LOCUS       NM_207606               7131 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kirre like nephrin family adhesion molecule 1
            (Kirrel1), mRNA.
ACCESSION   NM_207606 XM_006232677 XM_227486
VERSION     NM_207606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7131)
  AUTHORS   Takahashi,A., Fukusumi,Y., Yamazaki,M., Kayaba,M., Kitazawa,Y.,
            Tomita,M. and Kawachi,H.
  TITLE     Angiotensin II type 1 receptor blockade ameliorates proteinuria in
            puromycin aminonucleoside nephropathy by inhibiting the reduction
            of NEPH1 and nephrin
  JOURNAL   J Nephrol 27 (6), 627-634 (2014)
   PUBMED   25298195
  REMARK    GeneRIF: Irbesartan treatment ameliorates proteinuria in puromycin
            aminonucleoside nephropathy by inhibiting the reduction of NEPH1
            and nephrin in the kidney glomerulus.
REFERENCE   2  (bases 1 to 7131)
  AUTHORS   Kong,L., Choi,R.C., Tsim,K.W., Jing,N., Nakayama,D.K. and Wang,Z.
  TITLE     Distribution and expression of Kirre, an IgSF molecule, during
            postnatal development of rat cerebellum
  JOURNAL   Neurosci Lett 543, 22-26 (2013)
   PUBMED   23570724
  REMARK    GeneRIF: rKirre may play a potential role in postnatal developing
            rat cerebellum.
REFERENCE   3  (bases 1 to 7131)
  AUTHORS   Heikkila,E., Ristola,M., Havana,M., Jones,N., Holthofer,H. and
            Lehtonen,S.
  TITLE     Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion
            that associates with decreased tyrosine phosphorylation of nephrin
  JOURNAL   Biochem J 435 (3), 619-628 (2011)
   PUBMED   21306299
REFERENCE   4  (bases 1 to 7131)
  AUTHORS   Arif,E., Wagner,M.C., Johnstone,D.B., Wong,H.N., George,B.,
            Pruthi,P.A., Lazzara,M.J. and Nihalani,D.
  TITLE     Motor protein Myo1c is a podocyte protein that facilitates the
            transport of slit diaphragm protein Neph1 to the podocyte membrane
  JOURNAL   Mol Cell Biol 31 (10), 2134-2150 (2011)
   PUBMED   21402783
REFERENCE   5  (bases 1 to 7131)
  AUTHORS   Kong,L., Choi,R.C., Xie,H.Q., Wang,X., Peng,G., Xie,Z., Tsim,K.W.
            and Jing,N.
  TITLE     Expression of the IgSF protein Kirre in the rat central nervous
            system
  JOURNAL   Life Sci 88 (13-14), 590-597 (2011)
   PUBMED   21277866
  REMARK    GeneRIF: These results suggested that rKirre might play an
            essential role in neuronal differentiation and development in the
            central nervous system.
REFERENCE   6  (bases 1 to 7131)
  AUTHORS   Gerke,P., Benzing,T., Hohne,M., Kispert,A., Frotscher,M., Walz,G.
            and Kretz,O.
  TITLE     Neuronal expression and interaction with the synaptic protein CASK
            suggest a role for Neph1 and Neph2 in synaptogenesis
  JOURNAL   J Comp Neurol 498 (4), 466-475 (2006)
   PUBMED   16874800
REFERENCE   7  (bases 1 to 7131)
  AUTHORS   Beall,M.H., Amidi,F., Gayle,D.A., Wang,S., Beloosesky,R. and
            Ross,M.G.
  TITLE     Placental and fetal membrane Nephrin and Neph1 gene expression:
            response to inflammation
  JOURNAL   J Soc Gynecol Investig 12 (5), 298-302 (2005)
   PUBMED   15979540
  REMARK    GeneRIF: Fetal membranes and placenta of the rat express mRNA for
            the protein barriers nephrin and Neph 1, suggesting a role in the
            regulation of protein transfer from the fetus to mother
REFERENCE   8  (bases 1 to 7131)
  AUTHORS   Liu,G., Kaw,B., Kurfis,J., Rahmanuddin,S., Kanwar,Y.S. and
            Chugh,S.S.
  TITLE     Neph1 and nephrin interaction in the slit diaphragm is an important
            determinant of glomerular permeability
  JOURNAL   J Clin Invest 112 (2), 209-221 (2003)
   PUBMED   12865409
  REMARK    GeneRIF: nephrin and Neph1 interact and have roles in glomerular
            permeability
REFERENCE   9  (bases 1 to 7131)
  AUTHORS   Barletta,G.M., Kovari,I.A., Verma,R.K., Kerjaschki,D. and
            Holzman,L.B.
  TITLE     Nephrin and Neph1 co-localize at the podocyte foot process
            intercellular junction and form cis hetero-oligomers
  JOURNAL   J Biol Chem 278 (21), 19266-19271 (2003)
   PUBMED   12646566
  REMARK    GeneRIF: Nephrin and Neph1 form a hetero-oligomeric receptor
            complex in the plane of the membrane that might interact across the
            foot process intercellular junction through interactions between
            Nephrin with itself and Neph1
REFERENCE   10 (bases 1 to 7131)
  AUTHORS   Donoviel,D.B., Freed,D.D., Vogel,H., Potter,D.G., Hawkins,E.,
            Barrish,J.P., Mathur,B.N., Turner,C.A., Geske,R., Montgomery,C.A.,
            Starbuck,M., Brandt,M., Gupta,A., Ramirez-Solis,R., Zambrowicz,B.P.
            and Powell,D.R.
  TITLE     Proteinuria and perinatal lethality in mice lacking NEPH1, a novel
            protein with homology to NEPHRIN
  JOURNAL   Mol Cell Biol 21 (14), 4829-4836 (2001)
   PUBMED   11416156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006232677.4, NM_207606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2412491.1,
                                           SRR21887620.1898586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000002.1  174912693-174912960 c
            269-414             JAXUCZ010000002.1  174878545-174878690 c
            415-579             JAXUCZ010000002.1  174837964-174838128 c
            580-729             JAXUCZ010000002.1  174836108-174836257 c
            730-887             JAXUCZ010000002.1  174832639-174832796 c
            888-1038            JAXUCZ010000002.1  174830860-174831010 c
            1039-1144           JAXUCZ010000002.1  174830221-174830326 c
            1145-1293           JAXUCZ010000002.1  174829899-174830047 c
            1294-1421           JAXUCZ010000002.1  174829571-174829698 c
            1422-1548           JAXUCZ010000002.1  174828838-174828964 c
            1549-1649           JAXUCZ010000002.1  174828651-174828751 c
            1650-1848           JAXUCZ010000002.1  174826910-174827108 c
            1849-1956           JAXUCZ010000002.1  174825649-174825756 c
            1957-2096           JAXUCZ010000002.1  174825371-174825510 c
            2097-2174           JAXUCZ010000002.1  174824734-174824811 c
            2175-7131           JAXUCZ010000002.1  174819564-174824520 c
FEATURES             Location/Qualifiers
     source          1..7131
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..7131
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /note="kirre like nephrin family adhesion molecule 1"
                     /db_xref="GeneID:310695"
                     /db_xref="RGD:727883"
     exon            1..268
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..414
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..2651
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /note="kin of IRRE-like protein 1; nephrin-like protein 1;
                     kin of irregular chiasm-like protein 1; kin of IRRE like
                     1; nephrin 1"
                     /codon_start=1
                     /product="kin of IRRE-like protein 1 precursor"
                     /protein_id="NP_997489.2"
                     /db_xref="GeneID:310695"
                     /db_xref="RGD:727883"
                     /translation="MTLENRSTCLMTCQSSLLPKKPRFLSQKMWAPHLVVAYLIFVTL
                     ALALPGTQTRFSQEPADQTVVAGHRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWP
                     RYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGG
                     PVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLL
                     IQPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTC
                     QATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLV
                     NVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
                     VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGST
                     PPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN
                     SFGPGTAIIQLEEREVLPVGIIAGATIGAGILLVFSFAALVFFLYRRRKGSRKDVTLR
                     KLDIKVETVNREPLTMHSDREDDTTSISTATRVMKAIYSSFKDDVDLKQDLHCDTIET
                     REEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQL
                     NTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGY
                     PQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV"
     exon            415..579
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..729
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..887
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1038
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1144
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1293
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1421
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1548
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1649
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1848
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1956
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2096
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2174
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..7131
                     /gene="Kirrel1"
                     /gene_synonym="Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagagcg gcgcggaggt tgagagaggc ccggagagat aaagccggag ggcagaaatt
       61 attagggggc gcgggacgag aggaggggcc aggggagcga gcccgcggct agagaggcaa
      121 gcgagtgtgc gccttgtgtg caagggcggg agggagaaga gagagccagc ggcggcccgg
      181 cttgcgccga ctcgggccca gcggcgggcg gacagcatgc tgagcttcct catctggatc
      241 cccactctct tcaacacttt ctcacaagca gggctttagg aatgactctg gagaaccgta
      301 gcacatgtct aatgacctgc caatcaagcc tgctccccaa gaagcccagg tttctgagtc
      361 agaagatgtg ggctccacac ttagtcgttg cttatcttat ctttgtgact ttggctttgg
      421 cgttgcctgg gacccagact cgcttcagcc aggagccagc tgatcagacc gtggtagccg
      481 gacaccgggc agtgctcccg tgcgtgctcc tcaactactc tgggatcgta caatggacca
      541 aggacgggct ggctctgggt atgggccagg gcctcaaagc ctggccacgg taccgagtcg
      601 tgggctctgc ggatgctggg caatacaact tggagatcac ggatgccgag ctgtctgatg
      661 acgcttccta tgagtgccag gccacggagg ctgccctgcg ctctcggcgg gccaaactca
      721 ccgtgctcat tcctccagag gacacaagga ttgatggggg cccggtgatt ctgctgcaag
      781 caggcacccc ctacaacctc acatgccgag catttaatgc caagcctgct gccaccatca
      841 tttggttccg ggatgggaca cagcaggagg gggctgtgac tagcacggag ctgctgaagg
      901 atgggaaaag ggagactaca atcagccagc tactcattca gcccacagac ctagacatcg
      961 gccgcgtatt cacctgtcgc agcatgaatg aggccatccc caatggcaag gagacgtcca
     1021 ttgagctgga tgtacaccac cctcctacag tgactctgtc cattgagccc cagacagtgc
     1081 tggagggcga gcgcgtcatc tttacgtgcc aggccacagc caacccggag atcctgggct
     1141 acaggtgggc caaagggggg ttcctgattg aagacgccca tgagagtcgc tatgagacaa
     1201 atgttgatta ttccttcttc acggagcccg tgtcttgtga ggtttataac aaagtcggga
     1261 gcaccaatgt cagcacttta gtgaacgttc actttgcccc ccggattgta gtttacccaa
     1321 agcccacaac cacagacatt ggatctgatg tgaccctcac ttgtgtctgg gttgggaatc
     1381 cccccctcac cctcacctgg accaagaagg attcaaacat ggtcctgagt aacagcaatc
     1441 aactgttgct gaagtcagtg acccaggcag atgctggcac ctatacctgc cgtgccatag
     1501 tgcctcgaat cggagtggct gagcgagagg taccccttta tgtgaatgga ccccctatca
     1561 tctccagcga ggcggtgcag tttgctgtga gaggggatgg cggtaaggtg gagtgcttca
     1621 tcgggagtac cccccctccg gatcgaattg catgggcttg gaaggagaac ttcctagagg
     1681 tggggacact ggaacgatac actgtggaga ggacaaactc aggcagtggt gtgctgtcca
     1741 ctctcaccat caataacgtc atggaggccg acttccagac ccactacaac tgcactgcct
     1801 ggaacagctt tggaccaggc acagccatca tccagctgga ggagcgagag gtgttacctg
     1861 tgggcatcat cgctggggcc accatcggtg ctggcatcct gctcgtcttc tcttttgctg
     1921 ccttagtgtt ctttctctac cgacgtcgca aaggcagtcg aaaggatgtg acgttgagga
     1981 agctggacat caaggtagag acagtgaatc gggagccact tacaatgcac tctgaccggg
     2041 aggatgatac caccagcatt tccacggcaa ctcgggtcat gaaagccatc tactcgtcct
     2101 ttaaggatga tgtggatctg aaacaggacc tgcactgtga caccatcgag acccgggaag
     2161 agtatgagat gaaggatcca accaatggtt attacaacgt gcgtgcccac gaagatcgcc
     2221 catcttccag ggcggtgcta tatgctgact accgtgcccc tggccctact cgttttgatg
     2281 ggcgcccatc atcccgcctc tcccactcca gtggttatgc ccagctgaat acatacagcc
     2341 gagcccccgc ctctgactat ggcacagagc cgacaccctc tggcccttct gctccaggtg
     2401 gcaccgatac aaccagccag ctgtcctacg agaactatga gaagttcaac tcccacccct
     2461 ttcccggggc agctgggtat cctacctacc gtctaggcta cccccaggcc ccaccctctg
     2521 gcctggagag gaccccctat gaagcctatg accctattgg caagtatgcc accgccactc
     2581 ggttctccta cacctctcaa cactcagact acggccagcg attccagcag cgcatgcaga
     2641 ctcacgtgta gaggctggag tctggctggg gtatctctgc ggggcagagg agatggcttc
     2701 ccagcattcc ctgacattca gggacattgc tcgttgctcc tttcgtggac ccagcctttc
     2761 tcctcctggc catcacaaat aaggagcagg tctcccagta acaccccatc ccaaggatgg
     2821 tgctctgcgc atgccccagt ctcccgggcc agccctttcc tcttcttcag gaggatatct
     2881 cttctgacct ttgttctgcc tgacccaagc atggggaaag gagaggggag gttgggggag
     2941 gggaggagag aggagaggag cacagtctgt catttccttc tgtcctgctt ctctgagctc
     3001 ccgtaggtgg tcatggagat atgccgaggt gggcaggccg ctggaacgta ggagagcgca
     3061 ccagtcccgg tcttgatttc ttgatacctt gtgttcatct ttcccatctc aggggattac
     3121 agatgaaaca atgagttcaa atccagccct tggtcagctg gggtcaaaat accagtcact
     3181 ctggctgcta ctgtggctct ctgtctgagt gaagagggct tcaaaaaatc cccaagatca
     3241 ctgattcctt tcttctcagc tttgtgctgg accagccaag atgtgtcctg gatgtgagca
     3301 agtcgcggtc aggactaagt cctggttgac aggcaagggt ccactgtgta gtgcatggca
     3361 gtttccaggt ccagcactag tgggagccac gcaagtttcc ttcttctaaa cggtattggg
     3421 ccccacttct tggtgttgac tcttgagcct tggtagagca gaggctactt ttcatggggc
     3481 tgtctttcaa aagcaataaa acctcctttg gaatgagaag ttgtagggtt tccccgctat
     3541 acgcaagtcc ctatggaaag gaaaggggcg cccgccctcc agcaggctcc taacacctcg
     3601 tattgctcta gctgagtctc tgagcacttt gattctagta catacgatct ggatggtgag
     3661 acctgccttc tggtggattc tgatagagcg cagcagtgtc ccgagcctca ggctctacta
     3721 tcctacctgg tctaactact caccgtagct agaaactgcc ttgcagatgg cgtggtaggg
     3781 gctttatcca gacaaatttt ggtttcgtct cctcctcacc ggcccccatc ccacccaatc
     3841 agattccttc tttcattttc agtgccttga gtgtcaggtt tgtgatgatg tccctgtgtg
     3901 gggagcaggg accttgtgaa tctcagcttg tcccatgtta gcatccaggg agacacaaat
     3961 gaagaggatg gaagggaaag ggggccggga aatggctgcc ggaaaattct taccggccta
     4021 gatggtgatc ctagtgcaga agaacacacc aggcactgaa ttccataggc catgttgtct
     4081 ttcccacaca ttctgcacac atgagtgccc acacattcca tgccacgtct catctaccac
     4141 cttctgacca aagagaacct gtaactagtg tttcagcctc accttcccaa gaaaccaact
     4201 gcccaacagg attcttccat ccacagtccc gatgaggcct gcctgacagg aggaagtatt
     4261 cccagaatac tcctggcttc ttctcattgg tcaccattcg ttagtcatgt ttactttaat
     4321 gagttacctg ttcatcaggc ccgttccatc actaaccctc tagatgggtc tgtagggtga
     4381 cattccctgc catctccttt ccgataagga ccaggtaatg tccaggaatc aaggagagcc
     4441 gtttgcagcc tggctggcag gcaggcagct gctgcgtcct cttctccagt gagtgcgtcc
     4501 acacagagcg gcccttcctg cagcagtgac agactcatag ctgtattccg gttcagaaga
     4561 ctctcgcttt cacgagagct cagggaggca gtgtaggttc tagtgagtat ggatttgtgc
     4621 aggttttcag tttcactcgc acccgaagcc gtgggcgatc aaacatcctg tatagacttt
     4681 tgaagtctaa atagagtgac attttaaaca gcaatactcc ctaaagtagt catcttgttt
     4741 ggggtttggc ttgactatct tatttctctc tgatttaagt agtaggtccc tcctatggaa
     4801 accagagcat cactaaggaa aactgtggga gtcaagcatc atgcaaggga cgggaagcag
     4861 caacagaccc ctgcccctca cattccgcca tcagaatcag aggtgggccc tgctgagtga
     4921 ctggcgttgc ttgtcatggg aattgaaagt ctcttaatca cggggctctt ccgtctgaag
     4981 ctggagtctt ccagcttgtt gggactttga gtctaggcac cctgagtgta tcgctctagt
     5041 tgaagaaata acgatccaag agtcaagcgg tccaggattc cgtccgcagc cgccatttgc
     5101 tgagtacctg atggtacctc cttttcctcg cttctatctt ccggtctttg cctagagctg
     5161 cttgttctct gttggctcat ctgaggggca gattgcccat ccctcaggaa cagtaagcag
     5221 tcggggtgaa ggttggggca ggagagtcac tgcctgctag aaggagcttt aaccaccaac
     5281 cttttgatct tgtctgtcac cctaaccctg agtgaaatga agctattgtg ttgctctcct
     5341 gttagattca gtaggctgct gtgatcatgg tagggctcag ttatggatgc agacctgggg
     5401 agacagtctt tcacttcagt cttcaggaac ggtcatcgtg ctaaagacca ctctccttgt
     5461 tcaccaagca aggtgaagcc tacagtcccc gcagtcttga accagaaggc aggagtgagc
     5521 agttgacccc ttcctgtaga ctgaaaggga tggcgttaga gggaagaagg gggttagtgg
     5581 ttctgacata aactgcatat gcaataactt cttgtggcta tggataaacc tggccctttg
     5641 tagagatcct ggcctgcttg ctggatcctg gtgcccaccc taccccacca ctgccaaagt
     5701 ctaacagact atgcatggag cgggaaagag agaggaaagc tggtaggaat ggggcaatgc
     5761 tcagctctca ccaatgtctg ggtcaaaatg aggaagatga gctcgactaa caagattctg
     5821 ggtgacacaa ggcttgtcaa cctgtgtctt gcccccttgt gctctgtcag gagccacagc
     5881 tcctgggctc cttaaggtgg aattgggtga ccggtgaata cttggccccc tacatagcaa
     5941 tgttaggcaa tcgggattta tagaaactca tgttaaagcc aaagaccgtg tttggacatg
     6001 taaagtctgc tggcttagtc actgcctcat cctgctgtgt gagcagttct gtccctatgg
     6061 gtgaattaca tgacatccca aggccactgc aggctcaaga cacctgattt ctctgctatt
     6121 ccatttctgt ggaatctaag cccaagctct atctataccc atcgagccta gcactgatgg
     6181 tagaaccctg gggacacaga cctcaagact ccactggcaa tgtattgact gttatgaaag
     6241 gactctaaag ctgtcaccta aaacacaaca ttcccttctc cctgtgattt ttttccccct
     6301 cctctcctga agacagtgca ttctgaccag cgctgtctaa ccttcctcag cttgctgctg
     6361 acaccacccg tgtggggctg tagagagggc tgaggtctgt ggcttgttat atggatttga
     6421 gaggagggtg cagcatttag ctttcctgca tcactgtgag ggagccgcag gttcctttcc
     6481 cagaggaaaa taatcgttgc ccagaagaca gaggccatac taggaagtcc tggtgcaaac
     6541 ctgctctcaa cgaaagtaat aattttgtat gcacagaact cccttaccag tcctagtacc
     6601 acatcttagg tttttaacgt ccacaaccac tggcctttgt gaactagtgg ccgggatctt
     6661 ccgttggttt caggagcagt ccatcatccc tgggaacacc aggactggag ggagcagggg
     6721 gcggcgggca gaggggagca ttcagtttgc tgacaccatc aaatacatag gcttcttagc
     6781 aaagatgatg cacaaggccg tgctgcctcc acttttaact gctgacccca gtccttcctg
     6841 gggttcctat ctccatcctg acgctggttg aatcttctct accaaaatcc tcctcgtaaa
     6901 aggatccatg atgacaacta agaggaaaag aagtattttt gttaggatga accatcatag
     6961 atttttagcg atgtgtatct gtgtgtcctt tacgcctttt cctattctga cattttttcc
     7021 cctttttttt taaaaaaaaa atattgtgta ctatattttt agtctcaaac acacactata
     7081 tattatatat ttaattttat atatatataa atataaatgt tttaaaaagt a
//
