LOCUS       NM_001108195            2346 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus kelch-like family member 40 (Klhl40), mRNA.
ACCESSION   NM_001108195 XM_001078108 XM_006244106 XM_236723
VERSION     NM_001108195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Garg,A., O'Rourke,J., Long,C., Doering,J., Ravenscroft,G.,
            Bezprozvannaya,S., Nelson,B.R., Beetz,N., Li,L., Chen,S.,
            Laing,N.G., Grange,R.W., Bassel-Duby,R. and Olson,E.N.
  TITLE     KLHL40 deficiency destabilizes thin filament proteins and promotes
            nemaline myopathy
  JOURNAL   J Clin Invest 124 (8), 3529-3539 (2014)
   PUBMED   24960163
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Bowlin,K.M., Embree,L.J., Garry,M.G., Garry,D.J. and Shi,X.
  TITLE     Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage
  JOURNAL   Differentiation 86 (4-5), 184-191 (2013)
   PUBMED   24361185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006244106.4, NM_001108195.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1463623.1,
                                           SRR26360190.2288255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1238              JAXUCZ010000008.1  130318793-130320030
            1239-1399           JAXUCZ010000008.1  130320811-130320971
            1400-1507           JAXUCZ010000008.1  130321270-130321377
            1508-1693           JAXUCZ010000008.1  130321479-130321664
            1694-1840           JAXUCZ010000008.1  130323035-130323181
            1841-2346           JAXUCZ010000008.1  130323804-130324309
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2346
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /note="kelch-like family member 40"
                     /db_xref="GeneID:316088"
                     /db_xref="RGD:1305368"
     exon            1..1238
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1952
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /note="kelch repeat and BTB domain-containing protein 5;
                     kelch repeat and BTB (POZ) domain containing 5; kelch-like
                     40"
                     /codon_start=1
                     /product="kelch-like protein 40"
                     /protein_id="NP_001101665.2"
                     /db_xref="GeneID:316088"
                     /db_xref="RGD:1305368"
                     /translation="MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREF
                     PCHRLVLAACSPYFRARFLAEPDGAGELRLEEVSPDVVSQVLHYLYTSEIALDEASVQ
                     DLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARF
                     PLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDADVQAEHQRALP
                     TVFESIRCRLLPRAFLESRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKG
                     EQTARTKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPA
                     ANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEW
                     LGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPY
                     AVYGHSVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMKTARSLFGATVH
                     DGRIFVAAGVTDTGLTSSTEVYSIADNKWTPFEAFPQERSSLSLVSLAGTLYALGGFA
                     TLETESGELVPTELNDIWRFNEDEKKWEGVLREIAYAAGATFLPVRLNVLRLTKM"
     exon            1239..1399
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1507
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1693
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1840
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2346
                     /gene="Klhl40"
                     /gene_synonym="Kbtbd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcagtgc actgccccac aggagagcag aggtgtgcag ggcagccctt gacaaacaga
       61 cttgctgagt tccagagagc cgcaccatga cgctgggctt ggagcaggcg gaggagcagc
      121 gtctgtacca gcagacgctc ctgcaggatg gcctcaagga catgctggac cacggcaagt
      181 tcctggactg cgtagtgcgt gtgggtgagc gcgagttccc gtgccaccgc ctggtgctgg
      241 ctgcctgcag cccctacttc cgtgcgcgtt tcctggctga gccagatggc gcgggagagc
      301 tacgcctgga ggaggtgtcg cctgatgtag tgtcccaggt gctgcactac ctgtacacat
      361 cggagatcgc gctggacgag gcaagcgttc aggacctgtt tgccgcggcg catcgattcc
      421 agatcccgtc catcttcacc atctgcgtgt cgttcctgca gaagcgcctg tgcttggcta
      481 attgcctggc tgtcttccgc ctcggcctcc tgctggactg tgcgcgtcta gctgtggccg
      541 cgcgcgactt catctgcgca cgtttcccgc tggtggcacg cgacaacgac ttcctgggac
      601 tctcagctga tgagctgatc gccatcatct ccagcgatgg cctcaacgtg gagaaggagg
      661 aggcagtgtt cgaggctgtg atgcgctggg ccagcagcgg cgatgccgat gtgcaggccg
      721 agcaccagcg tgcgttgccc acggtcttcg agagcattcg ctgccgcctg ctgcctcgtg
      781 ctttcctgga gagccgcgtg gagcgccacc cacttgtgcg ctcccagcct gagctgttgc
      841 gcaaggtaca gatggtgaag gacgcacacg agggccgcct cactacgctg cgcaagaaaa
      901 agaaggagaa gggtgagcag acagctcgga ccaaggaggc caaccagggc acagaagaca
      961 ccaaggctga ggatgatgag gaacgagtgc tgcccgggat actcaatgat actctgcgct
     1021 tcggcatgtt cctgcaggat ctcatcttca tgatcagcga ggagggcgct gtggcgtacg
     1081 acccagctgc caacgagtgc tactgtgcat ccctgtccac ccagatcccc aaaaaccatg
     1141 tcagtctcgt gaccaaggag aaccaagtct tcgtggccgg tggcctcttc tacaacgagg
     1201 acaacaagga agaccctatg agtgcttact tcctgcagtt tgaccacttg gactctgagt
     1261 ggctggggat gccgcctctc ccctcacctc gctgcctctt cggcctgggg gaggctctta
     1321 atgccatcta cgtggtcggc ggccgggagc tcaaggacag cgaagacagc ctggactcag
     1381 tcctgtgcta cgacaggctg tcattcaaat ggggtgagtc agacccgctg ccctatgcgg
     1441 tttacggcca ttccgtgctt tcacacatgg accttgtcta tgtcattggc ggcaaaggca
     1501 aagacaggaa atgtctgaac aagatgtgtg tctacgaccc caagaagttt gagtggaagg
     1561 agctagcacc catgaagaca gcccgctcac tctttggggc caccgtccat gatggccgca
     1621 tctttgtggc tgcaggggtg acagacacag ggcttaccag ctccacagag gtgtacagca
     1681 tcgcagacaa caagtggacc ccctttgagg ccttccctca ggaacgcagc tcgctcagcc
     1741 tggtcagcct ggctggcacc ctttacgccc tgggcggctt tgccactctg gagacggagt
     1801 ctggagagct ggtccccacg gagctcaatg acatatggag attcaatgag gatgagaaaa
     1861 aatgggaggg ggtcctacga gagatcgcct acgcggccgg agccaccttc ctccctgtgc
     1921 gcctcaacgt gcttcgcctg accaagatgt gaccagtgca ggaccctcac tgagccttcc
     1981 tcctgtcctg tggcctcaga aaaaaaagca tcgtgggact cagagtggat ctgggagagg
     2041 ccagagccct tctggttccc agtatgagtc agaaagggta ctccagtcag gaaagggaca
     2101 ttgctacctg ctttccggtg tccctctggg gtcgccatgt cttctcaagg actgcaaagc
     2161 tacaggcagg catcctagat tgtgtcttgg ccctgcccgg gctggctgtg tgtgccatac
     2221 agtctcttga gggactcagt gcccgtgcca gtcagatggg agtgtctccg tcgatggcac
     2281 cttcttgtgc taacccagac ctcccttagg aatctcagga acaataaagt gctttctgag
     2341 catcta
//
