.2, NM_001107508.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1570484.1,
                                           SRR22582416.455695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000001.1  103359327-103359459
            134-189             JAXUCZ010000001.1  103359575-103359630
            190-349             JAXUCZ010000001.1  103360068-103360227
            350-606             JAXUCZ010000001.1  103361304-103361560
            607-740             JAXUCZ010000001.1  103362456-103362589
            741-1082            JAXUCZ010000001.1  103363845-103364186
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1082
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /note="kallikrein related-peptidase 12"
                     /db_xref="GeneID:308564"
                     /db_xref="RGD:1308975"
     exon            1..133
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
     exon            134..189
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..896
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /note="kallikrein 12; kallikrein k"
                     /codon_start=1
                     /product="kallikrein-12 precursor"
                     /protein_id="NP_001100978.2"
                     /db_xref="GeneID:308564"
                     /db_xref="RGD:1308975"
                     /translation="MKLNILLLLCVVGLSQADREKIYNGVECVKNSQPWQVGLFHGKY
                     LRCGGVLVDRKWVLTAAHCSGKYMVRLGEHSLSKLDLTEQLRLTTFSITHPSYHGAYQ
                     NHEHDLRLLRLNRPISLTYAVRPVALPSSCAPTGAKCHISGWGTTNKPWDPFPDRLQC
                     LDLSIVSNETCRAVFPGRVTENMLCAGGEAGKDACQGDSGGPLVCGGVLQGLVSWGSV
                     GPCGQKGIPGVYTKVCKYTDWIRVVIRNN"
     exon            190..349
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
     exon            350..606
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
     exon            607..740
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1082
                     /gene="Klk12"
                     /gene_synonym="Klnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacagtagg agaagtgact ctcaaggcgg ccggcatttg aaagggctgg aaggtaggtg
       61 aaccagaaga tagcagagcg agacagatag acaggctggg caggtgacaa accatcgaag
      121 acctggcaaa cagaccctgg aggcagtcca ccatgaagct caacattctc ttgctcctgt
      181 gtgttgtagg cctcagtcag gcagacaggg agaagatcta taatggcgtt gagtgtgtga
      241 agaactcaca gccttggcag gtggggctgt tccatggcaa atacctgcgc tgtggtggtg
      301 tcctcgtgga ccgcaagtgg gtccttacgg ctgctcactg cagtggcaag tacatggtgc
      361 gccttgggga acacagtctc tccaagctgg atttgacgga acagttgaga ctcaccacct
      421 tctccataac acaccccagc taccatggtg cctatcagaa ccatgagcat gatcttcgac
      481 tcctacggct gaacagaccc atcagcttga cctatgctgt ccggcccgtg gccctgccca
      541 gttcctgtgc acccactggg gccaagtgtc atatatcagg atggggtact acaaacaagc
      601 cgtgggaccc attcccagat cggctccagt gcctcgacct ctccattgtc tctaacgaga
      661 cgtgccgggc cgtatttcct ggaagagtga cagagaacat gttgtgtgca ggtggagaag
      721 ccggaaagga tgcctgtcag ggtgactctg gaggccccct ggtgtgtgga ggggttcttc
      781 aaggtctggt ttcctgggga tctgttgggc cttgtggtca aaaaggcatc ccaggggtct
      841 acaccaaggt ctgcaaatac acggactgga tcagagtagt catcaggaac aactaactgg
      901 ttccctcggt ctgcatgcag ctctgcttag ggccactccg accctcggag caccaatgtc
      961 tgtcccctcg ccactccaag ctcccaccct ttgagcttag aacctcttga aaccttggtt
     1021 gtatctatgg cagtggagag ggggctgtac aactgtctgg aataaaagtt atacaaacag
     1081 gg
//
