LOCUS       NM_012593                910 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kallikrein 1 (Klk1), mRNA.
ACCESSION   NM_012593
VERSION     NM_012593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Huang,S., Chen,M., Yu,H., Lin,K., Guo,Y. and Zhu,P.
  TITLE     Co-expression of tissue kallikrein 1 and tissue inhibitor of matrix
            metalloproteinase 1 improves myocardial ischemia-reperfusion injury
            by promoting angiogenesis and inhibiting oxidative stress
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33355364
  REMARK    GeneRIF: Coexpression of tissue kallikrein 1 and tissue inhibitor
            of matrix metalloproteinase 1 improves myocardial
            ischemiareperfusion injury by promoting angiogenesis and inhibiting
            oxidative stress.
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Lin,Y., Huang,G., Jin,Y., Fang,M. and Lin,D.
  TITLE     Effects and mechanism of urinary kallidinogenase in the survival of
            random skin flaps in rats
  JOURNAL   Int Immunopharmacol 74, 105720 (2019)
   PUBMED   31299611
  REMARK    GeneRIF: these findings suggest that urinary kallidinogenase
            attenuated flap ischemia and increased the survival of random skin
            flaps in rats
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Zhu,P., Yu,H., Huang,S., Xiang,H., Li,F. and Zheng,W.
  TITLE     Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of
            matrix metalloproteinase 1 co-expression vector on the
            proliferation of rat vascular smooth muscle cells
  JOURNAL   Mol Med Rep 12 (4), 5671-5678 (2015)
   PUBMED   26252163
  REMARK    GeneRIF: Tissue kallikrein 1 and TIMP1 expressed in a coexpression
            vector synergistically inhibited the proliferation of rat vascular
            smooth muscle cells.
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Son,D.N., Li,L., Katsuyama,H., Komatsu,N., Saito,M., Tanii,H. and
            Saijoh,K.
  TITLE     Abundant expression of Kallikrein 1 gene in human keratinocytes was
            mediated by GATA3
  JOURNAL   Gene 436 (1-2), 121-127 (2009)
   PUBMED   19232384
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Azurmendi,P.J., Oddo,E.M., Obika,L.F., Corbera,N.L., Martin,R.S.,
            Ibarra,F.R. and Arrizurieta,E.E.
  TITLE     Gonadectomy influences blood pressure through the kallikrein-kinin
            system
  JOURNAL   Kidney Blood Press Res 32 (5), 342-348 (2009)
   PUBMED   19816038
  REMARK    GeneRIF: Gonadectomy influences blood pressure through the
            kallikrein-kinin system.
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Elmoujahed,A., Gutman,N., Brillard,M. and Gauthier,F.
  TITLE     Substrate specificity of two kallikrein family gene products
            isolated from the rat submaxillary gland
  JOURNAL   FEBS Lett 265 (1-2), 137-140 (1990)
   PUBMED   2194829
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Brady,J.M. and MacDonald,R.J.
  TITLE     The expression of two kallikrein gene family members in the rat
            kidney
  JOURNAL   Arch Biochem Biophys 278 (2), 342-349 (1990)
   PUBMED   2183721
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Wines,D.R., Brady,J.M., Pritchett,D.B., Roberts,J.L. and
            MacDonald,R.J.
  TITLE     Organization and expression of the rat kallikrein gene family
  JOURNAL   J Biol Chem 264 (13), 7653-7662 (1989)
   PUBMED   2708383
REFERENCE   9  (bases 1 to 910)
  AUTHORS   Chen,Y.P., Chao,J. and Chao,L.
  TITLE     Molecular cloning and characterization of two rat renal kallikrein
            genes
  JOURNAL   Biochemistry 27 (19), 7189-7196 (1988)
   PUBMED   2849988
REFERENCE   10 (bases 1 to 910)
  AUTHORS   Kato,H., Nakanishi,E., Enjyoji,K., Hayashi,I., Oh-ishi,S. and
            Iwanaga,S.
  TITLE     Characterization of serine proteinases isolated from rat
            submaxillary gland: with special reference to the degradation of
            rat kininogens by these enzymes
  JOURNAL   J Biochem 102 (6), 1389-1404 (1987)
   PUBMED   3482210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM061085.1, SRR26643287.1062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000001.1  103779152-103779275
            125-284             JAXUCZ010000001.1  103781121-103781280
            285-571             JAXUCZ010000001.1  103782189-103782475
            572-708             JAXUCZ010000001.1  103782572-103782708
            709-910             JAXUCZ010000001.1  103783069-103783270
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..910
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /note="kallikrein 1"
                     /db_xref="GeneID:24523"
                     /db_xref="RGD:2969"
     exon            1..124
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..864
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /EC_number="3.4.21.35"
                     /note="glandular kallikrein-7, submandibular/renal; renal
                     kallikrein; esterase B; proteinase A; kallikrein 1-related
                     peptidase C7; tissue kallikrein; kallikrein-related
                     protein K1; kallikrein 5; kallikrein 7; Kallikrein 1,
                     renal/pancreas/salivary; kallikrein 1-like peptidase;
                     kallikrein a3"
                     /codon_start=1
                     /product="kallikrein 1 precursor"
                     /protein_id="NP_036725.2"
                     /db_xref="GeneID:24523"
                     /db_xref="RGD:2969"
                     /translation="MWFLILFLDLSLGQIDAAPPGQSRVIGGYKCEKNSQPWQVALYS
                     FSKYLCGGVLIDPSWVITAAHCSSNNYQVWLGRNNLLEDEPFAQHRLVSQSFPHPDYK
                     PFLMRNHTRKPGDDHSNDLMLLHLSQPADITDGVKVIDLPTEEPKVGSTCLASGWGST
                     KPLIWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCTGDSGGPLL
                     CDGVLQGITSWGSVPCAKTNMPAIYTKLIKFTSWIKEVMKENP"
     exon            125..284
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /inference="alignment:Splign:2.1.0"
     exon            285..571
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /inference="alignment:Splign:2.1.0"
     exon            572..708
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /inference="alignment:Splign:2.1.0"
     exon            709..910
                     /gene="Klk1"
                     /gene_synonym="Kal; KALA; Klk1c7; Klk1l; Klk5; Klk7;
                     Klna3; RATKALA; RGK-7; RSKG-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggagttt ttaaaggctc cccaaggagg ctcctcagct ccaagatcac cacctgctgc
       61 ccctggacac ctgataccat gtggttcctg atcctattcc tcgacctgtc cctggggcag
      121 attgatgctg cacctcccgg ccagtctcgg gttattggag gatataaatg tgagaagaat
      181 tcccaaccct ggcaagtggc tctatacagc ttcagcaaat acctctgcgg gggtgtcctg
      241 atagacccca gctgggtgat cacggctgcc cactgctcta gcaacaatta ccaggtttgg
      301 ctgggccgaa acaacctatt agaagatgaa ccatttgctc agcaccggct tgtcagtcaa
      361 agcttccctc accctgacta caaaccattc ctcatgagga accacacccg aaaacctggc
      421 gatgaccaca gcaatgatct gatgctgcta catctcagcc agcctgcgga catcacagat
      481 ggggtgaagg tcatcgatct gcccactgag gagcccaagg tggggagcac ctgccttgcc
      541 tcaggctggg gcagtaccaa accccttata tgggaattcc ctgatgatct ccagtgtgtg
      601 aacatccacc tactgtctaa tgagaagtgc atcaaagcct acaaagaaaa ggtgacagat
      661 ctgatgctgt gtgcaggaga gttggaagga ggcaaagaca cttgcacggg tgactcagga
      721 ggccccctcc tctgtgatgg tgtgctccag ggcatcacat catggggctc tgtcccatgc
      781 gccaaaacca acatgccagc catctacacc aaacttatta agttcacctc ctggataaaa
      841 gaagttatga aggaaaaccc ctgagtgtca cactgtcccc tggtctcaat aaaacccatc
      901 atgcagcaca
//
