LOCUS       NM_022264               3819 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus KIT proto-oncogene receptor tyrosine kinase
            (Kit), mRNA.
ACCESSION   NM_022264
VERSION     NM_022264.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3819)
  AUTHORS   Cao,X., Wu,S., Wang,X., Huang,J., Zhang,W. and Liang,C.
  TITLE     Receptor tyrosine kinase C-kit promotes a destructive phenotype of
            FLS in osteoarthritis via intracellular EMT signaling
  JOURNAL   Mol Med 29 (1), 38 (2023)
   PUBMED   36959556
  REMARK    GeneRIF: Receptor tyrosine kinase C-kit promotes a destructive
            phenotype of FLS in osteoarthritis via intracellular EMT signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3819)
  AUTHORS   Zheng,H., Liu,Y.J., Chen,Z.C. and Fan,G.Q.
  TITLE     miR-222 regulates cell growth, apoptosis, and autophagy of
            interstitial cells of Cajal isolated from slow transit constipation
            rats by targeting c-kit
  JOURNAL   Indian J Gastroenterol 40 (2), 198-208 (2021)
   PUBMED   33792838
REFERENCE   3  (bases 1 to 3819)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3819)
  AUTHORS   Ravegnini,G., Serrano,C., Simeon,V., Sammarini,G., Nannini,M.,
            Roversi,E., Urbini,M., Ferre,F., Ricci,R., Tarantino,G.,
            Pantaleo,M.A., Hrelia,P. and Angelini,S.
  TITLE     The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222
            binding site in gastrointestinal stromal tumour: a sponge-like
            mechanism conferring disease susceptibility
  JOURNAL   Epigenetics 14 (6), 545-557 (2019)
   PUBMED   30983504
REFERENCE   5  (bases 1 to 3819)
  AUTHORS   Deng,J.J., Lai,M.Y., Tan,X. and Yuan,Q.
  TITLE     Acupuncture protects the interstitial cells of Cajal by regulating
            miR-222 in a rat model of post-operative ileus
  JOURNAL   Acupunct Med 37 (2), 125-132 (2019)
   PUBMED   30852906
REFERENCE   6  (bases 1 to 3819)
  AUTHORS   Spritz,R.A., Giebel,L.B. and Holmes,S.A.
  TITLE     Dominant negative and loss of function mutations of the c-kit
            (mast/stem cell growth factor receptor) proto-oncogene in human
            piebaldism
  JOURNAL   Am J Hum Genet 50 (2), 261-269 (1992)
   PUBMED   1370874
REFERENCE   7  (bases 1 to 3819)
  AUTHORS   Blume-Jensen,P., Claesson-Welsh,L., Siegbahn,A., Zsebo,K.M.,
            Westermark,B. and Heldin,C.H.
  TITLE     Activation of the human c-kit product by ligand-induced
            dimerization mediates circular actin reorganization and chemotaxis
  JOURNAL   EMBO J 10 (13), 4121-4128 (1991)
   PUBMED   1721869
REFERENCE   8  (bases 1 to 3819)
  AUTHORS   Tsujimura,T., Hirota,S., Nomura,S., Niwa,Y., Yamazaki,M., Tono,T.,
            Morii,E., Kim,H.M., Kondo,K., Nishimune,Y. et al.
  TITLE     Characterization of Ws mutant allele of rats: a 12-base deletion in
            tyrosine kinase domain of c-kit gene
  JOURNAL   Blood 78 (8), 1942-1946 (1991)
   PUBMED   1912577
REFERENCE   9  (bases 1 to 3819)
  AUTHORS   Niwa,Y., Kasugai,T., Ohno,K., Morimoto,M., Yamazaki,M., Dohmae,K.,
            Nishimune,Y., Kondo,K. and Kitamura,Y.
  TITLE     Anemia and mast cell depletion in mutant rats that are homozygous
            at 'white spotting (Ws)' locus
  JOURNAL   Blood 78 (8), 1936-1941 (1991)
   PUBMED   1912576
REFERENCE   10 (bases 1 to 3819)
  AUTHORS   Giebel,L.B. and Spritz,R.A.
  TITLE     Mutation of the KIT (mast/stem cell growth factor receptor)
            protooncogene in human piebaldism
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8696-8699 (1991)
   PUBMED   1717985
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_022264.3.
            
            On Nov 26, 2020 this sequence version replaced NM_022264.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12524.1, EU247828.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000014.1  32978702-32978812   c
            112-381             JAXUCZ010000014.1  32947207-32947476   c
            382-663             JAXUCZ010000014.1  32944955-32945236   c
            664-800             JAXUCZ010000014.1  32943595-32943731   c
            801-975             JAXUCZ010000014.1  32939262-32939436   c
            976-1165            JAXUCZ010000014.1  32934020-32934209   c
            1166-1281           JAXUCZ010000014.1  32931753-32931868   c
            1282-1396           JAXUCZ010000014.1  32918476-32918590   c
            1397-1590           JAXUCZ010000014.1  32916703-32916896   c
            1591-1697           JAXUCZ010000014.1  32915007-32915113   c
            1698-1824           JAXUCZ010000014.1  32914783-32914909   c
            1825-1929           JAXUCZ010000014.1  32914407-32914511   c
            1930-2040           JAXUCZ010000014.1  32914195-32914305   c
            2041-2191           JAXUCZ010000014.1  32912574-32912724   c
            2192-2280           JAXUCZ010000014.1  32910729-32910817   c
            2281-2408           JAXUCZ010000014.1  32909898-32910025   c
            2409-2531           JAXUCZ010000014.1  32908751-32908873   c
            2532-2643           JAXUCZ010000014.1  32905722-32905833   c
            2644-2743           JAXUCZ010000014.1  32905511-32905610   c
            2744-2849           JAXUCZ010000014.1  32905071-32905176   c
            2850-3819           JAXUCZ010000014.1  32903033-32904002   c
FEATURES             Location/Qualifiers
     source          1..3819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3819
                     /gene="Kit"
                     /note="KIT proto-oncogene receptor tyrosine kinase"
                     /db_xref="GeneID:64030"
                     /db_xref="RGD:620568"
     exon            1..111
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2981
                     /gene="Kit"
                     /EC_number="2.7.10.1"
                     /note="protein kinase; c-kit receptor tyrosine kinase;
                     mast/stem cell growth factor receptor Kit; v-kit
                     Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;
                     Kit oncogene"
                     /codon_start=1
                     /product="mast/stem cell growth factor receptor Kit
                     precursor"
                     /protein_id="NP_071600.1"
                     /db_xref="GeneID:64030"
                     /db_xref="RGD:620568"
                     /translation="MRGARGAWDLLCVLLVLLRGQTGTSQPSASPGEPSPPSIQPAQS
                     ELIVEAGDTIRLTCTDPAFVKWTFEILDVRIENKQSEWIREKAEATHTGKYTCVSGSG
                     LRSSIYVFVRDPAVLFLVGLPLFGKEDNDALVRCPLTDPQVSNYSLIECDGKSLPTDL
                     KFVPNPKAGITIKNVKRAYHRLCIRCAAQREGKWMRSDKFTLKVRAAIKAIPVVSVPE
                     TSHLLKEGDTFTVICTIKDVSTSVDSMWIKLNPQPQSKAQVKRNSWHQGDFNYERQET
                     LTISSARVNDSGVFMCYANNTFGSANVTTTLKVVEKGFINIFPVKNTTVFVTDGENVD
                     LVVEFEAYPKPEHQQWIYMNRTPTNRGEDYVKSDNQSNIRYVNELRLTRLKGTEGGTY
                     TFLVSNSDVSASVTFDVYVNTKPEILTYDRLMNGRLQCVAAGFPEPTIDWYFCTGAEQ
                     RCTVPVPPVDVQIQNASVSPFGKLVVQSSIDSSVFRHNGTVECKASNAVGKSSAFFNF
                     AFKGNSKEQIQPHTLFTPLLIGFVVTAGLMGIIVMVLAYKYLQKPMYEVQWKVVEEIN
                     GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAV
                     KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLN
                     FLRRKRDSFIFSKQEEQADAALYKNLLHSKESSCDSSNEYMDMKPGVSYVVPTKTDKR
                     RSARIDSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARN
                     ILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSY
                     GIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLK
                     RPTFKQVVQLIEKQISDSSKHIYSNLANCNPNPENPVVVDHSVRVNSVGSSTSSTQPL
                     LVHEDA"
     exon            112..381
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            382..663
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            664..800
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            801..975
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1165
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1281
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1396
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1590
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1697
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1824
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1929
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2040
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2191
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2280
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2408
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2531
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2643
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2743
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2849
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3819
                     /gene="Kit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtagcag agagaggagc tcagagtcta gcgcagccac cgcgatgaga ggcgctcgcg
       61 gcgcctggga tctgctctgc gtcctgttgg tcctgctccg tggccagaca gggacttctc
      121 agccatctgc gagtccaggg gagccgtctc caccatccat ccagccggcc cagtcagagt
      181 taatagttga agccggcgac accatcaggc tgacgtgcac tgaccccgcc tttgtcaaat
      241 ggactttcga gatcctcgat gtaaggattg agaataagca gagcgaatgg attcgagaaa
      301 aagccgaggc cactcacacg ggcaaataca cgtgcgtcag cggcagcggc ctcaggagct
      361 ctatttacgt gttcgttaga gatcctgccg tacttttcct ggttggcctt cccttgtttg
      421 gcaaagaaga caatgacgca ctggtccgct gccccctgac agacccacag gtgtccaatt
      481 actccctcat tgagtgtgat gggaaatctc tccccacgga cctgaagttc gtccccaacc
      541 ccaaggctgg catcaccatc aaaaacgtga agcgcgccta ccaccggctg tgcatccggt
      601 gtgctgccca gcgtgagggc aaatggatgc ggtctgacaa attcaccctc aaagtgaggg
      661 cagccatcaa agctatccca gtggtgtctg tgcccgaaac aagtcatctc cttaaggaag
      721 gggacacatt tacggtgata tgcaccataa aagacgtgtc tacatccgtg gactccatgt
      781 ggataaagtt gaaccctcag cctcagagca aagcccaggt aaagcgcaat agctggcatc
      841 agggcgactt caattacgaa cgccaggaga cgctgactat cagctcagca agagttaacg
      901 attccggagt gttcatgtgt tatgccaata atacttttgg atcagcaaat gtcacaacaa
      961 ccttgaaagt agtagaaaag ggattcatca acatcttccc tgtgaagaac actacggtat
     1021 ttgtaactga tggggaaaat gtagacttgg ttgttgagtt cgaggcctac cctaaacctg
     1081 aacaccagca gtggatctac atgaacagga cgcctactaa cagaggggag gattatgtca
     1141 aatccgacaa ccaaagcaac atcagatatg tgaacgaact tcgcctgacc agattgaaag
     1201 gcacagaagg aggcacttac acctttctgg tgtccaactc tgatgtcagt gcttccgtga
     1261 catttgatgt ttatgtgaac acaaaaccag aaatcctgac atatgacagg ctcatgaatg
     1321 gcaggctcca gtgtgtggcg gcgggattcc cggagcccac aatagattgg tatttttgta
     1381 caggggcaga gcaaaggtgt accgttcctg tcccgccagt agacgtacag atccagaatg
     1441 cgtctgtgtc accatttgga aaactggtgg ttcagagttc catagactcc agcgtcttcc
     1501 ggcacaacgg cacggtggag tgtaaggcct ccaacgctgt gggcaagagc tctgccttct
     1561 ttaactttgc atttaaaggt aacagcaaag agcaaatcca gccccacacc ctgttcacgc
     1621 cgctgctcat tggcttcgtg gtcacagccg gcttgatggg gatcattgtg atggttcttg
     1681 cctacaaata tttgcagaaa cccatgtatg aagtacaatg gaaggttgtc gaggagataa
     1741 atgggaacaa ttatgtttac atagacccaa cgcagcttcc ttatgaccac aaatgggagt
     1801 ttcccagaaa caggctgagt tttggaaaga ccttgggagc tggtgccttt gggaaggtag
     1861 ttgaggccac tgcctatggc ttaattaagt cggatgccgc catgacggtt gccgtgaaga
     1921 tgctcaaacc aagtgcccat ttaacggaaa gggaggccct aatgtcagaa ctgaaggtcc
     1981 tgagctacct gggtaatcac atgaatatcg tcaacctcct tggagcgtgt accgtgggag
     2041 ggcccaccct ggtcattaca gaatactgtt gctatggtga tcttttgaat ttcttgagaa
     2101 gaaagcgtga ctcgtttatt ttctcaaagc aagaagaaca ggcagacgcc gcactttata
     2161 agaaccttct gcattcaaag gagtcttcct gtgacagctc aaacgagtac atggacatga
     2221 agcctggcgt ttcctacgtc gtaccaacca agacagacaa aaggagatcc gcaagaatag
     2281 actcgtatat agaaagagac gtgactcccg ccatcatgga agatgacgag ctggctctgg
     2341 acctggaaga tttgctgagc ttttcctacc aggtggccaa gggcatggcg ttcctcgcct
     2401 ccaagaactg tattcacaga gatttggcag ccaggaatat cctcctcact cacgggcgga
     2461 tcacaaagat ttgcgatttc ggcctagcca gagacatcag gaatgattcg aattacgtgg
     2521 taaaaggaaa tgcacggctg cccgtgaagt ggatggcacc ggagagcatt ttcaactgcg
     2581 tgtacacatt tgaaagtgac gtctggtcct atgggatttt cctctgggag ctattctctc
     2641 taggaagcag cccctaccca gggatgccgg tcgattccaa gttttacaag atgatcaagg
     2701 aaggtttccg aatgctcagc cctgagcacg cgcctgccgc aatgtatgaa gttatgaaga
     2761 cttgctggga tgctgatccc ctgaaaaggc caacattcaa gcaggttgtt cagctcattg
     2821 agaagcagat ctcagacagc agcaaacata tttactccaa cttagcaaac tgtaacccca
     2881 acccagagaa ccccgtggtg gtggaccatt ctgtgagggt caattccgtc ggcagcagca
     2941 cctcttccac acagcctctc cttgtgcatg aggacgcctg agtagaaacg gagcccgatg
     3001 ggcattgctg tggtctccaa ccccattctc ctggcttcta tgatggttat tttgttttcc
     3061 tttgacttgc atcctactcc agggtagcgg gatccccacc ccacccccaa ccccactgtg
     3121 attctgcctt ttatgagcac actttagtgg ctgatggcct ttccttttcg ccatcagcca
     3181 ccatcccacc aagaaggtcc gaacggtatg tatatatttt cccattagca aagtagcccc
     3241 tactgtaaac ggaaggcctc atgctttaga ggaggaaggg tagggtgcaa cggggatgcc
     3301 tggagttctt cacagtgctc ctccgagtgt gtttgaaaag tatggccagt agttcatttg
     3361 aagagtttag aagtagtccc gttttggccc agagagcctt ccataatgac gggcagatgt
     3421 atgtagcaag actagaaagg gaaacccaag ccctgtgtgt ggaaagtaga ccattattag
     3481 aacagaggac acatgagaac atctaggcct aagaagtctg gtcatgctga gaacgagacc
     3541 taggctgaga cggcgcaagc cctggaagcg tggacataga tgctctgttc tgggccgctg
     3601 cgcgggcttt tgcgcaagct tttgtacaac tgacctggtt tttaaatagt ctgctgttgg
     3661 ggagtagaat tggagacaag gcctcctccc tagccagcgt ttgtatatac tcactgtacg
     3721 ttgtatgcgt tcatactttg gagcggggga tccccccaca agctttagtt tctgtgtaca
     3781 accctgggat taggtctgct gtgtgtaaga atagattta
//
