LOCUS       NP_714952                568 aa            linear   ROD 10-OCT-2024
DEFINITION  kelch-like protein 12 [Rattus norvegicus].
ACCESSION   NP_714952
VERSION     NP_714952.1
DBSOURCE    REFSEQ: accession NM_153730.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 568)
  AUTHORS   McGourty,C.A., Akopian,D., Walsh,C., Gorur,A., Werner,A.,
            Schekman,R., Bautista,D. and Rape,M.
  TITLE     Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent
            Co-adaptor
  JOURNAL   Cell 167 (2), 525-538 (2016)
   PUBMED   27716508
REFERENCE   2  (residues 1 to 568)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 568)
  AUTHORS   Butkinaree,C., Guo,L., Ramkhelawon,B., Wanschel,A., Brodsky,J.L.,
            Moore,K.J. and Fisher,E.A.
  TITLE     A regulator of secretory vesicle size, Kelch-like protein 12,
            facilitates the secretion of apolipoprotein B100 and
            very-low-density lipoproteins--brief report
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (2), 251-254 (2014)
   PUBMED   24334870
  REMARK    GeneRIF: KLHL12 plays a critical role in facilitating the
            endoplasmic reticulum exit and secretion of apoB100-VLDL particles,
            suggesting that KLHL12 modulation would influence plasma lipid
            levels.
REFERENCE   4  (residues 1 to 568)
  AUTHORS   Jin,L., Pahuja,K.B., Wickliffe,K.E., Gorur,A., Baumgartel,C.,
            Schekman,R. and Rape,M.
  TITLE     Ubiquitin-dependent regulation of COPII coat size and function
  JOURNAL   Nature 482 (7386), 495-500 (2012)
   PUBMED   22358839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 568)
  AUTHORS   Funato,Y., Terabayashi,T., Sakamoto,R., Okuzaki,D., Ichise,H.,
            Nojima,H., Yoshida,N. and Miki,H.
  TITLE     Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a
            pool of inactive dishevelled protein
  JOURNAL   Curr Biol 20 (21), 1945-1952 (2010)
   PUBMED   20970343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.53278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..568
                     /product="kelch-like protein 12"
                     /note="CUL3-interacting protein 1; kelch-like protein
                     C3IP1; kelch-like 12"
                     /calculated_mol_wt=63131
     Region          12..135
                     /region_name="BTB_POZ_KLHL12_C3IP1_DKIR"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 12 (KLHL12); cd18242"
                     /db_xref="CDD:349551"
     Region          130..265
                     /region_name="BACK_KLHL12"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 12 (KLHL12); cd18452"
                     /db_xref="CDD:350527"
     Region          274..315
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          282..329
                     /region_name="Kelch"
                     /note="Kelch domain; smart00612"
                     /db_xref="CDD:128874"
     Region          282..329
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2H4.2)"
     Region          308..565
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          319..365
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          331..379
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2H4.2)"
     Region          369..412
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          380..426
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2H4.2)"
     Region          405..568
                     /region_name="Interaction with DVL3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2H4.2)"
     Region          416..459
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          463..507
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          510..555
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..568
                     /gene="Klhl12"
                     /gene_synonym="C3ip1"
                     /coded_by="NM_153730.3:370..2076"
                     /db_xref="GeneID:266772"
                     /db_xref="RGD:628717"
ORIGIN      
        1 mggimapkdi mtnthaksil nsmnslrksn tlcdvtlrve qkdfpahriv laacsdyfca
       61 mftselsekg kpyvdiqglt astmeilldf vytetvhvtv envqellpaa cllqlkgvkq
      121 acceflesql dpsnclgird faethncvdl mqaaevfsqk hfpevvqhee fillsqgeve
      181 klikcdeiqv dseepvfeav inwvkhakke reeslpdllq yvrmplltpr yitdvidaep
      241 fircslqcrd lvdeakkfhl rpelrsqmqg prtrarlgan evllvvggfg sqqspidvve
      301 kydpktqews flpsitrkrr yvasvslhdr iyviggydgr srlssvecld ytadedgvwy
      361 svapmnvrrg lagattlgdm iyvsggfdgs rrhtsmeryd pnidqwsmlg dmqtaregag
      421 lvvasgiiyc lggydglnil nsvekydpht ghwtnvtpma tkrsgagval lndhiyvvgg
      481 fdgtahlssv eaynirtdsw ttvtsmttpr cyvgatvlrg rlyaiagydg nsllssiecy
      541 dpiidswevv asmgtqrcda gvcvlrek
//
