LOCUS       NM_001394229            4693 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kelch-like family member 24 (Klhl24), transcript
            variant 1, mRNA.
ACCESSION   NM_001394229 XM_039088274
VERSION     NM_001394229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4693)
  AUTHORS   He,Y., Maier,K., Leppert,J., Hausser,I., Schwieger-Briel,A.,
            Weibel,L., Theiler,M., Kiritsi,D., Busch,H., Boerries,M.,
            Hannula-Jouppi,K., Heikkila,H., Tasanen,K., Castiglia,D.,
            Zambruno,G. and Has,C.
  TITLE     Monoallelic Mutations in the Translation Initiation Codon of KLHL24
            Cause Skin Fragility
  JOURNAL   Am J Hum Genet 99 (6), 1395-1404 (2016)
   PUBMED   27889062
REFERENCE   2  (bases 1 to 4693)
  AUTHORS   Lin,Z., Li,S., Feng,C., Yang,S., Wang,H., Ma,D., Zhang,J., Gou,M.,
            Bu,D., Zhang,T., Kong,X., Wang,X., Sarig,O., Ren,Y., Dai,L.,
            Liu,H., Zhang,J., Li,F., Hu,Y., Padalon-Brauch,G., Vodo,D.,
            Zhou,F., Chen,T., Deng,H., Sprecher,E., Yang,Y. and Tan,X.
  TITLE     Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of
            keratin 14 and human skin fragility
  JOURNAL   Nat Genet 48 (12), 1508-1516 (2016)
   PUBMED   27798626
REFERENCE   3  (bases 1 to 4693)
  AUTHORS   Laezza,F., Wilding,T.J., Sequeira,S., Coussen,F., Zhang,X.Z.,
            Hill-Robinson,R., Mulle,C., Huettner,J.E. and Craig,A.M.
  TITLE     KRIP6: a novel BTB/kelch protein regulating function of kainate
            receptors
  JOURNAL   Mol Cell Neurosci 34 (4), 539-550 (2007)
   PUBMED   17254796
  REMARK    GeneRIF: a novel neuronal protein of the BTB/kelch family, KRIP6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 8, 2021 this sequence version replaced XM_039088274.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219171.1, SRR26643295.44002.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000011.1  94381944-94382050   c
            108-170             JAXUCZ010000011.1  94376595-94376657   c
            171-1151            JAXUCZ010000011.1  94371409-94372389   c
            1152-1336           JAXUCZ010000011.1  94362700-94362884   c
            1337-1455           JAXUCZ010000011.1  94361645-94361763   c
            1456-1644           JAXUCZ010000011.1  94359708-94359896   c
            1645-1833           JAXUCZ010000011.1  94357913-94358101   c
            1834-4693           JAXUCZ010000011.1  94351157-94354016   c
FEATURES             Location/Qualifiers
     source          1..4693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4693
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /note="kelch-like family member 24"
                     /db_xref="GeneID:303803"
                     /db_xref="RGD:727971"
     exon            1..107
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..170
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1151
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2034
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /note="KRIP6; kainate receptor-interacting protein for
                     GluR6; kelch-like 24"
                     /codon_start=1
                     /product="kelch-like protein 24"
                     /protein_id="NP_001381158.1"
                     /db_xref="GeneID:303803"
                     /db_xref="RGD:727971"
                     /translation="MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSS
                     GSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRES
                     REMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE
                     EQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICS
                     DELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQ
                     NSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC
                     YDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVAS
                     LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
                     SCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG
                     GLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYD
                     PATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL"
     exon            1152..1336
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1455
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1644
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1833
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..4693
                     /gene="Klhl24"
                     /gene_synonym="Dre1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatgtttcc tttgttatga gcgagactgg tggtggctcc aggagacagc ggcgctgcag
       61 ggaccgcggg ggtcgccgct cgtgccgctt ccagcctgcg ccgagaggtg tgaaaattta
      121 aataacctga gtactttgcc tggggctttg gtcaaacaaa tgctgagaag ctacataaag
      181 aagatccctc ggagccattt ctcaacaatt atatagtcaa ctgatgtaac aatggtacta
      241 atattgggac gcagattaaa cagagaggat cttggggtgc gtgattcccc agcaaccaag
      301 cgtaaagttt ttgaaatgga ccccaaatct ctgacaggtc atgagtattt tgacttctct
      361 tcaggatcat cccatgctga aaacatcctc cagatattta atgagttccg agacagccgc
      421 ttattcacag atgttattat ctgtgtggaa ggcaaagagt tcccgtgcca tcgagctgtc
      481 ctctcagcct gtagcagcta cttcagagcc atgttctgta atgaccacag ggagagccga
      541 gaaatgctgg ttgagatcaa cggcatttta gccgaagcca tggagtgctt tttgcagtac
      601 gtgtatactg ggaaggtgaa gatcacaacg gagaatgtcc agtatctctt tgaaacctcc
      661 agcctctttc agataagtgt tctccgtgat gcttgcgcca agttcttaga ggagcagctt
      721 gatccttgca actgcttggg aatccagcgt ttcgccgaca cccactcact caaaacactc
      781 ttcacaaagt gcaagacctt tgcattgcag actttcgagg atgtgtccca gcatgaagag
      841 tttctcgagc ttgacaaaga tgaacttatt gattacatct gtagtgatga acttgttatt
      901 ggtaaggaag agatggtttt tgaggcagtc atgcgctggg tctaccgagc ggttgatctg
      961 cgaagaccgc tgctccatga gctcctgacg catgtcaggc ttcctctctt gcaccccaac
     1021 tactttgttc agacagttga ggtggaccag ttgatccaga attcccctga atgctaccag
     1081 ttgttgcacg aagcaagacg gtaccacata cttggcaatg aaatgatgtc cccaaggact
     1141 aggccacgca ggtctactgg ctactcagag gtgatagttg tggttggagg ctgtgaacga
     1201 gttggaggat ttaatcttcc atacactgag tgctatgatc cagtaacagg agaatggaag
     1261 tccttggcca agcttccaga atttaccaaa tcagagtatg ctgtctgtgc actgaggaat
     1321 gacattcttg tttcaggtgg aagaatcaac agccgtgatg tctggattta taactcacag
     1381 ttgaatatct ggatcagagt tgcttctcta aataaaggca gatggcgtca caaaatggct
     1441 gtccttcttg gtaaagtata tgttgttggc ggttatgatg ggcaaaacag acttagcagc
     1501 gtagaatgtt atgattcctt ttcaaatcgt tggacagaag ttgctccact taaagaagcc
     1561 gtgagctctc ctgcggtgac aagctgtata ggaaaattgt ttgtgattgg tgggggaccc
     1621 gatgataata cttgttctga taaggtccaa tcttatgacc cagaaaccaa ttcttggcta
     1681 cttcgtgcag ctatccccat cgccaagagg tgcataacag cagtctcttt aaacaacctg
     1741 atctacgttg ctggtggact gaccaaggcc gtgtattgtt acgatccagt cgaagactac
     1801 tggatgcacg tacaaaacac gttcagccgg caggaaaact gtggtatgtc tgtttgtaat
     1861 ggtaaaatct atatcctggg tggaagacgg gaaaatggag aagccacaga tactattctc
     1921 tgttacgatc ctgcgacaag tatcatcaca ggagtggctg cgatgcccag accagtgtcc
     1981 taccatggct gtgtgactat tcatagatac aatgagaaat gctttaagct ctaacaatac
     2041 ctcacacaag aagccaatgc caatccaaga ggaaagtttt taaaacgacc atgtgcgaac
     2101 acaactttgt gccatctgca aaaaagaaat aaataatcct gttgcctttc tgacccaaac
     2161 accagacttc aagctgtcaa atgtcagtcc ttttctgtaa tggggtgggg tggattacag
     2221 tgagccagga cctgcgtcta tcccagcacc cagaaggcag gtttctatac ttttgaaccc
     2281 agcctggtct gcataaaatg ttctaggcca gcaaaagtaa gaatttggcc tatgattata
     2341 cttttgcatt tttgaaaaac taggtggggt aggcagtaat gcccagtgta aacttcttag
     2401 ggatttgtgg accctctttc aggaatgtgt cctttttttg tcagttttgt agaaaatatt
     2461 gcatgactga agcttcattt aggttgaatt gcctgatgtt aagaatgttt agaactcatt
     2521 gtgaggggag gaaatgagtt tgtttgttcg ttgttttaac catttattta agttatgtgc
     2581 attggtgaaa ggggatcaga tcccttggaa ctagagttac agacagttat gaactgccct
     2641 gccatgtggg tgctggaaat tgaaccccag acctctggaa aaacagaccg tgctcttaac
     2701 cactgaacca tctctctcca gcccccagaa atgagtttta aatatctgtc acggacttta
     2761 tccctgccgg ttaattttat tgaaggcttt ttggggtttt gtttgttttt tcctaattat
     2821 aaaagtgtag taacaattca gctaccataa aacaccaaat tttatgactg tatagactgt
     2881 tctctgatat taaatacttt gtgagcttat gtaggagata gaaaagtaag aaaatttaaa
     2941 ttatacatta gtccctaagg aaaaattaaa gtaactattg aaaaaaaaaa tgtgatccac
     3001 tttggttctc agggtattta atgaatcatc tgtgagtcca ctaaaggagt tcttccctct
     3061 aaactaatct aggagctaac gtcccgctta cgggcaggcg ggtgtctgtg tccagggtgt
     3121 ttcccaggca tggcagtgca cacccgtgtc cagggtctgg aaggtacatc gaaagaaacc
     3181 aaatgggctg gacagagtgt tagtgaacac tcactgctcc cagcccctat caggtggctc
     3241 actaatttct gcagctctaa ttccagggaa tcgtaacacc ttctggcctc cctagatatc
     3301 tacaagcatg tggtgcacat acattcacac aggcacacat gtatgtaaaa gagatatatc
     3361 ttaagacaaa tatgcatttt gtaatactga aaaaaaaaga aagaaaggca agagcaggtt
     3421 tgctccctac ccagtctggc agagtttgat cttacgatgc tttgtgagtg ccactccgct
     3481 cgctcgttca ctgccatgta agcagttgtc agtctaggaa ggctgactga ttccttaaca
     3541 tcctacagtc actcttctca gtggggccac gtgtttgtga ctctgaccag cagcagttct
     3601 ggtcttcaga gagaaatctc ttattgggga gagctctttt atttgtataa aatactgatc
     3661 aacattttca gatttctatt aaagttttcc ctcaggttct tcacctccat tttataaaac
     3721 ttagtacttt tcaaagggaa atgtgaaatt tttcttagaa atataagtaa atacagcagg
     3781 aattagcata actaattatt gtaacttctg tgtggacaga taacgattta caatgcccta
     3841 ggctgcagca ggtctctcac tataatatac tccttgttga tgacaatagt gtcactagat
     3901 ttctgttcac gttaaggcag tcatcaaagc ctagcattgg cagacaactt ctttctcagc
     3961 ttaggagaat acaaacgttt ttaagagtca tgcttaattg gaatccaaat tctgagaaaa
     4021 atgcttacaa ggtatatttg ggaaattgtt gtcacgtcat aaatggtgag taatgtaaca
     4081 cagctaagga agcagctccg aaacagtcat ctgtcagtcg acagacagac gtacggatag
     4141 tcaagggtat ctgtactgta attttatagt aaatatcttc attagacttc tgttagagaa
     4201 tggagattgt ttggttcaga aattcttaaa cagtaaagtg tgtgaataaa ggtgttttat
     4261 aaatgcttag gactctgcag atgctaactg ttatgtatgt gtgtaagatc atgcccattc
     4321 ataaatacat atataaaact cggtcaaaat aaatttgtat cttagtattt ttgtctgttg
     4381 taaaagtatt atctacttgt atcttgtaat gtttatcttt catatatctt gtttattgta
     4441 aattggaaaa aaatcctcaa aatcagaatt tgtttaaaca cattactttt tctttatgtt
     4501 gcaaattata ttaaaagtta ccagaaagta cctgaatcct agaaaattaa ctttttaaag
     4561 atacccagtt gatattttaa cttcctttaa tttcttttct ttgctaattc ttgataaata
     4621 atggtggtaa gccccggttt aagaaaaata attttagagt ataattagtg cattaaaagg
     4681 gatacatcaa cca
//
