LOCUS       NM_001399325            4456 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kelch-like family member 18 (Klhl18), mRNA.
ACCESSION   NM_001399325 XM_006244005
VERSION     NM_001399325.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Moghe,S., Jiang,F., Miura,Y., Cerny,R.L., Tsai,M.Y. and Furukawa,M.
  TITLE     The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates
            Aurora-A
  JOURNAL   Biol Open 1 (2), 82-91 (2012)
   PUBMED   23213400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006244005.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.33746.1,
                                           SRR26643294.34853.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000008.1  119337569-119337719 c
            152-282             JAXUCZ010000008.1  119306159-119306289 c
            283-423             JAXUCZ010000008.1  119303029-119303169 c
            424-622             JAXUCZ010000008.1  119296779-119296977 c
            623-783             JAXUCZ010000008.1  119293558-119293718 c
            784-920             JAXUCZ010000008.1  119291937-119292073 c
            921-1158            JAXUCZ010000008.1  119289989-119290226 c
            1159-1263           JAXUCZ010000008.1  119286031-119286135 c
            1264-1375           JAXUCZ010000008.1  119282984-119283095 c
            1376-4456           JAXUCZ010000008.1  119279081-119282161 c
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4456
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /note="kelch-like family member 18"
                     /db_xref="GeneID:316012"
                     /db_xref="RGD:1310570"
     exon            1..151
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1762
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /note="kelch-like 18; kelch-like protein 18"
                     /codon_start=1
                     /product="kelch-like protein 18 isoform 2"
                     /protein_id="NP_001386254.1"
                     /db_xref="GeneID:316012"
                     /db_xref="RGD:1310570"
                     /translation="MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKI
                     GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA
                     IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAAN
                     SFIHQHFVEVSLSEEFLALPLEDVLELLSRDELNVKSEEQVFEAALAWIRYDREQRGP
                     CLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAF
                     RTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCHPMTTARSRV
                     GVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV
                     CGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFS
                     SVEQYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQ
                     WCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHE
                     GGVGVGCIPLLTI"
     exon            152..282
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            283..423
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            424..622
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            623..783
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            784..920
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1158
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1263
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1375
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..4456
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttgcgg cggccggtga agatggtgga ggacggcgcg gaggagctgg aagacttggt
       61 gcatttctcc gtgtcggagt tgcctagtcg cggctacggc gtcatggagg agatccggcg
      121 gcagggcaag ctatgcgacg tgacgctcaa gatcggggac cacaaattca gtgctcaccg
      181 gatcgtctta gcggcctcca tcccgtattt ccacgctatg ttcacgaatg acatgatgga
      241 gtgcaagcag gatgagattg taatgcaggg aatggaccca agtgcgctgg aggctctcat
      301 caacttcgct tataatggca accttgctat cgaccagcaa aatgtgcagt cactgttgat
      361 gggggcaagc ttcctgcagc tgcagagcat caaagatgct tgctgcacgt tcctccgaga
      421 gaggcttcac cccaaaaact gcctgggtgt gcgccagttt gctgagacga tgatgtgtgc
      481 tgtgctgtat gatgcagcca acagcttcat ccaccagcac tttgtagagg tgtctctgtc
      541 tgaagagttc ctggccctgc ccctggaaga tgtgcttgag ctgctgtctc gggatgagct
      601 gaatgtgaag tcagaggagc aggtttttga agctgcactg gcctggatca gatatgaccg
      661 ggagcagagg ggaccatgcc tgcctgagct gctgtccaat atccgcctgc ctctttgccg
      721 gccccagttc ttatcagacc gagtgcagca agatgacctg gtacggtgct gtcacaaatg
      781 cagggacctg gtggatgaag caaaggacta tcacctgatg ccagagcgcc ggccccacct
      841 gccagctttc aggactcggc ctcgatgctg cacatccatc gctgggctca tctacgctgt
      901 ggggggcctc aactcagcag caaattttta tgcaggtgat tccctgaatg tggtggaagt
      961 gttcgaccct atcgccaatc gctgggaaaa gtgccacccc atgacaacag cccgaagccg
     1021 tgtgggcgtg gctgtggtga acgggcttct ctatgctatc gggggatatg acggtcagtt
     1081 gcggctgagc accgtggagg cctacaatcc tgagacggac acatggaccc gagtggggag
     1141 catgaatagc aagcgaagtg ccatggggac agtcgtgctg gatggacaga tctacgtgtg
     1201 tggaggctat gacggcaact cctccctcaa ctctgtggag acctattcac ctgagacgga
     1261 caagtggaca gtggtgactc cgatgagctc aaaccggagt gccgctgggg tcacagtctt
     1321 cgagggcagg atatatgtgt caggaggcca cgacggcttg cagatcttca gcagtgtgga
     1381 acagtacaat caccacacgg ccacctggca cccagcagcc agcatgctca acaagcgctg
     1441 ccgacatggt gccgcctccc tggggagcaa gatgtttgtt tgtgggggct acgatggctc
     1501 tggtttcctc agcattgctg agatgtacag ctctgtggca gaccagtggt gcctcatagt
     1561 acccatgcac acacgccgga gtcgggtctc cctcgtggcc agctgcgggc gcctctacgc
     1621 agtgggaggt tatgatgggc agtcaaacct aagctcggtg gagatgtacg acccagagac
     1681 ggaccgctgg acatttatgg cccccatggc atgccatgag ggaggggttg gcgtgggctg
     1741 catccctctt ctcaccatct aaagagagga tgggatatgg tgggttaggg atctggtaca
     1801 agtctaggcg cttccttcca ggggtaagtc ctcccagaat aggcagtggt ggaccagaag
     1861 acagggtgta atgtgagctt gccagaggga cagtttttcc aggtgcttaa gtcctctctc
     1921 actgtgctgc ccttgtgacc ttaggttgtc aagatgcaca gcacaggaca ggagtccctc
     1981 tgggtcccac agccagtaac acggaagtgc tttgctgatc cgtgtacaca ggctgcgccc
     2041 aagcccagcg agcactggcc accgagctgg cagcgagtgc tcatgtgcag gaggtcttcc
     2101 agccgatgtt tctccttccc tgcctgtctg tagccctgtt gtggccaatt cgccatggga
     2161 agccacagtg tccaagcctt ttgggaagtg ggtagagctg gggagaaggg acaccttggt
     2221 gttctcactg cctgtggtgg tgcagctaga gcagcgagct acgtgcgtgc acacaggcct
     2281 tccttccgcc atggacacag aggactcgct ctctgtctcc agcaagcagg gagaacagaa
     2341 gtcttccccg tgcctgatgt tttgggaatc cagtgaggtc tctctccact tgtccgtaga
     2401 aacaggaggg gtagaggtgc tggagagaac tggaggaaat gtcagaaaat gttcaagaga
     2461 gactggaagg aaaagacttg aagtgaacat ttttcacagg aagaaaacat aaaagacact
     2521 aaaagcaaac gcacatttaa atggaaaacc atcaaacacg acaacagtgg tatccactcc
     2581 cacatccgga tcccagggtc ccgagtcctc ctaaagcagt tgggattccc tctgagcccc
     2641 acagtgtgtc tgagatcagg gcactcttga ctgacctgtg gcaaggtgct catggggttt
     2701 ggtctcctca cccaccatca caggactttt taaatcattg gcttagggag ccagttaaat
     2761 tactgccatg cttctctacc caggctccca gctgtcaccc cacgatcacc taccaccacc
     2821 agccagcgct cctacagatc cccactccta cataatcctt tccctctttg gccagcagga
     2881 aacaacatgt ctgcccagat taacacttac cagtcaccat ccttgaataa cttcctcatc
     2941 gtgatgcttc tggagcacat cgaccatttg tacctctagg acctaaccag gggcttgctc
     3001 ccaccagcca tggaccagct tggtcaggtg acttgtctgc cctgccattc ccctattttc
     3061 catccatttg ccaaccctgg gtgtccacct tctctccagc ccttgtcaga ttgaccagca
     3121 agatgggcct ttatattcaa gcaatgaacg ctggcgtcat gatataaagg cctacagact
     3181 aaaaaaatgt cttttgctgc tgcaaggaag agattttcta tttcttcctc taatcttggc
     3241 aaatgacctc gtgaagagac tcaatgctcc tccttcctct ggatgggacc ttaacccagc
     3301 acagaaggac ccagagagca gactttttgt taccagtgca ctgggcagtg gggcagactt
     3361 ccaactgctg ctgccaaaat ctgctttccg aaaattcttc cagcggagac tagagaatat
     3421 aattgttttt agccccaaac tgggtcttag ggtcccactg accacctgat tggtttcttg
     3481 ccctttgctg cctacctgga tcggcctaga ggacggttca gaaaggtgca gcgtgaagcc
     3541 tgctgggatc ccttgcccca gaccatcagg tttgccagtg tgtgcaattg ccacagagtc
     3601 acaaggaagg acttttggtc cagcgactca agagctgggc ctctgctata agcacttgaa
     3661 aatgttttta tcttaaacga cagaacaatc tgataactga taaattttaa ctaggctccc
     3721 agtggaaccc cagcatttct tcctgcccct cagtttccct gctgaggtag actctggggg
     3781 actgtgggtc ttggtttcct cttggtcctt taggatgacg ttcctcttaa gtcctgtgaa
     3841 tgtactgccc agcctcgact gtgaaggtgc tgagaaccag tcagcgggct cccagacggg
     3901 ccccctgggt ccttctgatg ctagcagact acatcactag agatgatacg tcatctcctc
     3961 ccggcctgct gctgtctgat tagccttcct gcacccactc ccacctccta gaatagaggc
     4021 taaaccgaga cagtgtttcc aagaacgacc aggtcagtgt tttaatctaa gctctgagca
     4081 cacttgagca agcaggaaca tttttatact cccttgcctg agggcaggtg gctgatctgt
     4141 ctcactagtg ttagaacagt aggatcatgg gaaagcagat atcacccaag gacactggaa
     4201 agaatgtaac aggaggtggg tctgacacac caccacagga ccatggggtc tggccactgt
     4261 ccttcctcat ctcttctcac tctgggcttc tccagagatc acaagcagaa gagagctgaa
     4321 gaccagcctc tgatggaact gaggaggggt cctgaccctc ttctcccaca gctgtttcac
     4381 aggaaacttt ttatttatag gacgcatgtc tttcgtgtta agaaaccaaa gagaaataaa
     4441 gagaacactc ctaata
//
