LOCUS       NM_057211               2795 bp    mRNA    linear   ROD 23-SEP-2023
DEFINITION  Rattus norvegicus KLF transcription factor 9 (Klf9), mRNA.
ACCESSION   NM_057211
VERSION     NM_057211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Han N, Zhang L, Guo M and Yu L.
  TITLE     Knockdown of Kruppel-Like Factor 9 Inhibits Aberrant Retinal
            Angiogenesis and Mitigates Proliferative Diabetic Retinopathy
  JOURNAL   Mol Biotechnol 65 (4), 612-623 (2023)
   PUBMED   36109428
  REMARK    GeneRIF: Knockdown of Kruppel-Like Factor 9 Inhibits Aberrant
            Retinal Angiogenesis and Mitigates Proliferative Diabetic
            Retinopathy.
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Li F, Peng J, Feng H, Yang Y, Gao J, Liu C, Xu J, Zhao Y, Pan S,
            Wang Y, Xu L, Qian W and Zong J.
  TITLE     KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by
            Inhibiting PPARgamma/NRF2 Signalling
  JOURNAL   Cells 11 (21), 3393 (2022)
   PUBMED   36359788
  REMARK    GeneRIF: KLF9 Aggravates Streptozotocin-Induced Diabetic
            Cardiomyopathy by Inhibiting PPARgamma/NRF2 Signalling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Yan Q, He B, Hao G, Liu Z, Tang J, Fu Q and Jiang CX.
  TITLE     KLF9 aggravates ischemic injury in cardiomyocytes through
            augmenting oxidative stress
  JOURNAL   Life Sci 233, 116641 (2019)
   PUBMED   31295469
  REMARK    GeneRIF: High KLF9 expression is associated with ischemic injury in
            cardiomyocytes.
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   Parga JA, Rodriguez-Perez AI, Garcia-Garrote M, Rodriguez-Pallares
            J and Labandeira-Garcia JL.
  TITLE     Angiotensin II induces oxidative stress and upregulates
            neuroprotective signaling from the NRF2 and KLF9 pathway in
            dopaminergic cells
  JOURNAL   Free Radic Biol Med 129, 394-406 (2018)
   PUBMED   30315936
  REMARK    GeneRIF: Angiotensin II induces oxidative stress and upregulates
            neuroprotective signaling from the NRF2 and KLF9 pathway in
            dopaminergic cells.
REFERENCE   5  (bases 1 to 2795)
  AUTHORS   Galvao J, Iwao K, Apara A, Wang Y, Ashouri M, Shah TN, Blackmore M,
            Kunzevitzky NJ, Moore DL and Goldberg JL.
  TITLE     The Kruppel-Like Factor Gene Target Dusp14 Regulates Axon Growth
            and Regeneration
  JOURNAL   Invest Ophthalmol Vis Sci 59 (7), 2736-2747 (2018)
   PUBMED   29860460
  REMARK    GeneRIF: These results link intrinsic and extrinsic regulators of
            axon growth and suggest modulation of the KLF9-Dusp14 pathway as a
            potential approach to improve regeneration in the adult CNS after
            injury.
REFERENCE   6  (bases 1 to 2795)
  AUTHORS   Cullingford TE, Butler MJ, Marshall AK, Tham el L, Sugden PH and
            Clerk A.
  TITLE     Differential regulation of Kruppel-like factor family transcription
            factor expression in neonatal rat cardiac myocytes: effects of
            endothelin-1, oxidative stress and cytokines
  JOURNAL   Biochim Biophys Acta 1783 (6), 1229-1236 (2008)
   PUBMED   18406357
REFERENCE   7  (bases 1 to 2795)
  AUTHORS   Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L Jr,
            Till SR, Fujii-Kuriyama Y, Simmen FA and Oh SP.
  TITLE     Subfertility, uterine hypoplasia, and partial progesterone
            resistance in mice lacking the Kruppel-like factor 9/basic
            transcription element-binding protein-1 (Bteb1) gene
  JOURNAL   J Biol Chem 279 (28), 29286-29294 (2004)
   PUBMED   15117941
REFERENCE   8  (bases 1 to 2795)
  AUTHORS   Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G and Simmen FA.
  TITLE     Molecular markers of endometrial epithelial cell mitogenesis
            mediated by the Sp/Kruppel-like factor BTEB1
  JOURNAL   DNA Cell Biol 21 (2), 115-128 (2002)
   PUBMED   11953011
  REMARK    GeneRIF: BTEB1 mediates the expression of growth-associated genes
            through direct and indirect transactivation mechanisms, one of
            which may involve the participation of a JNK family member.
REFERENCE   9  (bases 1 to 2795)
  AUTHORS   Imhof A, Schuierer M, Werner O, Moser M, Roth C, Bauer R and
            Buettner R.
  TITLE     Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and
            AP-2rep, a novel wt-1/egr-related zinc finger repressor
  JOURNAL   Mol Cell Biol 19 (1), 194-204 (1999)
   PUBMED   9858544
REFERENCE   10 (bases 1 to 2795)
  AUTHORS   Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A,
            Hayami M and Fujii-Kuriyama Y.
  TITLE     Two regulatory proteins that bind to the basic transcription
            element (BTE), a GC box sequence in the promoter region of the rat
            P-4501A1 gene
  JOURNAL   EMBO J 11 (10), 3663-3671 (1992)
   PUBMED   1356762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000047.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_057211.3.
            
            On Mar 8, 2021 this sequence version replaced NM_057211.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12769.1, CF110040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1015              JACYVU010000047.1  7720901-7721915
            1016-2795           JACYVU010000047.1  7744124-7745903
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..2795
                     /gene="Klf9"
                     /gene_synonym="Bteb; Bteb1"
                     /note="KLF transcription factor 9"
                     /db_xref="GeneID:117560"
                     /db_xref="RGD:70934"
     exon            1..1015
                     /gene="Klf9"
                     /gene_synonym="Bteb; Bteb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..1245
                     /gene="Klf9"
                     /gene_synonym="Bteb; Bteb1"
                     /note="BTE-binding protein 1; GC-box-binding protein 1;
                     transcription factor BTEB1; basic transcription
                     element-binding protein 1; Kruppel-like factor 9"
                     /codon_start=1
                     /product="Krueppel-like factor 9"
                     /protein_id="NP_476559.2"
                     /db_xref="GeneID:117560"
                     /db_xref="RGD:70934"
                     /translation="MSAAAYMDFVAAQCLVSISNRAAVPEHGGAPDAERLRLPEREVT
                     KEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDIGSDSDVTTE
                     SGSSPSHSPEERQDSGSAPSPLSLLHSGVASKGKHASEKRHKCPYSGCGKVYGKSSHL
                     KAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHL
                     TKHARRHTEFHPSMIKRSKKALASPL"
     exon            1016..2795
                     /gene="Klf9"
                     /gene_synonym="Bteb; Bteb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgtcg gcggacgcgg gaagaagtgt cttgtaggcg cggcgcccca ctcagccccg
       61 gcccccctca tccgcgtact cggctgatgc ctcagggcgt cagctcggcg gagaggcggt
      121 cgaggcgtgc gcctggctag cagttggctt tccccgtgac tcggacacgt ttgcagtcga
      181 ataaacttgc gaccgccacg tgtggcatct ctccaaggaa ccggctcagg aggagggcgc
      241 gcccatcgtg ggatcgcgcg gggcgcccgg cagggcggcg gcgacagcgg cagagccggc
      301 cgcggctgct gcgtgcggag gcgctgccgg ttacgtaaag atgaggggct gaggtcgcct
      361 cggcgctccc gcgagtcgca agctcccgcg cccccgcccc ctcggccgcg ccgcaccgcg
      421 ctcgtcgtcc gagaccaggg cagggctagc cgaagctccg cagccaccct caagtttggc
      481 cgcaccgccc gggctgccgt cgcccgcacc atgtccgcgg ccgcctacat ggacttcgtg
      541 gctgcccagt gtctggtttc catctccaac cgcgccgctg tgccggagca cgggggcgct
      601 ccggacgccg agcgactgcg actacctgag cgcgaggtga ccaaggaaca cggtgacccg
      661 ggggacacct ggaaggatta ttgcacactg gtcaccatcg ccaagagctt gttggacctg
      721 aacaaatacc gacccatcca gaccccctcg gtgtgcagcg acagtctgga gagtcccgat
      781 gaggatatag gatccgacag cgacgtgacc accgaatctg ggtcgagtcc ttcccacagc
      841 ccggaggaga gacaggattc tggcagcgcg cccagcccgc tctccctcct ccactctgga
      901 gtggcttcga aggggaaaca cgcctccgaa aagaggcaca agtgccccta cagtggctgt
      961 gggaaagtct atggaaaatc ctcccatctt aaagcccatt acagagtgca tacaggtgaa
     1021 cggcccttcc cctgcacgtg gccagactgc cttaaaaagt tctcgcgctc ggacgagctg
     1081 acccgccact accggaccca cactggcgag aagcagttcc gctgtccgct gtgtgagaag
     1141 agattcatga ggagtgacca cctcaccaag catgcccggc gccacaccga gttccacccc
     1201 agcatgatca agagatcaaa aaaggctctt gccagcccct tgtgaggtgc tccccatatg
     1261 gcaaccaggc agagatggtc ccggaaggac agagctccca ggaaacagac ggacacatgg
     1321 aaatctgcca ccgcagaggt gtgctggcca caggaggtca ctgctctttg gtcaatattc
     1381 tgacactctc cctgcgctgt ttccaaaaag cacacggtag cctaagatca aagtcaacat
     1441 ttggtcccct tgcagaggcc actctgaacc gtctctgact gttggagggc aggcaaataa
     1501 atgcttttgg tattttctcc tttgttttgg ggggtggggg gagggggcaa ggccaagact
     1561 tggggtagga tttttgaaga ttcaggctgg tgtacatacg tctgactggg tgagttgacc
     1621 cctggcctcc cacagtgact ctggatcctt gatgcttgct gactctcaga attgtttttc
     1681 ttctctctca atgtcacgac cagagtgctt cagcttgttt agcagagcca ctctcgaatc
     1741 acgttaactt ttgagattta aaaaacaaaa caaaacaaca aaaaaaaaaa aaaacccctc
     1801 catagcacag ctgtctttta tgcaagcaag agcacaccta ctccagcatg atctgtcatc
     1861 taaggacttc aaaacaaaac aaaacaaaaa aaaaagttac ttatagtcag tggataagca
     1921 gagtccgaat ttacactaat caagacagac cttcgagggg tcataagtcc ggaactttca
     1981 aaccttgctt cgtatgaatc gtactatctg aacataaact gcacttttat tttctaatac
     2041 cgagggtgaa tacggtaaat ccatgccttg agggtagaag ccgacattct gtttggcaca
     2101 cgttattatc tgcttatttt ccaggataca catttccctg agaacccacg gcagagatgt
     2161 gagggcagaa tgtatggaaa cacatgctga ggaggggaag gaggagggga gtgctttaaa
     2221 gatacaaaaa aaaaaaaaaa aaaaaaaaag agcaaacaat tttaacttca tgaatttgtt
     2281 tgaattttcc caagcttcag ataacaacgc cactcacggg actaggacgc tgcaagagca
     2341 ttgggctctg tgtagcatta gctgataaat gggtgtatag ccatcaccag acctggaaat
     2401 gccccctttt ggtgggggtg ggggtgtttc ttggtctctc tttcgttcct atgaaatttc
     2461 cactaagagg tgcaagagtt atatcaaagg aaagggaact gaaatatgga aaaaaaaaag
     2521 tttgcccctg taagtagtct ctagggaagg aagatgccac aatggtttca gaggcgactc
     2581 tgcagaacag tcccttctgc tgaacatagg tcagagaaac actcgtgaat ggcatcacat
     2641 cgccaactgt ctgcatcagt ggcccaccac tacttagctt gtatctcggt gtctacacaa
     2701 tggcctgaac cactataccc atcctttgcc atttactgaa aacataattt tggcttttac
     2761 atggccagaa aaacaaactc agttttcata gttta
//
