LOCUS       NM_023992               1502 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus KISS1 receptor (Kiss1r), transcript variant 1,
            mRNA.
ACCESSION   NM_023992
VERSION     NM_023992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Zhao,X.D., Li,Z.H., Hu,J.W., Chen,Y.L. and Xu,G.
  TITLE     [Effects of electroacupuncture on the secretion function of ovarian
            cells and kisspeptin/kiss1r system in rats with polycystic ovarian
            syndrome]
  JOURNAL   Zhen Ci Yan Jiu 48 (8), 804-811 (2023)
   PUBMED   37614139
  REMARK    GeneRIF: [Effects of electroacupuncture on the secretion function
            of ovarian cells and kisspeptin/kiss1r system in rats with
            polycystic ovarian syndrome].
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Ziarniak,K., Yang,T., Boycott,C., Beetch,M., Sassek,M., Grzeda,E.,
            Ma,Y., Sliwowska,J.H. and Stefanska,B.
  TITLE     DNA hypermethylation of Kiss1r promoter and reduction of hepatic
            Kiss1r in female rats with type 2 diabetes
  JOURNAL   Epigenetics 17 (13), 2332-2346 (2022)
   PUBMED   36094166
  REMARK    GeneRIF: DNA hypermethylation of Kiss1r promoter and reduction of
            hepatic Kiss1r in female rats with type 2 diabetes.
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Munoz de la Torre,L.P., Trujillo Hernandez,A., Eguibar,J.R.,
            Cortes,C. and Morales-Ledesma,L.
  TITLE     Sex-specific hypothalamic expression of kisspeptin, gonadotropin
            releasing hormone, and kisspeptin receptor in progressive
            demyelination model
  JOURNAL   J Chem Neuroanat 123, 102120 (2022)
   PUBMED   35718292
  REMARK    GeneRIF: Sex-specific hypothalamic expression of kisspeptin,
            gonadotropin releasing hormone, and kisspeptin receptor in
            progressive demyelination model.
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Santos,B.R., Dos Anjos Cordeiro,J.M., Santos,L.C., de
            Oliveira,L.S., Mendonca,L.D., Santos,E.O., de Macedo,I.O.,
            Szawka,R.E., Serakides,R. and Silva,J.F.
  TITLE     Maternal hypothyroidism reduces the expression of the
            kisspeptin/Kiss1r system in the maternal-fetal interface of rats
  JOURNAL   Reprod Biol 22 (2), 100615 (2022)
   PUBMED   35180577
  REMARK    GeneRIF: Maternal hypothyroidism reduces the expression of the
            kisspeptin/Kiss1r system in the maternal-fetal interface of rats.
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Risvanli,A., Ocal,H., Timurkaan,N., Ipek,P., Cevik,A. and Seker,I.
  TITLE     Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats
  JOURNAL   Exp Clin Transplant 18 (5), 618-625 (2020)
   PUBMED   31724927
  REMARK    GeneRIF: Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Kotani,M., Detheux,M., Vandenbogaerde,A., Communi,D.,
            Vanderwinden,J.M., Le Poul,E., Brezillon,S., Tyldesley,R.,
            Suarez-Huerta,N., Vandeput,F., Blanpain,C., Schiffmann,S.N.,
            Vassart,G. and Parmentier,M.
  TITLE     The metastasis suppressor gene KiSS-1 encodes kisspeptins, the
            natural ligands of the orphan G protein-coupled receptor GPR54
  JOURNAL   J Biol Chem 276 (37), 34631-34636 (2001)
   PUBMED   11457843
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Muir,A.I., Chamberlain,L., Elshourbagy,N.A., Michalovich,D.,
            Moore,D.J., Calamari,A., Szekeres,P.G., Sarau,H.M., Chambers,J.K.,
            Murdock,P., Steplewski,K., Shabon,U., Miller,J.E., Middleton,S.E.,
            Darker,J.G., Larminie,C.G., Wilson,S., Bergsma,D.J., Emson,P.,
            Faull,R., Philpott,K.L. and Harrison,D.C.
  TITLE     AXOR12, a novel human G protein-coupled receptor, activated by the
            peptide KiSS-1
  JOURNAL   J Biol Chem 276 (31), 28969-28975 (2001)
   PUBMED   11387329
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Clements,M.K., McDonald,T.P., Wang,R., Xie,G., O'Dowd,B.F.,
            George,S.R., Austin,C.P. and Liu,Q.
  TITLE     FMRFamide-related neuropeptides are agonists of the orphan
            G-protein-coupled receptor GPR54
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1189-1193 (2001)
   PUBMED   11414709
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Ohtaki,T., Shintani,Y., Honda,S., Matsumoto,H., Hori,A.,
            Kanehashi,K., Terao,Y., Kumano,S., Takatsu,Y., Masuda,Y.,
            Ishibashi,Y., Watanabe,T., Asada,M., Yamada,T., Suenaga,M.,
            Kitada,C., Usuki,S., Kurokawa,T., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Metastasis suppressor gene KiSS-1 encodes peptide ligand of a
            G-protein-coupled receptor
  JOURNAL   Nature 411 (6837), 613-617 (2001)
   PUBMED   11385580
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Lee,D.K., Nguyen,T., O'Neill,G.P., Cheng,R., Liu,Y., Howard,A.D.,
            Coulombe,N., Tan,C.P., Tang-Nguyen,A.T., George,S.R. and
            O'Dowd,B.F.
  TITLE     Discovery of a receptor related to the galanin receptors
  JOURNAL   FEBS Lett 446 (1), 103-107 (1999)
   PUBMED   10100623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 24, 2014 this sequence version replaced NM_023992.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051066.1, AF115516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               JAXUCZ010000007.1  10439007-10439424   c
            419-543             JAXUCZ010000007.1  10438368-10438492   c
            544-679             JAXUCZ010000007.1  10437096-10437231   c
            680-912             JAXUCZ010000007.1  10436677-10436909   c
            913-1502            JAXUCZ010000007.1  10435766-10436355   c
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1502
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /note="KISS1 receptor"
                     /db_xref="GeneID:78976"
                     /db_xref="RGD:70930"
     exon            1..418
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1365
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kiSS-1 receptor; kiSS-1R; rOT7T175; metastin receptor;
                     kisspeptins receptor; G-protein coupled receptor OT7T175;
                     orphan G protein-coupled receptor GPR54; G protein-coupled
                     receptor 54"
                     /codon_start=1
                     /product="kiSS-1 receptor isoform 1"
                     /protein_id="NP_076482.2"
                     /db_xref="GeneID:78976"
                     /db_xref="RGD:70930"
                     /translation="MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWL
                     VPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALL
                     YPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLAL
                     TVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLL
                     ATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACW
                     GPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAF
                     CRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVVRSPSVQDEH
                     TAPL"
     exon            419..543
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /inference="alignment:Splign:2.1.0"
     exon            544..679
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /inference="alignment:Splign:2.1.0"
     exon            680..912
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1502
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccacttt ccagcccctg ccgccagcta cagagaccag ggcgctggta tcccccggag
       61 agcggagagc ggccctcgcc ctgaggagga ggagcggggt cctccctctc gtccccacag
      121 tcccaggacg caatctgtga aggctgcctg gaggaagagg agggcgacag ggccatggcc
      181 gcagaggcga cgttgggtcc gaacgtgagc tggtgggctc cgtccaacgc ttcgggatgc
      241 ccgggctgcg gtgtcaatgc ctcggatggc ccaggctccg cgccaaggcc cctggatgcc
      301 tggctggtgc ccctgttttt cgctgcccta atgttgctgg ggctagtcgg gaactcactg
      361 gtcatcttcg ttatctgccg ccacaagcac atgcagaccg tcaccaattt ctacatcgct
      421 aacctggcgg ccacagatgt cactttcctt ctgtgctgcg tacccttcac cgcgctcctc
      481 tatccgctgc ccacctgggt gctgggagac ttcatgtgca aattcgtcaa ctacatccag
      541 caggtctcgg tgcaagccac atgtgccact ttgacagcca tgagtgtgga ccgctggtac
      601 gtgactgtgt tcccgctgcg tgcacttcac cgccgcactc cgcgcctggc cctgactgtc
      661 agccttagca tctgggtggg ttccgcagct gtttccgccc cggtgctggc tctgcatcgc
      721 ctgtcgcccg ggcctcacac ctactgcagt gaggcgtttc ccagccgtgc cctggagcgc
      781 gctttcgcgc tctacaacct gctggcccta tacctgctgc cgctgctcgc cacctgcgcc
      841 tgctacggtg ccatgctgcg ccacctgggc cgcgccgctg tacgccccgc acccactgat
      901 ggcgccctgc aggggcagct gctagcacag cgcgctggag cagtgcgcac caaggtctcc
      961 cggctggtgg ccgctgtcgt cctgctcttc gccgcctgct ggggcccgat ccagctgttc
     1021 ctggtgcttc aagccctggg cccctcgggg gcctggcacc ctcgaagcta tgccgcctac
     1081 gcgctcaaga tctgggctca ctgcatgtcc tacagcaatt ctgcgctcaa cccgctgctc
     1141 tatgccttcc tgggttccca cttcagacag gccttctgcc gcgtgtgccc ctgcggcccg
     1201 caacgccagc gtcggcccca cgcgtcagcg cactcggacc gagccgcacc ccatagtgtg
     1261 ccgcacagcc gggctgcgca ccctgtccgg gtcagaaccc ccgagcctgg gaaccctgtg
     1321 gtgcgctcgc cctctgttca ggatgaacac actgccccac tctgagccgc ccctgcctgt
     1381 gggataatcc aatccggctg cttggctggg cagctgtttc tagtttagtt aatctgtgta
     1441 aatgaccttt tcttccaatc tgcaccagca caccgtggtt ttggccgtgc atgttatgat
     1501 aa
//
