LOCUS       NM_001419565            3169 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kelch-like family member 2 (Klhl2), mRNA.
ACCESSION   NM_001419565 XM_039095082
VERSION     NM_001419565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3169)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3169)
  AUTHORS   Tseng,L.A. and Bixby,J.L.
  TITLE     Interaction of an intracellular pentraxin with a BTB-Kelch protein
            is associated with ubiquitylation, aggregation and neuronal
            apoptosis
  JOURNAL   Mol Cell Neurosci 47 (4), 254-264 (2011)
   PUBMED   21549840
REFERENCE   3  (bases 1 to 3169)
  AUTHORS   Soltysik-Espanola,M., Rogers,R.A., Jiang,S., Kim,T.A., Gaedigk,R.,
            White,R.A., Avraham,H. and Avraham,S.
  TITLE     Characterization of Mayven, a novel actin-binding protein
            predominantly expressed in brain
  JOURNAL   Mol Biol Cell 10 (7), 2361-2375 (1999)
   PUBMED   10397770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 11, 2023 this sequence version replaced XM_039095082.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55964.1,
                                           SRR26643287.32566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               JAXUCZ010000016.1  29627237-29627557
            322-447             JAXUCZ010000016.1  29643586-29643711
            448-554             JAXUCZ010000016.1  29655088-29655194
            555-676             JAXUCZ010000016.1  29667525-29667646
            677-839             JAXUCZ010000016.1  29699349-29699511
            840-949             JAXUCZ010000016.1  29715844-29715953
            950-1066            JAXUCZ010000016.1  29720388-29720504
            1067-1216           JAXUCZ010000016.1  29721710-29721859
            1217-1334           JAXUCZ010000016.1  29725806-29725923
            1335-1532           JAXUCZ010000016.1  29727722-29727919
            1533-1634           JAXUCZ010000016.1  29728678-29728779
            1635-1763           JAXUCZ010000016.1  29730692-29730820
            1764-1904           JAXUCZ010000016.1  29731332-29731472
            1905-2048           JAXUCZ010000016.1  29736767-29736910
            2049-3169           JAXUCZ010000016.1  29738660-29739780
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..3169
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /note="kelch-like family member 2"
                     /db_xref="GeneID:290692"
                     /db_xref="RGD:1306388"
     exon            1..321
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2077
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /note="kelch-like 2, Mayven; mayven"
                     /codon_start=1
                     /product="kelch-like protein 2"
                     /protein_id="NP_001406494.1"
                     /db_xref="GeneID:290692"
                     /db_xref="RGD:1306388"
                     /translation="MESPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFK
                     VMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEV
                     DGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG
                     IRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEK
                     VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLI
                     EAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWH
                     QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRST
                     LGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY
                     AVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL
                     VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT
                     TDKWTVVSSCMSTGRSYAGVTVIDKPL"
     exon            322..447
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            448..554
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            555..676
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            677..839
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            840..949
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1066
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1216
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1334
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1532
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1634
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1763
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1904
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2048
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..3169
                     /gene="Klhl2"
                     /gene_synonym="RGD1564686"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtggcc gagctgcgcg ctcgaccgct cgctcgcccg cccgtcccgc cgccgccgcc
       61 gtcgccctgc actcggggga gcgcgggagc cgcgccaggc acacgagcgc gcggggccga
      121 cgggccatgg ccgcgggggc cgccgccgca ggtggtggcg cgcggtgagg agcgctgcgc
      181 cccctcgggg cggatggaac acggctgggc gggcggacag tgccggcgtc cgcggctggt
      241 atggtgctgg cggcggcggt cggtgcctgc gttctgaagc ccgcgaggag ccacaatgga
      301 gtcgccgccg ctgcctcccg catgcacaaa gcagggtcat cagaagcccc tcgattcaaa
      361 agatgagaat cctgagaaac actgcccatt gacggtgaac ccttggcaca tgaagaaagc
      421 ctttaaagtc atgaacgaac taagaagtca aaatctgctg tgtgacgtca cgattgtggc
      481 agaggacatg gagattcctg ctcaccgagt ggtgctggcg gcctgcagcc cttacttcca
      541 cgccatgttt acaggggaga tgagcgagag ccgagcaaag agagttcgaa taaaagaggt
      601 cgacggctgg accctgagga tgctaattga ctatgtttac acggcagaaa ttcaggtcac
      661 agaagaaaac gtacaggtcc tcctcccagc agctggcctg ctacagttac aggatgtgaa
      721 gaagacatgc tgtgaattct tagaatccca gcttcaccct gtcaactgct taggaatccg
      781 ggcttttgcc gatatgcatg catgcacaga cctcctgaat aaagccaaca catatgcaga
      841 acaacatttt gcagatgtcg tacttagtga agagtttctc aacctcggca ttgagcaagt
      901 gtgcagctta atctcaagtg ataaactcac catttcctca gaggagaagg tatttgaagc
      961 agtaatagcc tgggtaaacc atgataagga cgtaaggcag gagttcatgg ctcggctcat
     1021 ggagcacgtc cgcttacccc tgcttcctcg ggagtacttg gtgcagaggg ttgaggagga
     1081 agcactggtg aagaacagca gtgcatgcaa agattacctc atcgaagcca tgaagtacca
     1141 cttgctgcca acggagcaac gcatgttaat gaagagcgtg cggacccggc tgaggacacc
     1201 catgaacctt cccaaattga tggtggtggt cgggggccag gcaccaaagg ccatccgaag
     1261 tgtggaatgc tacgacttca aagaggagcg atggcaccag gtggcagagt tgccgtccag
     1321 gaggtgcagg gcagggatgg tgtatatggc ggggctggtc tttgctgtcg gtggcttcaa
     1381 tggctcactg agagttcgca ctgtagattc ctacgaccct gtgaaagacc agtggaccag
     1441 cgtggcaaac atgcgcgacc gaaggagcac gctgggggca gcggtgctga acgggctgct
     1501 gtatgcagtg gggggctttg acggcagcac aggtttatca tctgtggaag catacaacat
     1561 aaaatctaat gagtggtttc atgtcgcgcc aatgaacacc aggaggagca gtgtgggcgt
     1621 tggcgttgtt ggaggtttgc tctatgctgt gggaggttac gatggagctt cacgccagtg
     1681 tcttagcaca gtagaatgct ataatgctac tgccaacgag tggacttaca tagcagaaat
     1741 gagcaccaga cggagtggag caggtgttgg cgtgttaaac aacttattat acgctgtagg
     1801 aggtcatgat ggtcctttag tacgaaaaag tgttgaagta tatgacccca ccacaaatgc
     1861 ctggagacag gtcgcagata tgaacatgtg cagaagaaat gcaggtgtct gcgcagttaa
     1921 tggtctgttg tatgttgtcg gaggagatga cggctcgtgt aacttggcat cagtagagta
     1981 ttataacccc accacagata aatggacagt tgtgtcctct tgtatgagca cggggagaag
     2041 ctacgcaggg gtcacagtta ttgataaacc attatgagcc tgaaggacat tttcagagta
     2101 tcactccgtg agaaccagtc gtcaacaagg atttctgaag ggactgagcc tctccacttg
     2161 tagccgcact ttaagtctca gcagaagacg agaccatcgg ccttcagagg cctcggatac
     2221 tgaagattac ttttggtaga agcactgtgt aggctttctc tgcaccaagc agcagctgac
     2281 tgactttaca agagacctag gccgcagtcc ctccctccac tgtggtcttt aggcagtcgc
     2341 tttcttaaaa actagttctt atcagcttca aatgactatg gattattttg tgaaagagaa
     2401 taaagttaat gtgtgttctt gtaaaattaa gttttatctt tattctttct cctgaaaaat
     2461 ctcctgggaa cagagaatct ttgggacaga ttaaaatcta tgtaagtatt cgacactgtt
     2521 gagggatgaa actgtttgct tttataaata tctttgatta catgactata ataaatcgtg
     2581 tgcatataaa tgtgtgtcta tatgctttcc tttaaatatg tttgaaaaga tgtttgatta
     2641 tctatttata attggcacag tactttgaat tatgccagtc ctacattgta aaacagagtt
     2701 gtattttttg atatttaaca atgcttaaca ctttaaaaac gccacttctg aggaatgaac
     2761 gaaccatggc gtgacacact ttaatatgtg tgatgccaaa cttttttaaa taaaatataa
     2821 attatgctta tttattattt ttctttagtt taatcttgat catgtttttg gtgtgtgttt
     2881 ttaatttttt ttcttaaagt aacacttttg gcatgaacat aacctgcagg tttttttgat
     2941 gaatgtaatg aatgtgtgga attcaactga atttgcatgg tcttaagaat ttttctgtgt
     3001 gtataaattt agctgctatt aatgggagag aaagctttct gtgactaatc atgtgtattg
     3061 agcagatagt ttttctgaga tcttcgatga atctctttaa agatgaccaa catgtgtctt
     3121 tcttgaaata tctttgaata aaagtttgta tattatttgt ttcacaatg
//
