LOCUS       NM_053394               3232 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Rattus norvegicus KLF transcription factor 5 (Klf5), mRNA.
ACCESSION   NM_053394
VERSION     NM_053394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Huang,Q., Su,J., Xu,J., Yu,H., Jin,X., Wang,Y., Yan,M., Yu,J.,
            Chen,S., Wang,Y. and Lv,G.
  TITLE     Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower
            saponins in rats with metabolic hypertension by inhibiting the
            activation of the renin-angiotensin-aldosterone system through
            complement 3
  JOURNAL   BMC Complement Med Ther 23 (1), 13 (2023)
   PUBMED   36653797
  REMARK    Erratum:[BMC Complement Med Ther. 2023 Mar 8;23(1):76. doi:
            10.1186/s12906-023-03893-1. PMID: 36890530]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Guo,Z., Chen,F., Chen,Y., Liu,C., Li,S. and Chen,P.
  TITLE     Inhibiting Intestinal Kruppel-Like Factor 5 Impairs the Beneficial
            Role of Renal Denervation in Gut Microbiota in Rats with Heart
            Failure
  JOURNAL   Microbiol Spectr 10 (5), e0218322 (2022)
   PUBMED   36135378
  REMARK    GeneRIF: Inhibiting Intestinal Kruppel-Like Factor 5 Impairs the
            Beneficial Role of Renal Denervation in Gut Microbiota in Rats with
            Heart Failure.
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   Xu,J., Yan,S., Tan,H., Ma,L., Feng,H., Han,H., Pan,M., Yu,L. and
            Fang,C.
  TITLE     The miR-143/145 cluster reverses the regulation effect of KLF5 in
            smooth muscle cells with proliferation and contractility in
            intracranial aneurysm
  JOURNAL   Gene 679, 266-273 (2018)
   PUBMED   30201338
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Zhang,J.Z., Chen,D., Lv,L.Q., Xu,Z., Li,Y.M., Wang,J.Y., Han,K.W.,
            Yu,M.K., Huang,C.G. and Hou,L.J.
  TITLE     miR-448-3p controls intracranial aneurysm by regulating KLF5
            expression
  JOURNAL   Biochem Biophys Res Commun 505 (4), 1211-1215 (2018)
   PUBMED   30322616
  REMARK    GeneRIF: miR-448-3p affects macrophage infiltration during
            intracranial aneurysm formation by regulating KLF5 expression.
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Yang,H., Chen,Q., Sun,F., Zhao,N., Wen,L., Li,L. and Ran,G.
  TITLE     Down-regulation of the klf5-c-Myc interaction due to klf5
            phosphorylation mediates resveratrol repressing the caveolin-1
            transcription through the PI3K/PKD1/Akt pathway
  JOURNAL   PLoS One 12 (12), e0189156 (2017)
   PUBMED   29211809
  REMARK    GeneRIF: demonstrated that RSV activated klf5 phosphorylation by
            inhibiting PI3K/PKD1/Akt pathway, and then attenuated the
            interaction of klf5 with c-Myc
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Mori,D., Okuro,N., Fujii-Kuriyama,Y. and Sogawa,K.
  TITLE     Gene structure and promoter analysis of the rat BTEB2 gene
  JOURNAL   Gene 304, 163-170 (2003)
   PUBMED   12568725
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Shindo,T., Manabe,I., Fukushima,Y., Tobe,K., Aizawa,K.,
            Miyamoto,S., Kawai-Kowase,K., Moriyama,N., Imai,Y., Kawakami,H.,
            Nishimatsu,H., Ishikawa,T., Suzuki,T., Morita,H., Maemura,K.,
            Sata,M., Hirata,Y., Komukai,M., Kagechika,H., Kadowaki,T.,
            Kurabayashi,M. and Nagai,R.
  TITLE     Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a
            target for angiotensin II signaling and an essential regulator of
            cardiovascular remodeling
  JOURNAL   Nat Med 8 (8), 856-863 (2002)
   PUBMED   12101409
REFERENCE   8  (bases 1 to 3232)
  AUTHORS   Sun,R., Chen,X. and Yang,V.W.
  TITLE     Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is
            a positive regulator of cellular proliferation
  JOURNAL   J Biol Chem 276 (10), 6897-6900 (2001)
   PUBMED   11152667
REFERENCE   9  (bases 1 to 3232)
  AUTHORS   Ogata,T., Kurabayashi,M., Hoshino,Y., Ishikawa,S., Takeyoshi,I.,
            Morishita,Y. and Nagai,R.
  TITLE     Inducible expression of BTEB2, a member of the zinc-finger family
            of transcription factors, in cardiac allograft arteriosclerosis
  JOURNAL   Transplant Proc 32 (7), 2032-2033 (2000)
   PUBMED   11120052
REFERENCE   10 (bases 1 to 3232)
  AUTHORS   Watanabe,N., Kurabayashi,M., Shimomura,Y., Kawai-Kowase,K.,
            Hoshino,Y., Manabe,I., Watanabe,M., Aikawa,M., Kuro-o,M.,
            Suzuki,T., Yazaki,Y. and Nagai,R.
  TITLE     BTEB2, a Kruppel-like transcription factor, regulates expression of
            the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene
  JOURNAL   Circ Res 85 (2), 182-191 (1999)
   PUBMED   10417400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Feb 11, 2021 this sequence version replaced NM_053394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.49365.1,
                                           SRR26643299.57540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               JAXUCZ010000015.1  82472081-82472614
            535-1399            JAXUCZ010000015.1  82474707-82475571
            1400-1459           JAXUCZ010000015.1  82476657-82476716
            1460-3232           JAXUCZ010000015.1  82485495-82487267
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..3232
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /note="KLF transcription factor 5"
                     /db_xref="GeneID:84410"
                     /db_xref="RGD:621446"
     exon            1..534
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1638
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /note="basic transcription element binding protein 2;
                     Kruppel-like factor 5 (intestinal); basic transcription
                     element binding protein BTEB2"
                     /codon_start=1
                     /product="Krueppel-like factor 5"
                     /protein_id="NP_445846.3"
                     /db_xref="GeneID:84410"
                     /db_xref="RGD:621446"
                     /translation="MPTRVLTMSARLGPVPQPPAAQDEPVFAQLKPVLGAANPVRDAA
                     LFPGDDLKHAHHHPPAPPPAAGPRLPSEELVQTRCEMEKYLTPQLPPVPIISEHKKYR
                     RDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTQIKTEPVTIFSH
                     QSESTAPPPPAPTQALPEFTSIFSSHQTTAPEVNNIFIKQELPIPDLHLSVPSQQGHL
                     YQLLNTPDLDMPSSTNQTAVMDTLNVSMAGLNSHPSAVPQTSMKQFQGMPPCTYTMPS
                     QFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPATLP
                     VNSPNIQPVRYNRRSNPDLEKRRIHFCDYDGCTKVYTKSSHLKAHLRTHTGEKPYKCT
                     WEGCDWRFARSDELTRHYRKHTGAKPFQCVVCNRSFSRSDHLALHMKRHQN"
     exon            535..1399
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1459
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..3232
                     /gene="Klf5"
                     /gene_synonym="bteb2; Bteb2; IKLF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgcgccc tcttagcttg ctggtggagc ttggaggtgg cgggagcggt tccggcgagg
       61 gagcgagcga gggagcgagc gagcgctggg gcggggcggg agaaagtggc ggtcggagta
      121 catcggcggt gacgcgtggc cgagcccagg agccccgatc ttcgtgcccg ccttcttgag
      181 cgtctggctg ccggcccagg ggtctcccgc tgcggccccg cgccgagtcc tccgtcctgt
      241 gccagcccgg gcgaggtggg aatcgcgatc gccccgtgcc ccgctcccgt agtctccaga
      301 ccgtccatgc ccacgcgggt gctgaccatg agcgcccgcc tgggaccagt gccccagccg
      361 ccggccgcgc aggacgagcc agtgttcgcg cagctcaagc cggtgctggg cgctgcgaac
      421 ccggtccgcg acgcggcgct cttccccgga gacgatctga aacacgcgca ccaccacccg
      481 cctgcgccgc cgccagccgc cggcccgcga ctgccttccg aggagctggt ccagacaaga
      541 tgtgaaatgg agaagtatct gacacctcag cttcctccag ttccgataat ttcagagcat
      601 aaaaaataca gacgagacag tgcctcagtg gtcgaccagt tcttcactga cactgaaggc
      661 ttaccttaca gcatcaacat gaacgtcttc ctccctgaca tcacgcacct gagaactggc
      721 ctctacaaat cccagagacc atgcgtaaca cagatcaaga cagaacctgt taccattttc
      781 agccaccaga gcgaatccac cgcccctcct cctccggccc ccacccaggc cctccctgag
      841 ttcaccagta tattcagctc ccaccagacc acagcgccag aggtgaacaa tatcttcatc
      901 aaacaagaac ttcctatacc agatcttcat ctctcggtcc cttcccagca gggccacctg
      961 taccagctgt tgaatacacc tgatctagac atgcccagtt cgacaaacca gacagcagtc
     1021 atggacaccc ttaatgtctc tatggctggc cttaactcac acccctctgc tgtgccacag
     1081 acgtccatga aacagttcca gggcatgcct ccttgcacgt acaccatgcc gagtcagttt
     1141 cttccacagc aggccaccta ctttccccca tcaccaccga gctcagagcc tggaagtcct
     1201 gatagacaag ctgagatgct ccagaatctg accccacctc cgtcctatgc tgctacaatt
     1261 gcttcgaaac tggcaattca caatccaaat ttacctgcca ctctgccagt taattcgcca
     1321 aatatccaac ctgtccgata caacagaagg agtaacccgg atctggagaa gcgacgcatc
     1381 catttctgtg attatgatgg ttgcacaaaa gtttatacaa agtcgtctca tttaaaagct
     1441 cacctgagga ctcatacggg cgagaagccc tacaagtgca cctgggaggg ctgcgactgg
     1501 aggtttgccc ggtcggacga gctgacccgc cactacagga agcacacggg tgccaagccg
     1561 ttccagtgcg tggtgtgcaa ccgcagcttc tcccgctccg accacctggc gctgcacatg
     1621 aagcgccacc agaactgagc actgcgcaca ccggctcgac gcctcgcagt ccgctcgcca
     1681 tcctttaaac cgcagaccta acttcatata aaaaaaaaaa tcaaaagaac tggaaatgta
     1741 tattttgtat atttgaggcc acagggaata cattgtatca ataccaaagt gtttggtcat
     1801 tttgagaacc cggaagcttg ctgtcatgct cactactagc ttttttccag caaacttcat
     1861 ctccagacag gcagtcgcat ctcagtatgg ggaactggtg ggggtgcacg gggtgcgtat
     1921 gctgtttcta tacagactgc gcacgcgcaa tcctgtgtga cattgtttag gataaacaaa
     1981 cccgcttggc aggcacccag acagattgtc aagattttac ttgacgcgga ctcgtttttc
     2041 ttaagactag attatttcca cagagaggag gtacacagtg tacctggcaa ttcacaaagt
     2101 agccattgaa caaatgtttt tgtttgtttt gttttttttt atatgagttg cctatatttg
     2161 ctattcagaa ttttgtaaat atgcaaatca gctttatagg tttattacaa gtttttaagg
     2221 attgtttggg gggggagaaa tcgtactttg aagataatta tgaatacatt tacagttaga
     2281 gtttgtggta agatacctca attaccaaat ccatttcttt ggggagggga taaatcattc
     2341 aaataagagt aaaatgcaaa tttcactcac tgattgaaat aagattttat tttaaatata
     2401 agacttttct tatgtgaatt taaactgaaa tgcttaaaga tagttaatac acagacatta
     2461 atggtcttac catagttgaa cagtatcatt ttttaagtgg agaaaggacg gttgtgtttc
     2521 ttgttgaact taaggacact gttttcacga gtggaagcat tgaacttccg gtgcagtttt
     2581 ttgtcagaca tggatgtttg ctcctgcagt gctgttggtt aaatgacaat ttatggattt
     2641 ttgcatgtaa tatccagtga gacagtaatt ttattgaaat tacagtgcca cgtagttaaa
     2701 tctgttatta atactgactc ggtgtctgcc tttgatatca gtgatgtgtt gaaagcttac
     2761 caatatgcaa tatggctagg aatgtgacat tgatgctgtt aaccaaaggg cagaaatcac
     2821 aagcaaaatg ccaaaagcag tcttaattaa aagtttaatt ttgtttttaa aatatttgtt
     2881 ttatcattat ttattttgtg gtaatatagt aagttttttt tttttagaaa acaattttca
     2941 taacttgata aattatagtt ttgtttgtta gaaaagttgc ttcgacgtgt aaataggcaa
     3001 caaacggtgt aaatagtttt gtaaggcttc tagatgttta tacgtggaca cacctacatc
     3061 aaaagcataa ctcggctgct gttctgctgc ttcgcccctt atttttgtat tgtggtaatt
     3121 tcctatgcaa atatcagcaa gcagctgtaa agctgtagaa ttttttgaga gaatgagatg
     3181 tttatatatt aacgacaatt tttttttttt gaaaataaaa agtgcctaaa ag
//
