LOCUS       NM_153730               1921 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus kelch-like family member 12 (Klhl12), mRNA.
ACCESSION   NM_153730
VERSION     NM_153730.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   McGourty,C.A., Akopian,D., Walsh,C., Gorur,A., Werner,A.,
            Schekman,R., Bautista,D. and Rape,M.
  TITLE     Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent
            Co-adaptor
  JOURNAL   Cell 167 (2), 525-538 (2016)
   PUBMED   27716508
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Butkinaree,C., Guo,L., Ramkhelawon,B., Wanschel,A., Brodsky,J.L.,
            Moore,K.J. and Fisher,E.A.
  TITLE     A regulator of secretory vesicle size, Kelch-like protein 12,
            facilitates the secretion of apolipoprotein B100 and
            very-low-density lipoproteins--brief report
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (2), 251-254 (2014)
   PUBMED   24334870
  REMARK    GeneRIF: KLHL12 plays a critical role in facilitating the
            endoplasmic reticulum exit and secretion of apoB100-VLDL particles,
            suggesting that KLHL12 modulation would influence plasma lipid
            levels.
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Jin,L., Pahuja,K.B., Wickliffe,K.E., Gorur,A., Baumgartel,C.,
            Schekman,R. and Rape,M.
  TITLE     Ubiquitin-dependent regulation of COPII coat size and function
  JOURNAL   Nature 482 (7386), 495-500 (2012)
   PUBMED   22358839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Funato,Y., Terabayashi,T., Sakamoto,R., Okuzaki,D., Ichise,H.,
            Nojima,H., Yoshida,N. and Miki,H.
  TITLE     Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a
            pool of inactive dishevelled protein
  JOURNAL   Curr Biol 20 (21), 1945-1952 (2010)
   PUBMED   20970343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ133126.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_153730.3.
            
            On Aug 30, 2012 this sequence version replaced NM_153730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ133126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132267, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1921              AJ133126.1         43-1963
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1921
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="kelch-like family member 12"
                     /db_xref="GeneID:266772"
                     /db_xref="RGD:628717"
     exon            1..202
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1714
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /note="CUL3-interacting protein 1; kelch-like protein
                     C3IP1; kelch-like 12"
                     /codon_start=1
                     /product="kelch-like protein 12"
                     /protein_id="NP_714952.1"
                     /db_xref="GeneID:266772"
                     /db_xref="RGD:628717"
                     /translation="MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDF
                     PAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVEN
                     VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQK
                     HFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPDL
                     LQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRAR
                     LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVI
                     GGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRR
                     HTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHT
                     GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTT
                     PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVASMGTQRCDAGVCVLR
                     EK"
     exon            203..356
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..574
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..724
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..839
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..946
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1142
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1301
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1400
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1587
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1824
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcttgatg ggcggcatta tggcccctaa agacataatg acaaatactc acgccaagtc
       61 catcctcaac tcaatgaact ccctcaggaa gagcaatacc ctctgtgacg tgaccttgag
      121 agtggagcag aaagacttcc ctgcccaccg gattgtgctg gctgcctgca gcgattattt
      181 ctgtgccatg ttcactagtg agctttcaga gaaggggaag ccatatgttg acattcaagg
      241 tttaactgct tctacaatgg aaatcctgtt ggacttcgtg tatacagaaa cagtacatgt
      301 gacagtggag aatgttcaag aactgctccc tgcagcctgt cttctccagt tgaaaggtgt
      361 aaaacaagcc tgctgtgagt tcttagaaag tcagttggat ccatctaatt gcctgggtat
      421 cagggatttt gctgaaactc acaattgcgt tgacctgatg caagcagctg aggtttttag
      481 ccagaagcat tttcctgaag tggtacagca cgaagagttc attcttctga gtcaaggaga
      541 ggtggagaag ctaatcaagt gcgatgagat tcaggtggat tctgaagagc cagtctttga
      601 ggctgtcatc aactgggtga agcatgccaa gaaggagcga gaggagtctt tgcctgacct
      661 cctgcagtat gttcggatgc ccctgctgac ccctaggtac attacagatg tgattgatgc
      721 tgagcctttt atccgctgta gtttacagtg cagggaccta gttgatgaag ccaagaagtt
      781 tcacctgagg cctgaacttc ggagtcagat gcaaggaccc aggacaagag cccgactagg
      841 agccaatgaa gtgcttctgg tggttggggg cttcggaagc cagcagtctc ctattgatgt
      901 ggtagagaaa tatgacccca agacacagga gtggagcttt ttgccaagta tcactcgcaa
      961 gagacggtat gtggcctcgg tttccttaca tgatcggatc tatgtgattg gtggctatga
     1021 tggccgttcc cgcctcagtt cagtggagtg tctagactac acagcagatg aagacggagt
     1081 gtggtactct gtggccccta tgaatgtgcg gcgaggcctt gctggagcca ccacactggg
     1141 agatatgatt tacgtttctg gaggctttga tggaagcagg cgtcatacaa gtatggagcg
     1201 gtatgaccca aacattgacc agtggagtat gctgggagat atgcagacag ctcgagaggg
     1261 cgcgggacta gtggtggcca gcggcataat ctactgtcta ggaggatatg atggcttgaa
     1321 tatattaaat tcagttgaga aatatgatcc ccatacagga cactggacta atgttacgcc
     1381 tatggccacc aagcgttctg gtgctggagt agccctactg aatgaccata tttatgtggt
     1441 gggagggttc gatggtacag cccacctttc ttctgttgaa gcttataaca ttcgcacgga
     1501 ttcctggaca actgtcacaa gtatgaccac accacgatgc tatgtagggg ccacagtgct
     1561 tcgagggaga ctctatgcaa tcgcaggata cgatgggaat tctctgctga gcagcattga
     1621 gtgttatgac cctatcatcg acagctggga agtagtggcc tccatgggaa cccagcgttg
     1681 tgacgctggt gtgtgtgttc tccgagaaaa gtaactgtta tttggacacc agctgggaac
     1741 agtttgtggg agaatgaagg atcctttcca gaatgttcac ttctcactgt gtgcacaggg
     1801 cgattacagg caccagtgct gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 a
//
