LOCUS       NP_076482                396 aa            linear   ROD 30-MAR-2024
DEFINITION  kiSS-1 receptor isoform 1 [Rattus norvegicus].
ACCESSION   NP_076482
VERSION     NP_076482.2
DBSOURCE    REFSEQ: accession NM_023992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Zhao,X.D., Li,Z.H., Hu,J.W., Chen,Y.L. and Xu,G.
  TITLE     [Effects of electroacupuncture on the secretion function of ovarian
            cells and kisspeptin/kiss1r system in rats with polycystic ovarian
            syndrome]
  JOURNAL   Zhen Ci Yan Jiu 48 (8), 804-811 (2023)
   PUBMED   37614139
  REMARK    GeneRIF: [Effects of electroacupuncture on the secretion function
            of ovarian cells and kisspeptin/kiss1r system in rats with
            polycystic ovarian syndrome].
REFERENCE   2  (residues 1 to 396)
  AUTHORS   Ziarniak,K., Yang,T., Boycott,C., Beetch,M., Sassek,M., Grzeda,E.,
            Ma,Y., Sliwowska,J.H. and Stefanska,B.
  TITLE     DNA hypermethylation of Kiss1r promoter and reduction of hepatic
            Kiss1r in female rats with type 2 diabetes
  JOURNAL   Epigenetics 17 (13), 2332-2346 (2022)
   PUBMED   36094166
  REMARK    GeneRIF: DNA hypermethylation of Kiss1r promoter and reduction of
            hepatic Kiss1r in female rats with type 2 diabetes.
REFERENCE   3  (residues 1 to 396)
  AUTHORS   Munoz de la Torre,L.P., Trujillo Hernandez,A., Eguibar,J.R.,
            Cortes,C. and Morales-Ledesma,L.
  TITLE     Sex-specific hypothalamic expression of kisspeptin, gonadotropin
            releasing hormone, and kisspeptin receptor in progressive
            demyelination model
  JOURNAL   J Chem Neuroanat 123, 102120 (2022)
   PUBMED   35718292
  REMARK    GeneRIF: Sex-specific hypothalamic expression of kisspeptin,
            gonadotropin releasing hormone, and kisspeptin receptor in
            progressive demyelination model.
REFERENCE   4  (residues 1 to 396)
  AUTHORS   Santos,B.R., Dos Anjos Cordeiro,J.M., Santos,L.C., de
            Oliveira,L.S., Mendonca,L.D., Santos,E.O., de Macedo,I.O.,
            Szawka,R.E., Serakides,R. and Silva,J.F.
  TITLE     Maternal hypothyroidism reduces the expression of the
            kisspeptin/Kiss1r system in the maternal-fetal interface of rats
  JOURNAL   Reprod Biol 22 (2), 100615 (2022)
   PUBMED   35180577
  REMARK    GeneRIF: Maternal hypothyroidism reduces the expression of the
            kisspeptin/Kiss1r system in the maternal-fetal interface of rats.
REFERENCE   5  (residues 1 to 396)
  AUTHORS   Risvanli,A., Ocal,H., Timurkaan,N., Ipek,P., Cevik,A. and Seker,I.
  TITLE     Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats
  JOURNAL   Exp Clin Transplant 18 (5), 618-625 (2020)
   PUBMED   31724927
  REMARK    GeneRIF: Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
REFERENCE   6  (residues 1 to 396)
  AUTHORS   Kotani,M., Detheux,M., Vandenbogaerde,A., Communi,D.,
            Vanderwinden,J.M., Le Poul,E., Brezillon,S., Tyldesley,R.,
            Suarez-Huerta,N., Vandeput,F., Blanpain,C., Schiffmann,S.N.,
            Vassart,G. and Parmentier,M.
  TITLE     The metastasis suppressor gene KiSS-1 encodes kisspeptins, the
            natural ligands of the orphan G protein-coupled receptor GPR54
  JOURNAL   J Biol Chem 276 (37), 34631-34636 (2001)
   PUBMED   11457843
REFERENCE   7  (residues 1 to 396)
  AUTHORS   Muir,A.I., Chamberlain,L., Elshourbagy,N.A., Michalovich,D.,
            Moore,D.J., Calamari,A., Szekeres,P.G., Sarau,H.M., Chambers,J.K.,
            Murdock,P., Steplewski,K., Shabon,U., Miller,J.E., Middleton,S.E.,
            Darker,J.G., Larminie,C.G., Wilson,S., Bergsma,D.J., Emson,P.,
            Faull,R., Philpott,K.L. and Harrison,D.C.
  TITLE     AXOR12, a novel human G protein-coupled receptor, activated by the
            peptide KiSS-1
  JOURNAL   J Biol Chem 276 (31), 28969-28975 (2001)
   PUBMED   11387329
REFERENCE   8  (residues 1 to 396)
  AUTHORS   Clements,M.K., McDonald,T.P., Wang,R., Xie,G., O'Dowd,B.F.,
            George,S.R., Austin,C.P. and Liu,Q.
  TITLE     FMRFamide-related neuropeptides are agonists of the orphan
            G-protein-coupled receptor GPR54
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1189-1193 (2001)
   PUBMED   11414709
REFERENCE   9  (residues 1 to 396)
  AUTHORS   Ohtaki,T., Shintani,Y., Honda,S., Matsumoto,H., Hori,A.,
            Kanehashi,K., Terao,Y., Kumano,S., Takatsu,Y., Masuda,Y.,
            Ishibashi,Y., Watanabe,T., Asada,M., Yamada,T., Suenaga,M.,
            Kitada,C., Usuki,S., Kurokawa,T., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Metastasis suppressor gene KiSS-1 encodes peptide ligand of a
            G-protein-coupled receptor
  JOURNAL   Nature 411 (6837), 613-617 (2001)
   PUBMED   11385580
REFERENCE   10 (residues 1 to 396)
  AUTHORS   Lee,D.K., Nguyen,T., O'Neill,G.P., Cheng,R., Liu,Y., Howard,A.D.,
            Coulombe,N., Tan,C.P., Tang-Nguyen,A.T., George,S.R. and
            O'Dowd,B.F.
  TITLE     Discovery of a receptor related to the galanin receptors
  JOURNAL   FEBS Lett 446 (1), 103-107 (1999)
   PUBMED   10100623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 24, 2014 this sequence version replaced NP_076482.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051066.1, AF115516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..396
                     /product="kiSS-1 receptor isoform 1"
                     /note="kiSS-1 receptor; kiSS-1R; rOT7T175; metastin
                     receptor; kisspeptins receptor; G-protein coupled receptor
                     OT7T175; orphan G protein-coupled receptor GPR54; G
                     protein-coupled receptor 54"
                     /calculated_mol_wt=42701
     Site            10
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924U1.2)"
     Site            18
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924U1.2)"
     Site            28
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          43..334
                     /region_name="7tmA_KiSS1R"
                     /note="KiSS1-derived peptide (kisspeptin) receptor, member
                     of the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15095"
                     /db_xref="CDD:320223"
     Region          44..70
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320223"
     Site            47..67
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          77..103
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320223"
     Site            91..111
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Site            order(99,102..103,115..120,122..123,126,171,173..177,201,
                     204..206,208..210,212..213,276,279..280,282..283,286,
                     301..302,304..306,309,312..313)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320223"
     Region          115..145
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320223"
     Site            121..138
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          157..177
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320223"
     Site            160..180
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          201..230
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320223"
     Site            203..223
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          256..286
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320223"
     Site            265..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          302..327
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320223"
     Site            306..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     Region          346..396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924U1.2)"
     CDS             1..396
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54"
                     /coded_by="NM_023992.2:175..1365"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:78976"
                     /db_xref="RGD:70930"
ORIGIN      
        1 maaeatlgpn vswwapsnas gcpgcgvnas dgpgsaprpl dawlvplffa almllglvgn
       61 slvifvicrh khmqtvtnfy ianlaatdvt fllccvpfta llyplptwvl gdfmckfvny
      121 iqqvsvqatc atltamsvdr wyvtvfplra lhrrtprlal tvslsiwvgs aavsapvlal
      181 hrlspgphty cseafpsral erafalynll alyllpllat cacygamlrh lgraavrpap
      241 tdgalqgqll aqragavrtk vsrlvaavvl lfaacwgpiq lflvlqalgp sgawhprsya
      301 ayalkiwahc msysnsalnp llyaflgshf rqafcrvcpc gpqrqrrpha sahsdraaph
      361 svphsraahp vrvrtpepgn pvvrspsvqd ehtapl
//
