LOCUS       NM_145671               2732 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus kelch-like family member 17 (Klhl17), mRNA.
ACCESSION   NM_145671
VERSION     NM_145671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2732)
  AUTHORS   Hu,H.T., Lin,Y.J., Wang,U.T., Lee,S.P., Liou,Y.H., Chen,B.C. and
            Hsueh,Y.P.
  TITLE     Autism-related KLHL17 and SYNPO act in concert to control
            activity-dependent dendritic spine enlargement and the spine
            apparatus
  JOURNAL   PLoS Biol 21 (8), e3002274 (2023)
   PUBMED   37651441
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2732)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 2732)
  AUTHORS   Salinas,G.D., Blair,L.A., Needleman,L.A., Gonzales,J.D., Chen,Y.,
            Li,M., Singer,J.D. and Marshall,J.
  TITLE     Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate
            receptor subunits to the ubiquitin-proteasome pathway
  JOURNAL   J Biol Chem 281 (52), 40164-40173 (2006)
   PUBMED   17062563
  REMARK    GeneRIF: Actinfilin acts as a scaffold, linking kainate-type
            glutamate receptor subunit GluR6 to the Cul3 ubiquitin ligase to
            provide a novel mechanism for kainate receptor degradation.
REFERENCE   4  (bases 1 to 2732)
  AUTHORS   Chen,Y. and Li,M.
  TITLE     Interactions between CAP70 and actinfilin are important for
            integrity of actin cytoskeleton structures in neurons
  JOURNAL   Neuropharmacology 49 (7), 1026-1041 (2005)
   PUBMED   16054660
REFERENCE   5  (bases 1 to 2732)
  AUTHORS   Chen,Y., Derin,R., Petralia,R.S. and Li,M.
  TITLE     Actinfilin, a brain-specific actin-binding protein in postsynaptic
            density
  JOURNAL   J Biol Chem 277 (34), 30495-30501 (2002)
   PUBMED   12063253
  REMARK    GeneRIF: a brain specific Kelch protein, which interacts with
            F-actin
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 2, 2020 this sequence version replaced NM_145671.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF505655.1, SRR26643299.25948.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000005.1  172100982-172101195 c
            215-474             JAXUCZ010000005.1  172100144-172100403 c
            475-596             JAXUCZ010000005.1  172099934-172100055 c
            597-818             JAXUCZ010000005.1  172099567-172099788 c
            819-935             JAXUCZ010000005.1  172098971-172099087 c
            936-1149            JAXUCZ010000005.1  172098537-172098750 c
            1150-1294           JAXUCZ010000005.1  172098145-172098289 c
            1295-1462           JAXUCZ010000005.1  172097890-172098057 c
            1463-1551           JAXUCZ010000005.1  172097435-172097523 c
            1552-1625           JAXUCZ010000005.1  172097246-172097319 c
            1626-1807           JAXUCZ010000005.1  172096868-172097049 c
            1808-2732           JAXUCZ010000005.1  172095701-172096625 c
FEATURES             Location/Qualifiers
     source          1..2732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2732
                     /gene="Klhl17"
                     /note="kelch-like family member 17"
                     /db_xref="GeneID:246757"
                     /db_xref="RGD:708444"
     exon            1..214
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2036
                     /gene="Klhl17"
                     /note="actinfilin; kelch-like 17"
                     /codon_start=1
                     /product="kelch-like protein 17"
                     /protein_id="NP_663704.1"
                     /db_xref="GeneID:246757"
                     /db_xref="RGD:708444"
                     /translation="MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQ
                     ARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIR
                     AHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNV
                     QTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQH
                     FVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLM
                     KCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRR
                     CEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAV
                     GGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNS
                     AERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSW
                     TPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRS
                     THDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLN
                     FPPPSSPTLSVSSTSL"
     exon            215..474
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            475..596
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            597..818
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            819..935
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1149
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1294
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1462
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1551
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1625
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1807
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2732
                     /gene="Klhl17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcggag accggcgagc gccggagtgg acatagcggc caggcagtct tcctaccgtc
       61 cgaatcagtc aagcagcgtc gcgctgtctg tcgcggggtt ggaggctgaa gttatgcagc
      121 cccgtggtga gcggcctgca ggcaggacac agagtccgga gcacagtagc ccggggcccg
      181 ggcctgaggc gccaccgccg ccccagccgc cggcccccga ggcagagcga gctcggccca
      241 ggcaggctcg gcctgcagcc cccatggaag gtgcgatgca gctgttgagc agagagggtc
      301 acagcgtggc acacaactcg aagcggcact accatgatgc ttttgtggct atgagccgca
      361 tgcggcagcg tggcctcctg tgtgacatcg tcctgcacgt ggcagccaag gagatccgtg
      421 ctcataaggt ggtgttggcc tcctgtagcc cctactttca cgccatgttc acaaatgaga
      481 tgagtgagag ccgccagaca catgtgacac tgcatgatat tgacccgcaa gccttagacc
      541 agctggtgca gtttgcatac acggctgaga ttgtggtggg cgagggcaac gttcagactc
      601 tactcccagc tgccagcctt ctgcagttaa atggtgttcg agatgcctgc tgcaagttcc
      661 tcctgagcca gctcgaccct tccaactgcc tgggcattcg aggatttgca gacacacact
      721 catgcagtga cctgctcaag gcagcacaca ggtacgtgct gcagcacttc gtggatgtgg
      781 ccaagactga ggagttcatg ctgttgccac tgaagcaggt gctggaattg gtctctagtg
      841 atagcctgaa tgtgccctca gaggaagatg tgtatcgtgc agtcctgagc tgggtcaagc
      901 atgatgtaga cactcggagg cagcatgtgc caaggctgat gaagtgtgta cggctgcctc
      961 tgctgagccg agacttccta ctgggccacg tggatgctga aagccttgtg aggcatcacc
     1021 ctgactgcaa ggatctgctc attgaggccc ttaagttcca cctgctgcct gaacagagag
     1081 gtgttctggg taccagccgc acaagacccc gtcgctgtga gggtgctggc cctgtgctct
     1141 ttgctgttgg tggggggagc ctttttgcta tccatggaga ctgtgaagca tatgacactc
     1201 gaactgaccg ctggcatgtg gtggcctcca tgtctacacg tcgggctcgt gtaggagtcg
     1261 ctgctgttgg gaaccgactg tatgctgtgg gcggctatga tggaacctca gacctggcta
     1321 cggtggagtc ctatgaccct gtgacaaaca catggcagcc cgaggtctcc atgggcacaa
     1381 ggcgaagctg cctaggtgta gctgccctgc atgggctcct gtatgcagcc ggtggctacg
     1441 atggggcttc ctgcctcaac agtgctgaac gatatgaccc actgacagga acgtggacat
     1501 ccattgctgc catgagcacc cggaggcgat atgtgcgtgt ggccacactt gatgggaacc
     1561 tgtacgccgt gggtggttat gacagctcat cacacctggc caccgtggag aagtatgagc
     1621 cccaggtgaa ttcatggaca cccgtggctt ccatgctgag ccggcgcagc tcagcaggag
     1681 tagcagtact ggagggtgcc ctgtacgtcg cagggggcaa tgacggcaca agctgcctca
     1741 actcagtgga gagatatagc accaaggctg gtgcctggga gagtgtggca cccatgaata
     1801 tccgcaggag cacgcatgac ctcgtggcca tggacggctg gctctacgct gtcgggggca
     1861 atgatggcag ctccagcctc aactccatag agaagtacaa cccgaggacc aacaagtggg
     1921 tggcagcatc ctgcatgttc acaagacgca gcagtgtggg tgtggcagtg ctggagctgc
     1981 tcaacttccc accaccttcc tcacccacgc tgtctgtgtc ctctaccagc ctctgacaca
     2041 cgtcagactg cacagaggcc ccgcagcctc ccacatgcct taaaccctac ggggtggccc
     2101 taccacctct gtctcctcca ccgagtgtta gggcagatcc catacccccc agagatttcc
     2161 tgttcttctg tcttggtctc tgtgttcatt tgtccttgtt catttatttg tgtgatgttc
     2221 gttcattcac ttatttattg attcactatt tattgatgga tgagaagtgc tgcagcttcc
     2281 agttcacaca tttactctca attgccagct ctcctgcatg taggggacca aggagccctt
     2341 cgagtgttct cttgcctgtc tccctttgtg gaacagcaga gaacgctggg ggcggacgct
     2401 cactgaaaga ggatgagcaa cacagctggg ccttgcaaac agtgaggggc agagcgactg
     2461 cggcaacagg agcagaggca agggattcct aagaagatgc agacccctag ccagcgcttg
     2521 cacatggcac ttacctgtct ctgccaggca ctgtccctga aggacacaaa gcagacttgt
     2581 ttcctacgtc tcgtgtatac agtgtgatgt cttttctggg tcttctatgg agctgggcac
     2641 acaacatgca cttagatcct acacagcaat atgagccaac ttgaacaata aacatgtttc
     2701 ttgggctcca tgggcctgag gctgaatgtc ca
//
