LOCUS       NM_053536               2457 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus KLF transcription factor 15 (Klf15), mRNA.
ACCESSION   NM_053536
VERSION     NM_053536.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2457)
  AUTHORS   Huang,Y., Wang,Z., Li,B., Ke,L., Xiong,Y. and Zhang,Y.
  TITLE     Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in
            endometriosis
  JOURNAL   J Endocrinol 261 (2), e230319 (2024)
   PUBMED   38513352
  REMARK    GeneRIF: Loss of KLF15 impairs endometrial receptivity by
            inhibiting EMT in endometriosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2457)
  AUTHORS   Liao,Z.X., Huang,L., Zhu,H.Z. and Zhu,M.J.
  TITLE     [KLF15/mTOR related proteins involved in effect of aerobic interval
            training on improving skeletal muscle lesions in rats with type 2
            diabetes]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (6), 676-681 (2022)
   PUBMED   37308416
  REMARK    GeneRIF: [KLF15/mTOR related proteins involved in effect of aerobic
            interval training on improving skeletal muscle lesions in rats with
            type 2 diabetes].
REFERENCE   3  (bases 1 to 2457)
  AUTHORS   Wu,L., Li,O., Zhu,F., Wang,X., Chen,P., Cai,G., Chen,X. and Hong,Q.
  TITLE     Krupsilonppel-like factor 15 suppresses renal glomerular mesangial
            cell proliferation via enhancing P53 SUMO1 conjugation
  JOURNAL   J Cell Mol Med 25 (12), 5691-5706 (2021)
   PUBMED   33949114
  REMARK    GeneRIF: Krupsilonppel-like factor 15 suppresses renal glomerular
            mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
REFERENCE   4  (bases 1 to 2457)
  AUTHORS   Zhao,T., Qiu,Z. and Gao,Y.
  TITLE     MiR-137-3p exacerbates the ischemia-reperfusion injured
            cardiomyocyte apoptosis by targeting KLF15
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 393 (6), 1013-1024 (2020)
   PUBMED   31822940
  REMARK    GeneRIF: MiR-137-3p exacerbates the ischemia-reperfusion injured
            cardiomyocyte apoptosis by targeting KLF15.
REFERENCE   5  (bases 1 to 2457)
  AUTHORS   Patel,S.K., Velkoska,E., Gayed,D., Ramchand,J., Lesmana,J. and
            Burrell,L.M.
  TITLE     Left ventricular hypertrophy in experimental chronic kidney disease
            is associated with reduced expression of cardiac Kruppel-like
            factor 15
  JOURNAL   BMC Nephrol 19 (1), 159 (2018)
   PUBMED   29970016
  REMARK    GeneRIF: Loss of cardiac KLF15 in chronic kidney disease induced
            left ventricular hypertrophy, is associated with trophic and
            fibrotic signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2457)
  AUTHORS   Horie,T., Ono,K., Nishi,H., Iwanaga,Y., Nagao,K., Kinoshita,M.,
            Kuwabara,Y., Takanabe,R., Hasegawa,K., Kita,T. and Kimura,T.
  TITLE     MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15
            and is involved in metabolic control in cardiac myocytes
  JOURNAL   Biochem Biophys Res Commun 389 (2), 315-320 (2009)
   PUBMED   19720047
  REMARK    GeneRIF: The present results indicated that miR-133 regulates the
            expression of GLUT4 by targeting KLF15 and is involved in metabolic
            control in cardiomyocytes.
REFERENCE   7  (bases 1 to 2457)
  AUTHORS   Cullingford,T.E., Butler,M.J., Marshall,A.K., Tham el,L.,
            Sugden,P.H. and Clerk,A.
  TITLE     Differential regulation of Kruppel-like factor family transcription
            factor expression in neonatal rat cardiac myocytes: effects of
            endothelin-1, oxidative stress and cytokines
  JOURNAL   Biochim Biophys Acta 1783 (6), 1229-1236 (2008)
   PUBMED   18406357
REFERENCE   8  (bases 1 to 2457)
  AUTHORS   Fisch,S., Gray,S., Heymans,S., Haldar,S.M., Wang,B., Pfister,O.,
            Cui,L., Kumar,A., Lin,Z., Sen-Banerjee,S., Das,H., Petersen,C.A.,
            Mende,U., Burleigh,B.A., Zhu,Y., Pinto,Y.M., Liao,R. and Jain,M.K.
  TITLE     Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 104 (17), 7074-7079 (2007)
   PUBMED   17438289
  REMARK    GeneRIF: These studies identify KLF15 as part of a heretofore
            unrecognized pathway regulating the cardiac response to hemodynamic
            stress
            Erratum:[Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13851.
            Pinto, Yigal [corrected to Pinto, Yigal M]]
REFERENCE   9  (bases 1 to 2457)
  AUTHORS   Yamamoto,J., Ikeda,Y., Iguchi,H., Fujino,T., Tanaka,T., Asaba,H.,
            Iwasaki,S., Ioka,R.X., Kaneko,I.W., Magoori,K., Takahashi,S.,
            Mori,T., Sakaue,H., Kodama,T., Yanagisawa,M., Yamamoto,T.T., Ito,S.
            and Sakai,J.
  TITLE     A Kruppel-like factor KLF15 contributes fasting-induced
            transcriptional activation of mitochondrial acetyl-CoA synthetase
            gene AceCS2
  JOURNAL   J Biol Chem 279 (17), 16954-16962 (2004)
   PUBMED   14960588
  REMARK    GeneRIF: together with the trans-activation of the AceCS2 promoter,
            it is suggested that fasting-induced AceCS2 expression is largely
            contributed by KLF15
REFERENCE   10 (bases 1 to 2457)
  AUTHORS   Gray,S., Feinberg,M.W., Hull,S., Kuo,C.T., Watanabe,M.,
            Sen-Banerjee,S., DePina,A., Haspel,R. and Jain,M.K.
  TITLE     The Kruppel-like factor KLF15 regulates the insulin-sensitive
            glucose transporter GLUT4
  JOURNAL   J Biol Chem 277 (37), 34322-34328 (2002)
   PUBMED   12097321
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053536.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000004.1  124523015-124523066
            53-253              JAXUCZ010000004.1  124525025-124525225
            254-1357            JAXUCZ010000004.1  124526813-124527916
            1358-2457           JAXUCZ010000004.1  124534512-124535611
FEATURES             Location/Qualifiers
     source          1..2457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2457
                     /gene="Klf15"
                     /note="KLF transcription factor 15"
                     /db_xref="GeneID:85497"
                     /db_xref="RGD:70918"
     exon            1..52
                     /gene="Klf15"
                     /inference="alignment:Splign:2.1.0"
     exon            53..253
                     /gene="Klf15"
                     /inference="alignment:Splign:2.1.0"
     exon            254..1357
                     /gene="Klf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1526
                     /gene="Klf15"
                     /note="Kruppel-like factor 15"
                     /codon_start=1
                     /product="Krueppel-like factor 15"
                     /protein_id="NP_445988.2"
                     /db_xref="GeneID:85497"
                     /db_xref="RGD:70918"
                     /translation="MVDHLLPVDETFSSPKCPVGYLGDRLASRQPYHMLPSPISEDDS
                     DVSSPCSCASPDSQAFCSCYSAGPGPEAQGSILDFLLSRATLGSGGASGGVGDGSGPV
                     TWGSWRRASVPVKEEHLCFPEFLSGDPDDVSRPFQPTLEEIEEFLEENMEAEVKEAPE
                     SSSRDLEACSQLSAGSHRSHLHPESGGRECRTPPPGGTSGGGTQGAGEGSAHDGPMPV
                     LLQIQPVAVKQEAGAGPASPGQAPESVKVAQLLVNIQGQTFALLPQVVPSSNLNLSSK
                     FVRIAPVPIAAKPIGSGSLGPGPAGLLVGQKFPKNPAAELLKMHKCTFPGCSKMYTKS
                     SHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARS
                     DHLSKHIKVHRFPRSSRAVRAIN"
     exon            1358..2457
                     /gene="Klf15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacggagcc gggccgcacg cgcgaggccg tgccaggcga cgccgagtcc aggcagtcct
       61 gttctgggtc ctgggacacc gtgtgcactg aatttgcgtg actgtacaga cgctaagtgc
      121 tcagtatgtg gaagttgttg agtattcgta taccctacgt ataggagcca cgtcacactg
      181 gcagcaaaca gatgtgcgca cagagacgtt gtgctgcttt cctgaggttg cacagctgac
      241 agctgcagac aagtcaccac aggctcggcc aggccagcat ggtggaccac ttgcttccag
      301 tggacgagac cttctcgtca ccgaaatgcc cagtgggata cctgggagat aggctggcca
      361 gccggcagcc ataccacatg ttgccctcgc ccatctccga ggatgacagc gatgtctcca
      421 gcccctgctc ttgtgccagc cctgactcgc aagccttctg ttcctgctat agtgcaggtc
      481 cgggccctga ggcccagggc agcatcttgg atttcctcct atcccgggcc acactgggca
      541 gtggtggtgc cagtggaggt gtcggagatg gcagtggccc tgtgacctgg ggatcgtgga
      601 ggagagcctc tgtgcctgtg aaggaggaac atctttgctt ccctgaattt ctgtcagggg
      661 accctgatga tgtctccagg cccttccagc ctaccctgga ggagattgaa gaattcttgg
      721 aagagaacat ggaggctgag gtcaaggagg ccccagagag cagcagcagg gacctggaag
      781 cctgtagcca gctctcagct gggtcacacc ggagccacct ccatccagag tccggtggga
      841 gagagtgccg taccccacca ccaggtggca ccagtggggg tggtacccaa ggtgcaggtg
      901 aggggtcagc tcatgatggc cccatgccgg tgctactgca gatccagcct gttgctgtga
      961 agcaggaagc aggtgcaggg ccagcctccc cagggcaggc cccggagagc gtcaaggtcg
     1021 cccagcttct ggtcaacatc caggggcaga cctttgcact cctgcctcaa gtggtaccat
     1081 cctccaactt gaacctgtcc tcaaagtttg tgcgaattgc gcctgtgccc attgccgcca
     1141 aacctattgg ctcaggatcc ctagggcccg gccctgctgg tctccttgtg ggccagaagt
     1201 tccccaagaa cccagcagca gaacttctca aaatgcacaa atgcactttc ccaggctgca
     1261 gcaagatgta caccaagagc agccacctca aggcccacct gcgccggcac acaggcgaga
     1321 agccctttgc ctgcacctgg ccgggctgcg gctggaggtt ttcacgctca gatgagttgt
     1381 cacggcaccg acgatctcac tcgggtgtga agccgtacca gtgtcccgta tgcgagaaga
     1441 aattcgcgcg gagtgaccac ctctccaaac acatcaaggt gcatcgcttc ccacgaagca
     1501 gccgcgcagt acgcgccatc aactgagcgc agtggccgcc ctcccctccc ccacctccac
     1561 attttgtttt taaatgcaat aacttattgc ctctttcaga aggatgtgac aatattacca
     1621 gtcccccttc tgaatcttag gaggtatgac ccagagccgc cgtggctgcc tttccgggga
     1681 ggacccagag tccccaaggt ccctgggggc tggttccccg gtggcccagg tggcccaggc
     1741 aggcctgtgc ccttgtgcct ttgtgccttc ctgccagctg gaagcagtgt ttggggggcc
     1801 cttgccctcc tcccattggg ctccctacca gggccaaagc caacattatc actggggaag
     1861 gagtgttttg gctgtgtcga aatagtagct cccagaggaa gccatgctga gaaaaaggaa
     1921 gtaggtcaaa agcgcagggc tgtactgtgg tgcgaggacc gccatatgca agaggcctct
     1981 gagggtccag gaggatggcc accctcgctc taggccctaa cgcaagtgct taaatgcaag
     2041 acaaatggag ccatatccat ccatacccag cctggctcac cctcctccag acgccaacct
     2101 cctggctgtg gtgggaagcg aaaggagcag gtctggtgga tgcaaagcga ctagctagcg
     2161 cctcccagtc tgacttagat ccgcattcct cgtcaggtct agaaattagt accaattgaa
     2221 ctagcttgtt tcgacaggtc tgtttcacat cctatgaatg tatgtaaata aactgtacat
     2281 aggtgcgcat ctacataaaa tatcttttaa taacacgttg acatttgtgt aaatttgaaa
     2341 tttaaaaaaa ttctatgaag tcagtgtaca tatgttacaa ttatgtatat tttctttggt
     2401 ccttcataaa aaatatattt actttgccaa taaaaagaga gaaaaaaaaa agaactc
//
