LOCUS       NM_001007684            1738 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus KLF transcription factor 2 (Klf2), mRNA.
ACCESSION   NM_001007684 XM_224722
VERSION     NM_001007684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Ma,Y., Peng,T., Yao,X., Sun,C. and Wang,X.
  TITLE     KLF2 reduces dexamethasone-induced injury to growth plate
            chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK
            signalling pathways
  JOURNAL   Autoimmunity 56 (1), 1-7 (2023)
   PUBMED   36343159
  REMARK    GeneRIF: KLF2 reduces dexamethasone-induced injury to growth plate
            chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK
            signalling pathways.
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Ji,X. and Zhao,Z.
  TITLE     Exposure to enriched environment ameliorated chronic unpredictable
            mild stress-induced depression-like symptoms in rats via regulating
            the miR-92a-3p/kruppel-like factor 2 (KLF2) pathway
  JOURNAL   Brain Res Bull 195, 14-24 (2023)
   PUBMED   36638871
  REMARK    GeneRIF: Exposure to enriched environment ameliorated chronic
            unpredictable mild stress-induced depression-like symptoms in rats
            via regulating the miR-92a-3p/kruppel-like factor 2 (KLF2) pathway.
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Wang,Q., Gong,L., Mao,S., Yao,C., Liu,M., Wang,Y., Yang,J., Yu,B.,
            Chen,G. and Gu,X.
  TITLE     Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral
            nerve injury
  JOURNAL   Exp Neurol 343, 113788 (2021)
   PUBMED   34147481
  REMARK    GeneRIF: Klf2-Vav1-Rac1 axis promotes axon regeneration after
            peripheral nerve injury.
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Chu,H.R., Sun,Y.C., Gao,Y., Guan,X.M., Yan,H., Cui,X.D.,
            Zhang,X.Y., Li,X., Li,H. and Cheng,M.
  TITLE     Function of Kruppel-like factor 2 in the shear stress-induced cell
            differentiation of endothelial progenitor cells to endothelial
            cells
  JOURNAL   Mol Med Rep 19 (3), 1739-1746 (2019)
   PUBMED   30628700
  REMARK    GeneRIF: hear stress may upregulate KLF2 expression, which may be
            associated with the integrinactin cytoskeleton system. Most
            importantly, the shear stressinduced differentiation of endothelial
            progenitor cells may be mediated by KLF2
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Shi,J., Zhou,L.R., Wang,X.S., Du,J.F., Jiang,M.M., Song,Z.,
            Han,G.C. and Mai,Z.T.
  TITLE     KLF2 attenuates bleomycin-induced pulmonary fibrosis and
            inflammation with regulation of AP-1
  JOURNAL   Biochem Biophys Res Commun 495 (1), 20-26 (2018)
   PUBMED   29079188
  REMARK    GeneRIF: KLF2 was remarkably downregulated in bleomycin-treated
            rats, both in mRNA and protein levels. Additionally, overexpression
            of KLF2 attenuated the destruction of the alveolar space and
            pulmonary interstitial collagen hyperplasia.
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   Basu,P., Morris,P.E., Haar,J.L., Wani,M.A., Lingrel,J.B.,
            Gaensler,K.M. and Lloyd,J.A.
  TITLE     KLF2 is essential for primitive erythropoiesis and regulates the
            human and murine embryonic beta-like globin genes in vivo
  JOURNAL   Blood 106 (7), 2566-2571 (2005)
   PUBMED   15947087
REFERENCE   7  (bases 1 to 1738)
  AUTHORS   Wick,M.J., Blaine,S., Van Putten,V., Saavedra,M. and Nemenoff,R.A.
  TITLE     Lung Kruppel-like factor (LKLF) is a transcriptional activator of
            the cytosolic phospholipase A2 alpha promoter
  JOURNAL   Biochem J 387 (Pt 1), 239-246 (2005)
   PUBMED   15540987
REFERENCE   8  (bases 1 to 1738)
  AUTHORS   Diessenbacher,P., Bartels,K., Koch-Nolte,F. and Haag,F.
  TITLE     T-cell survival regulator LKLF is not involved in inappropriate
            apoptosis of diabetes-prone BBDP rat T cells
  JOURNAL   Ann N Y Acad Sci 1010, 548-551 (2003)
   PUBMED   15033788
  REMARK    GeneRIF: LKLF gene is not defective in diabetic prone BB rats and
            its expression is not compromised by mutation. (Klf2)
REFERENCE   9  (bases 1 to 1738)
  AUTHORS   Wani,M.A., Means,R.T. Jr. and Lingrel,J.B.
  TITLE     Loss of LKLF function results in embryonic lethality in mice
  JOURNAL   Transgenic Res 7 (4), 229-238 (1998)
   PUBMED   9859212
REFERENCE   10 (bases 1 to 1738)
  AUTHORS   Anderson,K.P., Kern,C.B., Crable,S.C. and Lingrel,J.B.
  TITLE     Isolation of a gene encoding a functional zinc finger protein
            homologous to erythroid Kruppel-like factor: identification of a
            new multigene family
  JOURNAL   Mol Cell Biol 15 (11), 5957-5965 (1995)
   PUBMED   7565748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 31, 2022 this sequence version replaced NM_001007684.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50085.1,
                                           SRR26643298.70781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000016.1  17557681-17557768   c
            89-896              JAXUCZ010000016.1  17556545-17557352   c
            897-1738            JAXUCZ010000016.1  17555136-17555977   c
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1738
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="KLF transcription factor 2"
                     /db_xref="GeneID:306330"
                     /db_xref="RGD:1359220"
     exon            1..88
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1072
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /note="lung Kruppel-like factor; lung krueppel-like
                     factor; Kruppel-like factor 2 (lung)"
                     /codon_start=1
                     /product="Krueppel-like factor 2"
                     /protein_id="NP_001007685.1"
                     /db_xref="GeneID:306330"
                     /db_xref="RGD:1359220"
                     /translation="MALSEPILPSFATFASPCERGLQERWPRNEPEAGSTDEDLNSVL
                     DFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYGTPAAGLGTELLRPDLDAP
                     QGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAAGLARGPRGLKLEGALGATGACMRG
                     PAGRPPPPSDTPPLSPDGPPRLPAPGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAF
                     GLFDDAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTNCG
                     KTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCD
                     RAFSRSDHLALHMKRHM"
     exon            89..896
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1738
                     /gene="Klf2"
                     /gene_synonym="Lklf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacagtc cctgccatgg cgctcagcga gcctatcttg ccgtcctttg ccactttcgc
       61 cagcccctgc gagcgcggcc tccaggagcg ctggccgcga aatgagcccg aggcgggcag
      121 cacggatgag gacctaaaca gcgtgctgga cttcatcctg tccatgggac tggacggcct
      181 gggcgccgag aaccctcccg agcccccacc gcagcccccg cctcctgcgt tctactaccc
      241 ggagccgggt gcccctccgc cctatggcac cccggcggct ggcctgggaa cggagctgct
      301 gcgcccggat ctggatgcgc ctcaggggcc ggctctacac ggccgcttcc tcctcgcgcc
      361 tcccgggcgg ctggtgaaag ccgagccccc ggaggtggac ggcggcggct acgggtgcgc
      421 agccggcttg gctcgcggac cgcgcgggct gaagctcgag ggcgccctgg gagcgacagg
      481 tgcatgcatg cggggtcctg ctggccgtcc cccaccgccc tccgacacgc cgccgctcag
      541 ccccgacggc cccccgcgcc tcccggcgcc cggtccccgc aacccgttcc cgccaccctt
      601 cggccccggc cccagcttcg gcggccccgg ccccgcgttg cactacgggc cgcccgctcc
      661 cggcgctttc ggtctcttcg acgacgcggc ggcggctctg ggtcttgctc cccctgccac
      721 gcgcggtctc ctcacgccgc cctcgtcccc gctggagctg ttggaggcca agcccaagcg
      781 cggccgccgc tcctggcccc gcaagcgcgc cgccacgcac acttgcagct acaccaactg
      841 cggcaagacc tacaccaaga gttcgcacct aaaggcgcat ctgaggacgc acacaggtga
      901 gaagccttat cattgcaact gggacggctg cggctggaag ttcgcgcgct ctgacgagct
      961 tacccgccac taccgcaagc acacgggtca caggcccttc cagtgccact tgtgcgaccg
     1021 ggccttctcc aggtccgacc acctggctct gcacatgaag cgacacatgt agcctgggtc
     1081 gactcggcca gcccatgagc gactgtggcg ggttccacgc gccgggcacg gcccccttgc
     1141 aacaaactga ctgttattta ttggaccctg aggacggagt cggacaagag tggccacagg
     1201 aaaatgactt tgccaccagt tccggctccc accgtgactg aaggctccag gaaagaagac
     1261 aggagcctgt gaagaatgtt ttcaaaatgg tgcaataatt gacttctttc tctcgggttc
     1321 ccactagagg atcgaggcta gccttgtgag aaatgccttt gagtttacta tccccaacta
     1381 tccccaacgt tgtttttata atattgtata taagtgaccg tggcaatctg tatgactata
     1441 agggagacga tggcatctct gtcgcctgct tcgtttttat aactcttttt ttaattaaaa
     1501 aagttttgga tctttggagg aatcatggta gtgctgtggc tggggatgga ggaggggctg
     1561 cgggttctgt ataaatgtaa acatagtgtt tgaggattgg gcacaggcta ttttaagtct
     1621 gctactttga gccgtaattt tcccccttgt atcccagagc tgggaaagcg atggttccac
     1681 tgatgtggcc atcccttttt tagaaagaaa aaagaaaatt aaaaaccttt tcctggta
//
