LOCUS       NM_001081974            2386 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus kinesin light chain 1 (Klc1), transcript variant
            C, mRNA.
ACCESSION   NM_001081974
VERSION     NM_001081974.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Huang,S.H., Duan,S., Sun,T., Wang,J., Zhao,L., Geng,Z., Yan,J.,
            Sun,H.J. and Chen,Z.Y.
  TITLE     JIP3 mediates TrkB axonal anterograde transport and enhances BDNF
            signaling by directly bridging TrkB with kinesin-1
  JOURNAL   J Neurosci 31 (29), 10602-10614 (2011)
   PUBMED   21775604
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   von Otter,M., Landgren,S., Nilsson,S., Lundvall,C., Minthon,L.,
            Bogdanovic,N., Andreasen,N., Gustafson,D.R., Skoog,I., Wallin,A.,
            Hakansson,A., Nissbrandt,H., Zetterberg,M., Tasa,G., Blennow,K. and
            Zetterberg,H.
  TITLE     Kinesin light chain 1 gene haplotypes in three conformational
            diseases
  JOURNAL   Neuromolecular Med 12 (3), 229-236 (2010)
   PUBMED   19911314
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Aoyama,T., Hata,S., Nakao,T., Tanigawa,Y., Oka,C. and Kawaichi,M.
  TITLE     Cayman ataxia protein caytaxin is transported by kinesin along
            neurites through binding to kinesin light chains
  JOURNAL   J Cell Sci 122 (Pt 22), 4177-4185 (2009)
   PUBMED   19861499
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Loschi,M., Leishman,C.C., Berardone,N. and Boccaccio,G.L.
  TITLE     Dynein and kinesin regulate stress-granule and P-body dynamics
  JOURNAL   J Cell Sci 122 (Pt 21), 3973-3982 (2009)
   PUBMED   19825938
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Ward,B.M. and Moss,B.
  TITLE     Vaccinia virus A36R membrane protein provides a direct link between
            intracellular enveloped virions and the microtubule motor kinesin
  JOURNAL   J Virol 78 (5), 2486-2493 (2004)
   PUBMED   14963148
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Pigino,G., Morfini,G., Pelsman,A., Mattson,M.P., Brady,S.T. and
            Busciglio,J.
  TITLE     Alzheimer's presenilin 1 mutations impair kinesin-based axonal
            transport
  JOURNAL   J Neurosci 23 (11), 4499-4508 (2003)
   PUBMED   12805290
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Kamal,A., Almenar-Queralt,A., LeBlanc,J.F., Roberts,E.A. and
            Goldstein,L.S.
  TITLE     Kinesin-mediated axonal transport of a membrane compartment
            containing beta-secretase and presenilin-1 requires APP
  JOURNAL   Nature 414 (6864), 643-648 (2001)
   PUBMED   11740561
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Cyr,J.L., Pfister,K.K., Bloom,G.S., Slaughter,C.A. and Brady,S.T.
  TITLE     Molecular genetics of kinesin light chains: generation of isoforms
            by alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10114-10118 (1991)
   PUBMED   1946431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M75148.1.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_001081974.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M75148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2386
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /note="kinesin light chain 1"
                     /db_xref="GeneID:171041"
                     /db_xref="RGD:621411"
     exon            1..119
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..381
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1803
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /EC_number="2.7.1.21"
                     /note="isoform C is encoded by transcript variant C; KLC
                     1; kinesin 2"
                     /codon_start=1
                     /product="kinesin light chain 1 isoform C"
                     /protein_id="NP_001075443.1"
                     /db_xref="GeneID:171041"
                     /db_xref="RGD:621411"
                     /translation="MHDNMSTMVYMKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNS
                     ILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESE
                     KQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDD
                     ISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHN
                     LVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAN
                     LLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD
                     HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYL
                     KQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYG
                     GWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAE
                     VLNDPENVEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGMRKMKLGLVK"
     exon            382..612
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..691
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..917
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1005
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1107
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1281
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1381
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1431
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1499
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1608
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1770
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1820
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2368
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcggggt gaggatgctg cggggcggct gcggaggcgt cgcttgctgc tgaggcggct
       61 gggctctgcg cggcctcggc ccgtgacagc gcgacgagcg cggcgcttcc gatcggacga
      121 atgcatgaca acatgtccac aatggtgtac atgaaggaag agaagctgga gaagcttacg
      181 caggatgaaa tcatttctaa gaccaagcag gtgatccagg ggctggaggc cctgaagaat
      241 gagcacaact ccatcctgca gagtctgctg gagacgctga agtgcttgaa gaaggacgat
      301 gagagcaacc tggtggagga gaagtccagc atgatccgca agtccttgga gatgctggag
      361 ctcggcctga gcgaggcgca ggtgatgatg gccctgtcta atcacctgaa tgccgtggag
      421 tccgagaagc agaagctccg agctcaggtt cgacgtctgt gccaggagaa ccagtggctg
      481 cgggatgaac tggccaacac acagcagaag ttacagaaga gcgagcagtc cgtggctcag
      541 ctggaggagg agaagaagca cctggagttc atgaaccagc tgaagaaata cgacgacgac
      601 atctctccct cggaagacaa agactctgat tcttccaaag agccgttgga tgacctcttc
      661 ccgaatgatg aggatgaccc aggacaagga atccagcagc aacacagcag tgctgcggcc
      721 gccgcccagc agggcggcta cgagatccct gcccggctgc gcacgctcca caacctggtg
      781 atccagtatg cctcgcaggg gcgttacgag gtggcggtgc cactctgcaa gcaggccctg
      841 gaggacctgg agaagacttc cggccacgac caccctgatg tggccaccat gctcaacatc
      901 ctggccctgg tgtacaggga tcagaacaag tataaagacg cagcaaacct cctgaacgat
      961 gccctggcta tccgtgagaa aaccctgggc cgagatcacc ctgcggtggc tgcgaccctc
     1021 aacaacctag cagtgctgta cggtaagcgt ggcaagtaca aagaggccga gccgctgtgc
     1081 aaacgggccc tggagatcag ggagaaggtt ctgggaaagg atcaccctga tgttgctaag
     1141 caactaaata atctggcctt gctgtgccag aaccagggca agtacgagga ggtggagtat
     1201 tactaccaga gggccctgga gatctaccag acgaagctcg gacccgatga tcccaacgtg
     1261 gccaagacga agaataacct ggcttcctgt tatctgaaac aagggaagtt caaacaagca
     1321 gaaacattgt acaaggagat tctcacccgc gcacatgaac gggagtttgg atctgtggat
     1381 gatgaaaaca agcccatatg gatgcacgcg gaggagagag aggagtgcaa aggaaagcag
     1441 aaggacgggt cgtcttttgg agagtatggc ggctggtata aggcctgcaa agtggacagt
     1501 cccaccgtca caaccacctt gaaaaacctg ggagcacttt accgccgcca ggggaagttt
     1561 gaagctgcgg agacactgga ggaagctgcc ctgaggtcac gtaagcaggg tcttgacaat
     1621 gttcacaaac agagagtggc tgaagtgcta aatgaccctg agaacgtgga gaagcggagg
     1681 agccgggaga gcctcaatgt ggacgtggtc aagtacgaga gtggccctga cggaggggag
     1741 gaagtgagta tgagcgtaga gtggaatggg atgagaaaga tgaagctcgg gctggttaaa
     1801 tgacttgctc agcgtccatg gcctagccac ccggtgcctc ccctctgctc ctgcatgacg
     1861 ggcagcgcct cctccggccc ctccagtgct gtccgctgtc tagcagccct aggagcttgt
     1921 cagccgcacc tctgggactg gcccctcctt tcggtgctgt cgtcctatgg ggtcttgatt
     1981 tctggataca tgtagctttg ccagatatgt acttagaaat atcaaccgtg ttaataagcc
     2041 cattaatgtg taacacacaa gtttaacagt taagagagag tagctgttca tcttgaggac
     2101 aggcgttagt gtcacacagg tttattacag tggcatgata gtgacctgtg cagtcactga
     2161 gctgtaggag tgaggcatgt gctgcacgtc cctgtcgtac ttagagacct ggcagtgccc
     2221 tgctccgggc ctccccagga cacactgacg tagatttgct gtgtagtctt ggtgtggaaa
     2281 tttgaattct gcttttctct actaatctga agtgctccgt gatgtgtgta tgtgtctttc
     2341 taacttctaa taaactcact ccagctgaaa aaaaaaaaaa aaaaaa
//
