LOCUS       NM_057191               2291 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus kelch-like family member 41 (Klhl41), mRNA.
ACCESSION   NM_057191
VERSION     NM_057191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Gupta,V.A., Ravenscroft,G., Shaheen,R., Todd,E.J., Swanson,L.C.,
            Shiina,M., Ogata,K., Hsu,C., Clarke,N.F., Darras,B.T., Farrar,M.A.,
            Hashem,A., Manton,N.D., Muntoni,F., North,K.N., Sandaradura,S.A.,
            Nishino,I., Hayashi,Y.K., Sewry,C.A., Thompson,E.M., Yau,K.S.,
            Brownstein,C.A., Yu,T.W., Allcock,R.J., Davis,M.R.,
            Wallgren-Pettersson,C., Matsumoto,N., Alkuraya,F.S., Laing,N.G. and
            Beggs,A.H.
  TITLE     Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated
            Ubiquitination as an Alternate Pathway to Myofibrillar Disruption
            in Nemaline Myopathy
  JOURNAL   Am J Hum Genet 93 (6), 1108-1117 (2013)
   PUBMED   24268659
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   du Puy,L., Beqqali,A., van Tol,H.T., Monshouwer-Kloots,J.,
            Passier,R., Haagsman,H.P. and Roelen,B.A.
  TITLE     Sarcosin (Krp1) in skeletal muscle differentiation: gene expression
            profiling and knockdown experiments
  JOURNAL   Int J Dev Biol 56 (4), 301-309 (2012)
   PUBMED   22562206
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Paxton,C.W., Cosgrove,R.A., Drozd,A.C., Wiggins,E.L., Woodhouse,S.,
            Watson,R.A., Spence,H.J., Ozanne,B.W. and Pell,J.M.
  TITLE     BTB-Kelch protein Krp1 regulates proliferation and differentiation
            of myoblasts
  JOURNAL   Am J Physiol Cell Physiol 300 (6), C1345-C1355 (2011)
   PUBMED   21368295
  REMARK    GeneRIF: Data show that both knockdown and overexpression of Krp1
            inhibit myoblast differentiation assessed by expression of
            myogenin, MEF2C, MHC, and cell fusion.
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Gray,C.H., McGarry,L.C., Spence,H.J., Riboldi-Tunnicliffe,A. and
            Ozanne,B.W.
  TITLE     Novel beta-propeller of the BTB-Kelch protein Krp1 provides a
            binding site for Lasp-1 that is necessary for pseudopodial
            extension
  JOURNAL   J Biol Chem 284 (44), 30498-30507 (2009)
   PUBMED   19726686
  REMARK    GeneRIF: binding sites necessary for Krp1-Lasp1 interaction in
            vitro and function in vivo.
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Wang,X.J. and Zhang,D.D.
  TITLE     Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational
            level
  JOURNAL   PLoS One 4 (5), e5492 (2009)
   PUBMED   19424503
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Spence,H.J., McGarry,L., Chew,C.S., Carragher,N.O.,
            Scott-Carragher,L.A., Yuan,Z., Croft,D.R., Olson,M.F., Frame,M. and
            Ozanne,B.W.
  TITLE     AP-1 differentially expressed proteins Krp1 and fibronectin
            cooperatively enhance Rho-ROCK-independent mesenchymal invasion by
            altering the function, localization, and activity of
            nondifferentially expressed proteins
  JOURNAL   Mol Cell Biol 26 (4), 1480-1495 (2006)
   PUBMED   16449658
  REMARK    GeneRIF: Krp1, the AP-1 up-regulated protein that has a role in
            pseudopodial elongation in v-Fos-transformed fibroblast cells,
            forms a novel interaction with the nondifferentially expressed
            actin binding protein Lasp-1.
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Zhang,D.D., Lo,S.C., Sun,Z., Habib,G.M., Lieberman,M.W. and
            Hannink,M.
  TITLE     Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for
            Cul3, targets Keap1 for degradation by a proteasome-independent
            pathway
  JOURNAL   J Biol Chem 280 (34), 30091-30099 (2005)
   PUBMED   15983046
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Lu,S., Carroll,S.L., Herrera,A.H., Ozanne,B. and Horowits,R.
  TITLE     New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected
            by yeast two-hybrid screening: implications for myofibril assembly
  JOURNAL   J Cell Sci 116 (Pt 11), 2169-2178 (2003)
   PUBMED   12692149
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Lim,D.S., Roberts,R. and Marian,A.J.
  TITLE     Expression profiling of cardiac genes in human hypertrophic
            cardiomyopathy: insight into the pathogenesis of phenotypes
  JOURNAL   J Am Coll Cardiol 38 (4), 1175-1180 (2001)
   PUBMED   11583900
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Spence,H.J., Johnston,I., Ewart,K., Buchanan,S.J., Fitzgerald,U.
            and Ozanne,B.W.
  TITLE     Krp1, a novel kelch related protein that is involved in pseudopod
            elongation in transformed cells
  JOURNAL   Oncogene 19 (10), 1266-1276 (2000)
   PUBMED   10713668
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057191.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ293948.1, SRR26643296.9214.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1110              JAXUCZ010000003.1  74842118-74843227
            1111-1268           JAXUCZ010000003.1  74846510-74846667
            1269-1376           JAXUCZ010000003.1  74846771-74846878
            1377-1562           JAXUCZ010000003.1  74849384-74849569
            1563-1709           JAXUCZ010000003.1  74850674-74850820
            1710-2291           JAXUCZ010000003.1  74854663-74855244
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2291
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /note="kelch-like family member 41"
                     /db_xref="GeneID:117537"
                     /db_xref="RGD:620852"
     CDS             1..1821
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /note="kelch repeat and BTB domain-containing protein 10;
                     kel-like protein 23; kelch-related protein 1; sarcomeric
                     muscle protein; kelch repeat and BTB (POZ) domain
                     containing 10; kelch-like 41"
                     /codon_start=1
                     /product="kelch-like protein 41"
                     /protein_id="NP_476539.1"
                     /db_xref="GeneID:117537"
                     /db_xref="RGD:620852"
                     /translation="MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSF
                     PCHRLILSACSPYFREYFLSEIEEEKKKEMALDNVDPAILDLIIKYLYSASIDLNDGN
                     VQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSD
                     RFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEV
                     FDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKSAEKGGTG
                     EVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIP
                     RNHSSIVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVSSEWVGLPPLPSARCLFG
                     LGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIY
                     CLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGL
                     SASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVN
                     DIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL"
     exon            1..1110
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1268
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1376
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1562
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1709
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..2291
                     /gene="Klhl41"
                     /gene_synonym="Kbtbd10; Krp1; Sarcosin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggattccc agcgggagct tgcagaggaa ctccggcttt accaatccac ccttcttcag
       61 gatggtctaa aagatctcct ggaagagaaa aaattcatcg attgtaccct aaaagcaggt
      121 gacaaaagtt ttccttgcca cagactgata ttgtcggctt gtagccctta cttccgtgag
      181 tatttcttat ctgaaattga ggaggagaag aaaaaggaga tggcgctaga caatgtagat
      241 cctgctatac ttgatttgat catcaaatac ctgtactctg ccagtattga tctcaatgac
      301 gggaacgtgc aagacatctt cgccctgtcc agccgcttcc agattccgtc ggtgttcacc
      361 gtctgtgtgt cttaccttca gaaaagactg gctcctggta actgtctggc catcctaaga
      421 ttggggcttc ttctcgactg tccaagactt gccatttctg cccgggagtt tgtgtcagat
      481 cgctttgtgc agatttgtaa ggaagaagac ttcatgcaac tgtccccaca ggagctgatc
      541 tctgtcattt caaatgacag cctcaatgta gaaaaggagg aagtggtatt tgaggccgtg
      601 atgaaatggg tacggacaga caaagaaaac agggcgaaaa atcttagtga agtatttgac
      661 tgtattcgtt ttcgccttat ggctgagaaa tatttcaaag atcatgtcga gaaggatgac
      721 ataattaaaa gcaacccaga agtccagaaa aaaatcaaag ttctaaagga cgcttttgca
      781 ggcaaacttc cggaacccag caaaagcgca gagaaagggg ggacgggcga ggtgaacggt
      841 gatgttggtg atgaagactt acttcctggt tacctgaatg atatccccag gcatggaatg
      901 ttcgtcaaag atctcatcct cttggtcaat gacacagctg cagtggcgta tgaccccatg
      961 gaaaatgagt gttatcttac tgccctagct gagcagatcc ccagaaatca ttccagtatt
     1021 gttacccaac agaaccaggt ctacgtggtc ggaggactgt acgtggacga agagaataaa
     1081 gatcaacccc tgcaatccta ctttttccag cttgataacg tatcatctga gtgggttgga
     1141 ctaccgcctc tcccgtcagc caggtgcctc tttggtctgg gagaggtaga tgacaaaatc
     1201 tatgtggtcg ccggcaaaga ccttcagaca gaggcctccc tggattccgt gttatgctat
     1261 gatcctgtgg ctgcaaagtg gagcgaagtg aaaaatcttc ctattaaagt ttatggccat
     1321 aatgtgatct cacataatgg gatgatatac tgtctgggcg gaaagacaga tgacaaaaag
     1381 tgtacgaata gggtgtttat ctacaacccc aagaaaggag actggaagga tctggctcca
     1441 atgaaaaccc ctcgttccat gtttggagtg gcaatccaca aaggcaaaat cgtgatcgca
     1501 ggaggcgtca ctgaagatgg cctttcagct tcagttgaag ccttcgacct caaaaccaat
     1561 aagtgggaag tgatgacgga atttccccaa gaaagaagct ccatcagcct ggtgagcctg
     1621 gccggatccc tgtacgccat cggcggcttt gcgatgattc agttggaatc taaagagttc
     1681 gcgcccactg aagtcaatga catatggaag tatgaagatg ataaaaaaga atgggctggg
     1741 atgctgaagg agattcgata tgcttcggga gctagttgcc tagcaacacg cttaaatctg
     1801 tttaaactgt ctaaactata aaggaggtga caaagacacg gtttgagagg tggcttgttg
     1861 ggacaagagg gccttaatgt attgtccttc tttaagccta tacaatgatt catgtagggt
     1921 tacattgatc tgtgcagttc ccgggagata aaacagtgta accgaatccc aaggtgtttt
     1981 agcgtgtgga gtataaaacc gtttgctagg gagttagtat acagttgaac aatgtatttt
     2041 gtcaaacctt tctcatagaa gcgagctttc tacatcctga tgtttactaa tcctttgtat
     2101 tcttaaggta catttacact tgttttctat tataaatgaa atgcatatgt ctacactctc
     2161 aagagatgtt tgagtaacag aaacctctcc ccggttttga gctacgacag gaatcttgtg
     2221 cattttaatg aagatgactg gaagtgctgt ttaagaagtg taataaagga gtgtccagtc
     2281 ccttccccat t
//
