LOCUS       NM_053713               2393 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus KLF transcription factor 4 (Klf4), mRNA.
ACCESSION   NM_053713
VERSION     NM_053713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Xiaoshan,Z., Huan,C., Zhilin,G., Liwen,M., Yan,Z. and Yue,C.
  TITLE     Hypoxia-inducible factor-1alpha attenuates renal podocyte injury in
            male rats in a simulated high-altitude environment by upregulating
            Kruppel-like factor 4 expression
  JOURNAL   Exp Physiol 109 (7), 1188-1198 (2024)
   PUBMED   38774964
  REMARK    GeneRIF: Hypoxia-inducible factor-1alpha attenuates renal podocyte
            injury in male rats in a simulated high-altitude environment by
            upregulating Kruppel-like factor 4 expression.
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Kang,K., Sun,C., Li,H., Liu,X., Deng,J., Chen,S., Zeng,L., Chen,J.,
            Liu,X., Kuang,J., Xiang,J., Cheng,J., Liao,X., Lin,M., Zhang,X.,
            Zhan,C., Liu,S., Wang,J., Niu,Y., Liu,C., Liang,C., Zhu,J.,
            Liang,S., Tang,H. and Gou,D.
  TITLE     N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the
            phenotypic switch of pulmonary artery smooth muscle cells
  JOURNAL   Cell Mol Life Sci 81 (1), 256 (2024)
   PUBMED   38866991
  REMARK    GeneRIF: N6-methyladenosine-driven miR-143/145-KLF4 circuit
            orchestrates the phenotypic switch of pulmonary artery smooth
            muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Du,B.B., Zhang,J.L., Kong,L.Y., Shi,H.T., Zhang,D.H., Wang,X.,
            Yang,C.L., Li,P.C., Yao,R., Liang,C., Wu,L.M. and Huang,Z.
  TITLE     Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac
            Hypertrophy by Inhibiting Ubiquitination and Degradation of
            Kruppel-Like Factor 4
  JOURNAL   J Am Heart Assoc 12 (24), e029745 (2023)
   PUBMED   38084712
  REMARK    GeneRIF: Ovarian Tumor Domain-Containing 7B Attenuates Pathological
            Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of
            Kruppel-Like Factor 4.
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Xu,X.J., Liu,W. and Liland,S.
  TITLE     MicroRNA-29a-3p Accelerates Inflammatory Damage in Neonatal
            Pneumonia Via Targeting Kruppel-like Factor 4
  JOURNAL   Iran J Allergy Asthma Immunol 22 (5), 440-451 (2023)
   PUBMED   38085146
  REMARK    GeneRIF: MicroRNA-29a-3p Accelerates Inflammatory Damage in
            Neonatal Pneumonia Via Targeting Kruppel-like Factor 4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Huang,T., Yin,J., Ren,S. and Zhang,X.
  TITLE     Protective effects of KLF4 on blood-brain barrier and oxidative
            stress after cerebral ischemia-reperfusion in rats through the
            Nrf2/Trx1 pathway
  JOURNAL   Cytokine 169, 156288 (2023)
   PUBMED   37441941
  REMARK    GeneRIF: Protective effects of KLF4 on blood-brain barrier and
            oxidative stress after cerebral ischemia-reperfusion in rats
            through the Nrf2/Trx1 pathway.
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Segre,J.A., Bauer,C. and Fuchs,E.
  TITLE     Klf4 is a transcription factor required for establishing the
            barrier function of the skin
  JOURNAL   Nat Genet 22 (4), 356-360 (1999)
   PUBMED   10431239
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Yet,S.F., McA'Nulty,M.M., Folta,S.C., Yen,H.W., Yoshizumi,M.,
            Hsieh,C.M., Layne,M.D., Chin,M.T., Wang,H., Perrella,M.A.,
            Jain,M.K. and Lee,M.E.
  TITLE     Human EZF, a Kruppel-like zinc finger protein, is expressed in
            vascular endothelial cells and contains transcriptional activation
            and repression domains
  JOURNAL   J Biol Chem 273 (2), 1026-1031 (1998)
   PUBMED   9422764
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Garrett-Sinha,L.A., Eberspaecher,H., Seldin,M.F. and de
            Crombrugghe,B.
  TITLE     A gene for a novel zinc-finger protein expressed in differentiated
            epithelial cells and transiently in certain mesenchymal cells
  JOURNAL   J Biol Chem 271 (49), 31384-31390 (1996)
   PUBMED   8940147
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Shields,J.M., Christy,R.J. and Yang,V.W.
  TITLE     Identification and characterization of a gene encoding a
            gut-enriched Kruppel-like factor expressed during growth arrest
  JOURNAL   J Biol Chem 271 (33), 20009-20017 (1996)
   PUBMED   8702718
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Hamil,K.G. and Hall,S.H.
  TITLE     Cloning of rat Sertoli cell follicle-stimulating hormone primary
            response complementary deoxyribonucleic acid: regulation of TSC-22
            gene expression
  JOURNAL   Endocrinology 134 (3), 1205-1212 (1994)
   PUBMED   8161377
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF390546.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF390546.1, BC085720.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..2393
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /note="KLF transcription factor 4"
                     /db_xref="GeneID:114505"
                     /db_xref="RGD:621445"
     exon            1..81
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1525
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /note="Kruppel-like factor 4 (gut); Kruppel like factor 4"
                     /codon_start=1
                     /product="Krueppel-like factor 4"
                     /protein_id="NP_446165.1"
                     /db_xref="GeneID:114505"
                     /db_xref="RGD:621445"
                     /translation="MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRW
                     REELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALPRRETEEFNDLLDL
                     DFILSNSLSHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAA
                     GNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPG
                     GGLMGKFVLKASLSTPGSEYTSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQE
                     AVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCH
                     PGLPLPPGFHPHPGPSYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWP
                     RKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHY
                     RKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF"
     exon            82..202
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            203..1184
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1349
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2368
                     /gene="Klf4"
                     /gene_synonym="GKLF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttcgttg acttcggggt ttgggtaccc ctctctcttc ttcggactcc ggaggacctt
       61 ctgggccccc acattaatga ggcagccacc tggcgagtct gacatggctg tcagcgacgc
      121 tctgctcccg tccttctcca cgttcgcgtc cggcccggcg ggaagggaga agacactgcg
      181 tccagcaggt gccccgacta accgttggcg agaggaactc tctcacatga agcgacttcc
      241 cccacttccc ggccgcccct acgacctggc ggcgacggtg gccacagacc tggaaagtgg
      301 tggagctggt gcagcttgca gcagtaacaa cccggcccta ccccggaggg agaccgagga
      361 gttcaacgat ctcctggacc tagactttat cctttccaac tcgctatccc accaggaatc
      421 ggtggccgcc accgtgacca cctcggcgtc agcttcatcc tcgtcttccc cagctagcag
      481 cggccctgcc agcgcgccct ccacctgcag cttcagctat ccgatccggg ccgggggtga
      541 cccgggcgtg gctgcgggca acacaggtgg agggctcctc tacagccgag aatctgcgcc
      601 acctcccacg gcccccttca acctggcgga catcaatgac gtgagcccct cgggcggctt
      661 cgtggctgag ctcctgcggc cggagttgga cccagtatac attccgccac agcagcctca
      721 gccgccaggt ggcgggctga tgggcaagtt tgtgctgaag gcgtctctga gcacccctgg
      781 cagcgagtac accagccctt cggtcatcag tgttagcaaa ggaagcccag acggcagcca
      841 ccctgtggta gtggcgccct acagcggtgg cccgccgcgt atgtgcccca agattaagca
      901 agaggccgtc ccgtcctgca cggtcagccg gtccctagag gcccacttga gcgctggacc
      961 ccagctcagc aacggccaca ggcccaacac acacgacttc cccctggggc ggcagctccc
     1021 caccaggact acccctacac tgagtcccga ggaactgctg aacagcaggg actgtcaccc
     1081 tggcctgcct cttcccccag gattccatcc ccatccgggg cccagctacc ctcctttcct
     1141 gccagaccag atgcagtcgc aagtcccctc tctccattat caagagctca tgccaccggg
     1201 atcctgcctg ccagaggagc ccaagccaaa gaggggaaga aggtcttggc cccggaaaag
     1261 aacagccacc cacacttgtg actatgcagg ctgtggcaaa acctatacga agagttctca
     1321 tctcaaggca cacctgcgaa ctcacacagg cgagaaacct taccactgtg actgggacgg
     1381 ctgtgggtgg aaattcgccc gctcagatga actgaccagg cactaccgca aacacaccgg
     1441 gcaccggccc tttcagtgcc agaagtgcga cagggccttt tccaggtcgg accaccttgc
     1501 cttacacatg aagaggcact tttaaattcc acatcgtgga catgacccac actgccagga
     1561 gagagttcag tatttttttt taacctttca cactgtcttc ccacgagggg aggagcccag
     1621 ctggcaagcg ctacaatcat ggtcaagttc ccagcaagtc agcttgtgaa tggataatca
     1681 ggagaaagga agagtccaag ggacaaaaga aaagaaaaga aaaaaatact aaaaaacaaa
     1741 caaacaaaaa aaaaaaacaa aagaaaaaaa tcacagaaca gatggggtct gagactggat
     1801 cttctatcat tccaatacca aatccgactt gaacaagact ggacttacaa aatgccaagg
     1861 ggtgactgga agtttgtgga tatcagggta tacattaaat cagtgacctg gggggaggga
     1921 agaccagagt tcccttgaat tgtgcttcaa tgatgcaata tacatggaaa gaccaccttg
     1981 tatgctcttt gccttctaaa aagccattat gacgtcagag gaagaggaag caattcaggt
     2041 acagaacgtg ttctaatagc ctaaacgatg gtgcttggtg agtcgtggtt ctaaaggtac
     2101 caaacggggg agccaaagtt ctccaactgc tgcatacttt gacaaggaaa atctattttt
     2161 gtcttccgat ctacatttat gacctaagtc aggtaaataa gcctggttta tttctgtaac
     2221 attttttatg cagacagtct gttatgcact gtggtttcag atgtgcaata atttgtacaa
     2281 tggtttattc ccaagtatgc ctttaagcag aacaaatgtg tttttctata tagttccttg
     2341 ccttaataaa tatgtaatat aaatttaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
