LOCUS       NM_001007685            1850 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kelch domain containing 8B (Klhdc8b), mRNA.
ACCESSION   NM_001007685 XM_225000
VERSION     NM_001007685.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Krem,M.M. and Horwitz,M.S.
  TITLE     Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma
            pathogenesis
  JOURNAL   Commun Integr Biol 6 (3), e23544 (2013)
   PUBMED   23713010
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Krem,M.M., Luo,P., Ing,B.I. and Horwitz,M.S.
  TITLE     The kelch protein KLHDC8B guards against mitotic errors,
            centrosomal amplification, and chromosomal instability
  JOURNAL   J Biol Chem 287 (46), 39083-39093 (2012)
   PUBMED   22988245
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Krem,M.M., Salipante,S.J. and Horwitz,M.S.
  TITLE     Mutations in a gene encoding a midbody protein in binucleated
            Reed-Sternberg cells of Hodgkin lymphoma
  JOURNAL   Cell Cycle 9 (4), 670-675 (2010)
   PUBMED   20107318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083777.1.
            
            On Nov 29, 2004 this sequence version replaced XM_225000.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083777.1, SRR8487226.59781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1850
                     /gene="Klhdc8b"
                     /note="kelch domain containing 8B"
                     /db_xref="GeneID:306589"
                     /db_xref="RGD:1359445"
     exon            1..116
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
     exon            117..623
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1312
                     /gene="Klhdc8b"
                     /codon_start=1
                     /product="kelch domain-containing protein 8B"
                     /protein_id="NP_001007686.1"
                     /db_xref="GeneID:306589"
                     /db_xref="RGD:1359445"
                     /translation="MAAGGGQAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGL
                     PLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLA
                     DEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVLVYESRRDRWLSLPS
                     MPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCA
                     MAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVV
                     GSLGGNIVAIGGLGNQPCPLASVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVI
                     GGVAQGPSQAVEALCLRDGV"
     exon            624..788
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1013
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1115
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1845
                     /gene="Klhdc8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgccggag cggtgcggga gccccaccgg agcccagctt cagccctagc cagagccagc
       61 gtcagcggag gcggaacagc ggacccggtg ccctggcgac atctgagatc cagcgggtga
      121 aggcaaggtc ctttggactg ctctgacaca cccttccagc cctgacagaa tcaagatgag
      181 accttatcgt atccccccag tgaggcccgc agcctgagcg gatggcctgc cgctggcagt
      241 gagcaacatg gctgcaggag gtggccaggc ctttgcttgg caggtgttcc cccccatgcc
      301 cacttgccgg gtctatggca cagtggcgca ccaggatgga cacctgctgg tgttaggggg
      361 ctgtggccgg gctgggttac ctctggacac tgctgagaca ttggacatgg cctcacacac
      421 atggctggca ttagcaccct tgcccaccgc ccgggctggt gcagctgctg tggttctggg
      481 taagcaggtg ctagtggtgg gtggcgtgga tgaagtccag agcccagtag ctgctgtgga
      541 ggccttcttg gctgatgaag gccgctggga gcgccgggcg accctccctc aagcagccat
      601 gggtgttgcg actgtggaga gagatggtat ggtgtatgcc ctggggggaa tgggtcctga
      661 cacggccccc caggcccagg tactggtcta cgagtcccgc cgggaccgct ggctttcgct
      721 accctccatg cctacaccct gctacggggc ctccaccttc ctgcacggga acaagatcta
      781 cgtcctggga ggtcgccagg gcaagctccc agtgactgct tttgaagctt ttgatctgga
      841 gacacgtaca tggacccgac acccaagtct gcccagtcgc cgagcttttg ctggctgtgc
      901 tatggcggaa ggcagtgtct ttagcctggg tggcctgcag cagcctggcc cccacaattt
      961 ctactcccgc ccgcattttg tcaacactgt ggagatgttt gacctggagc atggatcctg
     1021 gactaagctg cctcgtagcc tgcggatgag ggataaaagg gcggattttg tggttggctc
     1081 ccttgggggc aacattgtgg ctattggggg tcttgggaac cagccgtgcc ccttggcctc
     1141 tgtggagagc ttcagtcttg cacggcgacg ctgggaggca ctgcctgcca tgcctacagc
     1201 ccgatgctcc tgttccagcc tgcaggctgg gccccgacta tttgttattg ggggtgtggc
     1261 ccagggcccg agtcaagctg tggaagcact gtgtctacgt gatggagtct gaagacctgg
     1321 tgagacctgt ctaccaggac agctcagtat agaagcagat caggctcctt ctacctgctg
     1381 agggggctcc ctatggctct gtgggacgag ggaggcacag gagagggcac ctgagttact
     1441 gccttaggga cttgcattgg ggagcccttg tcattagcac aggacacaca tgctcacacc
     1501 tattttatca ccatccacta cgaaccatag ctagccccac ccatgcccta ggagttacta
     1561 ggcccccggt cagctctgac aagtgagaca cagggcattg gcctcatggt ctacagctta
     1621 ggaccgaaga gctgaccagg ccctctctag tggccagtct ggaaaagtct gagcttccag
     1681 tcttccttgg gggttcctgt ggacctcagg agtattctga ggatggaagt cacagaagaa
     1741 atggaggaga gggggttggg gatttaggtc agtggtagag cacttgccta gcaagtgcaa
     1801 ggccctgggt tcggtctcca gctccgaaaa aaaaaaaaaa aaaaaaaaaa
//
