LOCUS       NM_001372084            3030 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus kinesin light chain 2 (Klc2), mRNA.
ACCESSION   NM_001372084 XM_003749043 XM_003753378
VERSION     NM_001372084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3030)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3030)
  AUTHORS   Du,J., Wei,Y., Liu,L., Wang,Y., Khairova,R., Blumenthal,R.,
            Tragon,T., Hunsberger,J.G., Machado-Vieira,R., Drevets,W.,
            Wang,Y.T. and Manji,H.K.
  TITLE     A kinesin signaling complex mediates the ability of GSK-3beta to
            affect mood-associated behaviors
  JOURNAL   Proc Natl Acad Sci U S A 107 (25), 11573-11578 (2010)
   PUBMED   20534517
REFERENCE   3  (bases 1 to 3030)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3030)
  AUTHORS   McGuire,J.R., Rong,J., Li,S.H. and Li,X.J.
  TITLE     Interaction of Huntingtin-associated protein-1 with kinesin light
            chain: implications in intracellular trafficking in neurons
  JOURNAL   J Biol Chem 281 (6), 3552-3559 (2006)
   PUBMED   16339760
REFERENCE   5  (bases 1 to 3030)
  AUTHORS   Muresan,Z. and Muresan,V.
  TITLE     Coordinated transport of phosphorylated amyloid-beta precursor
            protein and c-Jun NH2-terminal kinase-interacting protein-1
  JOURNAL   J Cell Biol 171 (4), 615-625 (2005)
   PUBMED   16301330
REFERENCE   6  (bases 1 to 3030)
  AUTHORS   Yang,J. and Li,T.
  TITLE     The ciliary rootlet interacts with kinesin light chains and may
            provide a scaffold for kinesin-1 vesicular cargos
  JOURNAL   Exp Cell Res 309 (2), 379-389 (2005)
   PUBMED   16018997
REFERENCE   7  (bases 1 to 3030)
  AUTHORS   Ligon,L.A., Tokito,M., Finklestein,J.M., Grossman,F.E. and
            Holzbaur,E.L.
  TITLE     A direct interaction between cytoplasmic dynein and kinesin I may
            coordinate motor activity
  JOURNAL   J Biol Chem 279 (18), 19201-19208 (2004)
   PUBMED   14985359
  REMARK    GeneRIF: the intermediate chain of dynein binds to kinesin light
            chains 1 and 2. The interaction is both direct and specific.
REFERENCE   8  (bases 1 to 3030)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and FQ103911.1.
            
            On or before Aug 8, 2019 this sequence version replaced
            XM_003749043.4, XM_003753378.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.6506.1,
                                           SRR26360194.287006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000001.1  211853869-211854160 c
            293-531             JAXUCZ010000001.1  211852947-211853185 c
            532-762             JAXUCZ010000001.1  211849901-211850131 c
            763-832             JAXUCZ010000001.1  211849741-211849810 c
            833-1055            JAXUCZ010000001.1  211848926-211849148 c
            1056-1143           JAXUCZ010000001.1  211847967-211848054 c
            1144-1245           JAXUCZ010000001.1  211847760-211847861 c
            1246-1419           JAXUCZ010000001.1  211847505-211847678 c
            1420-1519           JAXUCZ010000001.1  211847278-211847377 c
            1520-1569           JAXUCZ010000001.1  211846451-211846500 c
            1570-1637           JAXUCZ010000001.1  211846281-211846348 c
            1638-1746           JAXUCZ010000001.1  211845935-211846043 c
            1747-1905           JAXUCZ010000001.1  211845682-211845840 c
            1906-2030           JAXUCZ010000001.1  211845484-211845608 c
            2031-2088           JAXUCZ010000001.1  211845270-211845327 c
            2089-3012           JAXUCZ010000001.1  211843928-211844851 c
            3013-3030           FQ103911.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3030
                     /gene="Klc2"
                     /note="kinesin light chain 2"
                     /db_xref="GeneID:309159"
                     /db_xref="RGD:1307377"
     exon            1..292
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..531
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2172
                     /gene="Klc2"
                     /codon_start=1
                     /product="kinesin light chain 2"
                     /protein_id="NP_001359013.1"
                     /db_xref="GeneID:309159"
                     /db_xref="RGD:1307377"
                     /translation="MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLAS
                     HEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRL
                     VQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVP
                     KDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAV
                     PLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGK
                     DHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLC
                     QNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEI
                     LTRAHEKEFGSVNGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNT
                     TLRSLGALYRRQGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGGRGDRRGS
                     RDVAGGAGPRSESDLEESGPAAEWSGDGSGSLRRSGSFGKLRDALRRSSEMLVRKLQG
                     GGPQEPPNSRMKRASSLNFLNKSVEEPVQPGGTGLSDSRTLSSSSMDLSRRSSLVG"
     exon            532..762
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..832
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1055
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1143
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1245
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1419
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1519
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1569
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1637
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1746
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1905
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2030
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2088
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..3013
                     /gene="Klc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccgaagc cggccaggcc catggggccc ctttaaggca gcgagctggc cggctggaac
       61 gtgtttcgcc ccctccgacg ccgccgaggt agcggcttca cctttaaggc ggcgcgggga
      121 ctgctgggaa ggccggcggg atggaggcag cgagacgagc tcacggtcga ggatccgggt
      181 gaagcgggac aggagcaaga gccagagccg gaccaaagca gaaggtgcag gtcggcgcgg
      241 gccggttggg ccgggagacc cggtcaggcc ggacggtgag aagcggttgc agaccgcaag
      301 accatggcca cgatggtgct tcctcgagag gagaagctga gtcaggacga gatagtactg
      361 ggcaccaagg cggttatcca gggtttagag acccttcgag gggagcatcg tgccctgcta
      421 gctcccctag cttctcatga ggcaggcgag gccgagccgg gctcacagga gcgctgcctc
      481 ctcctgcgcc gctccctgga ggccatcgag ctggggcttg gggaggctca ggtgatcttg
      541 gcattgtcaa gccatctggg ggctgtggag tcagagaagc agaagctgcg ggctcaggtg
      601 cggcgcctgg tacaagagaa ccagtggttg cgtgaggagc tggcagggac acagcagaag
      661 ctgcagcgca gtgaacaggc ggtggctcag ctggaggaag aaaagcagca cctgctattc
      721 atgagtcaga tccgaaagct ggatgaggat gcttccccaa atgaggagaa gggtgatgtt
      781 cccaaggact ccctggatga cctgtttccc aatgaagacg aacagagccc agcccccagc
      841 cctggaggag gggatgtagc tgcacagcat gggggctatg aaatcccggc acggctacgc
      901 acccttcaca atctggtgat ccagtatgct tcacaaggcc gctatgaggt ggccgtgccc
      961 ctctgcaagc aggcactgga ggatttggag aaaacatcag gccatgacca ccccgatgtg
     1021 gccaccatgc tgaacatcct ggcactggtt tatcgggacc agaataagta caaggatgct
     1081 gctcacctgc tcaatgatgc cctggctatc cgggaaaaga cactgggcaa ggaccaccca
     1141 gctgtggctg caaccctcaa caatctggct gttttgtatg gcaaacgggg caagtacaaa
     1201 gaggctgaac cactgtgcaa gagagcattg gagatccggg aaaaggtcct gggcaagttt
     1261 catccagatg tggccaagca gctcagcaac ctggccttgc tgtgccagaa ccagggcaaa
     1321 gctgaggagg tggaatacta ctaccggaga gccttggaga tctatgccac acgccttggt
     1381 cctgatgacc ccaatgtagc gaagaccaag aacaacctgg cttcctgcta cctgaaacag
     1441 ggcaagtacc aggatgcaga gaccctgtac aaggagatcc ttacccgtgc tcatgagaaa
     1501 gagtttggct cagtcaatgg agagaacaag cccatctgga tgcatgcaga ggaacgagag
     1561 gagagcaagg ataagcgccg ggacagtgcc ccctatgggg agtacggcag ctggtacaaa
     1621 gcctgtaaag ttgacagtcc cacagtcaac accactctgc gaagcttggg cgccctgtac
     1681 cggcgccagg gcaagctgga agctgcacac acactggaag actgtgccag ccgcagccgc
     1741 aaacagggcc tggatcctgc cagccagacc aaggtggtag aactgctaaa agatggtagt
     1801 ggtggacgag gagaccgccg tggcagcaga gatgtggccg ggggtgctgg gcctcggtct
     1861 gagtctgacc tggaggaatc agggcctgca gctgaatgga gtggggatgg cagtggctct
     1921 ttgaggcgca gtggctcctt tgggaagctc cgggatgccc tcagacgcag cagtgagatg
     1981 ctggtgagga agctgcaggg aggtggccca caggagcccc ctaattctag gatgaagagg
     2041 gccagctctc ttaacttcct taacaagagt gtggaagaac cagtccagcc tggaggcacg
     2101 ggtctttctg acagccgcac tttgagctcc agctccatgg acctctcccg aagaagctcc
     2161 ctcgtgggct aaagctgaag gggcagccag tcaccagaac ctccatctga catgatccct
     2221 ccccctagcc ctgcgcatgg gcctgctgct tgtcctgcct gcccctccca aggacccctg
     2281 tcttttctgt tcaatctcag ggtaacttcc tcccttgtca tctcagccaa ggccctggag
     2341 gatgggcctg ccggctccag ctctgctcct tatttattcc ttccagcagg gggcctctct
     2401 tccctatgta ctgggcctgt gggagtggtg gcctacctac ccagtcccca aagccaagaa
     2461 cactaagtac ttgctgtccc ctcagcacct ttcccctcca ctcccggccg ttgcttctgt
     2521 atatagagaa ataagttatt ggccgtgtca ttcaaccctc ctcccctcag tccacggtat
     2581 tcccgggcca ccacctgcct ctctcttatc cagtggtacc gcccaggcct taaatcaccc
     2641 tgttcccagt ggtggtatct tccaagctcc aagttctggg accagagcct cccaaaaggg
     2701 gttcctagac ctcttcgcct ggtcttggag ggatttccac tccaccttgc aaatgcccgg
     2761 atcccccaca ccacggggcc ctgtgctgcc tcctggactt aatgcactgt tctttcaacc
     2821 tagccccgcc caggcatggc ctgaccccac cctgggcaca gcccgttgag ccatcctgcc
     2881 acgcctccct agcctcagct tctgatgtcc cccttccccc cacacacagg agggactacc
     2941 ccatttgttg ggtaaggcag tcgctctcta ttttcagatg ttgctgtaga aataaagacg
     3001 atttgaacct gaaaaaaaaa aaaaaaaaaa
//
