LOCUS       NM_001107730            3702 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kinesin family member 5C (Kif5c), mRNA.
ACCESSION   NM_001107730 XM_001064328 XM_241981
VERSION     NM_001107730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Mingardi,J., Paoli,C., La Via,L., Carini,G., Misztak,P., Cifani,C.,
            Popoli,M., Barbon,A. and Musazzi,L.
  TITLE     Involvement of miR-135a-5p Downregulation in Acute and Chronic
            Stress Response in the Prefrontal Cortex of Rats
  JOURNAL   Int J Mol Sci 24 (2), 1552 (2023)
   PUBMED   36675068
  REMARK    GeneRIF: Involvement of miR-135a-5p Downregulation in Acute and
            Chronic Stress Response in the Prefrontal Cortex of Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Brachet,A., Lario,A., Fernandez-Rodrigo,A., Heisler,F.F.,
            Gutierrez,Y., Lobo,C., Kneussel,M. and Esteban,J.A.
  TITLE     A kinesin 1-protrudin complex mediates AMPA receptor synaptic
            removal during long-term depression
  JOURNAL   Cell Rep 36 (5), 109499 (2021)
   PUBMED   34348158
  REMARK    GeneRIF: A kinesin 1-protrudin complex mediates AMPA receptor
            synaptic removal during long-term depression.
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Budaitis,B.G., Jariwala,S., Reinemann,D.N., Schimert,K.I.,
            Scarabelli,G., Grant,B.J., Sept,D., Lang,M.J. and Verhey,K.J.
  TITLE     Neck linker docking is critical for Kinesin-1 force generation in
            cells but at a cost to motor speed and processivity
  JOURNAL   Elife 8, e44146 (2019)
   PUBMED   31084716
  REMARK    GeneRIF: These results demonstrate that the neck linker serves as a
            mechanical element for kinesin-1 transport under physiological
            conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Oksdath,M., Guil,A.F.N., Grassi,D., Sosa,L.J. and Quiroga,S.
  TITLE     The Motor KIF5C Links the Requirements of Stable Microtubules and
            IGF-1 Receptor Membrane Insertion for Neuronal Polarization
  JOURNAL   Mol Neurobiol 54 (8), 6085-6096 (2017)
   PUBMED   27699600
  REMARK    GeneRIF: We conclude that the enrichment of stable microtubules in
            the future axon enhances KIF5C-mediated vesicular transport of
            syntaxin 6 and VAMP4, which in turn mediates the polarized
            insertion of IGF-1r in the plasmalemma, a key step for neuronal
            polarization
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Sanger,A., Yip,Y.Y., Randall,T.S., Pernigo,S., Steiner,R.A. and
            Dodding,M.P.
  TITLE     SKIP controls lysosome positioning using a composite kinesin-1
            heavy and light chain-binding domain
  JOURNAL   J Cell Sci 130 (9), 1637-1651 (2017)
   PUBMED   28302907
  REMARK    GeneRIF: cargo recognition and concurrent activation of kinesin-1
            proceed in hierarchical stepwise fashion driven by a dynamic
            network of inter- and intra-molecular interactions.
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Verhey,K.J., Meyer,D., Deehan,R., Blenis,J., Schnapp,B.J.,
            Rapoport,T.A. and Margolis,B.
  TITLE     Cargo of kinesin identified as JIP scaffolding proteins and
            associated signaling molecules
  JOURNAL   J Cell Biol 152 (5), 959-970 (2001)
   PUBMED   11238452
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Kanai,Y., Okada,Y., Tanaka,Y., Harada,A., Terada,S. and Hirokawa,N.
  TITLE     KIF5C, a novel neuronal kinesin enriched in motor neurons
  JOURNAL   J Neurosci 20 (17), 6374-6384 (2000)
   PUBMED   10964943
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Kozielski,F., Sack,S., Marx,A., Thormahlen,M., Schonbrunn,E.,
            Biou,V., Thompson,A., Mandelkow,E.M. and Mandelkow,E.
  TITLE     The crystal structure of dimeric kinesin and implications for
            microtubule-dependent motility
  JOURNAL   Cell 91 (7), 985-994 (1997)
   PUBMED   9428521
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Sack,S., Muller,J., Marx,A., Thormahlen,M., Mandelkow,E.M.,
            Brady,S.T. and Mandelkow,E.
  TITLE     X-ray structure of motor and neck domains from rat brain kinesin
  JOURNAL   Biochemistry 36 (51), 16155-16165 (1997)
   PUBMED   9405049
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Lockhart,A., Crevel,I.M. and Cross,R.A.
  TITLE     Kinesin and ncd bind through a single head to microtubules and
            compete for a shared MT binding site
  JOURNAL   J Mol Biol 249 (4), 763-771 (1995)
   PUBMED   7602588
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473983.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_241981.4, XM_001064328.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..3702
                     /gene="Kif5c"
                     /note="kinesin family member 5C"
                     /db_xref="GeneID:311024"
                     /db_xref="RGD:1308539"
     exon            1..477
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..3219
                     /gene="Kif5c"
                     /note="kinesin heavy chain neuron-specific 2; kinesin-1"
                     /codon_start=1
                     /product="kinesin heavy chain isoform 5C"
                     /protein_id="NP_001101200.1"
                     /db_xref="GeneID:311024"
                     /db_xref="RGD:1308539"
                     /translation="MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGEETVVIGQG
                     KPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHD
                     PQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDK
                     NRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENV
                     ETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTH
                     VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVN
                     LELTAEEWKKKYEKEKEKNKALKSVIQHLEVELNRWRNGEAVPEDEQISAKDQKNLEP
                     CDNTPIIDNITPVVDGISAEKEKYDEEITSLYRQLDDKDDEINQQSQLAEKLKQQMLD
                     QDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKT
                     RANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGT
                     NDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQTDSNRKMNASERE
                     LAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQ
                     DKEKEHLTRLQDAEEVKKALEQQMESHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQK
                     LQLEQERLSSDYNKLKIEDQEREVKLEKLLLLNDKREQAREDLKGLEETVSRELQTLH
                     NLRKLFVQDLTTRVKKSVELDSDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNAD
                     LRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMAR
                     RAHSAQIAKPIRPGHYPASSPTAVHAVRGGGGSSNSTHYQK"
     exon            478..568
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            569..642
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            643..747
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            748..796
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            797..852
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            853..940
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1065
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1170
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1319
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1468
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1641
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1710
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1917
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2064
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2253
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2371
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2448
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2558
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2660
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2721
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2793
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2898
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3115
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3226
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3702
                     /gene="Kif5c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgccggag cgaggtggtg ctgatgcagg atggctgagc gcgccggagc ccgggaggtc
       61 tgagccgggc tgggattgct ccctaagcat cgcctagtcc gcccgccgct tggtcgcggg
      121 caggtggacc agggcgcagg accgggctgg aggtcagcag cagggcggcc cagctgctct
      181 ccttcccggc ggcagagctg ctgggcgtcc ggcgcaggct tgcgatgacc tgctgagaag
      241 ctgcgggagg cggcctagca gccggcagcg gttggctcgc ggcctctttg gtggagctgc
      301 ccagccggac cccctatccc atccctgtgt cccctcctgc cgcggcccga gatggcggat
      361 ccagccgaat gcagcatcaa agtgatgtgc cggttccggc ccctcaacga agctgagatc
      421 ctccgcgggg acaaattcat ccccaaattc aaaggcgagg agacggtggt gatcgggcaa
      481 gggaagccgt atgtctttga ccgagttctg ccgcccaaca caacccagga gcaggtctac
      541 aatgcctgtg cgaagcagat tgtcaaagat gtcctcgagg gttacaatgg gacaattttt
      601 gcatacgggc agacttcatc aggaaaaact cataccatgg aggggaagct gcacgatcct
      661 cagcttatgg gtatcatacc caggatcgca cacgatattt tcgatcacat ctattccatg
      721 gatgagaact tggagtttca tatcaaggtt tcctattttg agatctactt ggacaaaata
      781 agggacttgc ttgacgtgtc caagaccaac ttggctgttc atgaagacaa aaacagagtc
      841 ccctatgtaa aggggtgcac cgagaggttt gtgtcaagcc cggaggaggt catggatgtg
      901 atcgatgagg gcaaagcaaa ccgacatgtg gctgtgacaa acatgaacga acacagctcc
      961 aggagtcaca gtatcttcct gattaacatt aaacaagaga atgtggagac tgaaaaaaaa
     1021 ctcagcggga agctgtattt ggttgatttg gctgggagtg aaaaggtcag caaaactggt
     1081 gccgagggag ctgttcttga tgaagctaaa aatatcaaca agtctttgtc tgctcttgga
     1141 aatgtgatct ctgccttggc agaagggaca aaaacacatg tgccataccg ggacagcaag
     1201 atgactcgga ttctccagga ctctctgggt gggaactgca ggaccaccat tgtcatttgc
     1261 tgttctcctt cagtcttcaa tgaggctgag accaagtcca cgctgatgtt tggacagaga
     1321 gcaaagacca tcaagaatac agtctctgtg aacttggaac taacagcaga agaatggaag
     1381 aagaaatatg aaaaagagaa agagaagaat aaggccctga agagtgtcat ccagcatctg
     1441 gaggtggagc tgaacaggtg gaggaacggg gaagctgtgc ctgaggatga acagatcagt
     1501 gccaaggacc agaagaacct ggagccctgc gacaacacac ccatcataga caacatcaca
     1561 cctgtggttg acggcatctc tgctgagaaa gagaagtatg acgaggaaat caccagtctg
     1621 taccgacagc tggatgacaa ggacgatgaa attaaccagc agagccagct ggctgaaaag
     1681 ctgaagcaac agatgttgga tcaggacgag cttctagctt ccaccagaag ggactacgag
     1741 aaaatccagg aggagctgac ccgcctccag attgaaaacg aggcggctaa agacgaggtg
     1801 aaggaggtcc tccaggccct ggaggagctg gctgtcaatt acgaccagaa gtcacaggaa
     1861 gtggaggaca agacccgggc caacgagcaa ctgaccgatg agctggccca gaaaacgacg
     1921 acactgacaa ccacccagcg ggagctgagt cagctacagg agcttagcaa ccaccagaag
     1981 aagagggcca cggagatcct gaacctgctt ctcaaggatc tgggcgagat aggtggaatt
     2041 atcggcacca acgatgtgaa gaccctggca gatgtgaatg gagtcatcga agaggagttc
     2101 accatggccc gcctgtacat tagcaagatg aagtcggagg tcaagtctct cgtgaaccgc
     2161 agcaagcagc tggagagcgc ccagacggac tccaacagga agatgaatgc cagcgagcgg
     2221 gagctggcag cttgccagtt gcttatctcg cagcatgaag ccaagatcaa gtctctgaca
     2281 gactacatgc agaacatgga acagaagagg cggcagctgg aagagtcgca ggactccctc
     2341 agcgaggagc tggccaagct ccgggcccaa gaaaaaatgc acgaagtcag tttccaagat
     2401 aaggaaaagg agcacctgac gaggctgcag gatgctgagg aagtgaagaa ggctctggag
     2461 cagcagatgg agagtcaccg ggaagcgcac caaaagcagc tgtccagact tcgtgatgag
     2521 attgaggaga agcagagaat cattgatgag attcgggatt tgaatcagaa gctgcaactg
     2581 gaacaggaga ggctcagctc tgattataac aagctgaaaa tagaggacca ggagagagaa
     2641 gtgaagctgg agaagctcct attgctcaat gacaaaagag agcaagccag ggaggacctc
     2701 aagggactgg aagagactgt gtccagagaa ctccagactc ttcacaacct gcgcaaactc
     2761 ttcgtccagg acttgaccac ccgggtgaaa aagagtgtgg agctggacag cgacgatgga
     2821 gggggtagtg ccgcccagaa gcagaagatc tccttcctgg agaacaacct ggagcagctt
     2881 accaaggtgc acaagcagct ggtccgggac aatgcggatt tgcgctgtga actccccaag
     2941 ctggagaaga ggctccgtgc tactgcagag cgtgtcaagg ccttggagag tgcgctcaaa
     3001 gaggccaagg agaatgccat gagggaccga aagcgctacc agcaggaagt ggatcgcatc
     3061 aaggaggctg tgcgggccaa gaacatggcc aggagggcac attcggctca gatcgccaag
     3121 cccatccgcc caggacacta tcctgcatca tctccaacag ccgtccatgc cgtccgggga
     3181 ggaggtggat cttcaaactc cactcactac cagaagtaaa tgcagaatat gaccccacgt
     3241 agcatgaaaa ggactatatt agtcatcagt tcctttattt ccctcctata cagtttccgt
     3301 ttctttttac acttgcttgc ccagccgtct gtagtacacc agattcaggt gtttgcgctg
     3361 tgtagaattt gtgtgcacag atacgtgctt ggatccttct cctaagaagt tggaaggagg
     3421 tggttacgca atacccactt cctgctcaga cgttgccact tctcagcctc cggggttgcg
     3481 tggtctctgg aggcccctgc agtgcactgg cccattggaa tggaatgccc tactgtgcta
     3541 tcccagaggg acaaccaagt gctgtggaac cagtgaccat gctctgcctc gactgtccgg
     3601 tttcctgtaa aataaacaca tcactttata tttttaggga acaaaaaaaa gtgctgctat
     3661 agggttcaaa attttcattc tgaacacttt tccaaaacca ac
//
