LOCUS       NM_001107079            2562 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kelch-like family member 22 (Klhl22), mRNA.
ACCESSION   NM_001107079 XM_001063385 XM_221268
VERSION     NM_001107079.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   2  (bases 1 to 2562)
  AUTHORS   Beck,J., Maerki,S., Posch,M., Metzger,T., Persaud,A., Scheel,H.,
            Hofmann,K., Rotin,D., Pedrioli,P., Swedlow,J.R., Peter,M. and
            Sumara,I.
  TITLE     Ubiquitylation-dependent localization of PLK1 in mitosis
  JOURNAL   Nat Cell Biol 15 (4), 430-439 (2013)
   PUBMED   23455478
REFERENCE   3  (bases 1 to 2562)
  AUTHORS   Maerki,S., Olma,M.H., Staubli,T., Steigemann,P., Gerlich,D.W.,
            Quadroni,M., Sumara,I. and Peter,M.
  TITLE     The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone
            microtubules in anaphase and is required for cytokinesis
  JOURNAL   J Cell Biol 187 (6), 791-800 (2009)
   PUBMED   19995937
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221268.4, XM_001063385.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2562
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /note="kelch-like family member 22"
                     /db_xref="GeneID:303792"
                     /db_xref="RGD:1306288"
     exon            1..31
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     exon            32..294
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1972
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /note="kelch-like 22"
                     /codon_start=1
                     /product="kelch-like protein 22"
                     /protein_id="NP_001100549.1"
                     /db_xref="GeneID:303792"
                     /db_xref="RGD:1306288"
                     /translation="MAEEQDFAQLCKLSTQPSHSHCVNNTYRSTQHSQALLRGLLALR
                     DSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMC
                     QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAE
                     LFDLNRLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL
                     LYHYSMEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLGPSPLRDTVASALMY
                     HRNESLQPSLQGPHTELRSDFQCVVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTAS
                     LAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADL
                     CVCVVGKYIYAVAGRDYHNNLSAVERYDPATNSWEYVAPLKKEVYAHAGTTLQGKMYI
                     TCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNNDAGYR
                     RDVHQVACYSCTSRQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIY
                     DMEKDCWEEGPQLNNSISGLAACVLTLPRSLLHEQPRGTPNRSQADADFASEVMSVSD
                     WEEFDNSSED"
     exon            295..460
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1179
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1372
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1606
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2562
                     /gene="Klhl22"
                     /gene_synonym="RGD1306288"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagagcggc cacagcttgc ggcagcacca gctgactaca gtagtgaggg ctgctgcggc
       61 tgtcaggatg gctgaggagc aggactttgc ccagctgtgc aagctgtcca cacagccctc
      121 ccactcacac tgcgtcaaca atacctatcg aagcacacag cactcccagg ccctgctccg
      181 gggactgctt gctttgcgag acagtgggat cctctttgat gttgtcctgg tggtagaggg
      241 gaggcacatt gaggcccatc ggattctgct ggctgcatca tgtgattact tcagaggaat
      301 gtttgctggg ggattgaagg aaatggagca ggaagaggtc ttgatccatg gtgtgtctta
      361 caatgccatg tgccagatcc tgcacttcat atacacttct gagctagagc tgagcctcag
      421 caatgtgcag gagaccctgg ttgctgcctg ccaacttcag ataccagaaa ttatccactt
      481 ttgctgtgat ttcctcatgt catgggtcga tgaggagaac atccttgatg tttaccggct
      541 ggcagagctc tttgacttga accgtctgac ccaacagcta gatacctaca tcctcaaaaa
      601 ctttgtggcc ttctcaagaa ctgacaagta ccgccagctt cccttggaga aggtctactc
      661 tctcctcagc agcaatcgcc tggaggtttc ctgtgagact gaagtgtatg aaggggccct
      721 gctctaccat tactccatgg aacaggtgca ggctgaccag atctcactgc atgaaccccc
      781 caagctccta gagactgtgc gttttcccct gatggaagct gaggtcctcc agcggctgca
      841 cgacaagctt ggtcctagcc cactgaggga cacagtggcc agtgccctta tgtaccaccg
      901 gaatgagagc ctgcagccca gccttcaggg cccacacaca gagcttcgct cagacttcca
      961 gtgtgttgtg ggctttgggg gcattcactc cacaccatct acaatcctca gtgaccaggc
     1021 caagtacctg aatccccttc tgggagagtg gaaacacttc actgcctctc tagcgccccg
     1081 aatgtccaac cagggcattg cagtgctcaa caacttcgtg tacttaattg gaggggacaa
     1141 taatgtccaa ggattccgag ctgagtcccg atgctggagg tatgacccaa gacacaatcg
     1201 ctggttccag atccagtcct tgcagcagga acatgcagac ttgtgcgtgt gtgtagtggg
     1261 gaagtacatc tacgctgtgg caggccgtga ctaccacaat aacctgagtg ctgtggagcg
     1321 ctatgaccct gccaccaact cctgggaata tgtggcccca ctcaagaagg aggtatatgc
     1381 ccatgcaggc accacgctgc aagggaagat gtacatcacc tgtggtcgca gaggagagga
     1441 ctacctgaaa gagacacact gctatgaccc aggaagcaac acgtggcaca ctctagccga
     1501 tgggcctgtt cgacgcgcct ggcacggcat ggctgcgctc cttgacaagc tgtttgtgat
     1561 tggaggcagc aacaatgatg ccggctacag gagagatgtg caccaggtgg cttgctacag
     1621 ttgtacatct cgtcagtggt catcggtctg cccactgcca gctgggcatg gtgagcctgg
     1681 cattgctgtg ctagacaaca ggatatatgt gctgggcggc cgctctcaca accgaggcag
     1741 ccgcacaggc tacgtgcaca tctacgacat ggagaaagac tgctgggaag agggacccca
     1801 gctgaacaat tccatctcag gcctggcagc ctgtgtgctc accctgcccc gctctctgct
     1861 ccatgagcaa ccccgaggga ctcccaaccg tagccaggca gatgcagact ttgcctctga
     1921 ggtgatgagt gtgtctgact gggaagagtt tgacaactct agcgaggact agggctctcc
     1981 ccagtgtgtg ggtgttcagg aggggtaatg gacagtgaag gccatagagc ttgggttaga
     2041 acaccaggct ccaggggagg ggcccttccc caagccatcc tggttcacca gctgcccttt
     2101 ttcactcttg tttcttcaac tagctggctg ccagcatttg caaactccat gactgtgaat
     2161 tatgttacaa agaaaagtgc tggggaggct atatctgagg gaatgaccag gcccattctc
     2221 tataaactct gaactaatgc tatctatttg gcctcttctc cttagcctgg tccctgacgg
     2281 gttaagtaag gtccttcctg caagaggtcc tggggacagc actcctagcc acagccaaag
     2341 tttgtggctc cccttctgtg aaccatggtc tgtctggtga gcagctccag ctgcctgcag
     2401 ccagggcatt gagcagctgt ggagttctca aggtatatgt actgttagag ataacagtcc
     2461 acctgaaact ggccctaggg atgaagagat acccttatgc tctgtttctg acccaatatt
     2521 gttgaaaaat gaaataaaac attatgcaaa aggtgttgca tc
//
