LOCUS       NP_001386254             579 aa            linear   ROD 31-MAR-2024
DEFINITION  kelch-like protein 18 isoform 2 [Rattus norvegicus].
ACCESSION   NP_001386254 XP_006244067
VERSION     NP_001386254.1
DBSOURCE    REFSEQ: accession NM_001399325.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   2  (residues 1 to 579)
  AUTHORS   Moghe,S., Jiang,F., Miura,Y., Cerny,R.L., Tsai,M.Y. and Furukawa,M.
  TITLE     The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates
            Aurora-A
  JOURNAL   Biol Open 1 (2), 82-91 (2012)
   PUBMED   23213400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 6, 2022 this sequence version replaced XP_006244067.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.33746.1,
                                           SRR26643294.34853.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..579
                     /product="kelch-like protein 18 isoform 2"
                     /note="kelch-like 18; kelch-like protein 18"
                     /calculated_mol_wt=64141
     Region          19..134
                     /region_name="BTB_POZ_KLHL18"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 18 (KLHL18); cd18247"
                     /db_xref="CDD:349556"
     Region          34..557
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          135..241
                     /region_name="BACK_KLHL18"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 18 (KLHL18); cd18457"
                     /db_xref="CDD:350532"
     Region          282..327
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          331..374
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          378..422
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          425..469
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          472..516
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          519..562
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..579
                     /gene="Klhl18"
                     /gene_synonym="RGD1310570"
                     /coded_by="NM_001399325.1:23..1762"
                     /db_xref="GeneID:316012"
                     /db_xref="RGD:1310570"
ORIGIN      
        1 mvedgaeele dlvhfsvsel psrgygvmee irrqgklcdv tlkigdhkfs ahrivlaasi
       61 pyfhamftnd mmeckqdeiv mqgmdpsale alinfayngn laidqqnvqs llmgasflql
      121 qsikdacctf lrerlhpknc lgvrqfaetm mcavlydaan sfihqhfvev slseeflalp
      181 ledvlellsr delnvkseeq vfeaalawir ydreqrgpcl pellsnirlp lcrpqflsdr
      241 vqqddlvrcc hkcrdlvdea kdyhlmperr phlpafrtrp rcctsiagli yavgglnsaa
      301 nfyagdslnv vevfdpianr wekchpmtta rsrvgvavvn gllyaiggyd gqlrlstvea
      361 ynpetdtwtr vgsmnskrsa mgtvvldgqi yvcggydgns slnsvetysp etdkwtvvtp
      421 mssnrsaagv tvfegriyvs gghdglqifs sveqynhhta twhpaasmln krcrhgaasl
      481 gskmfvcggy dgsgflsiae myssvadqwc livpmhtrrs rvslvascgr lyavggydgq
      541 snlssvemyd petdrwtfma pmacheggvg vgcipllti
//
