LOCUS       NM_001012187            2878 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus kelch-like family member 7 (Klhl7), mRNA.
ACCESSION   NM_001012187 XM_342616
VERSION     NM_001012187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Angius,A., Uva,P., Buers,I., Oppo,M., Puddu,A., Onano,S.,
            Persico,I., Loi,A., Marcia,L., Hohne,W., Cuccuru,G., Fotia,G.,
            Deiana,M., Marongiu,M., Atalay,H.T., Inan,S., El Assy,O.,
            Smit,L.M., Okur,I., Boduroglu,K., Utine,G.E., Kilic,E., Zampino,G.,
            Crisponi,G., Crisponi,L. and Rutsch,F.
  TITLE     Bi-allelic Mutations in KLHL7 Cause a Crisponi/CISS1-like Phenotype
            Associated with Early-Onset Retinitis Pigmentosa
  JOURNAL   Am J Hum Genet 99 (1), 236-245 (2016)
   PUBMED   27392078
  REMARK    Erratum:[Am J Hum Genet. 2018 Apr 5;102(4):713. doi:
            10.1016/j.ajhg.2018.03.020.. PMID: 29625027]
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Kigoshi,Y., Tsuruta,F. and Chiba,T.
  TITLE     Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by
            autosomal dominant retinitis pigmentosa causative mutation
  JOURNAL   J Biol Chem 286 (38), 33613-33621 (2011)
   PUBMED   21828050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083903.1.
            
            On Feb 11, 2005 this sequence version replaced XM_342616.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083903.1, SRR8487230.131692.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2878
                     /gene="Klhl7"
                     /note="kelch-like family member 7"
                     /db_xref="GeneID:362303"
                     /db_xref="RGD:1305564"
     exon            1..145
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1786
                     /gene="Klhl7"
                     /note="kelch-like 7"
                     /codon_start=1
                     /product="kelch-like protein 7"
                     /protein_id="NP_001012187.1"
                     /db_xref="GeneID:362303"
                     /db_xref="RGD:1305564"
                     /translation="MATSGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQRTLC
                     DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA
                     YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE
                     LKSTADDFIHQHFTEVYKTDEFLQLDVKRVTHLLSQDTLTVRAEDQVYDAAVRWLKYD
                     EPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED
                     REELAGGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW
                     DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV
                     GNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLSS
                     CEVYDPATETWTELCSMIEPRKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW
                     KMVSPMPWRGVTVKCAAVGSVIYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPV
                     TSCLICVVDTCGANEETLET"
     exon            146..248
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            249..342
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            343..467
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            468..643
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            644..818
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            819..961
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1202
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1404
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1502
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..2856
                     /gene="Klhl7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaacccgca gagggcaagg agaggatggc cacctcgggc gtggagaaga gtagcaagaa
       61 gaaaaccgag aagaaacttg cggctcgcga agaagccaag ctgctggcgg ggttcatggg
      121 cgtcatgaac aacatgagga agcagagaac attatgtgat gtgatcctca tggtccagga
      181 aagaaagata cctgctcacc gtgttgtcct ggctgcagcc agtcacttct ttaacttaat
      241 gttcacaact aacatgcttg agtctaagtc cttcgaagta gaactcaaag atgccgagcc
      301 tgatattatt gaacagctgg tggaattcgc ctacactgcg agaatttctg tgaatagcaa
      361 caatgttcag tctttgttag atgcagcaaa tcagtaccag attgagcctg tgaagaaaat
      421 gtgtgttgat tttttgaaag aacaagttga tgcttcaaat tgtcttggta taagtgtgct
      481 tgcggagtgt ctggactgtc ccgagctgaa gtctacagcc gacgacttca tccatcagca
      541 cttcactgaa gtttacaaaa ctgacgaatt tctacagctt gacgtcaagc gagtgacaca
      601 tcttctcagc caggacaccc tgactgtgag agcagaggat caggtctacg acgctgcagt
      661 gaggtggttg aaatatgacg agcccaatcg tcagccgttt atggttgata tccttgctaa
      721 agtcaggttt cctcttatat cgaagaattt cctaagtaaa acagtacaag ctgaacctct
      781 tattcaagat aatcctgaat gccttaaaat ggtgatcagt ggaatgaggt accatctgct
      841 gtctcctgag gatcgggaag aacttgcagg gggcacaagg cctagaagaa agaaacatga
      901 ttaccgcata gctctgttcg gaggctccca gccacaatcc tgtagatatt ttaacccaaa
      961 ggattacagt tggacagaca ttcgctgccc ctttgaaaaa cgaagagatg cagcttgtgt
     1021 gttttgggac aacgtagtgt acattttggg aggttctcag cttttcccca taaagcgaat
     1081 ggattgctac aatgttgtaa aggatagctg gtattccaaa ctgggacctc caacacctcg
     1141 agacagcctt gctgcctgtg ctgcagaagg caaaatttat acatctggag gttcagaagt
     1201 aggaaactca gccctgtatt tgtttgagtg ctatgatacc agaactgaga gctggcacac
     1261 gaagcccagc atgctgactc agcgctgcag ccatgggatg gtggaggcca atggcctcat
     1321 ctatgtgtgt ggcggaagct tgggaaacaa tgtttctggg agagtgttga gttcctgtga
     1381 ggtgtatgat cctgccacag aaacatggac tgagctgtgt tcaatgattg agcccaggaa
     1441 gaatcatggg ctggtgtttg taaaggacaa gatatttgct gttggtggtc agaatggttt
     1501 agggggcctg gacaacgtgg agtattatga catcaagtta aatgaatgga agatggtgtc
     1561 accgatgccg tggaggggcg tgacagtgaa gtgtgcagca gttggctctg tcatctatgt
     1621 cctggcaggg tttcagggtg taggccgatt ggggcacatc cttgaataca acactgagac
     1681 agacaagtgg gtagccaact ccaaagtccg cgctttccca gtcacaagct gtttgatttg
     1741 tgtggttgat acctgcgggg caaacgaaga gaccctggaa acatgagggg acggtgaacg
     1801 gactccggtc atctgaaact tagacatatg gccgccagtg gtttagtcca agagttcggt
     1861 tatgaagttc tgatctagta ttttgataaa gtaagattcc agtaagatat cagtttatat
     1921 catctggacc tccttactta attcaaagac catattttag ttggccatat aaccaagaac
     1981 ctatcagcca gaaaacgtga aaagttgcaa gcacttcttg caaacaggaa tcgcaactgt
     2041 gtaaccgatt gtggcagagt ggggcatgct catcagagaa gtagcctcag cttagctcta
     2101 gattctattt tcctaattgt gtccgtgctg tgtagttagg tctttttgtt tctggttggt
     2161 cgagaactaa gtagtagtat gaattacaat ccgagatggt aaactctgat gatagagaaa
     2221 ctataatagt gttatgtgtt ttgcttgtct tcatttattt catttagtgc caaattactc
     2281 cattttaaag taagcaagag cagctcaaac atgtatatct tctcacaaaa catcacagat
     2341 ttgggggact taacactgta cccaagtact cataaaatat attcagtcca attaaatgaa
     2401 atattacaca tttctgtata aaatattaag cttagcaccc atcgttaatt tatatggttt
     2461 tactgaacag tgtgaaaagt gctgtatgtc ctcattccct actgcgagag ccaatcagta
     2521 agaacagtta accaacagaa gaaatgctgt ttgaagaaat ttctagatta ctagaaaagc
     2581 actgataatt tagcccagaa tcatatggat cttaaaagat acgttttttt ttctctctct
     2641 tagcagaaca tgttagagat aactgagttt tctctaaaag ttttgtaata attggcatta
     2701 aatatatcac tattcattgc ttttatttgg acaacaaatt accaaacaga ctataaattt
     2761 tcccagcaat gttttaccct ttgactatgt atgaaatgtg ccatgttaaa ctgtcaatca
     2821 atgtttttat ccgatattaa atatttttaa cttaaaaaaa aaaaaaaaaa aaaaaaaa
//
