LOCUS       NM_021843               5360 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus KIT ligand (Kitlg), transcript variant 1, mRNA.
ACCESSION   NM_021843
VERSION     NM_021843.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5360)
  AUTHORS   Zheng,H., Liu,Y.J., Chen,Z.C. and Fan,G.Q.
  TITLE     miR-222 regulates cell growth, apoptosis, and autophagy of
            interstitial cells of Cajal isolated from slow transit constipation
            rats by targeting c-kit
  JOURNAL   Indian J Gastroenterol 40 (2), 198-208 (2021)
   PUBMED   33792838
REFERENCE   2  (bases 1 to 5360)
  AUTHORS   Sudo,H.
  TITLE     Microtubule Hyperacetylation Enhances KL1-Dependent Micronucleation
            under a Tau Deficiency in Mammary Epithelial Cells
  JOURNAL   Int J Mol Sci 19 (9), 2488 (2018)
   PUBMED   30142893
  REMARK    GeneRIF: The data suggest that microtubule acetylation upregulates
            KL1 and induces more aneuploidy if tau is deficient.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5360)
  AUTHORS   Zhang,W., Wu,T., Zhang,C., Luo,L., Xie,M. and Huang,H.
  TITLE     Cadmium exposure in newborn rats ovary induces developmental
            disorders of primordial follicles and the differential expression
            of SCF/c-kit gene
  JOURNAL   Toxicol Lett 280, 20-28 (2017)
   PUBMED   28801138
  REMARK    GeneRIF: It was concluded that the exposure of cadimium on newborn
            rats ovaries could inhibit follicle development. SCF/c-kit system
            might mediate follicle development damage caused by cadmium, which
            is associated with DNA hypomethylation of SCF/c-kit promoter region
            may be worthy of further study.
REFERENCE   4  (bases 1 to 5360)
  AUTHORS   Qin,Q., Liu,J., Ma,Y., Wang,Y., Zhang,F., Gao,S. and Dong,L.
  TITLE     Aberrant expressions of stem cell factor/c-KIT in rat testis with
            varicocele
  JOURNAL   J Formos Med Assoc 116 (7), 542-548 (2017)
   PUBMED   27707610
  REMARK    GeneRIF: the SCF/c-KIT system is aberrantly expressed in
            varicocele(VC) testis, which could be involved in male infertility
            caused by VC.
REFERENCE   5  (bases 1 to 5360)
  AUTHORS   Lee,J.H., Lee,M., Ahn,C., Kang,H.Y., Tran,D.N. and Jeung,E.B.
  TITLE     Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene
            Diepoxide-Induced Ovarian Failure Model
  JOURNAL   Int J Environ Res Public Health 14 (2), 161 (2017)
   PUBMED   28208728
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5360)
  AUTHORS   Ploemacher,R.E., van Soest,P.L., Boudewijn,A. and Neben,S.
  TITLE     Interleukin-12 enhances interleukin-3 dependent multilineage
            hematopoietic colony formation stimulated by interleukin-11 or
            steel factor
  JOURNAL   Leukemia 7 (9), 1374-1380 (1993)
   PUBMED   7690439
REFERENCE   7  (bases 1 to 5360)
  AUTHORS   Tsuji,K., Lyman,S.D., Sudo,T., Clark,S.C. and Ogawa,M.
  TITLE     Enhancement of murine hematopoiesis by synergistic interactions
            between steel factor (ligand for c-kit), interleukin-11, and other
            early acting factors in culture
  JOURNAL   Blood 79 (11), 2855-2860 (1992)
   PUBMED   1375116
REFERENCE   8  (bases 1 to 5360)
  AUTHORS   Lu,H.S., Clogston,C.L., Wypych,J., Fausset,P.R., Lauren,S.,
            Mendiaz,E.A., Zsebo,K.M. and Langley,K.E.
  TITLE     Amino acid sequence and post-translational modification of stem
            cell factor isolated from buffalo rat liver cell-conditioned medium
  JOURNAL   J Biol Chem 266 (13), 8102-8107 (1991)
   PUBMED   1708771
REFERENCE   9  (bases 1 to 5360)
  AUTHORS   Martin,F.H., Suggs,S.V., Langley,K.E., Lu,H.S., Ting,J.,
            Okino,K.H., Morris,C.F., McNiece,I.K., Jacobsen,F.W., Mendiaz,E.A.
            et al.
  TITLE     Primary structure and functional expression of rat and human stem
            cell factor DNAs
  JOURNAL   Cell 63 (1), 203-211 (1990)
   PUBMED   2208279
REFERENCE   10 (bases 1 to 5360)
  AUTHORS   Zsebo,K.M., Wypych,J., McNiece,I.K., Lu,H.S., Smith,K.A.,
            Karkare,S.B., Sachdev,R.K., Yuschenkoff,V.N., Birkett,N.C.,
            Williams,L.R. et al.
  TITLE     Identification, purification, and biological characterization of
            hematopoietic stem cell factor from buffalo rat liver--conditioned
            medium
  JOURNAL   Cell 63 (1), 195-201 (1990)
   PUBMED   2208278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 7, 2012 this sequence version replaced NM_021843.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.28270.1,
                                           SRR26643288.29727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000007.1  36782660-36782848
            190-303             JAXUCZ010000007.1  36818174-36818287
            304-366             JAXUCZ010000007.1  36829316-36829378
            367-537             JAXUCZ010000007.1  36841239-36841409
            538-694             JAXUCZ010000007.1  36844143-36844299
            695-778             JAXUCZ010000007.1  36844999-36845082
            779-888             JAXUCZ010000007.1  36850549-36850658
            889-956             JAXUCZ010000007.1  36851277-36851344
            957-1032            JAXUCZ010000007.1  36852297-36852372
            1033-5360           JAXUCZ010000007.1  36859465-36863792
FEATURES             Location/Qualifiers
     source          1..5360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..5360
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /note="KIT ligand"
                     /db_xref="GeneID:60427"
                     /db_xref="RGD:3086"
     exon            1..189
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..996
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /EC_number="3.2.1.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mast cell growth factor; C-kit ligand;
                     hematopoietic growth factor KL; stem cell factor KL-1;
                     steel factor/kit ligand"
                     /codon_start=1
                     /product="kit ligand isoform 1 precursor"
                     /protein_id="NP_068615.1"
                     /db_xref="GeneID:60427"
                     /db_xref="RGD:3086"
                     /translation="MKKTQTWIITCIYLQLLLFNPLVKTQEICRNPVTDNVKDITKLV
                     ANLPNDYMITLNYVAGMDVLPSHCWLRDMVTHLSVSLTTLLDKFSNISEGLSNYSIID
                     KLGKIVDDLVACMEENAPKNVKESLKKPETRNFTPEEFFSIFNRSIDAFKDFMVASDT
                     SDCVLSSTLGPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAAKSPEDPGLQWTAM
                     ALPALISLVIGFAFGALYWKKKQSSLTRAVENIQINEEDNEISMLQQKEREFQEV"
     exon            190..303
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            304..366
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            367..537
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            538..694
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            695..778
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            779..888
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            889..956
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1032
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..5360
                     /gene="Kitlg"
                     /gene_synonym="Kitl; Mgf; SCF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggactga gagtgccgcg ggaaagcaac ggccaaggac ggggcgctgc gctcgagcta
       61 cccaatgctg ggactatctg cagccgctgc tcgtgcaata tgctggagct ccagaacagc
      121 taaacggagt cgccacaccg ctgcctgggc tggatcgcag cgctgccttt ccttatgaag
      181 aagacacaaa cttggattat cacttgcatt tatcttcaac tgctcctatt taatcctctc
      241 gtcaaaactc aggagatctg caggaatcct gtgactgata atgtaaaaga cattacaaaa
      301 ctggtggcga atcttccaaa tgactatatg ataaccctca actatgtcgc cgggatggat
      361 gttttgccta gtcattgttg gttacgagat atggtaacac acttatcagt cagcttgact
      421 actcttctgg acaagttttc aaatatttct gaaggcttga gtaattattc catcatagac
      481 aaacttggga aaatagtgga tgacctcgtg gcatgtatgg aagaaaatgc acctaagaat
      541 gtaaaagaat cactgaagaa gccagaaact agaaacttta ctcctgaaga attctttagt
      601 attttcaata gatccattga tgccttcaag gacttcatgg tggcatctga cactagtgat
      661 tgtgtgctct cttcaacatt aggtcctgag aaagattcca gagtcagtgt cacaaaacca
      721 tttatgttac cccctgttgc agccagttcc cttaggaatg acagcagtag cagtaatagg
      781 aaagccgcaa agtcccctga agacccaggc ctacaatgga cagcaatggc actgccggct
      841 ctcatttcgc ttgtaattgg ctttgctttt ggagccttat actggaagaa gaaacagtca
      901 agtcttacaa gggcagttga aaatatacag attaatgaag aggataatga gataagtatg
      961 ttgcaacaga aagagagaga gtttcaagag gtgtaattgt ggatgtatca acattgttac
     1021 cttcgcacag tggctggtaa cagttcatgt ttgcttcata aatgaagcag ctttaaacaa
     1081 attcctattc ctgtctcaag tgacagacct catctttacc tgttcttgct acccgtgacc
     1141 ttgtatggat gactcagaag ttggagcaga gtgttttgct gtgaaacctg cactgaatta
     1201 tcatctgtaa agaagaagtt gcacggagca ggactctgaa ggttttgcaa gtgatgatgg
     1261 ggacgagaac acgtgtccag tctacttgcg ccattcgcat ggcttgggaa atgtctgaag
     1321 tgctgaaaac ccgcccagct ttgttcatta gttaacaacc tgcagcccgt agtttaatta
     1381 tggtctctac aagtagattt cagcctggat agttgggggg ggagggggca tttttttttc
     1441 acaaagggat gtagaaaaca atttaaagaa acagtaactc cgtagcatca gccactgtat
     1501 ggagttgaaa gccatgggga gtatttttct ttttcttttg agcaggctca ttcgtctgct
     1561 ctgtagttat ggattaacaa gagcagccta aatgtcagct cttccatgac gtaagtcatg
     1621 tgcatcatat ctgactagaa aggtggacat gggtagctag ttctatccaa gcagtggagc
     1681 ccgtgctgaa ctgcagtatg atgccacggt gtatggaaga ttctctggaa gagtctttac
     1741 aggaaaaaat tgtcaatgtg gaccagcgga agaacatgcc aaggaagaca tttggctcct
     1801 agtgaagccg gtcttttccc ttgacagtca ctctagagtg tgtaaatcat gtttgcaaag
     1861 atataatgtg acacgtttta tgttttgaaa ctactgcaga tttgggagaa aatgctgaat
     1921 gtttaaggat tccatttttt ttttctaaat cctgatggga gagaataaga atgaatgatg
     1981 gtatttagta cctaagatta gaaatagaca ctttattcta atatgggagt tgcaaactaa
     2041 gtcactcgta ttctgcaaga gtgcaaggag tcagaaaaca ttagttattt gcagtataac
     2101 cattatctct ttaaacatag ccatttattt aaaatctggc actctgtata cattaaggtt
     2161 tatgaaatga aatagagaga gcttttatgt atttgtgcat gtcagtttgc tatttaacat
     2221 gtgtgacagc atttctcata ttagacagaa attggcagcg attccacgac gaacattgcg
     2281 ctttcaaagc agaatttacc acatgtgcta gcgatgcccc tgcttgaact atattgaaag
     2341 caattggcta aaatcaaact atgacttttc ttctgccttt atttttggtg aagactcttt
     2401 tcacctaccc tagacctacg aagtttaaag cttttcacac tataacttca ttcttgctag
     2461 tagttttatt tgcccagtgc taaaacctta agacaaacca ttttcaatgt aatgacacag
     2521 aagtgcatgg aaacctaact gctagcttct attctgtctt ggagctgcat gaaaagttgt
     2581 agcttaaatg ctcaaagctc gtccaagtac aaacccagta catggtggct gctcttcttt
     2641 gtaccaaaga gttcaaatgg tttctatggc tccttctcta atgctccgag gttcctccaa
     2701 tactatcatt cctgcaatat gaagccccaa gacactgtat ttacttgttt gagctctcag
     2761 attagtccag gatagaactg attaggaatc agtgagaaat cagctcagtt actgaaaggg
     2821 cctagattgt tgcttggcat tgattgctct gagagtaaaa gtagcaggag ggcaccatga
     2881 gtcacaggta taggtgtata taggttgagc ctattgttac ctctcagttt tgtggcttcg
     2941 tttatttatc tggtagtttc attttgctca ggcttatgaa gatgctatct actggacttg
     3001 agagtacaat aaatagacat ttctactcaa agctagcagt tggattttaa cactcacaag
     3061 cccggtctta atcagtagca ctaaataaac aaattcaaca ggtcgtagta tcggacatgg
     3121 tagaaggtga acgacgtgtc ttgcgtatta aacatgtcgg ttcactgaga ataacataga
     3181 ttgtcaattt ttttaaaaat gctaaggttc aataaaatgc atgaacaata ggaaactgct
     3241 gaacattatt ttgaatgcta gctgcttgga cattaactac ggcatatctg cttccagatt
     3301 aaaagtgcgt atccttcgcc tagcgtatct catgtatgct ctgaatattt ctcttaaatt
     3361 atgaaaaccc cacaactgag aagataaaag tataaaatcg ccctttaaat tgcccatttt
     3421 tctgagagtt ctcttttgta atgtgtccag tttgattctt gaaaaatgat ctaagaaatc
     3481 tgcagccttg tgtctccttg gtgggaagca agcccatagc aagactattt gtgtgatcag
     3541 tgggtagtgt tagagcagtc ctggtttttg tattgttatc taacatgctt aacacactgc
     3601 catgttttaa tgaaccacag aagaactgaa gctttctatt agtaataaaa aaaaacctta
     3661 aattttgcat tacaaaaagt attgcgtagg agaaaaaaat gaaaatacat aaaagtatgt
     3721 gtccactttg agataagaat taaacacact tcggtgaact ttcacatgct ttgaaagaaa
     3781 caatttcacg tgcgtcgcag agtttggtac ccgaattcaa tcgaagttat aaatgaatgg
     3841 aagaatcttt tgtggaatct ttgattgttt tccactctgt ttctcacagt aggttttgat
     3901 ttcatgactt aattctgata cggaatctta gctatcctgt acacagtgtt gaagaaatat
     3961 gtttttcaaa ttaggcagtt aggtgtaggt gggtgaacat tgagagagat agccaggagg
     4021 ttggtctact ttgccacaaa tggatataat gtccccactc tctttggatc tcagtgttgt
     4081 ctttgtgtgt agataggtca gaggtcactc ttcttcggga gtgagccctt atgccacaca
     4141 gttaacaaag caaagaaaac agcaaaaaga atcctaaaaa aaatacctgg ctctggcttc
     4201 tgaacaatag tttggacaat gagaagtcct tgctgtttta gtttctagtg taaatagggt
     4261 ccattagtaa aagtgaattc agtcttaggt cgggtggatt ggacaaccat ttacacataa
     4321 gatggctttt atctttgctt aaataaatgt tttgggatca cctctgaaga atcaagacca
     4381 atagtgcatt ttcatcatga ggagatacaa gatgtgtata acatttggaa atgtgtcaga
     4441 gggtaaattt aaatgttctt gttgtattga aagctaagaa caaataaatg tagggtgcta
     4501 ctaaggatct tggatgccaa gagatatttt aaagccaatt tgtaaaaatg gtaatgcata
     4561 aattccattt acaattgggg aatgtaggac aagacttgta aagtaagcca gtttatcttt
     4621 gaaacagtat tgtgaaattg gctttaaata tagccattcc gatcaaaaat gtattcatga
     4681 agtctgacta cacaaccctt ggcactgccg tcccacacag tctttaaggc ctttgtcacg
     4741 agagaatgac agtatctcat tcataactgg tgtgggttta ggagggagcc acactaaggt
     4801 gaacatttat gatcccggaa tgtttgtaag cattgtagct gcacaactgc catctccaaa
     4861 tattttctta taagactgtt tttagaagaa gaaaattgtc taaaacaagc aaaaactatg
     4921 gtattttcat ttactcaatt tctaggctaa aagagttcac taaataacgt tttccaatca
     4981 aattcctata gtcttcttct ccagtagtct aggcattaat atgtgattat tgtgtctctc
     5041 ggccactgtt ttttttaagt ccatggactt gagaagtatt ccgacactta tatggcttca
     5101 cagatatatt gctagttcag tcatagattg gagtttgcat attgtaatgt aagtgttatg
     5161 tcaacactat tctaaatagt ttatgactga agtttaatta aataaaaggt tgtaaaatgt
     5221 gatgtgtatg tgtatatact gtatgtgtac tttttaaaat aggtatatgt cctgaccctt
     5281 ttgatacagg tttgaatttg aaattacatt atataaacat atactttatt gttctaaata
     5341 aagaatttta tgcaccatca
//
