LOCUS       XM_039092743            4694 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus klotho beta (Klb), mRNA.
ACCESSION   XM_039092743
VERSION     XM_039092743.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051349.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039092743.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4694
                     /gene="Klb"
                     /note="klotho beta; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 8 ESTs, 4 Proteins, and
                     96% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:289625"
                     /db_xref="RGD:1308227"
     CDS             1..3132
                     /gene="Klb"
                     /codon_start=1
                     /product="beta-klotho"
                     /protein_id="XP_038948671.1"
                     /db_xref="GeneID:289625"
                     /db_xref="RGD:1308227"
                     /translation="MKTGCAAGSPGNEWVFFSSDERSTRSRKTMSNGALQRSAVLSAL
                     VLLRAVTGFSGDGKAIWDKKQYVSPVNPGQLFLYDTFPKNFSWGVGTGAFQVEGSWKA
                     DGRGPSIWDRYVDSHLRGVNSTDRSTDSYVFLEKDLLALDFLGVSFYQFSISWPRLFP
                     NGTVAAVNAKGLQYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLF
                     NDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKA
                     HSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTENMEDVINCQHSMSSVLGWFANPI
                     HGDGDYPEFMKTSSVIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSL
                     NLRQVLNWIKLEYDNPRILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEI
                     QVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPL
                     QESTPDMKGQFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVR
                     LKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKINRQVLRYYRCV
                     VSEGLKLGISPMVTLYHPTHSHLGLPMPLLSSGGWLNTNTAKAFQDYAGLCFQELGDL
                     VKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSL
                     HSDWAEPANPYVESHWKAAERFLQFEIAWFADPLFKTGDYPLAMKEYIASKKQRGLSS
                     SVLPRFTLKESRLVKGTIDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSS
                     PSRLAVTPWGMRKLLGWIRRNYRDMDIYVTANGIDDLALEDDQIRKYYLEKYVQEALK
                     AYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFKAKSSVQFYSKLISSSGFSSENRSP
                     ACGQPPEDTECAICSFLTQKKPLIFFGCCFISTLAALLSITIFHHRKRRKFQKARNLQ
                     NIPLKKGHSRVFS"
ORIGIN      
        1 atgaagacag gctgtgcagc agggtctcca gggaatgaat gggttttctt cagctctgat
       61 gaaagaagca cacgctctag gaaaacaatg tccaacggag cactgcaaag atctgccgtg
      121 ctgtctgcat tggttctgct gcgagctgtt accggcttct ctggagacgg aaaagcaata
      181 tgggataaaa aacaatacgt gagtccggta aacccaggtc agctgttcct ctatgacact
      241 ttccctaaaa acttttcctg gggcgttggg accggagcat ttcaagtgga agggagttgg
      301 aaggcagatg gaagaggacc ctcgatctgg gaccgttatg tcgactcaca cctgagaggt
      361 gtcaacagca cagacagatc cactgacagt tatgtctttc tggaaaagga cttgctggct
      421 ctggattttt taggagtttc tttttatcag ttctcaatct cctggccgcg gttgttcccc
      481 aacggaacag tagcagctgt gaatgcaaaa ggtctccagt actacagagc acttctggac
      541 tcgctggtac ttaggaatat cgaacccatt gttaccttat accattggga tttgcctttg
      601 acgctacagg aagaatatgg gggctggaaa aatgcaacta tgatagatct cttcaatgac
      661 tatgccacat actgcttcca gacctttgga gaccgtgtca aatattggat tacaattcac
      721 aacccttacc tcgttgcttg gcatgggttt ggcacaggta tgcatgcgcc aggagagaag
      781 ggaaatttaa cagctgtcta cactgtggga cacaacctga tcaaggcgca ttcgaaagtg
      841 tggcataact acgacaaaaa cttccgccct catcagaagg gttggctctc catcaccttg
      901 gggtcccatt ggatagaacc aaacagaaca gaaaacatgg aggacgtgat caactgccag
      961 cactccatgt cttctgtgct cggatggttt gccaacccca tccacggaga cggcgactac
     1021 cccgagttca tgaagacgag ctccgtaatc cccgagttct ctgaggcaga gaaggaggag
     1081 gtgcggggca ctgctgactt ctttgccttt tccttcgggc ccaacaattt caggccctcg
     1141 aacaccgtgg taaaaatggg acaaaatgta tcactcaact taagacaggt gctgaactgg
     1201 attaaactag aatatgacaa ccctcgaatc ttgatttcgg agaacggctg gttcacagat
     1261 agttatataa agacggaaga taccacggcc atctacatga tgaagaattt cctcaaccag
     1321 gttcttcaag caataaagtt tgatgaaata caagtgtttg gttatacggc ttggactctc
     1381 ctggatggct ttgagtggca ggatgcctac acgacccgac gagggctgtt ttatgtggac
     1441 tttaatagtg agcagaaaga gaggaaaccc aagtcctccg ctcattacta caaacagatt
     1501 atacaagaca acggtttccc tttgcaagaa tccacaccag acatgaaggg tcagtttccc
     1561 tgtgacttct cctggggagt cactgagtct gttcttaagc cggagtttac ggtgtcctcc
     1621 ccacagttta ctgatcctca cctgtatgtg tggaatgtca ctggcaacag attgctatac
     1681 cgagtggaag gagtcaggct aaaaacaaga ccgtcccaat gcacagatta tgtgagcatc
     1741 aaaaaacgag ttgaaatgtt ggccaaaatg aaagtcaccc actaccagtt tgctctggac
     1801 tggacctcta tcctccctac cggaaatctg tctaaaatta atagacaagt gttgaggtac
     1861 tataggtgtg tggtgagcga aggactgaag ctgggcatct cccctatggt gacgttgtac
     1921 cacccgaccc actcccatct aggcctcccc atgccacttc tgagcagtgg gggatggcta
     1981 aacaccaaca cagccaaggc cttccaggac tacgcaggcc tgtgcttcca ggagctgggg
     2041 gacttggtaa agctctggat caccatcaat gaacccaata ggctgagtga catgtacaac
     2101 cgcacgagta acgacaccta ccgtgcggcc cacaacctga tgatcgccca tgcccaggtc
     2161 tggcacctct atgataggca gtataggccg gtccagcacg gggctgtgtc gctgtcctta
     2221 cattccgact gggcagaacc tgccaacccc tatgtggagt ctcactggaa ggcagccgag
     2281 cgcttcctcc agtttgagat cgcctggttt gcggatccac tcttcaagac tggtgactac
     2341 ccgctggcca tgaaggaata catcgcctcc aagaagcagc gagggctgtc tagctcagtc
     2401 ctgccgcgct ttaccttgaa ggagagcagg ctggtgaagg ggaccatcga cttttacgca
     2461 ctgaaccact tcactactag attcgtgata cacaagcagt tgaataccaa ccgctcagtg
     2521 gcagacaggg acgtccagtt cctgcaggac atcacccgcc tgagctcgcc cagtcgccta
     2581 gccgtaacgc cctggggaat gcgcaagctc cttgggtgga tccggaggaa ctacagagac
     2641 atggatatct acgtcacagc caatggcatt gatgatcttg ctctagagga cgatcagatt
     2701 agaaagtact acttggagaa gtacgtccag gaggctctga aagcatatct gattgacaag
     2761 gtcaaaatca aaggctacta tgcattcaaa ctgactgaag agaaatctaa gcctagattt
     2821 ggatttttca catctgactt caaagctaaa tcttctgtac agttttatag caagctgatc
     2881 agcagcagcg gcttctcctc tgagaacaga agtcctgcct gtggtcagcc tccagaagac
     2941 acagaatgcg ccatttgctc cttccttaca cagaagaaac cactcatctt ctttggttgt
     3001 tgcttcatct ccactctggc tgcactgcta tcaatcacta tttttcatca tcggaagaga
     3061 agaaaattcc agaaagcaag gaacttacaa aatataccat tgaagaaagg gcacagcaga
     3121 gtttttagct aaactatcat ttctgtcagt ttaaagattc actccagttc cgcctactga
     3181 taacttacaa tgagagacag ctctaaccca ggtgaagaca atcgttgcct ttgaagtgtg
     3241 gttcaaatca tacctttagg taccgacaat cagtgaatca gttcttggag ctgaagatat
     3301 ccaacagtaa ctctgggcat gaccctgaac attgcttcgg gaagtgtgaa tcgctatttc
     3361 acatcccttt ttctcggtaa atagcaatct attcacggca aagaaattaa ttttaaaaag
     3421 tgaaatcttg tcttagactt cgtagtttaa acctgctttg acgtcattgt tgttttgaga
     3481 caggtctatt acatagctct ggctttcatg aaccttgcta tgtagaccag gctagcctca
     3541 aagtcttagg tccgcctgcc tctcagcctt ctgagtactg ggactaaagg tgtgtatcac
     3601 atgcccagct aaaactattt aaacctgaca gtcagtgaca cactctcatc acgtctgaca
     3661 aggtgctgtt ggttaggtca gggctgtcct cagatggaat ttacagacac aacagggctt
     3721 tagctcacac ttgtccccag gccaagcata ggctctaaac acaccaatgc tagctttcag
     3781 gcacttctta aacatccaag tttgtgagct ctctctcact ggacttgtaa ttttttttct
     3841 atttattttt tgtggcttgg tgagtgggtt caagacaggg tttttctgtc ctgatacttg
     3901 ctctgtagag accaggctgg ctgaaactta ggagctccgc ctgcctccca cgtgctgaga
     3961 ttaaaggtgg acaccactat gcccagtttg gacttctgat cttaaaggag cttcatgggt
     4021 ggaaagatgg ctcagaggtt gagagaactg gctggtcttc caaagatcct agtccaattc
     4081 ccagcacccg catggcagct tacaactgtc tgtcatccca gttttagatc tgacaccttc
     4141 atacagacat acatgtaggt agaacaccaa tgtacacaaa ataccatccc cattttaaaa
     4201 taaagtggca ttacccctat tttgcccttt tttttttttg aggtgacacg atttgccaca
     4261 ctgagcaaag tttaaaagat ggattaccaa taatgatcaa aggatcatta tttgtagttg
     4321 tgcattgttg ttacacacac acgcacaccc agaatatctg gagccagtca cattatccag
     4381 tcattgtcaa ccttcttcag gaatttagag tcaaagaaaa gtggctcttc cacaaagagt
     4441 cttagtgata aaccataaac taaaatgtta aagtgatttt taattgcatt tcagatctat
     4501 ctactgttaa acctaaggca taactaggat tctttttgca tttttcaaga cagcgtttgt
     4561 gtagcactgg ctatcctgga actctctgta cactaggctg gccttgaacc cacctgcctc
     4621 cgcctcccaa atactggtat taaaggagtg catcaccact gccaatatat taaaattctt
     4681 ataatcagca ctaa
//
