LOCUS       NM_001394673            4102 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kelch-like family member 1 (Klhl1), mRNA.
ACCESSION   NM_001394673 XM_017599639
VERSION     NM_001394673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Jiang,S., Seng,S., Avraham,H.K., Fu,Y. and Avraham,S.
  TITLE     Process elongation of oligodendrocytes is promoted by the
            Kelch-related protein MRP2/KLHL1
  JOURNAL   J Biol Chem 282 (16), 12319-12329 (2007)
   PUBMED   17324934
  REMARK    GeneRIF: MRP2/KLHL1 has a role, through its interaction with actin,
            in the process elongation of oligodendrocytes
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Seng,S., Avraham,H.K., Jiang,S., Venkatesh,S. and Avraham,S.
  TITLE     KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase
            3beta-dependent manner
  JOURNAL   Mol Cell Biol 26 (22), 8371-8384 (2006)
   PUBMED   16982692
  REMARK    GeneRIF: This study provides, for the first time, insights into the
            involvement of MRP2 in neurite outgrowth, which occurs in a
            GSK3beta-dependent manner.
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   He,Y., Zu,T., Benzow,K.A., Orr,H.T., Clark,H.B. and Koob,M.D.
  TITLE     Targeted deletion of a single Sca8 ataxia locus allele in mice
            causes abnormal gait, progressive loss of motor coordination, and
            Purkinje cell dendritic deficits
  JOURNAL   J Neurosci 26 (39), 9975-9982 (2006)
   PUBMED   17005861
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Nemes,J.P., Benzow,K.A., Moseley,M.L., Ranum,L.P. and Koob,M.D.
  TITLE     The SCA8 transcript is an antisense RNA to a brain-specific
            transcript encoding a novel actin-binding protein (KLHL1)
  JOURNAL   Hum Mol Genet 9 (10), 1543-1551 (2000)
   PUBMED   10888605
  REMARK    Erratum:[Hum Mol Genet 2000 Nov 1;9(18):2777]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Feb 7, 2022 this sequence version replaced NM_001394673.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1418388.1,
                                           SRR26360176.627458.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1282              JAXUCZ010000015.1  79549403-79550684   c
            1283-1465           JAXUCZ010000015.1  79379377-79379559   c
            1466-1602           JAXUCZ010000015.1  79370840-79370976   c
            1603-1799           JAXUCZ010000015.1  79347261-79347457   c
            1800-2012           JAXUCZ010000015.1  79284272-79284484   c
            2013-2199           JAXUCZ010000015.1  79245195-79245381   c
            2200-2424           JAXUCZ010000015.1  79201019-79201243   c
            2425-2587           JAXUCZ010000015.1  79141725-79141887   c
            2588-2800           JAXUCZ010000015.1  79129768-79129980   c
            2801-2972           JAXUCZ010000015.1  79113280-79113451   c
            2973-4102           JAXUCZ010000015.1  79106164-79107293   c
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..4102
                     /gene="Klhl1"
                     /note="kelch-like family member 1"
                     /db_xref="GeneID:290426"
                     /db_xref="RGD:1307452"
     exon            1..1282
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             780..3032
                     /gene="Klhl1"
                     /note="kelch-like 1"
                     /codon_start=1
                     /product="kelch-like protein 1"
                     /protein_id="NP_001381602.1"
                     /db_xref="GeneID:290426"
                     /db_xref="RGD:1307452"
                     /translation="MSGSGRKDFDVKHILRLRWKLFSHPSPASGSSAGGSCLQQDSGG
                     GSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSTSSSSSSSASSSPFSPLNGTLLPVA
                     TRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFPGPQDKGLALKELQAEPASSIQA
                     TGEGCGHRLTTTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVIL
                     IVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGC
                     LELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKV
                     AHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRR
                     CGDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQS
                     PRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDD
                     KLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGW
                     SYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDP
                     HTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTW
                     TMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRA
                     GACVVVIKQP"
     exon            1283..1465
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1602
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1799
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2012
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2199
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2424
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2587
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2800
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2972
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..4102
                     /gene="Klhl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atactgtgag gaccttgaca gctttcctgg gcgggctttt cttgtggcgg ctctatgttt
       61 tttttccccg ggatatttat ttttctcctt tacaaactga ctatataaat ccgccccttt
      121 tctcctctca gaaagcattt gactgtcctc cggacacctg gcaagctctc agggcattct
      181 cccagaggac agggtcaggg agcaggtgca cagactccgc ttggggttgg ggatgcacta
      241 cttctcgact tgaggctctt tttttttgtc tgcactcttc aaacacggaa ctctgagctg
      301 cgaagacgag agagagatct gaatagcttc caaaccacag ctcggaactg agtgtgtatc
      361 agtgcagtgg atctagctgc ggccacctct ggagctgggg agagctctga cctccctctg
      421 ttcctcttgc attttcagcc tctcttccct ccgggtggtc accacagggg tccccgcaag
      481 ctccttgtgg attctaagcc ccaggtatcc caggacttca tttgatctag acaggagctt
      541 tctcaaagct cagttcccag gaaaacgacc cggactgagc cataaggctc tgcagcgcgc
      601 tctaggtgct ggtgtagtcg cctggtgagg cgcacagccc gcttgaccac ctttggcact
      661 ccgtatacac ggggcgcatc ctgcctcttt ctcgtctcca gaagccattg gccaccccag
      721 tccgctcgcc aggctactgg tgtgtgagct gcagtccctt ggtcctccgt gcattaagca
      781 tgtccggctc tgggcgaaaa gatttcgatg tgaagcacat cctgcgactc cgctggaaac
      841 tcttcagcca tccctcacca gcctccggta gctcagcggg gggcagctgc ctgcaacagg
      901 acagcggggg aggcagcttt gagcactggg gtcctagcca gagtcggctg ctcaaaaacc
      961 aggaaaaggg cagtgtgagc gctttctgga aaaaaccttc ttcctcttcg acatcatcat
     1021 catcctcgtc ctctgcttca tcctctcctt tcagtccgct gaatggcacc ttactaccag
     1081 ttgccacgag gctgcaacaa ggggctcctg ggcagggcac ccagcagccc gccaggactc
     1141 ttttctacgt ggagtcccta gaggaggagg tagtgacagg catggacttt cctggaccac
     1201 aggacaaagg attggccctg aaagagctcc aagcagagcc tgccagctct atccaggcaa
     1261 caggtgaagg atgtggacac aggttgacaa cgaccaatca ttcactgaca cctcaaagtg
     1321 atttggactc cagtagctct gaagaattct atcaagctgt tcaccatgct gagcaatcat
     1381 ttaggaagat ggagaattat ctaaagcaac agcagctgtg tgatgtcatc ctgatagtgg
     1441 ggaatcgaaa gatacctgct cataggcttg tcctgagctc tgtctctgac tactttgctg
     1501 ccatgtttac aagcgatgtc tgtgaagcca agcaagagga gatcaagatg gaaggcatag
     1561 acccaaatgc actctgggat cttgttcaat ttgcatatac aggttgcttg gaattaaaag
     1621 aggacactat tgaaaacctt cttgcagccg cgtgccttct ccagctccct caagtggtcg
     1681 aagtgtgttg tcacttcctc atgaaacttc ttcatccatc caactgctta ggaatccggg
     1741 catttgcaga cgctcaagga tgtattgaat taatgaaggt ggcacacagc tacaccatgg
     1801 aaaacataat ggaagtaatc agaaatcaag agtttttact ccttccagcc gaagagctcc
     1861 ataaactact ggccagtgat gacgtaaatg tgcctgatga agagaccatc ttccatgcat
     1921 taatgatgtg ggtcaagtac gacatgcagc ggagatgcgg cgacctgagt atgctcctcg
     1981 ccttcataag actgccactg cttccaccac agatactggc tgaccttgag aatcatgcac
     2041 tattcaagaa tgatttagaa tgtcaaaaac tgattctgga agcaatgaaa taccatctat
     2101 tgccagaaag aagaacttta atgcaaagcc caagaactaa gcccagaaaa tctacagttg
     2161 gaactcttta tgcggtgggg ggaatggata ataacaaagg ggctacaacc atagagaagt
     2221 atgacctcag aacaaatctg tggattcagg caggaatgat gaatggcaga aggcttcagt
     2281 tcggtgttgc cgtcattgat gataagctct ttgtaattgg aggtcgagat ggcttaaaga
     2341 ctttgaacac agttgaatgt tacaatccta aaaccaagac atggactgtt ttaccaccga
     2401 tgtcaacaca caggcatggt cttggagtaa ctgtcctcga agggcctatt tatgcagtgg
     2461 gaggccatga tggttggagc tatctgaaca cagtggagag gtgggatcca cagagccagc
     2521 agtggacata tgtagccagt atgtccattg cgcggagcac tgtgggagtg gcagcgctga
     2581 atggcaagtt gtattcagtt gggggccgag atggaagttc ttgtttgagt tcgatggaat
     2641 attatgatcc tcatacaaat aagtggagta tgtgtgcccc gatgtgtaag aggagaggag
     2701 gtgttggcgt ggccacctgt gatggtttcc tttatgcagt gggcggccac gatgctcctg
     2761 cttcaaatca ctgttccagg ctcctggact atgtggaaag gtatgatcca aaaacagaca
     2821 catggaccat ggtggctcct ttgagtatgc ctagagatgc tgttggtgtt tgtctccttg
     2881 gtgacagatt atatgctgtt ggtggctatg atggacaaac atacctcaat accatggagt
     2941 cctatgatcc acaaactaat gagtggacac agatggcttc tctgaatatt gggagagcag
     3001 gtgcctgtgt ggtcgtcatc aagcaacctt gactgactta tgtaatgttt ggagggattt
     3061 tctttgctac tgtagttgtt ttatatcatg tggtaagaat gagaaagaac ttcctgagac
     3121 aagaacttct caggaacagg ctttttatgg atttatctgc tggtgccaaa agcagtaaaa
     3181 gatcaaacag aattatagaa gaaaagagaa catcagacac aacatctggc caattgttaa
     3241 ttagttcagg aatggttatt gctaaggttt ttcattgtag cacaccataa ctagagttac
     3301 caaaggctgg tttatcaaaa ggacacatat ttgtgatata gatagttagt taatgactga
     3361 ccactcactc acttgttctt ataatctgtg atgataaccc aacaggctgc caaaagtagg
     3421 aattataata tttcatctca caaaatctga atgattttat gtttttctaa ttgaatgtga
     3481 taataccaag aagaatgtat tgttgaaaca aatttgcttc ttcctcgttt ctctcagcta
     3541 tgaaaacaat tagagagaca aatgactgtc tcctgcattc agaaaacaaa ctgccctgct
     3601 aatcacggct gcatattgta tccaatatga taattggatt ttattacaac tgtgtcatca
     3661 gtctggagct ggcaaacaaa aaggactttt cataaagctt gccacatcgc tttgcgttgt
     3721 caataccctg agccaaagag tcactacagc tatgggcatt tgcctcatgc agagttcagt
     3781 ataagcatgg atactagtta ttctgaacat taatataccc actgcatgcc gaaatccctt
     3841 agaactttgt gctttaaaac aaaatttaga attttgagac aaaattttcc aactcattaa
     3901 attgagatgg ttatgataac agctagaagg atgactgact acagattctc atttcccatt
     3961 ttcaaacatc tatcattgat atgcacatta ttttaaacca actgtttgta actgtttcaa
     4021 agcaaaacat tatgtaacat cattaatata tgtccatgta aattatgaat atagttaata
     4081 aatgataaag catttgcttt ta
//
