LOCUS       NP_001402729            1606 aa            linear   ROD 31-MAR-2024
DEFINITION  kinesin-like protein KIF21B [Rattus norvegicus].
ACCESSION   NP_001402729 XP_006249920
VERSION     NP_001402729.1
DBSOURCE    REFSEQ: accession NM_001415800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1606)
  AUTHORS   Ghiretti,A.E., Thies,E., Tokito,M.K., Lin,T., Ostap,E.M.,
            Kneussel,M. and Holzbaur,E.L.F.
  TITLE     Activity-Dependent Regulation of Distinct Transport and
            Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B
  JOURNAL   Neuron 92 (4), 857-872 (2016)
   PUBMED   27817978
  REMARK    GeneRIF: KIF21B is a molecular regulator of activity-dependent
            trafficking and microtubule dynamicity in dendrites.
REFERENCE   2  (residues 1 to 1606)
  AUTHORS   Chan,W.M., Andrews,C., Dragan,L., Fredrick,D., Armstrong,L.,
            Lyons,C., Geraghty,M.T., Hunter,D.G., Yazdani,A., Traboulsi,E.I.,
            Pott,J.W., Gutowski,N.J., Ellard,S., Young,E., Hanisch,F., Koc,F.,
            Schnall,B. and Engle,E.C.
  TITLE     Three novel mutations in KIF21A highlight the importance of the
            third coiled-coil stalk domain in the etiology of CFEOM1
  JOURNAL   BMC Genet 8, 26 (2007)
   PUBMED   17511870
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1606)
  AUTHORS   Yamada,K., Andrews,C., Chan,W.M., McKeown,C.A., Magli,A., de
            Berardinis,T., Loewenstein,A., Lazar,M., O'Keefe,M., Letson,R.,
            London,A., Ruttum,M., Matsumoto,N., Saito,N., Morris,L., Del
            Monte,M., Johnson,R.H., Uyama,E., Houtman,W.A., de Vries,B.,
            Carlow,T.J., Hart,B.L., Krawiecki,N., Shoffner,J., Vogel,M.C.,
            Katowitz,J., Goldstein,S.M., Levin,A.V., Sener,E.C., Ozturk,B.T.,
            Akarsu,A.N., Brodsky,M.C., Hanisch,F., Cruse,R.P., Zubcov,A.A.,
            Robb,R.M., Roggenkaemper,P., Gottlob,I., Kowal,L., Battu,R.,
            Traboulsi,E.I., Franceschini,P., Newlin,A., Demer,J.L. and
            Engle,E.C.
  TITLE     Heterozygous mutations of the kinesin KIF21A in congenital fibrosis
            of the extraocular muscles type 1 (CFEOM1)
  JOURNAL   Nat Genet 35 (4), 318-321 (2003)
   PUBMED   14595441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 30, 2022 this sequence version replaced XP_006249920.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.16294.1,
                                           SRR26643292.49184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..1606
                     /product="kinesin-like protein KIF21B"
                     /calculated_mol_wt=179459
     Region          7..372
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(16,87,90,92..95,274)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(324,327,330)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          367..>1090
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          401..1095
                     /region_name="Interaction with TRIM3.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          521..540
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          553..624
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            580
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            583
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          832..861
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          925..1006
                     /region_name="Rcc_KIF21B"
                     /note="regulatory coiled-coil domain found in kinesin-like
                     protein KIF21B; cd22262"
                     /db_xref="CDD:410203"
     Site            order(928..929,932..933,935..936,939..940,942..943,
                     946..947,949..950,953..954,956..957,960..961,964,967..968,
                     974..975,977..978,981..982,984..985,988..989,991..992,
                     995..996,998..999,1002..1003)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410203"
     Site            1145
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75037; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            1163
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75037; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1194..1248
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            1212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75037; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            1234
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            1238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75037; propagated from
                     UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1289..1597
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Region          1290..1327
                     /region_name="WD 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Site            order(1291,1307,1311,1317..1318,1330..1331,1349,
                     1358..1359,1372..1373,1412,1422..1423,1436,1456,1461,
                     1467..1468,1486..1487,1503,1507,1513..1514,1527..1528,
                     1545,1550,1556..1557,1569..1570,1586,1590,1596..1597)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          1296..1330
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1330..1368
                     /region_name="WD 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1335..1371
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1391..1434
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1394..1432
                     /region_name="WD 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1435..1477
                     /region_name="WD 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1440..1484
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1486..1523
                     /region_name="WD 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1493..1525
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1527..1566
                     /region_name="WD 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1M5N7.2)"
     Region          1532..1556
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1606
                     /gene="Kif21b"
                     /coded_by="NM_001415800.1:333..5153"
                     /db_xref="GeneID:289397"
                     /db_xref="RGD:1306206"
ORIGIN      
        1 magqgdccvk vavrirpqls kekiegchic tsvtpgepqv llgkdkafty dfvfdldtwq
       61 eqiystcvsk liegcfegyn atvlaygqtg agktytmgtg fdtvtseeeq giipraiahl
      121 frgiderkrr aqeqgvtgpe fkvsaqflel yneeildlfd strdpdarhr rsnikiheda
      181 nggiyttgvt srlinsqeel iqclkqgals rttastqmnv qssrshaift ihlcqmrvca
      241 qpdlvnetvt glpdgtaptg teyetltakf hfvdlagser lkrtgatger akegisincg
      301 llalgnvisa lgdqskkvvh vpyrdskltr llqdslggns qtimiacvsp sdrdfmetln
      361 tlkyanrarn iknkvvvnqd ktsqqisalr aeiarlqmel meykagkrvi gedgaegysd
      421 lfrenamlqk engalrlrvk amqeaidain nrvtqlmsqe anlllakagd gneaigaliq
      481 nyireieelr tklleseamn eslrrslsra sarnpyslga spagpafggs passmedase
      541 virrakqdle rlkkkevrqr rkspekeafk kraklqqens eetdeneaee eeeerdesgc
      601 eeeededsgs eeslvdsdsd peekevnfqa dladltceie ikqklidele nsqrrlqtlk
      661 hqyeeklill qnkirdtqle rdrvlqnlst mecyteekan kikadyekrl remnrdlqkl
      721 qaaqkeharl lknqsryere lkklqtevae mkkakvalmk qmreeqqrrr lvetkrnrei
      781 aqlkkeqrrq efqiralesq krqqeivlrr ktqevsalrr lakpmserva grvglkppnm
      841 dsgaevsast tsseaesgar svssivrqwn rkinhflgdh ptatvngarp arkkfqkkga
      901 sqsfskaarl kwqslerrii divmqrmtiv nleadmerli kkreelfllq ealrrkrerl
      961 qaespeeekg lqelaeeiev laanidyind sitdcqatim qleetkeeld stdtsvviss
     1021 cslaearlll dnflkasidk glqvaqkeaq irllegrlrq tdmtgssqnh llldalreka
     1081 eahpelqali ynvqhengya stdeevsefs egsfsqsftm kgstshddfk fkgepklsaq
     1141 mkavsaeclg ppldsstkni tkslaslvei kedgvgfsir dpyyrdkvsr tvslptrgst
     1201 fprqsrgatd tspltrrksy drgqpirstd igftppsspp trprndrnvf srltsnqsqg
     1261 saldkgiitp iggakgarta plqcvsmaeg htkpilclda tdellftgsk drsckmwnlv
     1321 tgqeiaalkg hpnnvvsiky cshsglvfsv sssyvkvwdi rdsakcirtl tssgqvisgd
     1381 acmatstrai tssqgehqin qmalspsgtm lyvasgnavr iwelnrfqpi gkltghigpv
     1441 mcltvtqtsn qhdlvvtgsk dhyvkmfqlg dcvtgtigpt hnfepphydg ieclaiqgdi
     1501 lfsgsrdngi kkwdldqqel iqqipnahkd wvcalafvpg rpmllsacra gfikvwnvdn
     1561 ftpigeikgh dspinaictn skhiftassd ltvkfwsmrr lpaahp
//
