LOCUS       NM_001408926            8490 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kinesin family member 1A (Kif1a), mRNA.
ACCESSION   NM_001408926 XM_039084753
VERSION     NM_001408926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8490)
  AUTHORS   Hummel,J.J.A. and Hoogenraad,C.C.
  TITLE     Specific KIF1A-adaptor interactions control selective cargo
            recognition
  JOURNAL   J Cell Biol 220 (10) (2021)
   PUBMED   34287616
  REMARK    GeneRIF: Specific KIF1A-adaptor interactions control selective
            cargo recognition.
REFERENCE   2  (bases 1 to 8490)
  AUTHORS   Budaitis,B.G., Jariwala,S., Rao,L., Yue,Y., Sept,D., Verhey,K.J.
            and Gennerich,A.
  TITLE     Pathogenic mutations in the kinesin-3 motor KIF1A diminish force
            generation and movement through allosteric mechanisms
  JOURNAL   J Cell Biol 220 (4) (2021)
   PUBMED   33496723
  REMARK    GeneRIF: Pathogenic mutations in the kinesin-3 motor KIF1A diminish
            force generation and movement through allosteric mechanisms.
REFERENCE   3  (bases 1 to 8490)
  AUTHORS   Zaniewski,T.M., Gicking,A.M., Fricks,J. and Hancock,W.O.
  TITLE     A kinetic dissection of the fast and superprocessive kinesin-3
            KIF1A reveals a predominant one-head-bound state during its
            chemomechanical cycle
  JOURNAL   J Biol Chem 295 (52), 17889-17903 (2020)
   PUBMED   33082143
  REMARK    GeneRIF: A kinetic dissection of the fast and superprocessive
            kinesin-3 KIF1A reveals a predominant one-head-bound state during
            its chemomechanical cycle.
REFERENCE   4  (bases 1 to 8490)
  AUTHORS   Guedes-Dias,P., Nirschl,J.J., Abreu,N., Tokito,M.K., Janke,C.,
            Magiera,M.M. and Holzbaur,E.L.F.
  TITLE     Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic
            Cargo Delivery to the Presynapse
  JOURNAL   Curr Biol 29 (2), 268-282 (2019)
   PUBMED   30612907
  REMARK    GeneRIF: The delivery of synaptic vesicle precursors to en passant
            synapses in hippocampal neurons is specified by an interplay
            between the kinesin-3 KIF1A motor and presynaptic microtubules.
            KIF1A binds more weakly to GTP-tubulin than GDP-tubulin and
            competes with end-binding proteins for binding to the microtubule
            plus end.
REFERENCE   5  (bases 1 to 8490)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
  REMARK    GeneRIF: liprin-alpha and TANC2 are not part of the KIF1A-cargo
            complex but capture dense core vesicles at dendritic spines.
REFERENCE   6  (bases 1 to 8490)
  AUTHORS   Chung,C.Y., Koprich,J.B., Siddiqi,H. and Isacson,O.
  TITLE     Dynamic changes in presynaptic and axonal transport proteins
            combined with striatal neuroinflammation precede dopaminergic
            neuronal loss in a rat model of AAV alpha-synucleinopathy
  JOURNAL   J Neurosci 29 (11), 3365-3373 (2009)
   PUBMED   19295143
REFERENCE   7  (bases 1 to 8490)
  AUTHORS   Ikegami,K., Heier,R.L., Taruishi,M., Takagi,H., Mukai,M.,
            Shimma,S., Taira,S., Hatanaka,K., Morone,N., Yao,I., Campbell,P.K.,
            Yuasa,S., Janke,C., Macgregor,G.R. and Setou,M.
  TITLE     Loss of alpha-tubulin polyglutamylation in ROSA22 mice is
            associated with abnormal targeting of KIF1A and modulated synaptic
            function
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3213-3218 (2007)
   PUBMED   17360631
REFERENCE   8  (bases 1 to 8490)
  AUTHORS   Lee,J.R., Shin,H., Choi,J., Ko,J., Kim,S., Lee,H.W., Kim,K.,
            Rho,S.H., Lee,J.H., Song,H.E., Eom,S.H. and Kim,E.
  TITLE     An intramolecular interaction between the FHA domain and a coiled
            coil negatively regulates the kinesin motor KIF1A
  JOURNAL   EMBO J 23 (7), 1506-1515 (2004)
   PUBMED   15014437
REFERENCE   9  (bases 1 to 8490)
  AUTHORS   Shin,H., Wyszynski,M., Huh,K.H., Valtschanoff,J.G., Lee,J.R.,
            Ko,J., Streuli,M., Weinberg,R.J., Sheng,M. and Kim,E.
  TITLE     Association of the kinesin motor KIF1A with the multimodular
            protein liprin-alpha
  JOURNAL   J Biol Chem 278 (13), 11393-11401 (2003)
   PUBMED   12522103
  REMARK    GeneRIF: results suggest that liprin-alpha functions as a KIF1A
            receptor, linking KIF1A to various liprin-alpha-associated proteins
            for their transport.
REFERENCE   10 (bases 1 to 8490)
  AUTHORS   Lee,J.R., Shin,H., Ko,J., Choi,J., Lee,H. and Kim,E.
  TITLE     Characterization of the movement of the kinesin motor KIF1A in
            living cultured neurons
  JOURNAL   J Biol Chem 278 (4), 2624-2629 (2003)
   PUBMED   12435738
  REMARK    GeneRIF: KIF1A mediates neuronal transport at a high velocity and
            processivity in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jul 1, 2022 this sequence version replaced XM_039084753.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000009.1  101094678-101094777 c
            101-264             JAXUCZ010000009.1  101076862-101077025 c
            265-341             JAXUCZ010000009.1  101071181-101071257 c
            342-521             JAXUCZ010000009.1  101070171-101070350 c
            522-587             JAXUCZ010000009.1  101069478-101069543 c
            588-766             JAXUCZ010000009.1  101068615-101068793 c
            767-878             JAXUCZ010000009.1  101067413-101067524 c
            879-956             JAXUCZ010000009.1  101066287-101066364 c
            957-1022            JAXUCZ010000009.1  101065474-101065539 c
            1023-1040           JAXUCZ010000009.1  101064814-101064831 c
            1041-1116           JAXUCZ010000009.1  101061926-101062001 c
            1117-1195           JAXUCZ010000009.1  101060537-101060615 c
            1196-1338           JAXUCZ010000009.1  101059642-101059784 c
            1339-1365           JAXUCZ010000009.1  101059147-101059173 c
            1366-1499           JAXUCZ010000009.1  101057786-101057919 c
            1500-1579           JAXUCZ010000009.1  101056513-101056592 c
            1580-1655           JAXUCZ010000009.1  101056142-101056217 c
            1656-1735           JAXUCZ010000009.1  101054345-101054424 c
            1736-1842           JAXUCZ010000009.1  101053824-101053930 c
            1843-1926           JAXUCZ010000009.1  101052709-101052792 c
            1927-2107           JAXUCZ010000009.1  101050281-101050461 c
            2108-2180           JAXUCZ010000009.1  101050137-101050209 c
            2181-2274           JAXUCZ010000009.1  101049864-101049957 c
            2275-2423           JAXUCZ010000009.1  101048973-101049121 c
            2424-2602           JAXUCZ010000009.1  101048417-101048595 c
            2603-2740           JAXUCZ010000009.1  101046654-101046791 c
            2741-3019           JAXUCZ010000009.1  101045629-101045907 c
            3020-3138           JAXUCZ010000009.1  101040941-101041059 c
            3139-3224           JAXUCZ010000009.1  101038195-101038280 c
            3225-3363           JAXUCZ010000009.1  101037201-101037339 c
            3364-3532           JAXUCZ010000009.1  101036933-101037101 c
            3533-3623           JAXUCZ010000009.1  101036681-101036771 c
            3624-3742           JAXUCZ010000009.1  101036165-101036283 c
            3743-3798           JAXUCZ010000009.1  101035302-101035357 c
            3799-3907           JAXUCZ010000009.1  101034438-101034546 c
            3908-3974           JAXUCZ010000009.1  101033912-101033978 c
            3975-4059           JAXUCZ010000009.1  101033729-101033813 c
            4060-4165           JAXUCZ010000009.1  101031237-101031342 c
            4166-4280           JAXUCZ010000009.1  101020747-101020861 c
            4281-4414           JAXUCZ010000009.1  101019694-101019827 c
            4415-4476           JAXUCZ010000009.1  101018565-101018626 c
            4477-4622           JAXUCZ010000009.1  101018059-101018204 c
            4623-4823           JAXUCZ010000009.1  101017460-101017660 c
            4824-4901           JAXUCZ010000009.1  101016866-101016943 c
            4902-5026           JAXUCZ010000009.1  101016327-101016451 c
            5027-5179           JAXUCZ010000009.1  101015562-101015714 c
            5180-5372           JAXUCZ010000009.1  101014798-101014990 c
            5373-5491           JAXUCZ010000009.1  101013925-101014043 c
            5492-8490           JAXUCZ010000009.1  101010447-101013445 c
FEATURES             Location/Qualifiers
     source          1..8490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..8490
                     /gene="Kif1a"
                     /note="kinesin family member 1A"
                     /db_xref="GeneID:363288"
                     /db_xref="RGD:1304996"
     exon            1..100
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            101..264
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..5534
                     /gene="Kif1a"
                     /note="neuron-specific kinesin motor KIF1A; axonal
                     transport of synaptic vesicles-like"
                     /codon_start=1
                     /product="kinesin-like protein KIF1A"
                     /protein_id="NP_001395855.1"
                     /db_xref="GeneID:363288"
                     /db_xref="RGD:1304996"
                     /translation="MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPK
                     ETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAG
                     KSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNP
                     KNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSH
                     AVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLT
                     TLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPA
                     DINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
                     DTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETE
                     KIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNE
                     DPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTL
                     EPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAE
                     PVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEA
                     LQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAI
                     FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEV
                     QDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWF
                     RLVGSSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTEPAEEQSVGEEEEEEE
                     EEEEEEEEEDLEDDVFPEHTLCDGQDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRV
                     AIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPV
                     VGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLLDSPEKAALDGPL
                     DTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGP
                     PLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHF
                     PRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGM
                     PCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILS
                     LNILSSGYVHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENC
                     TQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADA
                     GSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRH
                     YLLLREKLETTQRPVPEVLSPASSEDSESRSSSGASSPLSAEGQPSPLEVPNERQREL
                     AVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCP
                     SLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDI
                     QEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQ
                     VEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRR
                     RSAQMRV"
     exon            265..341
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            342..521
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            522..587
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            588..766
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            767..878
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            879..956
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1022
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1040
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1116
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1195
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1338
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1365
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1499
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1579
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1655
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1735
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1842
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1926
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2107
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2180
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2274
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2423
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2602
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2740
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..3019
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3138
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3224
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3363
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3532
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3623
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3742
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3798
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3907
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..3974
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4059
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4165
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4280
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4414
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4476
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4477..4622
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4823
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4824..4901
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..5026
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5179
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5372
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..5491
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..8490
                     /gene="Kif1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcaccaa gagcagccag caagaagcat cagttccagg ctcggggacc ctctccggta
       61 ccagtgccca tgcacggcca tcaccagtga cgcccgagag gtgactctgc cctctctggg
      121 gcaactgcag ctgctgactg acccccaact ccacagaaat ggctggggcc tctgtgaagg
      181 tggcggtgcg cgtccgcccc ttcaactccc gggaaatgag ccgcgactcc aagtgcatca
      241 ttcagatgtc tggaagcacc accaccattg tcaaccccaa acagcccaag gagacaccca
      301 agagcttcag cttcgattac tcctactggt cacatacctc gcccgaggac atcaactatg
      361 cctctcagaa gcaggtctac agggacattg gggaggagat gctacagcat gcctttgagg
      421 gctacaacgt gtgcatcttt gcctatggac agacaggggc tggcaagtcc tacaccatga
      481 tgggcaaaca agagaaggac cagcaaggca tcatcccaca gctctgtgaa gacctcttct
      541 ctcgaatcaa tgacacgacc aacgacaaca tgtcctattc tgtggaggtc agctacatgg
      601 agatttactg tgagcgagtc cgcgacctcc tgaaccccaa gaacaaaggc aacctgcgtg
      661 tgagggagca ccctctgctg gggccttatg tggaggacct ctccaagctg gctgtgacct
      721 cctacaatga catccaggac ctcatggact cagggaacaa ggccaggact gtggcggcca
      781 caaacatgaa tgagaccagc agccgttctc acgccgtctt caacatcatc ttcacccaga
      841 agcgccatga tgcggagacc aacatcacca cagagaaagt gagcaaaatc agcctggtgg
      901 acctggcggg cagtgaacga gccgactcca cgggagccaa gggcacacga ctcaaggagg
      961 gagccaacat caacaagtct ttgaccaccc tgggaaaggt catctctgct ctcgctgaaa
     1021 tggactctgg acccaataag aacaagaaaa agaagaagac agacttcatc ccttaccgag
     1081 actcggtatt gacatggctt ctccgggaaa acctgggcgg caactcaagg acagccatgg
     1141 tggcagccct gagccctgcg gacatcaact atgatgagac cctcagcaca ctgagatatg
     1201 cagaccgggc caaacagatc cgctgcaacg ccattatcaa tgaggaccct aacaacaagc
     1261 tgattcgaga actgaaggat gaggtgacca ggctgcgaga tctgctgtac gcccaaggtc
     1321 ttggcgatat cactgacacc aacactgtgc ctggaggacc caaattgacc aatgccctgg
     1381 tgggcatgag cccctcgtct tcgctctcag ccctgtccag ccgtgcggcc tctgtgtcca
     1441 gtctccacga gcgcatcttg tttgctccag gcagcgagga ggctattgaa aggctgaagg
     1501 aaacagagaa gatcattgct gagctcaatg agacgtggga ggagaagcta cggcggacag
     1561 aagccatccg gatggagagg gaagccctgc tggccgagat gggtgtggcc atgagggaag
     1621 atggtggcac cttgggagtg ttttctccca aaaagacacc tcatcttgtc aacctgaacg
     1681 aggatccttt gatgtctgaa tgcctccttt actacatcaa agatggcgtc accagagtgg
     1741 gcagagaaga cgcagagagg cggcaagaca ttgtcctgag tgggcacttc atcaaggagg
     1801 aacactgcat cttccggagc gactcccgag gaggcggaga agctgtggtg accctggagc
     1861 cctgtgaagg agcagatacc tatgtgaacg gcaagaaagt cactgagccc agcatcctac
     1921 ggtcaggaaa ccgcatcatc atgggaaaaa gccacgtgtt ccggtttaac caccccgagc
     1981 aggctcgtca ggagcgtgag cggacacctt gtgcagagac acccgctgag ccagtggact
     2041 gggcctttgc ccagagggag ctgctggaga agcagggcat tgacatgaag caggagatgg
     2101 agcagaggct ccaggagctg gaggaccagt accggaggga gcgggaggag gccacatacc
     2161 tgctggagca gcagaggctg gactatgaga gtaagctgga ggccctacag aaacagatgg
     2221 actccaggta ctacccagag gtgaacgagg aggaggaaga accagaggat gaagtccaat
     2281 ggacggagcg ggagtgtgag ttggcactgt gggccttccg gaaatggaag tggtaccagt
     2341 tcacttctct tcgggacctg ctgtggggca atgccatctt cctgaaggag gccaatgcca
     2401 tcagtgtgga gctaaagaag aaggtccagt tccagttcgt cctcctcaca gataccctct
     2461 actccccact gccgccagac ctactccccc cagaagctgc caaagaccga gagacacgac
     2521 ccttccccag gaccatcgtg gccgtggagg tccaggacca gaagaatggg gccacccact
     2581 actggacgct agagaaactc aggcaacgcc tggacctgat gcgggaaatg tatgaccggg
     2641 ctgcagaggt cccctccagc gtcgttgagg actgtgacaa tgtggtgact ggtggagacc
     2701 ccttctatga ccgcttcccc tggttccggc tggtgggcag ttcagtcatc tctggctgca
     2761 acagctaccc tcttctcaac acatgcatga gcgagcgcat ggctgctctc accccctccc
     2821 ccaccttctc aagccccgac tccgacacca ccgagcctgc cgaggagcag agcgtggggg
     2881 aggaggagga ggaggaggag gaggaggagg aggaggagga ggaggaggac ctggaggacg
     2941 acgtctttcc ggagcacacg ctgtgcgacg gccaggaccc gttttacgac cggccccccc
     3001 tgttcagttt agtaggaagg gccttcgtat acctgagcaa cttgctgtac cctgtgcccc
     3061 tggtgcaccg cgtggccatc gtcagcgaaa agggagaggt gaaaggcttc ctccgtgtgg
     3121 cggtgcaggc catctcagct gatgaggagg ctccggatta tggatcaggt gtccgtcagt
     3181 caggaacggc taaaatctcc ttcgatgacc agcactttga aaagttccag tctgagtcct
     3241 gccctgtggt ggggatgtcc cgctcaggga cctcccagga ggagctgcgc attgtagaag
     3301 gccagggtca gggggctgat gctgggcctt cagccgatga agtgaacaac aacacttgct
     3361 cagctgtgcc tcctgaaggc ctcctagata gcccagagaa ggctgccctg gatggacccc
     3421 tagacacagc cctggaccac ctccgtctgg gcagtacctt caccttccgg gttacagtcc
     3481 tgcaggcgtc cagtatctcg gccgaatatg ctgacatctt ctgccagttc aactttatcc
     3541 accgccacga tgaggccttc tccactgaac ccctgaagaa cactggcagg ggaccccctc
     3601 ttggcttcta ccatgttcag aatattgcag tagaggtgac caagtccttc atcgaataca
     3661 tcaagagcca gcccattgtg ttcgaggtct tcgggcacta ccaacagcat ccattcccac
     3721 ctctttgcaa ggatgttctc agccccctga ggccctcacg tcgccacttc cccagggtca
     3781 tgccgctatc caagccagtg cctgccacta agctcagtac aatgacacgg ccttccccag
     3841 gtccctgcca ttgcaagtat gacctgctgg tctacttcga gatctgcgag ctggaagcca
     3901 atggcgatta catccctgct gtggtagacc accgtggcgg catgccgtgc atggggacct
     3961 tccttctcca tcagggcatc cagagacgga taaccgtgac cctgttgcat gagacaggaa
     4021 gccacatccg ctggaaggaa gtgcgagagc tggttgtggg tcgcatccga aatactccag
     4081 aaactgacga agctctgatt gaccccaaca tcttgtccct caacatcctg tcatcaggat
     4141 acgtccatcc agcccaggat gaccggacct tctaccagtt tgaggcagcc tgggacagtt
     4201 ccatgcataa ctccctcctg ctgaatcgag tcacccctta ccgggagaaa atctacatga
     4261 cactctctgc ctacattgag atggagaact gcacccagcc agctgtcatc actaaggact
     4321 tctgcatggt tttctactcc cgtgacgcca agctgcccgc ctcacgctcc attcgcaacc
     4381 tgtttggcag tgggagcctg agggccacag aaggcaaccg tgtgactggt gtgtatgagc
     4441 tcagcctttg ccatgtggcc gatgcaggca gcccaggcat gcagcgccgc cgcaggcggg
     4501 tgctggacac atcagtagcc tacgtccgtg gtgaggagaa cctggctggc tggaggcccc
     4561 ggagtgacag cctgatccta gaccaccagt gggagctgga gaaactgagc ctcttacagg
     4621 aggtggaaaa gaccaggcac tacctgctcc tacgggagaa gctggagacc acacagcggc
     4681 ctgtgcctga ggtgctgtcg ccagcttcca gtgaggactc tgagtcccgt agctcttcag
     4741 gtgcctcttc gccattgtca gccgagggtc agccgtcacc tctggaggtt cccaatgaga
     4801 ggcagaggga gctggccgtc aagtgcttac gactcctcat gcacacgttc aacagggagt
     4861 acacccacag ccacgtctgt atcagcgcca gcgagagcaa gctctcagag atgtctgtca
     4921 ccctgatgcg ggacccatcc atgtctcctc tgggtgcggc tacgctcact ccctcctcca
     4981 cttgcccctc tctgattgaa ggacgctatg gtgccactga tgtgaggacc ccccaacctt
     5041 gctcccggcc cgccagccca gagcccgagc tccttccaga acttgactcc aagaagactc
     5101 cctcccctgt tcgggcaaca gagacagaga aggagcccca gagactgctg gtccctgata
     5161 tccaagagat ccgagtcagc ccaatcgtct ccaagaaggg atacttgcac ttcctggagc
     5221 cacacacagc tggctgggcc aagcgcttcg tggtggtgag gcgtccctat gcttacatgt
     5281 acaacagtga caaggacaca gtggagagat ttgtgctcaa cctctccaca gcccaggtgg
     5341 agtacagcga ggaccagcag gccatgctca agacacccaa cacgttcgct gtgtgcacgg
     5401 agcaccgagg catcctgctg caggccaata gtgacaagga catgcacgac tggctatatg
     5461 ccttcaaccc actcctggct gggaccattc ggtccaagct ctcccgaagg agatctgcgc
     5521 agatgcgggt ctgagcagaa agccttccgg acttccagtg gcccagacca ctcccccgtc
     5581 cttaccatct gttctgtcat ctgccattca gcccttcccc caccagggga cacctgtgct
     5641 gggcccagca accccacctc tggcgggagg cctataccac atgacgaatt gtgctccccc
     5701 ccggaggttg tgcgtgttgt ggtttcttcc aaaattgctc tggtgggaag ttcggaatgc
     5761 caggaaggtc agagggcacg agacccaggg tattgccgct gttctaatat ttttctaagc
     5821 atagacggac ttataattaa tatacattag ttagtggcgt tgaaacagtc ctctgagaca
     5881 ttaactataa gactgtgttc tgtttgtaag tatttatttc taatgcctcc aggtagggct
     5941 gtaaggttca tgtggggcta ccttcccctc ccccaccccc acccccacct ccacccccac
     6001 ctccaccccc acccccagcc tggccctgtt ggttgccacc tgtatctcca gtctactagg
     6061 ggcagaggga gggagggatg tgaacaagcc atggctcctc acggcctggc atagggaagc
     6121 tctctgtcct ggcctgtttg tctgaaatga acctagtaca gtatgtgtgt gaggggttct
     6181 gcaaatcccg agacttagac agttcagaaa gcattgtgag ctacttctga gggaacggtt
     6241 cccaaaatgg agcaataagg gtggtgtggg cagcttcacc tcagaataag gaggatcagg
     6301 tgaggtgtat ggtcaaccct cgcaaggcag actggctcca actgagctgt gtccaggcta
     6361 ttgggtaggc ggccatgttt acacacggct gtgggtgaca gagaccatgg gagttcagaa
     6421 tggggtctct gactgtagcc tcgatgtcga tgagcagagg aatgaatatg tagctctgga
     6481 aaggttctgt gatcagtgat ctgccccagt tgtggcattc ctgtaaatct cagcaagaga
     6541 actcagtgaa tgatgtatga ggatgacctg cgatggtctt ggtaaaggga ctcttctgca
     6601 ccttctgcgc ttggggaatt ttcatgccat gtccatttgg aaagccagaa accaaacctg
     6661 aagtccccag ggcctatcag gagcagttac actcagcatc cagctattcc aaggttctcc
     6721 ctccaccttg gtcagcccct ccccgcccct ctagatcaac tgatgggtct aagttcccca
     6781 tcatctcaag ctgtctccac atggcactga catgacctgg atactcttga gaccaatgct
     6841 cacagcatct ctacagtctg gatggtcgta gaaggttctg gcttcaaagg tcccttggca
     6901 cagttatcaa gggtcctgtc cttcatccaa gtatcaagat tcagggtagt ggcagggctc
     6961 gaagtagtgt gtgcacctgc catccagtgt gagcccagcg gaaactgaga attcacccat
     7021 cactggggtc aggtgccata tgggtggcca ccctcatgcc tggccaccgt catcccccag
     7081 ggcttgaggt aagagtcaat agcatcaagt gtcaggagac cctatctatg aagtgtagaa
     7141 taagacttat ttccaagaat acaaatcaag gttaagcccg aactagaaac caggtgacct
     7201 gagctgtcta tggtggacct tggaggcaga aggctgagac cacaaagtgg agagaagacg
     7261 gctgtgttca gaaactcact ctggtgctca tggcctattc aaaggaggga aggagcgagt
     7321 tgcttcaatg tcttggttcc caagggccac ggagccacac agcccccagc aggcagagag
     7381 gcagtcgggc ctgccgcgct cgctcaggtc agccaacctg aagctgaggc cttggaagag
     7441 tccggctcca cccagcaggt gggtgtctga ggccagccaa cctacagagc acctgtgcct
     7501 gggtcgggtt gtagaaaggt cgggaggtgt agtgcccacc ctgccccatt cgggggtatc
     7561 ttggcccagt gttgtcctgg cattgtctag ggaaccaagg tgggctctcg gcttttgtgg
     7621 gtggtcctga gtcagaaact agtaaccaga actgatggac caagagatcc gtctacagct
     7681 caggaaacct gatttcttca tgccctcctt gccccaaatt acctgtatat catgtcagct
     7741 gaaggtcatt tgtccaacat ccgtgacggg gagggatgac acggggacta gggataggcc
     7801 aagccttcct agctggggtc tgtgtttcct gcttggaaca gagggtgaga tggatccgga
     7861 aaaccacctc cacagacagt ttggtgttga tacttgatgt tgcccaggct gggacctcaa
     7921 cttagtttgg aataataatc atctttcctg gagagggagg ggctgtttct gcctcatacc
     7981 aacaccttat tcaacacaca acacacacac acacacacac acagctgttg taaatggctt
     8041 cctctatcct ggtccctgga gacccctaac tatcttcaga ttactgaatg tggctgatgt
     8101 tacagatgtg aacaagacca agatgttggt cccctgctcc acccagcatg tggacctcaa
     8161 aagacattcc tttacccctg ggactggagc agtgcagtcc cccaggatgg acagatatgg
     8221 ctgacctgag tctctccttg agcctggacc tcctgtagtt tgtctatacc gaggggcccc
     8281 tgcaactcaa gaggctgttt ccctgacctg tacatatgtg gttgctgtgg gcgccccctg
     8341 gcccttgtgt cataaccacc tgacataatg actagtatcc tgctgtttac acctgagtgt
     8401 tagctgtagg ctcctgtact gtttgtgtgc acttagggct ctgtccaatt aagaaataaa
     8461 tgtggctctc atgcaacaca catccattca
//
