LOCUS       NM_001109529            1396 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Kin17 DNA and RNA binding protein (Kin), mRNA.
ACCESSION   NM_001109529 XM_001066201
VERSION     NM_001109529.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M and Coulombe
            B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J,
            Moutiez M, Gondry M, Angulo JF and Zinn-Justin S.
  TITLE     A tandem of SH3-like domains participates in RNA binding in KIN17,
            a human protein activated in response to genotoxics
  JOURNAL   J Mol Biol 364 (4), 764-776 (2006)
   PUBMED   17045609
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Araneda S, Pelloux S, Radicella JP, Angulo J, Kitahama K, Gysling K
            and Forray MI.
  TITLE     8-oxoguanine DNA glycosylase, but not Kin17 protein, is
            translocated and differentially regulated by estrogens in rat brain
            cells
  JOURNAL   Neuroscience 136 (1), 135-146 (2005)
   PUBMED   16182450
  REMARK    GeneRIF: Estrogens differentially regulate expression of
            8-oxoguanine DNA glycosylase, but not of Kin17 protein, in specific
            regions of rat brain. (Kin17 protein)
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Miccoli L, Biard DS, Frouin I, Harper F, Maga G and Angulo JF.
  TITLE     Selective interactions of human kin17 and RPA proteins with
            chromatin and the nuclear matrix in a DNA damage- and cell
            cycle-regulated manner
  JOURNAL   Nucleic Acids Res 31 (14), 4162-4175 (2003)
   PUBMED   12853634
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   Biard DS, Miccoli L, Despras E, Harper F, Pichard E, Creminon C and
            Angulo JF.
  TITLE     Participation of kin17 protein in replication factories and in
            other DNA transactions mediated by high molecular weight nuclear
            complexes
  JOURNAL   Mol Cancer Res 1 (7), 519-531 (2003)
   PUBMED   12754299
REFERENCE   6  (bases 1 to 1396)
  AUTHORS   Miccoli L, Biard DS, Creminon C and Angulo JF.
  TITLE     Human kin17 protein directly interacts with the simian virus 40
            large T antigen and inhibits DNA replication
  JOURNAL   Cancer Res 62 (19), 5425-5435 (2002)
   PUBMED   12359749
REFERENCE   7  (bases 1 to 1396)
  AUTHORS   Tissier A, Kannouche P, Mauffrey P, Allemand I, Frelat G, Devoret R
            and Angulo JF.
  TITLE     Molecular cloning and characterization of the mouse Kin17 gene
            coding for a Zn-finger protein that preferentially recognizes bent
            DNA
  JOURNAL   Genomics 38 (2), 238-242 (1996)
   PUBMED   8954809
REFERENCE   8  (bases 1 to 1396)
  AUTHORS   Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P,
            Benarous R and Devoret R.
  TITLE     Identification and expression of the cDNA of KIN17, a zinc-finger
            gene located on mouse chromosome 2, encoding a new DNA-binding
            protein
  JOURNAL   Nucleic Acids Res 19 (19), 5117-5123 (1991)
   PUBMED   1923796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473990.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001066201.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ107678.1, FM067418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1396
                     /gene="Kin"
                     /note="Kin17 DNA and RNA binding protein"
                     /db_xref="GeneID:689197"
                     /db_xref="RGD:1596107"
     exon            1..161
                     /gene="Kin"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1226
                     /gene="Kin"
                     /note="antigenic determinant of rec-A protein homolog"
                     /codon_start=1
                     /product="DNA/RNA-binding protein KIN17"
                     /protein_id="NP_001102999.1"
                     /db_xref="GeneID:689197"
                     /db_xref="RGD:1596107"
                     /translation="MGKSDFLSPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCH
                     CMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHR
                     EHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKK
                     QDLDDEEKTAKFIEEQVRRGLEGKEQETPVFTELSRENDEEKVTFNLNKGAGSSAGAT
                     TSKSSSLGPSALKMLGSTASVRRKESSQSSAQPAKKKKKSALDEIMEIEEEKKRTART
                     DSWLQPGIIVKIITKKLGEKYHKKKGVVKEVIDRYTAVVKMTDSGDRLKLDQTHLETV
                     IPAPGKRVLVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRLEGIQYEDISKLA
                     "
     exon            162..256
                     /gene="Kin"
                     /inference="alignment:Splign:2.1.0"
     exon            257..300
                     /gene="Kin"
                     /inference="alignment:Splign:2.1.0"
     exon            301..423
                     /gene="Kin"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1396
                     /gene="Kin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagttccg cttccgacgg cttcgctgtt gtactctcag ggtcgccatg ggcaagtcag
       61 attttctgag ccccaaggcc atcgcgaata gaattaagtc taaagggctg cagaagcttc
      121 gctggtactg ccagatgtgc caaaaacaat gccgcgacga gaatggtttc aagtgtcact
      181 gtatgtccga gtctcatcaa agacagctgt tgctggcttc agaaaatcct cagcagttta
      241 tggattattt ttcagaggaa ttccgaaatg actttctgga acttctgaga agacgctttg
      301 gcactaagag agtccacaac aacattgtct acaatgaata catcagccac cgagagcaca
      361 tccacatgaa cgccactcag tgggagacgc tgactgactt taccaagtgg ctgggcagag
      421 agggcttgtg taaagtggat gagacaccaa aaggctggta cattcagtac atagacagag
      481 acccagaaac tatacgtcgg caactggaat tagaaaaaaa gaagaagcaa gatcttgacg
      541 atgaagaaaa aactgccaaa ttcattgagg agcaggtgag aagaggccta gaagggaaag
      601 agcaggagac gcctgtcttt acagagttaa gtcgagaaaa tgatgaagaa aaggtcacgt
      661 tcaatctgaa taaaggagcg ggtagctcag cgggagcaac aacgtccaag tcaagctcgc
      721 tgggaccgag cgcactgaag atgctgggga gcacagcatc cgtgaggcgg aaagagtctt
      781 cacagagctc agctcagcct gcgaagaaga agaagaagtc tgccctggat gagatcatgg
      841 agattgagga ggaaaagaaa aggaccgcac ggacagactc ctggttacag cctgggatca
      901 ttgtgaaaat tataacgaag aagcttgggg agaaatacca caagaagaaa ggggtcgtta
      961 aggaagtgat tgacagatac acagctgtgg taaagatgac tgactccgga gacaggctga
     1021 aactggacca gactcattta gagacagtca ttccagcccc agggaaaaga gttctagttt
     1081 taaacggagg ctacagagga aatgaaggca ccctcgagtc catcaatgaa aagacttttt
     1141 cagccacgat agtcattgaa acgggacctt tgaaagggcg cagacttgaa ggtattcagt
     1201 atgaagacat atctaaactt gcttgagttt gacaatttgt taataacaca ttgaaattgt
     1261 aaagcatcaa attgatgtta gccacggcac tgtgtaactc tactgtgtta ggggatttgt
     1321 ttataaagaa agtcatctat ttaaatacca ctggatagct gtttgggtaa atttataata
     1381 aaatctaatt tttttt
//
