LOCUS       NM_001037354            3780 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus KLF transcription factor 11 (Klf11), mRNA.
ACCESSION   NM_001037354 XM_234008
VERSION     NM_001037354.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Li,Y., Shi,X., Li,J., Zhang,M. and Yu,B.
  TITLE     Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via
            JAK2/STAT3 signaling in H9c2
  JOURNAL   Apoptosis 22 (4), 510-518 (2017)
   PUBMED   27848055
  REMARK    GeneRIF: In hypoxia/reoxygenation injury of rat cardiomyocytes,
            inhibition of KLF11 by siRNA suppressed apoptosis, the activity of
            caspase3, the expression of cleaved-caspase3 and cytochrome C in
            the cytoplasm and the damage of mitochondrial membrane.  KLF11
            knockdown elevated the expression of p-JAK2 and p-STAT3. KLF11
            silencing protects against H/R injury by activating the JAK2/STAT3
            signaling pathway .
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Duncan,J., Wang,N., Zhang,X., Johnson,S., Harris,S., Zheng,B.,
            Zhang,Q., Rajkowska,G., Miguel-Hidalgo,J.J., Sittman,D., Ou,X.M.,
            Stockmeier,C.A. and Wang,J.M.
  TITLE     Chronic Social Stress and Ethanol Increase Expression of KLF11, a
            Cell Death Mediator, in Rat Brain
  JOURNAL   Neurotox Res 28 (1), 18-31 (2015)
   PUBMED   25739536
  REMARK    GeneRIF: Kruppel-like factor 11 protein is up-regulated following
            chronic exposure to stress or ethanol in a region-specific manner
            and may contribute to pro-apoptotic signaling in ethanol-treated
            rats.
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Bonnefond,A., Lomberk,G., Buttar,N., Busiah,K., Vaillant,E.,
            Lobbens,S., Yengo,L., Dechaume,A., Mignot,B., Simon,A.,
            Scharfmann,R., Neve,B., Tanyolac,S., Hodoglugil,U., Pattou,F.,
            Cave,H., Iovanna,J., Stein,R., Polak,M., Vaxillaire,M., Froguel,P.
            and Urrutia,R.
  TITLE     Disruption of a novel Kruppel-like transcription factor
            p300-regulated pathway for insulin biosynthesis revealed by studies
            of the c.-331 INS mutation found in neonatal diabetes mellitus
  JOURNAL   J Biol Chem 286 (32), 28414-28424 (2011)
   PUBMED   21592955
  REMARK    GeneRIF: an important role for KLF11 in the regulation of INS
            transcription via the novel c.-331 KLF site.
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Fernandez-Zapico,M.E., Lomberk,G.A., Tsuji,S., DeMars,C.J.,
            Bardsley,M.R., Lin,Y.H., Almada,L.L., Han,J.J., Mukhopadhyay,D.,
            Ordog,T., Buttar,N.S. and Urrutia,R.
  TITLE     A functional family-wide screening of SP/KLF proteins identifies a
            subset of suppressors of KRAS-mediated cell growth
  JOURNAL   Biochem J 435 (2), 529-537 (2011)
   PUBMED   21171965
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Gutierrez-Aguilar,R., Froguel,P., Hamid,Y.H., Benmezroua,Y.,
            Jorgensen,T., Borch-Johnsen,K., Hansen,T., Pedersen,O. and Neve,B.
  TITLE     Genetic analysis of Kruppel-like zinc finger 11 variants in 5864
            Danish individuals: potential effect on insulin resistance and
            modified signal transducer and activator of transcription-3 binding
            by promoter variant -1659G>C
  JOURNAL   J Clin Endocrinol Metab 93 (8), 3128-3135 (2008)
   PUBMED   18505768
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Cullingford,T.E., Butler,M.J., Marshall,A.K., Tham el,L.,
            Sugden,P.H. and Clerk,A.
  TITLE     Differential regulation of Kruppel-like factor family transcription
            factor expression in neonatal rat cardiac myocytes: effects of
            endothelin-1, oxidative stress and cytokines
  JOURNAL   Biochim Biophys Acta 1783 (6), 1229-1236 (2008)
   PUBMED   18406357
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   Neve,B., Fernandez-Zapico,M.E., Ashkenazi-Katalan,V., Dina,C.,
            Hamid,Y.H., Joly,E., Vaillant,E., Benmezroua,Y., Durand,E.,
            Bakaher,N., Delannoy,V., Vaxillaire,M., Cook,T.,
            Dallinga-Thie,G.M., Jansen,H., Charles,M.A., Clement,K., Galan,P.,
            Hercberg,S., Helbecque,N., Charpentier,G., Prentki,M., Hansen,T.,
            Pedersen,O., Urrutia,R., Melloul,D. and Froguel,P.
  TITLE     Role of transcription factor KLF11 and its diabetes-associated gene
            variants in pancreatic beta cell function
  JOURNAL   Proc Natl Acad Sci U S A 102 (13), 4807-4812 (2005)
   PUBMED   15774581
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Song,C.Z., Gavriilidis,G., Asano,H. and Stamatoyannopoulos,G.
  TITLE     Functional study of transcription factor KLF11 by targeted gene
            inactivation
  JOURNAL   Blood Cells Mol Dis 34 (1), 53-59 (2005)
   PUBMED   15607700
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Wang,Z., Peters,B., Klussmann,S., Bender,H., Herb,A. and
            Krieglstein,K.
  TITLE     Gene structure and evolution of Tieg3, a new member of the Tieg
            family of proteins
  JOURNAL   Gene 325, 25-34 (2004)
   PUBMED   14697507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001037354.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ232764.2, SRR26643298.34990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000006.1  47014448-47014537
            91-342              JAXUCZ010000006.1  47016065-47016316
            343-1273            JAXUCZ010000006.1  47017365-47018295
            1274-3780           JAXUCZ010000006.1  47023646-47026152
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3780
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /note="KLF transcription factor 11"
                     /db_xref="GeneID:313994"
                     /db_xref="RGD:1306646"
     exon            1..90
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1554
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /note="transcription factor CP2-like 2; Kruppel-like
                     factor 11"
                     /codon_start=1
                     /product="Krueppel-like factor 11"
                     /protein_id="NP_001032431.2"
                     /db_xref="GeneID:313994"
                     /db_xref="RGD:1306646"
                     /translation="MHSPGSTGPGDARAADIMDICESILERKRHDSERSTCSILEQTD
                     IEAVEALVCMSSWGQRSQVRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITP
                     PQSPELMEPTGTPVPSQVINSQGCMATALPPSPTGGPRTLSKGEPPEPSSESSCRAVM
                     TSVIRHTGESPAPTCFPTGPTQEQPASDSRGGQDPLLDHLEALQDTRLADGLLVTNLV
                     SCQPCLHKSGGLFPIDKGQQTVWPTAVQTCLPKNPESDLSRKTTPFISVPVSSPPVLC
                     QMIPVAGQNGMLSAFLRPPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQ
                     STFPQPAACPSSVMAIGNTKLLPLAPAPVFVASSQNCAPQVDFSRRRNYVCNFPGCRK
                     TYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDR
                     RFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRITLAESPRSILEPLPASG"
     exon            91..342
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1273
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..3780
                     /gene="Klf11"
                     /gene_synonym="Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctcc tgcctcgcag cattgctgcc tgcaggccgt acggcaccat gcactcgcca
       61 ggctccaccg gcccgggcga cgcgcgcgcg gctgacatca tggacatttg tgagtcaatc
      121 ctggagagga agcggcacga cagcgaaagg tccacgtgca gcatcctgga gcagacagat
      181 atcgaagctg tggaagctct cgtttgcatg agttcttggg gtcaaaggtc ccaggtgaga
      241 cccctcacgc ccgtctctga ttctggtgac gtcaccacgg cggtgcttat ggacacagct
      301 gcacctgatc taccaaagga cttccattct ttttcaactc tgtgtataac tcctcctcag
      361 agcccagagc tcatggagcc aacagggacc cctgttcctt cccaagtaat caattcccaa
      421 ggatgcatgg ccactgccct ccccccatcc cctactgggg gccccagaac actgagcaag
      481 ggggaaccac cggagccatc ctcagagtcc tcctgcaggg ccgtgatgac gagcgtgatc
      541 cgtcacactg gggagagccc agctccgaca tgttttccaa ctggtccaac tcaagagcag
      601 ccagcgtccg acagcagagg aggacaagac ccgttgctgg accacctcga agccttgcag
      661 gacacacgtt tggcagatgg cttacttgtc actaacttgg tttcctgtca gccttgcttg
      721 cacaagtctg gtggcctgtt ccccatcgac aaaggccaac agacagtatg gcccactgcc
      781 gttcagacct gcttaccaaa gaatcctgaa agtgacttgt caaggaaaac cacccctttt
      841 atttctgtcc ctgtctctag cccccctgtc ctttgccaga tgatccctgt ggctggacaa
      901 aatggcatgc tctcagcttt tttgaggcct cctacccagt tgcctgcagg gactatcaag
      961 cccatcctac cccaagctgc ttcaatgtct cagcctgtgt tcatgggccc gcctgtgcct
     1021 cagggaactg tgatgctggt cttgccacag agcaccttcc cccagcctgc tgcctgtcca
     1081 tccagtgtca tggccattgg aaataccaaa ctcttgcccc ttgcccctgc cccagtgttc
     1141 gtcgcctcca gccagaactg tgcgcctcag gtagactttt ccagaaggag gaactatgtt
     1201 tgcaatttcc caggctgccg gaagacctac ttcaaaagtt cccaccttaa agctcatctt
     1261 cgcacccaca caggggagaa gccttttacc tgcagctggg acggctgtga caaaaagttt
     1321 gcaaggtcag atgaactgtc tcgccaccgc agaactcaca ctggagagaa gaagtttgtg
     1381 tgtcctgtgt gtgaccggcg cttcatgagg agtgaccacc tgaccaagca cgctcgtcgc
     1441 cacatgacaa caaagaagat cccaggctgg caggcagagg tgggcaagct gaacagaatc
     1501 accttagcag agagccccag gagcatcctc gaacctttgc cggcctctgg ctgaggcttc
     1561 ctgtggcatc catcacctgt gggcttcttc gaaaacctct tcaggaatgg aacctgtgtg
     1621 ttcctctcca aaaataacca tgtctctggg ctgttgaagt ggggagctgg ttctgatgga
     1681 agtgtattaa ttttactttt ctggttggga ccctgttcta tatcttttgt agtttcagaa
     1741 ctgtctgtct gtctctgtgt gtctctgtct ctgtctgtct ctctcttttg taaggaaatg
     1801 gaagaaaatt tgatctaaat caccagcatt caaacaaata ttcctgcaat aaagtttaca
     1861 aagtctggat ttttttttta tacctttcta ttcatgtttt gtagaaatgt gacagggtac
     1921 taatttttat actttttata aaaatattta tattgtgctc aaatcaccaa tttgtgggta
     1981 gacaatttta cagccttctt ttccatgttt tataacgttt tgtaataacc ctgcttaaga
     2041 gtgagcctgg tagttagaaa gaaacaaata ccaagtttgt taccagcctt ttatagtgat
     2101 tgttttagat cagaactggt tgaataaaga actcttaaag gggaaaataa actttgtagt
     2161 tagcatcttt gtatcatttt caggggaaat tctagcagcc actcctgtag cccacagaac
     2221 taagattgtg gttgggtaga aggaatcatg tgagcgatgt ccctgaggag ggtgtgcccg
     2281 ggtctgcctg ggctgctggc cagctgagca ggggcgaatg tggaatgttg acttctgggc
     2341 catctgtctg ctaatggcaa atggtcccat gtcctgcctg tacttaagca ccaaaaccaa
     2401 gaacgtggat gcagaaactt tgtagattgc ccggtggctt ctgttgtgga tttgtactgc
     2461 atggcggatt gaccacacag agaaagggaa atgtctaaat gggttggtta aactttccac
     2521 cggagagcac cttccacaaa gcaaggccct ttgtacacag tcggctctgg ggttcagatg
     2581 cctttcttat ggacaaaaca ccgagaaatg tgtcactaaa tggcagtcag taccacccaa
     2641 ctaccttccc ggtcattgtg tgtgaaggaa atgattttgc tcaaacaaga agacttgggg
     2701 tggggatttt gtagtttgcc tgaaaacatc tggggaactg cttttacgcc ttgtgagcgc
     2761 gcgtcctgca tccaggtggt cacaaaaaat ggttttagtt aaagtttagt taaattgtat
     2821 tgctcgggca atacagttaa gtgtgagaac aaagtatatt gtgctgtttg ggcaacctga
     2881 gaatatattt gtgtggtacg tgttaagttt tgtatttgcc ttttaatgat tggcattcaa
     2941 ctttattaaa tgatggcaag gtagaaatat taaacagata aaatgaggtt tctgtgttca
     3001 ggtcttttga gccttatata accattacgt ggtcatacat tgtatgttac ttgatccatg
     3061 ttaagctgcc ttggtagcca agttttgtat gtacgcgtgt ttaggaactg tccaggcagt
     3121 gctgttactg tctttcaaca caatggagtg caggagaact aactgtatat agctcacatg
     3181 tgtcccagca ccctggtcct gtccacctgt cttaagacag catccacact ggtgactgta
     3241 agtgataaat ggcatccaat ttggaatgtc tttttttcat tgtgacatgc agaagtgatg
     3301 ttccttgtcc tggtgtttct gtgggtaacg gcaggccttg gggggttcgg ttgctcatca
     3361 cagaactttc tcagaccagt attgtttcta aatgatggat gtgttgaaat accattagct
     3421 ttccatttcc taattagatt taggaacccc ttttctgaaa gagcccccaa catttgtcta
     3481 ctgaaaagaa aacagttcgt atctgaatag gactcctgag ccccagagcc ccgggagtgg
     3541 ctgctccctt gagggtcctc cccaacttcc cgcggcgtga tggtgattcc agtgcacttt
     3601 attgcttgag aagttcttga tttgattttt tttcactttg ttgagccttt cagtagtttt
     3661 agtgataaaa atttaaatgt taactacttt tgttttatgt aacagacctt gacttattta
     3721 aatgaatatg tgtaatgtaa cttttttttc cctttgaatc atataaaact ttcttggttc
//
