LOCUS       NM_001085369            2765 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kinesin family member 2C (Kif2c), transcript
            variant 1, mRNA.
ACCESSION   NM_001085369
VERSION     NM_001085369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Shrestha,R.L. and Draviam,V.M.
  TITLE     Lateral to end-on conversion of chromosome-microtubule attachment
            requires kinesins CENP-E and MCAK
  JOURNAL   Curr Biol 23 (16), 1514-1526 (2013)
   PUBMED   23891108
  REMARK    Erratum:[Curr Biol. 2013 Dec 2;23(23):2440-1]
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Tanenbaum,M.E., Macurek,L., van der Vaart,B., Galli,M.,
            Akhmanova,A. and Medema,R.H.
  TITLE     A complex of Kif18b and MCAK promotes microtubule depolymerization
            and is negatively regulated by Aurora kinases
  JOURNAL   Curr Biol 21 (16), 1356-1365 (2011)
   PUBMED   21820309
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Honnappa,S., Gouveia,S.M., Weisbrich,A., Damberger,F.F.,
            Bhavesh,N.S., Jawhari,H., Grigoriev,I., van Rijssel,F.J.,
            Buey,R.M., Lawera,A., Jelesarov,I., Winkler,F.K., Wuthrich,K.,
            Akhmanova,A. and Steinmetz,M.O.
  TITLE     An EB1-binding motif acts as a microtubule tip localization signal
  JOURNAL   Cell 138 (2), 366-376 (2009)
   PUBMED   19632184
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Parra,M.T., Gomez,R., Viera,A., Llano,E., Pendas,A.M., Rufas,J.S.
            and Suja,J.A.
  TITLE     Sequential assembly of centromeric proteins in male mouse meiosis
  JOURNAL   PLoS Genet 5 (3), e1000417 (2009)
   PUBMED   19283064
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Holmfeldt,P., Zhang,X., Stenmark,S., Walczak,C.E. and Gullberg,M.
  TITLE     CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is
            essential for bipolar spindle formation
  JOURNAL   EMBO J 24 (6), 1256-1266 (2005)
   PUBMED   15775983
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Cassimeris,L. and Morabito,J.
  TITLE     TOGp, the human homolog of XMAP215/Dis1, is required for centrosome
            integrity, spindle pole organization, and bipolar spindle assembly
  JOURNAL   Mol Biol Cell 15 (4), 1580-1590 (2004)
   PUBMED   14718566
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Andrews,P.D., Ovechkina,Y., Morrice,N., Wagenbach,M., Duncan,K.,
            Wordeman,L. and Swedlow,J.R.
  TITLE     Aurora B regulates MCAK at the mitotic centromere
  JOURNAL   Dev Cell 6 (2), 253-268 (2004)
   PUBMED   14960279
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Sperry,A.O. and Zhao,L.P.
  TITLE     Kinesin-related proteins in the mammalian testes: candidate motors
            for meiosis and morphogenesis
  JOURNAL   Mol Biol Cell 7 (2), 289-305 (1996)
   PUBMED   8688559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and FN805204.1.
            
            On Mar 12, 2015 this sequence version replaced NM_001085369.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.494204.1,
                                           SRR26360181.1607998.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 JAXUCZ010000005.1  135899211-135899212 c
            3-515               FN805204.1         1-513
            516-630             FN805204.1         517-631
            631-703             FN805204.1         633-705
            704-719             JAXUCZ010000005.1  135889321-135889336 c
            720-736             FN805204.1         720-736
            737-832             JAXUCZ010000005.1  135888713-135888808 c
            833-887             JAXUCZ010000005.1  135886935-135886989 c
            888-1050            JAXUCZ010000005.1  135886685-135886847 c
            1051-1141           JAXUCZ010000005.1  135883836-135883926 c
            1142-1205           JAXUCZ010000005.1  135883556-135883619 c
            1206-1297           JAXUCZ010000005.1  135883387-135883478 c
            1298-1440           JAXUCZ010000005.1  135882436-135882578 c
            1441-1645           JAXUCZ010000005.1  135881451-135881655 c
            1646-1756           JAXUCZ010000005.1  135881173-135881283 c
            1757-1824           JAXUCZ010000005.1  135878312-135878379 c
            1825-1930           JAXUCZ010000005.1  135877889-135877994 c
            1931-2035           JAXUCZ010000005.1  135877692-135877796 c
            2036-2765           JAXUCZ010000005.1  135873925-135874654 c
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2765
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /note="kinesin family member 2C"
                     /db_xref="GeneID:171529"
                     /db_xref="RGD:620239"
     exon            1..146
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2251
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF2C; mitotic centromere-associated
                     kinesin; kinesin-related protein 2"
                     /codon_start=1
                     /product="kinesin-like protein KIF2C isoform 1"
                     /protein_id="NP_001078838.1"
                     /db_xref="GeneID:171529"
                     /db_xref="RGD:620239"
                     /translation="MESLHARLFPGLSINIQRSNGLIHSANISTVNLEKSCVSVEWTE
                     GGTTKGKEIDIDDVAAINPELVQLLPLRPKDSLPLQENVTIPKQKRKSVNSKIPGPKE
                     GLRSRSTRISTVSEVRIPAQENEMEVELPVSTNSRKPFPIHSHPRPSCSTVTELPLLM
                     ISEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSEIRIKRAQE
                     YDNSFPNWEFARMIKEFRVTMDCNPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDV
                     ISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFE
                     GGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRSLNLE
                     VYVTFFEIYNGKVFDLLNKKAKLRVLEDSKQQVQVVGLQEYLVTCADDVIKMINMGSA
                     CRTSGQTFANSNSSRSHACFQILLRAKGRLHGKFSLVDLAGNERGADTSSADRQTRME
                     GAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGIS
                     SCEYTLNTLRYADRVKELSPHSGPSGEQAVQMETEEMDASSHGASLTGNEEEELSSQM
                     SSFNEAMTQIRELEERAMEELREIIQQGPSWLELSEMTDQPDYDLETFVNKAESALTQ
                     QAKQAKHFSALQEVIKALRLAMQLEEQASKQINSKKRHQ"
     exon            147..241
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            242..343
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            344..392
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            393..515
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            516..635
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            636..736
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            737..832
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            833..887
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1050
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1141
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1205
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1297
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1440
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1645
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1756
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1824
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1930
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2035
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2765
                     /gene="Kif2c"
                     /gene_synonym="KRP2; MCAK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcgtta acacagctca gtatctgcag agtcgtggtt tctaaacttc ttgcatttgc
       61 gttacccgtt gctgtttccg agtccatgga gtcgcttcac gcacgattgt ttcccggtct
      121 ctccatcaac attcaacgca gcaatgggtt aattcacagc gccaatataa gcacggtgaa
      181 cttggagaaa tcctgtgttt cagtggaatg gaccgaagga ggtaccacaa agggcaaaga
      241 gattgacatt gacgatgtgg ctgccataaa cccagagctt gtacagcttc ttcccttacg
      301 accgaaggac agtctgccac tgcaggagaa cgtaaccatc ccaaagcaaa aacgcaagtc
      361 cgtcaactcc aaaattccag gtccaaaaga aggccttcga agtcgttcca ctcgcatatc
      421 cactgtctcc gaagttcgaa tccctgctca ggagaatgaa atggaggtgg agctgcctgt
      481 gtccacaaac tctcgcaagc catttcccat tcacagccac cctaggccct cctgctccac
      541 agtgacagaa ttaccgttgt tgatgatcag cgaggaggca gaagagcaag cccactccac
      601 ccgaagcacc tcttctgcaa accctgggaa ttcagttcgg aggaaatcat gtattgtgaa
      661 ggagatggag aaaatgaaga acaagcgaga agagaagagg gcccagaact cggagataag
      721 aataaagcga gctcaggaat atgacaacag ctttccaaac tgggaatttg cccggatgat
      781 taaggagttt cgggttacta tggactgtaa tcctctcact gtgacagacc ctattgaaga
      841 acacaggatc tgtgtctgtg tcaggaaacg cccactgaat aaacaagaac tggccaagaa
      901 agaaatcgat gtgatttctg ttcccagcaa gtgtctcctc ctggtgcatg aacccaagct
      961 gaaagtggac ttaacgaagt acctggagaa ccaggctttt tgcttcgact ttgcctttga
     1021 tgaaactgct tccaatgagg tcgtctacag gttcacagca aggccactgg tacagacgat
     1081 ttttgaaggg gggaaagcaa cgtgctttgc ctatgggcag acaggcagtg gaaagacaca
     1141 cacaatgggt ggagacctgt ctggtaaaag tcagaatgca tctaaaggga tctacgcaat
     1201 ggcttcccgg gatgtcttcc ttctgaagaa tcagcctcgc taccggagct taaacctgga
     1261 agtttatgtg acgttcttcg agatctacaa tgggaaggta tttgatctgc tcaacaagaa
     1321 ggccaagtta cgtgtgctgg aggacagcaa gcagcaggtg caggttgtgg ggctgcagga
     1381 gtacctggtt acctgtgccg atgatgtcat caagatgatc aacatgggca gcgcctgcag
     1441 gacttcggga caaacatttg ccaactccaa ttcctcccgc tcccacgcct gcttccagat
     1501 tcttcttcga gctaaaggga gattacacgg caaattctct ttggtggatc tggcagggaa
     1561 tgaacgagga gccgacacgt ctagtgctga ccgacagact cgcatggagg gtgcagaaat
     1621 taacaagtct ctcctggctc tgaaggaatg catccgggcg ctgggacaga acaaggctca
     1681 taccccattc cgtgagagca agctgactca ggtgctgagg gactccttca ttggggagaa
     1741 ctcgaggaca tgcatgatcg ccatgatctc accggggata agctcctgtg aatacacttt
     1801 aaacacactg agatacgcag acagagtcaa ggagctgagc ccccacagcg ggcccagtgg
     1861 agaacaggca gtccagatgg agacagagga gatggacgcc agctctcatg gggcctctct
     1921 gacaggcaat gaagaggagg agctgtcctc ccagatgtcc agctttaatg aagccatgac
     1981 tcagatcagg gagctggaag agagggccat ggaagagctc agagagatca tacagcaagg
     2041 accaagctgg cttgagctct ctgagatgac ggatcagcca gactatgact tggagacctt
     2101 cgtgaacaag gcagaatctg ccctgacaca gcaggctaag caggctaagc acttctcagc
     2161 ccttcaagaa gtcatcaagg ccctacgcct ggccatgcaa ctggaagaac aggctagcaa
     2221 acaaataaac agcaagaaac ggcaccaatg atgacttcaa ataaagatct gtttggtatc
     2281 acactagcct cttcccctcc ccagaaaact tcgggcacct ctggctttgg ttagggcctg
     2341 agtggacagg ttttggtaaa tgtcaagtac agggcgtcaa gccctggaaa gcttggggag
     2401 aggccatgtt cttttcctca gtttggatca ggaagaagga actttaatga ctgtgcttcc
     2461 tctcctccct gtcaggagtg ctgtttgata gtttcctggt acagcatcca gctgctggta
     2521 gagaagcttc gagatgcagg ctctggcaga gaagcagtgc ttgtccggct cctgctgcct
     2581 ctggctgcca gcatcaatca cctttagtct gagcgctctc gtgttttata ctttcagaaa
     2641 aaaggttttg agacctcttt gtttttgttt ttgaagccta agaaaatctc tagttcttgc
     2701 tttttatgta tttatatgtt gcacctaaca ataaagaaaa aaaaaacatt ttgtgtgatt
     2761 atcag
//
