LOCUS       NM_053376               4255 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus kinesin family member 2A (Kif2a), mRNA.
ACCESSION   NM_053376 XM_001065116 XM_001065173 XM_003753516 XM_345150
VERSION     NM_053376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Wang,J., Chen,J., Chen,J., Liu,X., Yang,H., Liu,J., He,A., Gao,X.
            and Xin,Y.
  TITLE     KIF2 mediates the neuroprotection in cerebral ischaemia injury by
            affecting NF-kappaB pathway
  JOURNAL   Clin Exp Pharmacol Physiol 47 (2), 274-280 (2020)
   PUBMED   31514228
  REMARK    GeneRIF: KIF2 mediates the neuroprotection in cerebral ischaemia
            injury by affecting NF-kappaB pathway.
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Seira,O., Liu,J., Assinck,P., Ramer,M. and Tetzlaff,W.
  TITLE     KIF2A characterization after spinal cord injury
  JOURNAL   Cell Mol Life Sci 76 (21), 4355-4368 (2019)
   PUBMED   31041455
  REMARK    GeneRIF: KIF2A at the injured axonal tips may contribute to neurite
            outgrowth inhibition after injury, and that its increased
            expression in inhibitory spinal neurons adjacent to the injury site
            might contribute to an intrinsic wiring-control mechanism
            associated with neuropathic pain. Further studies will determine
            whether KIF2A may be a potential target for the development of
            regeneration-promoting or pain-preventing therapies.
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Krahling,A.M., Alvarez,L., Debowski,K., Van,Q., Gunkel,M.,
            Irsen,S., Al-Amoudi,A., Strunker,T., Kremmer,E., Krause,E.,
            Voigt,I., Wortge,S., Waisman,A., Weyand,I., Seifert,R., Kaupp,U.B.
            and Wachten,D.
  TITLE     CRIS-a novel cAMP-binding protein controlling spermiogenesis and
            the development of flagellar bending
  JOURNAL   PLoS Genet 9 (12), e1003960 (2013)
   PUBMED   24339785
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Sonnen,K.F., Schermelleh,L., Leonhardt,H. and Nigg,E.A.
  TITLE     3D-structured illumination microscopy provides novel insight into
            architecture of human centrosomes
  JOURNAL   Biol Open 1 (10), 965-976 (2012)
   PUBMED   23213374
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Jang,C.Y., Wong,J., Coppinger,J.A., Seki,A., Yates,J.R. 3rd and
            Fang,G.
  TITLE     DDA3 recruits microtubule depolymerase Kif2a to spindle poles and
            controls spindle dynamics and mitotic chromosome movement
  JOURNAL   J Cell Biol 181 (2), 255-267 (2008)
   PUBMED   18411309
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Debernardi,S., Fontanella,E., De Gregorio,L., Pierotti,M.A. and
            Delia,D.
  TITLE     Identification of a novel human kinesin-related gene (HK2) by the
            cDNA differential display technique
  JOURNAL   Genomics 42 (1), 67-73 (1997)
   PUBMED   9177777
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Noda,Y., Sato-Yoshitake,R., Kondo,S., Nangaku,M. and Hirokawa,N.
  TITLE     KIF2 is a new microtubule-based anterograde motor that transports
            membranous organelles distinct from those carried by kinesin heavy
            chain or KIF3A/B
  JOURNAL   J Cell Biol 129 (1), 157-167 (1995)
   PUBMED   7535303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and FM092220.1.
            
            On or before Sep 8, 2012 this sequence version replaced
            XM_001065173.3, XM_001065116.3, XM_003753516.1, XM_345150.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.7601.1,
                                           SRR26643293.10303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000002.1  40164671-40164780   c
            111-205             JAXUCZ010000002.1  40131711-40131805   c
            206-322             JAXUCZ010000002.1  40131015-40131131   c
            323-377             JAXUCZ010000002.1  40127726-40127780   c
            378-500             JAXUCZ010000002.1  40125431-40125553   c
            501-601             JAXUCZ010000002.1  40124760-40124860   c
            602-697             JAXUCZ010000002.1  40122514-40122609   c
            698-752             JAXUCZ010000002.1  40121056-40121110   c
            753-905             JAXUCZ010000002.1  40120564-40120716   c
            906-1162            FM092220.1         1-257
            1163-1305           JAXUCZ010000002.1  40116915-40117057   c
            1306-1510           JAXUCZ010000002.1  40116579-40116783   c
            1511-1621           JAXUCZ010000002.1  40115451-40115561   c
            1622-1689           JAXUCZ010000002.1  40114565-40114632   c
            1690-1840           JAXUCZ010000002.1  40108696-40108846   c
            1841-1942           JAXUCZ010000002.1  40106452-40106553   c
            1943-2078           JAXUCZ010000002.1  40105706-40105841   c
            2079-4255           JAXUCZ010000002.1  40101548-40103724   c
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..4255
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /note="kinesin family member 2A"
                     /db_xref="GeneID:84391"
                     /db_xref="RGD:70974"
     exon            1..110
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2164
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /note="kinesin heavy chain member 2; kinesin-2; kinesin
                     heavy chain family, member 2; kinesin heavy chain member
                     2A"
                     /codon_start=1
                     /product="kinesin-like protein KIF2A"
                     /protein_id="NP_445828.1"
                     /db_xref="GeneID:84391"
                     /db_xref="RGD:70974"
                     /translation="MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWI
                     ENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPEIPPPSSSSKVNKIVKNRRTVASIKN
                     DPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVK
                     EVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPI
                     DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFD
                     YAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCS
                     KGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQ
                     VQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHG
                     KFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKL
                     TQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIM
                     HHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVV
                     EDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKS
                     FRAALQEEEQASKQINPKRPRAL"
     exon            111..205
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..322
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..377
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..500
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..601
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..697
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..752
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..915
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1006
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1070
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1162
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1305
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1510
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1621
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1689
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1942
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2078
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..4255
                     /gene="Kif2a"
                     /gene_synonym="Kif2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccccgtctg tttcgcccgc ccgccgccgc cgctccggat gaggtgatgg caacggctaa
       61 cttcggcaag atccagatcg ggatttacgt ggaaatcaag cgcagcgatg gccgaataca
      121 ccaggcaatg gtgacatcat taaatgaaga taatgaaagt gtcacagtcg agtggataga
      181 aaatggagac acaaaaggaa aagagattga cttggaaagc atcttttcac ttaaccctga
      241 ccttgtacct gatgaagaca ttgagccaag tccagaaata cctccaccct cctcatcctc
      301 aaaagtaaac aaaattgtaa agaaccgacg gactgtggca tctattaaga acgaccctcc
      361 ccccagagat aatagagtgg ttggttcagc acgcgcacgg cctagtcaac ttcctgagca
      421 gtcatcttct gcacaacaga atggtagcgt ttcagatata tctccagttc aagctgcaaa
      481 aaaggagttt ggacctcctt cacgtagaaa atctaattgt gtgaaagaag tagaaaaatt
      541 gcaagaaaaa cgagaaaaaa gaagattgca acagcaagaa cttagagaaa aaagagccca
      601 ggatgtcgat gccacaaatc caaattacga gattatgtgt atgatcagag acttcagagg
      661 gagcttggac tatagacccc tcacaacagc tgatcctatt gatgaacata ggatatgtgt
      721 ttgtgtaaga aaacgaccac tcaataaaaa agaaactcag atgaaagatc ttgatgtcat
      781 cacaatccct agtaaagatg ttgtgatggt tcatgaaccc aaacagaaag tagacttaac
      841 aaggtactta gaaaaccaga catttcgttt tgattatgcc tttgatgact cagctcctaa
      901 tgaaatggtt tacagattta ctgccaggcc actggtggaa acaatatttg aaaggggcat
      961 ggctacctgc tttgcttatg ggcagactgg aagtgggaaa actcacacta tgggtggtga
     1021 cttttcagga aagaaccagg attgctctaa gggaatttat gcattagcag ctcgagatgt
     1081 gtttttaatg ctgaagaagc caaactataa gaaactagaa ctccaagtat atgcaacatt
     1141 ttttgaaatt tatagtggaa aggtgtttga cttactaaat aggaaaacaa agttaagagt
     1201 cctagaggat ggaaagcagc aggtgcaagt ggtagggctg caggaacggg aggtcaagtg
     1261 tgtggaagac gtgctgaagc tcatcgacat cggcaacagc tgcagaacat ctggtcagac
     1321 atctgcaaat gcacactcat ctcggagcca tgcagtgttt cagatcattc ttaggaggaa
     1381 ggggaaacta catggtaaat tttctctcat cgacctggct gggaacgaaa gaggagctga
     1441 tacgtccagt gcagacaggc aaaccaggct tgaaggtgct gaaattaata aaagcctttt
     1501 agcactcaag gagtgcatcc gagccttagg tagaaataaa ccccacactc ctttccgagc
     1561 aagtaaactc actcaggtgt tgagagattc cttcataggt gagaattctc gcacttgcat
     1621 gattgccacg atctctccag gaatggcatc ctgtgaaaac actcttaata cattaagata
     1681 tgcaaatagg gtgaaagaac tgactgtgga tccaactgct gctggtgatg tccgtccaat
     1741 aatgcaccat ccaccaagcc agattgacga cctagagaca cagtgggggg tggggagttc
     1801 ccctcagaga gatgatctga aacttctttg tgaacaaaat gaagaagaag tttctccaca
     1861 gttgtttact ttccacgaag ccgtctccca gatggtagag atggaggaac aggttgtgga
     1921 agaccacagg gcagtgttcc aggaatccat tcgctggata gaagatgaaa aggctctcct
     1981 agagatgact gaagaagtag actatgatgt agactcatat gctacacagc ttgaagctat
     2041 tcttgagcaa aaaatagaca ttttaactga gttacgagat aaagtgaaat cttttcgtgc
     2101 agcgctacaa gaagaagaac aagccagcaa gcagattaac cccaagagac cccgagccct
     2161 ctaagttggt atttgctact aaaggatcgc tggaatcccc aatactgtaa cacatggtgg
     2221 tccaactgta aaggccactt gaacgttttt gaaatcttaa gtgtgtggaa aatatcttgt
     2281 ccttcatctg aatgacattt caattttgtg aaacactcct ttgtctacaa aatgcttcta
     2341 gtccaagagg cacaagtaac aattgggatt agtgaagtat tttgtttcat ttacccacat
     2401 agtgattgct tttcgatatc cttgccaatt ttatttaaag gttgtggaag taatccagaa
     2461 gtggaaaata ggggaaacca cagaatttcc tttaactcac atcaattttg gtagcaagac
     2521 tgagcagttt tgagtcctct gcgtgcatgc atacctcatc agtgatgtac atacttcgcc
     2581 tactcctagg gccagttgtg gttactcatc ctcctgtgcc ttccctaagg ctagcgactg
     2641 caggcttctg aaacacagcc acgagaagta cattccttgt ttgtaactgt aagttccttt
     2701 attgcgtgtg cattttactg tattgaggcg cgtgtgtgtg tgtgtgacta gtcactttgg
     2761 caggatgagc cgtatcagtt gaacgggact gcggcctgac agtgggcaag ctgctggacc
     2821 acttcgtctt acgtgtaaag aaatctggaa ttatgatttt aataccatga catgcgatta
     2881 taactttctt accactttct ctgtaaaaac taaaatataa actagttggt gtataataaa
     2941 aagtaaagaa attctgagag gacttttatc ttaggataat acatatatac atgcagtgtg
     3001 tgtgcagtgg tgttaacaag actcatagtg gaatctggtc cttagcgatg ccgttattga
     3061 agttgaagtg tttattagct caccaaaacg taacgtactg ttaaaggaga ctggtttctg
     3121 atgcatgaac atttgtatgt acactgaaag tagtccatag cataagttag atagccaagc
     3181 atagagtatg taaccaaccc cgggatgtgt tgacgactta caaggcaggt ctttccaagc
     3241 tccatctaat acctgggatg tgatggttat ttggtgagaa tcatatttca cctatagatt
     3301 ggtggtaaaa taggctactc tttaaatggc agcactcatt tttatagctg ctcgtctaaa
     3361 aaagaaaact ggccaatttt catgtaaata ttgtttaaag atatatatat atatgtatat
     3421 ctctaggagt tttcccttgg ttccccctac atagtccagt aggtgaacca aagaacctcc
     3481 catggatctc gtgattaact ctagggaacc tgctgattca gtaggtgaac caaggggaaa
     3541 tctatgaata gagtcaatga gccagattct ttattctcat tcacttgtca taaatgagag
     3601 ggtagctgtg aggaatccta acaccatggt caaaaagctc tgtaaacatg aaatctaaat
     3661 caaatgtaga ttttttcaca atatgcttat taataaatga aatttatgaa acaaatttag
     3721 aaataatgta cttcaatata atcacctttg ttttggaagg aactcaggtt ttcttgcagt
     3781 tttatgatat attctatttg tgtttgtttc aaagacaagc tgtttaagaa ggtaattttt
     3841 gctgagtaca tgcctttaat cccagcaatt ggaagcaaag gcaggtggat ttctgagttc
     3901 agggccagcc tggtgtacat actaagttcc aggacggcca gctctatgta ccttgtcccc
     3961 agttttgagg gtggctgtta atgtagtggg caataaaggc acaaaattgc ttataacttg
     4021 caaaatagtt taatgttatt ggcattggac aggcattgtc tttgaaggtc ctaataggga
     4081 tatgttgcct tattggctcc gtcctgatct gtagtcagta aacattctgg gaggtaagat
     4141 gagcctcagc tttacagagg gaagctttag tcagcagaaa actagctgag aaagcctggc
     4201 caagcagaaa cgtctcccta aggtagaagt ggtaagagct aactctgcaa agctg
//
