LOCUS       NM_212523               3485 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kinesin family member 5A (Kif5a), mRNA.
ACCESSION   NM_212523 XM_243525
VERSION     NM_212523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3485)
  AUTHORS   Yokota,S., Shah,S.H., Huie,E.L., Wen,R.R., Luo,Z. and Goldberg,J.L.
  TITLE     Kif5a Regulates Mitochondrial Transport in Developing Retinal
            Ganglion Cells In Vitro
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 4 (2023)
   PUBMED   36862119
  REMARK    GeneRIF: Kif5a Regulates Mitochondrial Transport in Developing
            Retinal Ganglion Cells In Vitro.
REFERENCE   2  (bases 1 to 3485)
  AUTHORS   Cao,J.W., Tang,Z.B., Song,J.H., Yao,J.L., Sheng,X.M. and Su,Z.Q.
  TITLE     HIF-1alpha protects PC12 cells from OGD/R-induced cell injury by
            regulating autophagy flux through the miR-20a-5p/KIF5A axis
  JOURNAL   Acta Neurobiol Exp (Wars) 82 (3), 358-372 (2022)
   PUBMED   36214718
  REMARK    GeneRIF: HIF1alpha protects PC12 cells from OGD/Rinduced cell
            injury by regulating autophagy flux through the miR20a5p/KIF5A
            axis.
REFERENCE   3  (bases 1 to 3485)
  AUTHORS   Brachet,A., Lario,A., Fernandez-Rodrigo,A., Heisler,F.F.,
            Gutierrez,Y., Lobo,C., Kneussel,M. and Esteban,J.A.
  TITLE     A kinesin 1-protrudin complex mediates AMPA receptor synaptic
            removal during long-term depression
  JOURNAL   Cell Rep 36 (5), 109499 (2021)
   PUBMED   34348158
  REMARK    GeneRIF: A kinesin 1-protrudin complex mediates AMPA receptor
            synaptic removal during long-term depression.
REFERENCE   4  (bases 1 to 3485)
  AUTHORS   Blakeslee,W.W., Lin,Y.H., Stratton,M.S., Tatman,P.D., Hu,T.,
            Ferguson,B.S. and McKinsey,T.A.
  TITLE     Class I HDACs control a JIP1-dependent pathway for
            kinesin-microtubule binding in cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 112, 74-82 (2017)
   PUBMED   28886967
  REMARK    GeneRIF: HDAC-dependent regulatory circuit that promotes formation
            of JIP1:KIF5A:microtubule complexes that regulate intracellular
            transport of cargo such as autophagosomes, is reported.
REFERENCE   5  (bases 1 to 3485)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   6  (bases 1 to 3485)
  AUTHORS   Reid,E., Kloos,M., Ashley-Koch,A., Hughes,L., Bevan,S.,
            Svenson,I.K., Graham,F.L., Gaskell,P.C., Dearlove,A.,
            Pericak-Vance,M.A., Rubinsztein,D.C. and Marchuk,D.A.
  TITLE     A kinesin heavy chain (KIF5A) mutation in hereditary spastic
            paraplegia (SPG10)
  JOURNAL   Am J Hum Genet 71 (5), 1189-1194 (2002)
   PUBMED   12355402
REFERENCE   7  (bases 1 to 3485)
  AUTHORS   Setou,M., Seog,D.H., Tanaka,Y., Kanai,Y., Takei,Y., Kawagishi,M.
            and Hirokawa,N.
  TITLE     Glutamate-receptor-interacting protein GRIP1 directly steers
            kinesin to dendrites
  JOURNAL   Nature 417 (6884), 83-87 (2002)
   PUBMED   11986669
REFERENCE   8  (bases 1 to 3485)
  AUTHORS   Vignali,G., Lizier,C., Sprocati,M.T., Sirtori,C., Battaglia,G. and
            Navone,F.
  TITLE     Expression of neuronal kinesin heavy chain is developmentally
            regulated in the central nervous system of the rat
  JOURNAL   J Neurochem 69 (5), 1840-1849 (1997)
   PUBMED   9349526
REFERENCE   9  (bases 1 to 3485)
  AUTHORS   Vignali,G., Niclas,J., Sprocati,M.T., Vale,R.D., Sirtori,C. and
            Navone,F.
  TITLE     Differential expression of ubiquitous and neuronal kinesin heavy
            chains during differentiation of human neuroblastoma and PC12 cells
  JOURNAL   Eur J Neurosci 8 (3), 536-544 (1996)
   PUBMED   8963445
REFERENCE   10 (bases 1 to 3485)
  AUTHORS   Niclas,J., Navone,F., Hom-Booher,N. and Vale,R.D.
  TITLE     Cloning and localization of a conventional kinesin motor expressed
            exclusively in neurons
  JOURNAL   Neuron 12 (5), 1059-1072 (1994)
   PUBMED   7514426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY535015.1.
            
            On Aug 30, 2004 this sequence version replaced XM_243525.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY535015.1, FQ212220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN14984043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3485
                     /gene="Kif5a"
                     /note="kinesin family member 5A"
                     /db_xref="GeneID:314906"
                     /db_xref="RGD:1303035"
     exon            1..326
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..3281
                     /gene="Kif5a"
                     /note="NKHC; neuronal kinesin heavy chain; kinesin heavy
                     chain neuron-specific 1"
                     /codon_start=1
                     /product="kinesin heavy chain isoform 5A"
                     /protein_id="NP_997688.1"
                     /db_xref="GeneID:314906"
                     /db_xref="RGD:1303035"
                     /translation="MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGG
                     KPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHD
                     PQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDK
                     NRVPFVRGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENI
                     ETEQKLSGKLYLADLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSY
                     VPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVN
                     LELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALAAE
                     ICEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQML
                     DQEELLVSTRGDNEKVQRELSHLQSENDAAKEEVKEVLQALEELAVNYDQKSQEVEEK
                     SQQNQLLVDELSQKVATMLSLESEPQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVG
                     NGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGR
                     ELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELAKLQAQETVHEVAL
                     KDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLDQKLQL
                     ELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLR
                     KLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTEVHKQLVRDNADLRC
                     ELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGH
                     SAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDVYFA
                     SNGATSVAPLASYQKANTDNGNATDINDNRSDLPCGYEAEDPAKLFPLHQETAAS"
     exon            327..414
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            415..488
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            489..593
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            594..642
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            643..698
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            699..786
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            787..911
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1016
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1165
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1314
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1490
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1559
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1766
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1913
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2102
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2220
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2285
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2395
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2497
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2558
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2630
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2735
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2952
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3106
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3174
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3202
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3314
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3467
                     /gene="Kif5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaagccca ggtcgcccgc atccagtgcc gcaggacacc aaaagcgcac cttcgcctgg
       61 gcatcccagc tgctcccttg gcctcagcga cagatcacct gtcctccgcc tcaaccccaa
      121 cccagcgctc ccttcctccg gagcacacgc taccgttgca gccggagacg cgccccagcc
      181 cctcgacgtc gaccaccatg gcggagacca ataacgaatg cagcatcaag gtgctttgcc
      241 gatttcggcc cctgaaccag gccgagatcc tgcgggggga caagttcatc cccattttcc
      301 aaggggacga cagcgtcatt attgggggaa agccatatgt cttcgaccgt gtattccccc
      361 caaacacgac tcaggagcag gtttaccacg cctgtgccat gcagatcgtc aaagacgtcc
      421 ttgctggcta caacggcaca atttttgctt atggacagac atcctcaggg aaaacgcaca
      481 ccatggaggg aaagctgcac gaccctcagc tcatgggcat cattccccgg atcgcccgag
      541 acatcttcaa ccacatctac tccatggatg agaaccttga gttccacatt aaggtgtctt
      601 actttgagat ttacctggat aagatccgtg accttttgga tgtgaccaag acaaacctgt
      661 ctgtgcatga ggacaaaaac cgggtgccgt ttgtcagggg ttgtaccgaa cgctttgtgt
      721 ccagcccaga ggagattctg gatgtgattg atgaggggaa gtcgaaccgt cacgttgccg
      781 tcaccaacat gaatgagcac agctctcgga gtcacagcat cttcctcatc aacatcaagc
      841 aggagaacat agagacggag cagaagctca gcgggaaact gtaccttgcg gatctggccg
      901 gaagcgagaa ggtcagcaag acaggagcag agggagccgt tctggatgag gcaaagaata
      961 tcaataagtc gctgtcggcc ctggggaatg tgatctctgc tctggccgag ggcactaaaa
     1021 gctacgtgcc gtaccgtgac agcaaaatga cgaggattct ccaggactct ctgggaggga
     1081 actgcaggac caccatgttc atctgctgct caccatccag ctacaatgac gcagagacca
     1141 agtccacact catgtttggg cagcgggcaa agaccatcaa gaacactgcc tcagtgaatc
     1201 tggagttgac tgctgagcaa tggaagaaga aatatgagaa ggagaaggag aagaccaagg
     1261 cccagaagga gacaattgcg aagctggagg ctgagcttag ccggtggcgc aatggagaga
     1321 atgtgcctga gactgagcgc ctggctggag aggactcagc tctggcagcc gagatctgtg
     1381 aggagacccc tgtgaatgac aactcatcca tcgtggtacg catcgcaccg gaggaaaggc
     1441 agaaatacga ggaagagatc cgccgtctct acaagcagct cgacgacaag gatgatgaga
     1501 tcaaccagca gagccaactc attgagaagc tgaagcagca gatgctggac caggaagagc
     1561 tgctagtgtc cactcgggga gacaatgaga aggtccagcg ggagctgagc cacctgcagt
     1621 ctgagaacga tgccgcgaag gaggaggtga aggaagtgtt gcaggccctg gaggagctgg
     1681 cagtcaacta tgaccagaag tcccaggagg tggaggagaa gagccagcag aaccagctgc
     1741 tggtggatga gctgtcccag aaagtggcca ccatgctgtc cctggagtct gagccacagc
     1801 ggctccagga agtcagtgga caccagcgaa aacggatcgc tgaggtgctg aatggactga
     1861 tgaaggacct gagtgagttc agtgtcatcg tgggcaacgg cgagattaag ctgcctgtgg
     1921 agatcagtgg ggccatcgaa gaggagttca cggtggcccg actctacatc agcaagatca
     1981 agtcagaggt gaagtccgtg gttaagcgat gccggcagct ggagaacctc caagtggagt
     2041 gtcatcgcaa gatggaggtg accggtaggg agctgtcgtc ttgccagctg ctcatctcac
     2101 agcacgaggc caagatccgt tcgctcacgg aatacatgca gactgtggag ttgaagaagc
     2161 ggcacctgga agagtcctat gactccctga gcgatgagct agccaagctc caggcgcagg
     2221 aaactgtaca cgaggtagct ctgaaagaca aggagccaga tacgcaggat gcggaggagg
     2281 tgaagaaggc cctggaacta cagatggaga atcatcgtga ggcccatcac cggcagctgg
     2341 cccgcctccg agatgagatc aatgagaaac agaagaccat tgatgagctt aaagacctgg
     2401 accagaagct ccagttagag ctggagaagc ttcaggctga ttacgagaga ctgaagaacg
     2461 aagagaacga gaagagtgcc aagctccagg agctgacatt tctgtatgag cggcatgagc
     2521 agtccaagca ggacctcaag gggctggagg agacagttgc ccgtgaactc cagaccctcc
     2581 acaacctgcg caagctgttc gttcaagacg tcacgactcg agtcaagaaa agtgcagaaa
     2641 tggagcccga ggacagtggg gggattcatt cccaaaagca gaagatctcc tttcttgaga
     2701 acaacctgga acagcttaca gaggttcaca aacagctggt acgtgacaat gcagatctgc
     2761 gttgtgagct tcctaaattg gaaaaacgac ttcgggctac ggctgagaga gttaaggccc
     2821 tggagggtgc actgaaggag gccaaggagg gcgctatgaa ggacaagcgc cgataccagc
     2881 aggaggtgga ccgcatcaag gaagctgtgc ggtacaagag ctctggcaag cggggccact
     2941 ctgcccagat tgctaagcct gtgaggcccg gccactatcc tgcctcctca cccaccaacc
     3001 cctacggtac ccggagtccc gagtgtatca gctacaccaa caacctcttc cagaactacc
     3061 agaacctgca cctgcaggct gcgcctagct ccacctcaga cgtgtacttt gccagcaacg
     3121 gagccacatc tgttgccccc ttggcttcct accagaaggc caacacggac aatggaaacg
     3181 ccacagatat caacgacaac aggagtgacc tgccctgcgg ctatgaggct gaggacccag
     3241 ccaagctttt ccctctccac caagagacgg cagccagcta actcccaatc ctggctgcat
     3301 atctgcactt tcagtttcta agagggactg aggcctcttc tctcagcatg ctgcaaaacc
     3361 tgtggtctct gacactaact ccctccccag cccgtgtcgt tggactgttt gatgtctcct
     3421 tctactctgt atctctttgt accctgtatc tatttatcag aagctgcaaa aaaaaaaaaa
     3481 aaaaa
//
