LOCUS       NM_001105742            4989 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus KLF transcription factor 3 (Klf3), mRNA.
ACCESSION   NM_001105742 XM_001078358 XM_223423
VERSION     NM_001105742.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4989)
  AUTHORS   Kitamura T, Suzuki H and Tamura TA.
  TITLE     Mouse Wee1 gene is repressed by Kruppel-like factor 3 (KLF3) via
            interaction with multiple upstream elements
  JOURNAL   Gene 492 (2), 361-367 (2012)
   PUBMED   22115574
REFERENCE   2  (bases 1 to 4989)
  AUTHORS   Eaton SA, Funnell AP, Sue N, Nicholas H, Pearson RC and Crossley M.
  TITLE     A network of Kruppel-like Factors (Klfs). Klf8 is repressed by Klf3
            and activated by Klf1 in vivo
  JOURNAL   J Biol Chem 283 (40), 26937-26947 (2008)
   PUBMED   18687676
REFERENCE   3  (bases 1 to 4989)
  AUTHORS   Cullingford TE, Butler MJ, Marshall AK, Tham el L, Sugden PH and
            Clerk A.
  TITLE     Differential regulation of Kruppel-like factor family transcription
            factor expression in neonatal rat cardiac myocytes: effects of
            endothelin-1, oxidative stress and cytokines
  JOURNAL   Biochim Biophys Acta 1783 (6), 1229-1236 (2008)
   PUBMED   18406357
REFERENCE   4  (bases 1 to 4989)
  AUTHORS   Szpirer C, Van Vooren P, Riviere M, Scohy S, Collau G and Szpirer
            J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000252.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_001105742.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001105742.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680421,
                              SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JACYVU010000252.1  23485043-23485233   c
            192-287             JACYVU010000252.1  23480478-23480573   c
            288-771             JACYVU010000252.1  23474520-23475003   c
            772-922             JACYVU010000252.1  23473829-23473979   c
            923-1083            JACYVU010000252.1  23469342-23469502   c
            1084-4989           JACYVU010000252.1  23462791-23466696   c
FEATURES             Location/Qualifiers
     source          1..4989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4989
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /note="KLF transcription factor 3"
                     /db_xref="GeneID:114845"
                     /db_xref="RGD:1593290"
     exon            1..191
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..287
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1265
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /note="Basic Kruppel- like factor; Kruppel-like factor 3
                     (basic); Kruppel like factor 3"
                     /codon_start=1
                     /product="Krueppel-like factor 3"
                     /protein_id="NP_001099212.1"
                     /db_xref="GeneID:114845"
                     /db_xref="RGD:1593290"
                     /translation="MLMFDPVPVKQEAMDPVTVSYPSNYIESMKPNKYGVIYSTPLPD
                     KFFQTPEGLAHGIQMEPVDLTVNKRGSPPSAAGSPSSLKFPSHRRASPGLSMPSSSPP
                     IKKYSPPSPGVQPFGVPLSMPPVMAAALTRHGIRSPGILPVIQPVVVQPVPFMYTSHL
                     QQPLMVSLSEEMDNSNSGMPVPVIESYEKPILQKKIKIEPGIEPQRTDYYPEEMSPPL
                     MNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHL
                     KAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHL
                     ALHRKRHMLV"
     exon            288..771
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..922
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1083
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..4989
                     /gene="Klf3"
                     /gene_synonym="Bklf; Tef-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagggcg gatcactggc tccttgggtc actgcatccc atctgacacg aaatagtgaa
       61 cttctccctt ttacaaaaca acgttagtgc agaaataagt gcactaacgt tgaaataacg
      121 aagaaataag agaggcaaag actcggagac ccccagtggg attctgttca ggtcgacagt
      181 ggaagagcga ggccagacat cagaacaccc tagaaggctt aaccaaaaga atgctcatgt
      241 ttgacccagt ccctgtcaag caagaggcca tggaccccgt cacggtgtcc tacccatcaa
      301 attacataga atcaatgaag cccaacaaat atggggtcat ttactctaca ccattacctg
      361 acaagttctt ccagacccca gaaggcctcg ctcacgggat acagatggag cctgtggacc
      421 tcactgtgaa caagcggggc tccccgcctt ctgctgctgg ttctccttcc tctctgaaat
      481 ttccatcaca ccggagagca tcaccggggc tcagcatgcc ttcctccagc ccacccatta
      541 agaaatactc acccccctct cctggtgtgc aacccttcgg agtaccactg tccatgccac
      601 ctgtgatggc cgctgcactg accagacatg ggatccggag cccgggcatc ctccctgtca
      661 tccagcccgt cgtggtacaa cctgtcccct tcatgtacac cagccacctg cagcagcctc
      721 tcatggtctc cttgtcagaa gaaatggaca attcaaacag cggcatgcca gtacccgtaa
      781 ttgaatccta tgagaagccc atattacaga aaaaaattaa aatagaacct ggaatcgaac
      841 cacagaggac tgactattac cctgaagaaa tgtcaccccc tttaatgaac tcagtgtccc
      901 ccccgcaagc gttgttgcaa gagaaccacc cttccgtcat tgtgcagccc gggaagagac
      961 ctctacctgt ggaatccccg gatacccaaa ggaagcgcag gatacacaga tgcgactatg
     1021 atggatgcaa taaggtctac actaagagct cgcacttgaa agcacacaga agaacccata
     1081 caggggaaaa gccgtacaaa tgcacctggg aaggctgcac gtggaagttt gctcggtctg
     1141 atgaactgac gagacatttc cgaaaacaca ctggaatcaa acctttccag tgtccagact
     1201 gtgaccgaag cttctctcgc tccgaccacc ttgccctaca taggaaacgc cacatgctag
     1261 tctgaaagcc tgtctccagc tcagtgtgat tccccgctct tcctggcaca cacacacctc
     1321 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc cccccccccc
     1381 cccctgtcct cctgcccatt ttctaactca tttttatatg tacattttaa tttcgattca
     1441 gctggtctgg atccctgaat ttatatcatt caagacttcc atatggtcag tagttgatac
     1501 tctaaccccc cctctcctta ccacgggtca gacctaaaga atgtgaacat tttttccggg
     1561 gatgctaagc aaaccctcct tacagataca tttaatgtaa tgagaacaag ggaacatgta
     1621 aactaacgac caatttgtcg gtttctccat gtattcctca aaagaatgtc aaagtaaatg
     1681 tattagaaat acagtgtatc cagcctgcta gtccttgcca gagaccttcg tacttctgcc
     1741 tcattttgtg tttgacgaca gaaagaatgc ggtccctttt accagctatc aagacgtcga
     1801 gatgtcaagc tgatcccacc ctctcaccat tacccttccc acggtttgct cgttggcctg
     1861 tcttaccaac tcagctaaat caagcccttt gtctgctgtg gcacctgaag ctcatgtgga
     1921 ggctttgcca tccctgggag ctgagcagga gctgttggcg taggtgggcc gtgtgctcct
     1981 atagtgtgag gaagaagcag aagatgttgg gaatggagga ggaagtcagc cattcctggc
     2041 taggagtggc tggaccatcc acagtgtctg ggccactcac attagctgtg cagtgcattt
     2101 gttaactgtg catccccagg cgtaacttga ccaagcacac ctttgctaca aagctggata
     2161 ccgagagggt tatccaagcc accacctccg ttcctgcagg ttccttcatt atcaatctcg
     2221 aggcattgag agtaaggaat ccacagaaac atttgcgcag ttatgttaaa aaaaaaaaaa
     2281 gaagcaaaaa cttttgagat agagtataaa atggtctctt acccccaccc ccacccccac
     2341 cccccaacct actaagagtg tttttgcaaa caggaaaacg ttgcgtggta cttatatccc
     2401 catagccaat tagtcacata gctttcatac aaagctgttc tgtgtgagct gtatggtgcc
     2461 aaaccagcta tcatttgtgt ctgtgacaca caacacagta tacaagagca tccactaagc
     2521 ttgagtaaag tcattcaatt aagacctggg tgacactatt tgtaaatact cctagtgtga
     2581 agcacataga tctttatttt ggtgacagat tttttttttt aaatagagaa aatcacaatt
     2641 cagggatttg tatatgtagc ttgaagattc ccacaagttt ctcccagagc tagcaatttc
     2701 ctgttggcta ccaggtaccc tgttaggaca aacaaaaagc aatgacttgt gctgatgttg
     2761 cagataaata gcaccattat ttgggggtgg ggggagtatt tgttttttca aaagcaggct
     2821 tttgaacacc acagtctcaa tgccaacaaa aacagttcac atgcagaaag gccactggtt
     2881 acaaatgggc acaacggtca gatacggcta cctgtgacca atagtccctg catcccctta
     2941 caggggcgtg gaggagaaga gaagagagga atcattcatc ccagccacaa ctcaggatcc
     3001 aacaccaccc gaactggggg gaacatcacc ctacctgatt gttcttgaat gaccggtgaa
     3061 tgagagacct tgggggcctt ggaggcctgt acttgcaggc agcttgcttc aatggcgctg
     3121 tgttcacatt tgcagggact gcattcagga ggtcctgctc ggccctgtga accatctgag
     3181 ggggactgtg ggtgaaaact gcaaagaaat gttatcttgg ctcttgggtt cctttccttc
     3241 ctattttagc actgggggga aatctgttca ggctattaaa gtacgccaat taggctcttg
     3301 cctttctcta ttgtttgcaa ctatgacatg aatcgaggag tggattgtct cttgggaaag
     3361 cagggtctcc cttgtcagtt tccgttgcat gtatgccaac accatcctgt cttgaaatgg
     3421 ttcttctgca gagcactgaa gagtccagtt tgtgtgctcc aacccagtga agtgggggtg
     3481 ggggggttgc aaggaaggac agttagcttt gctttcgctt caaaccagag tatttaggag
     3541 ctccatgatg tatttaaatt ttgttcagaa gtctttatta cattactctt tagcttgctt
     3601 agatcatgtt aacagaaaga tccattttaa ctctgaagta acccagagaa gccattctct
     3661 attcccacgc tagtctgata tacttttagt taattggccc ttaccaaatt tcttttctat
     3721 atatataaaa tgtatgtatg tatgtatgta tgtatgtatt tgtattttac tatgatagtt
     3781 gagaaattta gtctcttttt agtgtttgtt tgtttgtttg tttggttggt tggttggttg
     3841 gctttttttt tttttaatct gtttttgtgg aagacgtaag atgccctgga tcttccattt
     3901 ttgatggtgt gctacgtcac tgtcagtgta gctcagctgc actgaattga tgagaaccag
     3961 ctgtaaacat gaaaccagca ctgtgtaaat cgttacagag ttcattcaag tactgctcaa
     4021 gtgtcatctt ggggaagttc caaaataatc agaatcttat gttttcgagt ttgatggtgg
     4081 gagggtgcat cattcaatgg gcattttgcg ctctaaagtc acttggtttg gagactgtgt
     4141 gtagaaaagc tttgttcaac taagaagata ctagatatgc agacgttgca agagccttgg
     4201 aacaattaga ggggagagat atgtgtatat gtatgtttta ttaaacaccc acctgcacta
     4261 ccagtactgc actaatgtgg agttcaagag actgttgctg atactgcagt ctgcacacca
     4321 ttccttagat tgttacaaag acaatctcag atcagaggtt tttaagtcat ttggtttgaa
     4381 actagaattg tcttgaagga gttgctaatg tacatgaagt cacttgagtt tcctttattc
     4441 tcttcctggt caaggttaac agtttctaaa tgattgcaaa ttcacttaag taatacattt
     4501 acaaagccat tttacatgca ttaaaagagg gctacaatgt gttttacaaa tactagcact
     4561 ttttttttcc tgttatgtac ctagtgttag agggtcagaa taacctttct gcttggcatc
     4621 tcttaaaccc tacctgcaag catagcaggc ttactgcatt tacagtactt taatacttgt
     4681 ataaactatg cagaaatttt taataaagtg taatatattt tataagctaa taagactgaa
     4741 tgggtaaagg tttttagcat gcttagtata cttgcaaata ctgaaacatt ttggtaatct
     4801 ttcttactaa agatgtgaat gtttaatgta ccttctctgt ttctaccctg tagtccaatg
     4861 ggaattcagt aatgacattt tgtcatgtca aactgtgaac ataaatttgt actgtacagt
     4921 cctcatatac tatatacatt atgcaatata tgtattatat acttgttaat aaaaccatct
     4981 gaatattac
//
