LOCUS       NM_031135               2962 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus KLF transcription factor 10 (Klf10), mRNA.
ACCESSION   NM_031135
VERSION     NM_031135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Li,Q., Shen,P., Zeng,S. and Liu,P.
  TITLE     TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by
            Inhibiting Transcription Factor GATA4
  JOURNAL   J Cardiovasc Pharmacol 66 (2), 196-203 (2015)
   PUBMED   26252173
  REMARK    GeneRIF: A novel role for TIEG1 was determined as an inhibitor in
            angiotensin II-induced cardiomyocyte hypertrophy.
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Martinez-Armenta,M., Diaz de Leon-Guerrero,S., Catalan,A.,
            Alvarez-Arellano,L., Uribe,R.M., Subramaniam,M., Charli,J.L. and
            Perez-Martinez,L.
  TITLE     TGFbeta2 regulates hypothalamic Trh expression through the TGFbeta
            inducible early gene-1 (TIEG1) during fetal development
  JOURNAL   Mol Cell Endocrinol 400, 129-139 (2015)
   PUBMED   25448845
  REMARK    GeneRIF: TGFbeta2 regulates hypothalamic TRH expression through
            TIEG1 during fetal development.
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Iizuka,K., Takeda,J. and Horikawa,Y.
  TITLE     Kruppel-like factor-10 is directly regulated by carbohydrate
            response element-binding protein in rat primary hepatocytes
  JOURNAL   Biochem Biophys Res Commun 412 (4), 638-643 (2011)
   PUBMED   21856285
  REMARK    GeneRIF: these data suggest that crosstalk between ChREBP and
            KLF-10 is involved in the regulation of the lipogenic pathway.
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Spittau,G., Happel,N., Behrendt,M., Chao,T.I., Krieglstein,K. and
            Spittau,B.
  TITLE     Tieg1/Klf10 is upregulated by NGF and attenuates cell cycle
            progression in the pheochromocytoma cell line PC12
  JOURNAL   J Neurosci Res 88 (9), 2017-2025 (2010)
   PUBMED   20155803
  REMARK    GeneRIF: our results identify Tieg1/Klf10 as a new NGF target gene
            and substantiate its anti-proliferative function in the NGF
            signaling pathway in PC12 cells
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Hirota,T., Kon,N., Itagaki,T., Hoshina,N., Okano,T. and Fukada,Y.
  TITLE     Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box
            and controls circadian clockwork
  JOURNAL   Genes Cells 15 (2), 111-121 (2010)
   PUBMED   20070857
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Subramaniam,M., Gorny,G., Johnsen,S.A., Monroe,D.G., Evans,G.L.,
            Fraser,D.G., Rickard,D.J., Rasmussen,K., van Deursen,J.M.,
            Turner,R.T., Oursler,M.J. and Spelsberg,T.C.
  TITLE     TIEG1 null mouse-derived osteoblasts are defective in
            mineralization and in support of osteoclast differentiation in
            vitro
  JOURNAL   Mol Cell Biol 25 (3), 1191-1199 (2005)
   PUBMED   15657444
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Noti,J.D., Johnson,A.K. and Dillon,J.D.
  TITLE     The zinc finger transcription factor transforming growth factor
            beta-inducible early gene-1 confers myeloid-specific activation of
            the leukocyte integrin CD11d promoter
  JOURNAL   J Biol Chem 279 (26), 26948-26958 (2004)
   PUBMED   15087465
REFERENCE   8  (bases 1 to 2962)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   9  (bases 1 to 2962)
  AUTHORS   Hevroni,D., Rattner,A., Bundman,M., Lederfein,D., Gabarah,A.,
            Mangelus,M., Silverman,M.A., Kedar,H., Naor,C., Kornuc,M.,
            Hanoch,T., Seger,R., Theill,L.E., Nedivi,E., Richter-Levin,G. and
            Citri,Y.
  TITLE     Hippocampal plasticity involves extensive gene induction and
            multiple cellular mechanisms
  JOURNAL   J Mol Neurosci 10 (2), 75-98 (1998)
   PUBMED   9699150
  REMARK    Review article
REFERENCE   10 (bases 1 to 2962)
  AUTHORS   Tachibana,I., Imoto,M., Adjei,P.N., Gores,G.J., Subramaniam,M.,
            Spelsberg,T.C. and Urrutia,R.
  TITLE     Overexpression of the TGFbeta-regulated zinc finger encoding gene,
            TIEG, induces apoptosis in pancreatic epithelial cells
  JOURNAL   J Clin Invest 99 (10), 2365-2374 (1997)
   PUBMED   9153278
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097309.1.
            
            On Jun 3, 2007 this sequence version replaced NM_031135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097309.1, U78875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2962
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /note="KLF transcription factor 10"
                     /db_xref="GeneID:81813"
                     /db_xref="RGD:621652"
     exon            1..82
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1489
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /note="TIEG-1; TGFB-inducible early growth response
                     protein 1; zinc finger transcription factor homolog CPG20;
                     transforming growth factor-beta-inducible early growth
                     response protein 1; TGFB inducible early growth response;
                     Kruppel-like factor 10"
                     /codon_start=1
                     /product="Krueppel-like factor 10"
                     /protein_id="NP_112397.1"
                     /db_xref="GeneID:81813"
                     /db_xref="RGD:621652"
                     /translation="MLNFGASLQQASEGKMELISEKSKEGAHPWDKAEQSDFEAVEAL
                     MSMSCDWKSHFKKYLENRPVTPVSDTSEEDSLLPGTPDLQTVPAFCLTPPYSPSDFEP
                     SQGSNLTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTAD
                     AQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSPNRPKPEPSTAAN
                     GAEKAGTAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVSTGGVPPLPVICQM
                     VPLPANNSLVTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVV
                     SPNGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRT
                     HTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARR
                     HLSAKKLPNWQMEVSKLNDIALPPATASAQ"
     exon            83..313
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1229
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2937
                     /gene="Klf10"
                     /gene_synonym="Tieg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccagcag ccaagcagct cgcgacctac ggccaggcag ccaaccatgc ttaacttcgg
       61 cgcttctctc cagcaagctt cggaggggaa aatggaacta atttctgaaa agtccaaaga
      121 gggagcacat ccctgggaca aagctgaaca gagtgacttt gaagctgtgg aagcgctcat
      181 gtccatgagc tgcgactgga agtctcactt caagaaatac cttgaaaaca ggcctgtcac
      241 accagtgtct gatacctcag aggaagacag tttgcttcca gggacgcctg accttcagac
      301 cgtcccagca ttctgtttga ctccacctta cagcccctct gacttcgaac cctcgcaggg
      361 gtcaaatctg acggcaccag cgccacctac tggtcacttc agatcgctct ccgatgctgc
      421 caagcctccc agcatcgctc cttttaaaga ggaggaaaag agcccattag ctgcccctcc
      481 cctccctaag gctcaagcca ccagtgtcat ccgtcacaca gctgatgccc aactctgtaa
      541 ccaccagtcc tgccctgtga aagcagctag catcctcaac taccaggaca attctttccg
      601 gagaagaacc cacataaatg tcgaggctac tcgaaagaac ataccctgtg ctgctgtgtc
      661 accaaacaga cccaagcctg agcccagcac agcggcgaat ggcgctgaga aggccggcac
      721 tgcgccgtat gactttgctg tgccttcctc agagacagtc atctgtaggt cttctcagcc
      781 agctcccacg tccccagtac agaagtcagt actgatgtct tcacctacag tgtccactgg
      841 gggagtgcca cccttgcctg tcatctgcca gatggttccc cttccagcaa acaactctct
      901 cgttaccaca gttgtcccca gcagtccgcc cagccagcca cccgctgtct gctcacccgt
      961 gttgttcatg ggcactcagg tgcccaaggg cacggtcatg tttgtggtac cccagcccgt
     1021 tgtacagagc ccaaagcctc cagtggtgag ccccaatggc accagactgt ctcccattgc
     1081 ccctgcgcct ggattctctc cttcagcagc aagggttact ccccagattg attcgtccag
     1141 agtaagaagt cacatctgta gccacccagg atgtggcaag acttacttta aaagttccca
     1201 tctgaaggcc cacgtgagaa cacacacagg ggaaaaacct ttcagctgca gctggaaagg
     1261 ctgtgaaagg aggtttgctc gttccgatga actgtccaga caccggcgga cacacacagg
     1321 tgagaagaaa tttgcctgtc ccatgtgtga ccgtcggttc atgagaagtg accatttaac
     1381 caaacatgcc cggcgacacc tatcagccaa gaagctgcca aactggcaaa tggaagtgag
     1441 caagttaaat gacatcgctc tgcctccggc cacagcgtcg gcacagtgac ggccagaaga
     1501 tggagactca gaataaactt tggtcagagt cgagccggtg accgtgtcaa atgcttctgc
     1561 aagtctgcgg ccctccaaca gggcctaaag cagaagcccc tggcctgggg ggaggcccag
     1621 cctgggttag atgacgagaa gtgcttcagc cacaggcagt tcacagaagg gcggggttca
     1681 tttcttacca cgtagagaga tgagaacact cgtgtccctt gagtagtttt ggaaggtttc
     1741 ggatgagatg agcacagcac aggttttgaa tcacatacac atcaggtact ttgtttttgc
     1801 catttatact tgagaccagc tttgcagtgt gattctttta aagcgttggt ttcgagaata
     1861 tagaggctga aattacggta cagaaatgca gctagaaagt gagtttgtgt catcttctcc
     1921 tagagttatc ttgcttatta ttcctagtct ttacagtcaa ctccgtggac gtggctaagt
     1981 atagaaaact atcatttctt ccactgttgt tggtatttga ggttgaacag ctgtacattg
     2041 ctaaggggag cccaaggatt ggaactctca ttaatttaat tgcttggaag tgcagctaaa
     2101 gttctttttt ttggcctttt gttttgaaag tttaggcatt ttactctacc ttagatatta
     2161 gtttgcttgc agttttttgt gtagatttga aaactgtaca ccaatgtgtt tcctatagac
     2221 ttaagatacg ctgcgctttg tttagaaaac aatctggcag tgaaaatatg tgtcgtaaag
     2281 aagagatgtc aagaatttga gatgactcct tgagaaagat ggcttatgtc atcagcaaag
     2341 gacacttacg tcagacgtac actgtttcta tcaaatcagg aagttagtga ccatcacaga
     2401 tggacaggtg tccttttatt tataggagtt tgtcaggatg tctgagtaga taggtaggaa
     2461 attgttacta gaacattcac ttccgacttg acaaggatat tcatggtgca gatacgttct
     2521 tcctgccgct gcagtgtctg ggtgtccggg aaactccgag actttaaagt gtcataatgt
     2581 ggtcacacct gcagttctgg ggatccagag ccttgcttgt gttctgtaag ctctgtcacc
     2641 gagttgtatc cccacctgaa agcagtgact tttgctaaca gtatttctgt tctgttgtaa
     2701 agtggataga agacacactt ggtagtaaag gtaaattatt caaagtccac agtgaaaaac
     2761 tcaccatacc ttcccattta aaccgtttct gtatctcata ggtttctgac atgcaaactt
     2821 gaacccttga aaaaaagagt tttcttaaaa attataaaaa aaatcacgag ttacaatttg
     2881 cacaatattt tttgttgtac tttatacctt gtttacaata aagacttttc tttggtaaaa
     2941 aaaaaaaaaa aaaaaaaaaa aa
//
