LOCUS       NM_001004100            1404 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kallikrein related-peptidase 10 (Klk10), mRNA.
ACCESSION   NM_001004100 XM_238105
VERSION     NM_001004100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1404)
  AUTHORS   Kioulafa,M., Kaklamanis,L., Stathopoulos,E., Mavroudis,D.,
            Georgoulias,V. and Lianidou,E.S.
  TITLE     Kallikrein 10 (KLK10) methylation as a novel prognostic biomarker
            in early breast cancer
  JOURNAL   Ann Oncol 20 (6), 1020-1025 (2009)
   PUBMED   19150938
REFERENCE   2  (bases 1 to 1404)
  AUTHORS   Oikonomopoulou,K., Li,L., Zheng,Y., Simon,I., Wolfert,R.L.,
            Valik,D., Nekulova,M., Simickova,M., Frgala,T. and Diamandis,E.P.
  TITLE     Prediction of ovarian cancer prognosis and response to chemotherapy
            by a serum-based multiparametric biomarker panel
  JOURNAL   Br J Cancer 99 (7), 1103-1113 (2008)
   PUBMED   18766180
REFERENCE   3  (bases 1 to 1404)
  AUTHORS   Ewan King,L., Li,X., Cheikh Saad Bouh,K., Pedneault,M. and Chu,C.W.
  TITLE     Human kallikrein 10 ELISA development and validation in breast
            cancer sera
  JOURNAL   Clin Biochem 40 (13-14), 1057-1062 (2007)
   PUBMED   17585892
REFERENCE   4  (bases 1 to 1404)
  AUTHORS   Santin,A.D., Diamandis,E.P., Bellone,S., Marizzoni,M., Bandiera,E.,
            Palmieri,M., Papasakelariou,C., Katsaros,D., Burnett,A. and
            Pecorelli,S.
  TITLE     Overexpression of kallikrein 10 (hK10) in uterine serous papillary
            carcinomas
  JOURNAL   Am J Obstet Gynecol 194 (5), 1296-1302 (2006)
   PUBMED   16647913
REFERENCE   5  (bases 1 to 1404)
  AUTHORS   Bharaj,B.B., Luo,L.Y., Jung,K., Stephan,C. and Diamandis,E.P.
  TITLE     Identification of single nucleotide polymorphisms in the human
            kallikrein 10 (KLK10) gene and their association with prostate,
            breast, testicular, and ovarian cancers
  JOURNAL   Prostate 51 (1), 35-41 (2002)
   PUBMED   11920956
REFERENCE   6  (bases 1 to 1404)
  AUTHORS   Kroon,E., MacDonald,R.J. and Hammer,R.E.
  TITLE     The transcriptional regulatory strategy of the rat tissue
            kallikrein gene family
  JOURNAL   Genes Funct 1 (5-6), 309-319 (1997)
   PUBMED   17366701
  REMARK    GeneRIF: Klk10 rat gene was expressed at high levels in the
            submandibular glands of transgenic mice.
REFERENCE   7  (bases 1 to 1404)
  AUTHORS   Ma,J.X., Chao,J. and Chao,L.
  TITLE     Molecular cloning and characterization of rKlk10, a cDNA encoding
            T-kininogenase from rat submandibular gland and kidney
  JOURNAL   Biochemistry 31 (44), 10922-10928 (1992)
   PUBMED   1420203
REFERENCE   8  (bases 1 to 1404)
  AUTHORS   Gutman,N., Elmoujahed,A., Brillard,M., Du Sorbier,B.M. and
            Gauthier,F.
  TITLE     Microheterogeneity of rat submaxillary gland kallikrein k10, a
            member of the kallikrein family
  JOURNAL   Eur J Biochem 197 (2), 425-429 (1991)
   PUBMED   2026164
REFERENCE   9  (bases 1 to 1404)
  AUTHORS   Xiong,W., Chen,L.M. and Chao,J.
  TITLE     Purification and characterization of a kallikrein-like
            T-kininogenase
  JOURNAL   J Biol Chem 265 (5), 2822-2827 (1990)
   PUBMED   2303430
REFERENCE   10 (bases 1 to 1404)
  AUTHORS   Kato,H., Nakanishi,E., Enjyoji,K., Hayashi,I., Oh-ishi,S. and
            Iwanaga,S.
  TITLE     Characterization of serine proteinases isolated from rat
            submaxillary gland: with special reference to the degradation of
            rat kininogens by these enzymes
  JOURNAL   J Biochem 102 (6), 1389-1404 (1987)
   PUBMED   3482210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 12, 2022 this sequence version replaced NM_001004100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1515139.1,
                                           SRR22582416.738811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000001.1  103371638-103371713
            77-203              JAXUCZ010000001.1  103372053-103372179
            204-387             JAXUCZ010000001.1  103373151-103373334
            388-662             JAXUCZ010000001.1  103373896-103374170
            663-796             JAXUCZ010000001.1  103374810-103374943
            797-1404            JAXUCZ010000001.1  103375311-103375918
FEATURES             Location/Qualifiers
     source          1..1404
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1404
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /note="kallikrein related-peptidase 10"
                     /db_xref="GeneID:292850"
                     /db_xref="RGD:1303242"
     exon            1..76
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
     exon            77..203
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..952
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /EC_number="3.4.21.35"
                     /function="serine protease"
                     /note="kallikrein-10; kallikrein j"
                     /codon_start=1
                     /product="kallikrein-10 precursor"
                     /protein_id="NP_001004100.1"
                     /db_xref="GeneID:292850"
                     /db_xref="RGD:1303242"
                     /translation="MRVPLLHLPTASGSLSLVKLLLPLLMMQLWAAQALLLPGNTTRE
                     DLEAFGTLCPSVSQPWQVSLFHNLQFQCAGVLVDQNWVLTAAHCWRNKPLRARVGDDH
                     LLLFQSEQLRSTNSPVFHPKYQPCSGPVLPLRSDEHDLMMLKLSSPVVLTSKVHPVQL
                     PFQCAQPRQECQVSGWGTTANRRVKYNRSLSCSRVTLLSQKQCETFYPGVITNNMICA
                     GMDRDQDSCQSDSGGPLVCDNTLHGILSWSIYPCGAATQYPAVYAKICNYTNWIRRVI
                     RSK"
     exon            204..387
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
     exon            388..662
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
     exon            663..796
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1404
                     /gene="Klk10"
                     /gene_synonym="Klnj"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcagagga ctgtttgcag tccatactgc tgggcaagag acacttctga gtcgcctcct
       61 ttcttcttac tcccaggtct ccactccagc ctctgcaagc ccgacatcag ctatgagggt
      121 cccgcttctt cacctcccta ctgcctctgg ctccttgtcc ctggtgaagc tactgctgcc
      181 gctactgatg atgcaactct gggcggcgca ggctctgctg ctcccgggaa acaccacgcg
      241 cgaggacctc gaggccttcg gcactctgtg cccgagtgtc tctcaaccct ggcaggtctc
      301 cctcttccat aacctccagt tccaatgtgc gggtgtcctc gtggaccaga actgggtgct
      361 cacggccgca cattgctgga gaaataagcc actgagggct cgagttggag atgaccacct
      421 gctgcttttc cagagcgagc aactgaggtc cacgaattcc cctgttttcc accccaagta
      481 ccagccttgc tcaggtcccg ttctgccact ccgctcagat gaacacgacc tcatgatgct
      541 aaaactgagc agtcctgtgg tgctgacgtc caaagtgcat cccgtgcaat tgcccttcca
      601 gtgtgctcag ccaaggcagg agtgccaggt ctcaggctgg gggaccacag ccaaccgaag
      661 agtgaaatac aacaggagcc tgagctgctc cagggtaact ctcctcagcc agaagcagtg
      721 tgagaccttc tacccgggtg tgatcaccaa caacatgatt tgtgctggga tggacagaga
      781 ccaagattct tgccagagtg actccggtgg acccctggtg tgtgacaaca ccctgcatgg
      841 cattctttca tggagcattt acccatgcgg ggctgctacc cagtacccag ctgtctacgc
      901 taagatctgc aactacacca actggattcg aagagtcatc cgttccaaat gacccgcctc
      961 tcacaccctt cgtcctcact tcatctgtcc accccccact ccgtcctcct ctcatgggtg
     1021 cccacacctc tgagaatgca tcctcttctc tcacccccgc ccactcctgt tctccactca
     1081 caagtgtaga aaatggtggc tgggagttct agggcctcaa ggaagccggc agtctccaag
     1141 tctctaagag aagttatctg ttattcaacc tggctttctc tacctccctc ctctgtgtga
     1201 ctgggacaat gagccttagt ttccttgtct gaaaaatggg gacaatgaat tgtctacctc
     1261 ttacatacat tgtatggggt ctgtgatgga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1321 gtgtgtgtgt gtgtgtgttt atggtaattg tcacagagac gtgaaaccat ctggttatcg
     1381 ccgattaaac agtacctgat ctga
//
