LOCUS       NM_001081973            1917 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kinesin light chain 1 (Klc1), transcript variant
            B, mRNA.
ACCESSION   NM_001081973
VERSION     NM_001081973.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Huang,S.H., Duan,S., Sun,T., Wang,J., Zhao,L., Geng,Z., Yan,J.,
            Sun,H.J. and Chen,Z.Y.
  TITLE     JIP3 mediates TrkB axonal anterograde transport and enhances BDNF
            signaling by directly bridging TrkB with kinesin-1
  JOURNAL   J Neurosci 31 (29), 10602-10614 (2011)
   PUBMED   21775604
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   von Otter,M., Landgren,S., Nilsson,S., Lundvall,C., Minthon,L.,
            Bogdanovic,N., Andreasen,N., Gustafson,D.R., Skoog,I., Wallin,A.,
            Hakansson,A., Nissbrandt,H., Zetterberg,M., Tasa,G., Blennow,K. and
            Zetterberg,H.
  TITLE     Kinesin light chain 1 gene haplotypes in three conformational
            diseases
  JOURNAL   Neuromolecular Med 12 (3), 229-236 (2010)
   PUBMED   19911314
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1917)
  AUTHORS   Aoyama,T., Hata,S., Nakao,T., Tanigawa,Y., Oka,C. and Kawaichi,M.
  TITLE     Cayman ataxia protein caytaxin is transported by kinesin along
            neurites through binding to kinesin light chains
  JOURNAL   J Cell Sci 122 (Pt 22), 4177-4185 (2009)
   PUBMED   19861499
REFERENCE   5  (bases 1 to 1917)
  AUTHORS   Loschi,M., Leishman,C.C., Berardone,N. and Boccaccio,G.L.
  TITLE     Dynein and kinesin regulate stress-granule and P-body dynamics
  JOURNAL   J Cell Sci 122 (Pt 21), 3973-3982 (2009)
   PUBMED   19825938
REFERENCE   6  (bases 1 to 1917)
  AUTHORS   Ward,B.M. and Moss,B.
  TITLE     Vaccinia virus A36R membrane protein provides a direct link between
            intracellular enveloped virions and the microtubule motor kinesin
  JOURNAL   J Virol 78 (5), 2486-2493 (2004)
   PUBMED   14963148
REFERENCE   7  (bases 1 to 1917)
  AUTHORS   Pigino,G., Morfini,G., Pelsman,A., Mattson,M.P., Brady,S.T. and
            Busciglio,J.
  TITLE     Alzheimer's presenilin 1 mutations impair kinesin-based axonal
            transport
  JOURNAL   J Neurosci 23 (11), 4499-4508 (2003)
   PUBMED   12805290
REFERENCE   8  (bases 1 to 1917)
  AUTHORS   Kamal,A., Almenar-Queralt,A., LeBlanc,J.F., Roberts,E.A. and
            Goldstein,L.S.
  TITLE     Kinesin-mediated axonal transport of a membrane compartment
            containing beta-secretase and presenilin-1 requires APP
  JOURNAL   Nature 414 (6864), 643-648 (2001)
   PUBMED   11740561
REFERENCE   9  (bases 1 to 1917)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 1917)
  AUTHORS   Cyr,J.L., Pfister,K.K., Bloom,G.S., Slaughter,C.A. and Brady,S.T.
  TITLE     Molecular genetics of kinesin light chains: generation of isoforms
            by alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10114-10118 (1991)
   PUBMED   1946431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M75147.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001081973.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M75147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1917
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /note="kinesin light chain 1"
                     /db_xref="GeneID:171041"
                     /db_xref="RGD:621411"
     exon            1..133
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..395
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1790
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /EC_number="2.7.1.21"
                     /note="isoform B is encoded by transcript variant B; KLC
                     1; kinesin 2"
                     /codon_start=1
                     /product="kinesin light chain 1 isoform B"
                     /protein_id="NP_001075442.1"
                     /db_xref="GeneID:171041"
                     /db_xref="RGD:621411"
                     /translation="MHDNMSTMVYMKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNS
                     ILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESE
                     KQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDD
                     ISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHN
                     LVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAN
                     LLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD
                     HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYL
                     KQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYG
                     GWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAE
                     VLNDPENVEKRRSRESLNVDVVKYESGPDGGEEMRKMKLGLVK"
     exon            396..626
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..705
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..931
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1019
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1121
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1295
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1395
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1445
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1513
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1622
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1757
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1807
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1917
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgga gcgcgggtcg gggtgaggat gctgcggggc ggctgcggag gcgtcgcttg
       61 ctgctgaggc ggctgggctc tgcgcggcct cggcccgtga cagcgcgacg agcgcggcgc
      121 ttccgatcgg acgaatgcat gacaacatgt ccacaatggt gtacatgaag gaagagaagc
      181 tggagaagct tacgcaggat gaaatcattt ctaagaccaa gcaggtgatc caggggctgg
      241 aggccctgaa gaatgagcac aactccatcc tgcagagtct gctggagacg ctgaagtgct
      301 tgaagaagga cgatgagagc aacctggtgg aggagaagtc cagcatgatc cgcaagtcct
      361 tggagatgct ggagctcggc ctgagcgagg cgcaggtgat gatggccctg tctaatcacc
      421 tgaatgccgt ggagtccgag aagcagaagc tccgagctca ggttcgacgt ctgtgccagg
      481 agaaccagtg gctgcgggat gaactggcca acacacagca gaagttacag aagagcgagc
      541 agtccgtggc tcagctggag gaggagaaga agcacctgga gttcatgaac cagctgaaga
      601 aatacgacga cgacatctct ccctcggaag acaaagactc tgattcttcc aaagagccgt
      661 tggatgacct cttcccgaat gatgaggatg acccaggaca aggaatccag cagcaacaca
      721 gcagtgctgc ggccgccgcc cagcagggcg gctacgagat ccctgcccgg ctgcgcacgc
      781 tccacaacct ggtgatccag tatgcctcgc aggggcgtta cgaggtggcg gtgccactct
      841 gcaagcaggc cctggaggac ctggagaaga cttccggcca cgaccaccct gatgtggcca
      901 ccatgctcaa catcctggcc ctggtgtaca gggatcagaa caagtataaa gacgcagcaa
      961 acctcctgaa cgatgccctg gctatccgtg agaaaaccct gggccgagat caccctgcgg
     1021 tggctgcgac cctcaacaac ctagcagtgc tgtacggtaa gcgtggcaag tacaaagagg
     1081 ccgagccgct gtgcaaacgg gccctggaga tcagggagaa ggttctggga aaggatcacc
     1141 ctgatgttgc taagcaacta aataatctgg ccttgctgtg ccagaaccag ggcaagtacg
     1201 aggaggtgga gtattactac cagagggccc tggagatcta ccagacgaag ctcggacccg
     1261 atgatcccaa cgtggccaag acgaagaata acctggcttc ctgttatctg aaacaaggga
     1321 agttcaaaca agcagaaaca ttgtacaagg agattctcac ccgcgcacat gaacgggagt
     1381 ttggatctgt ggatgatgaa aacaagccca tatggatgca cgcggaggag agagaggagt
     1441 gcaaaggaaa gcagaaggac gggtcgtctt ttggagagta tggcggctgg tataaggcct
     1501 gcaaagtgga cagtcccacc gtcacaacca ccttgaaaaa cctgggagca ctttaccgcc
     1561 gccaggggaa gtttgaagct gcggagacac tggaggaagc tgccctgagg tcacgtaagc
     1621 agggtcttga caatgttcac aaacagagag tggctgaagt gctaaatgac cctgagaacg
     1681 tggagaagcg gaggagccgg gagagcctca atgtggacgt ggtcaagtac gagagtggcc
     1741 ctgacggagg ggaggaaatg agaaagatga agctcgggct ggttaaatga cttgctcagc
     1801 gtccatggcc tagccacccg gtgcctcccc tctgctcctg catgacgggc agcgcctcct
     1861 ccggcccctc cagtgctgtc cgctgtctag cagccctagg agcttgtcag ccgcacc
//
