LOCUS       NM_001137642            3001 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus kinesin family member 18A (Kif18a), mRNA.
ACCESSION   NM_001137642 XM_342486
VERSION     NM_001137642.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Wang,L., Yang,S., Sun,R., Lu,M., Wu,Y. and Li,Y.
  TITLE     [Expression of KIF18A in gastric cancer and its association with
            prognosis]
  JOURNAL   Zhonghua Wei Chang Wai Ke Za Zhi 19 (5), 585-589 (2016)
   PUBMED   27215532
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Nagahara,M., Nishida,N., Iwatsuki,M., Ishimaru,S., Mimori,K.,
            Tanaka,F., Nakagawa,T., Sato,T., Sugihara,K., Hoon,D.S. and Mori,M.
  TITLE     Kinesin 18A expression: clinical relevance to colorectal cancer
            progression
  JOURNAL   Int J Cancer 129 (11), 2543-2552 (2011)
   PUBMED   21213216
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Liu,X.S., Zhao,X.D., Wang,X., Yao,Y.X., Zhang,L.L., Shu,R.Z.,
            Ren,W.H., Huang,Y., Huang,L., Gu,M.M., Kuang,Y., Wang,L., Lu,S.Y.,
            Chi,J., Fen,J.S., Wang,Y.F., Fei,J., Dai,W. and Wang,Z.G.
  TITLE     Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired
            Chromosome Congression and Dysregulated BubR1 and CENP-E
  JOURNAL   Genes Cancer 1 (1), 26-39 (2010)
   PUBMED   20981276
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Zusev,M. and Benayahu,D.
  TITLE     The regulation of MS-KIF18A expression and cross talk with estrogen
            receptor
  JOURNAL   PLoS One 4 (7), e6407 (2009)
   PUBMED   19636373
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Zusev,M. and Benayahu,D.
  TITLE     New insights on cellular distribution, microtubule interactions and
            post-translational modifications of MS-KIF18A
  JOURNAL   J Cell Physiol 217 (3), 618-625 (2008)
   PUBMED   18680169
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Mayr,M.I., Hummer,S., Bormann,J., Gruner,T., Adio,S., Woehlke,G.
            and Mayer,T.U.
  TITLE     The human kinesin Kif18A is a motile microtubule depolymerase
            essential for chromosome congression
  JOURNAL   Curr Biol 17 (6), 488-498 (2007)
   PUBMED   17346968
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Luboshits,G. and Benayahu,D.
  TITLE     MS-KIF18A, a kinesin, is associated with estrogen receptor
  JOURNAL   J Cell Biochem 100 (3), 693-702 (2007)
   PUBMED   17006958
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On Nov 14, 2008 this sequence version replaced XM_342486.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132294,
                              SAMD00132296 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q34"
     gene            1..3001
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /note="kinesin family member 18A"
                     /db_xref="GeneID:362186"
                     /db_xref="RGD:1561740"
     exon            1..153
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2489
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /codon_start=1
                     /product="kinesin-like protein KIF18A"
                     /protein_id="NP_001131114.1"
                     /db_xref="GeneID:362186"
                     /db_xref="RGD:1561740"
                     /translation="MKWIAEEAGLGLNLWLCLERLEANSAKLSRSLLVFAYGATGSGK
                     THTMLGSTAEPGVMYLTMLDLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLLTNSGPL
                     AVREDAQKGVVVQGLTLHQPKSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIY
                     LRQQDKTASINQNVHIAKMSLIDLAGSERASISGTKGTRFVEGTNINKSLLALGNVIN
                     ALADTKRRNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANR
                     AKDIKSSQLKSNVVNLSSHISQYVKICNMQKAEILMLKEKLKAYEGQKALTDRNDCAK
                     LVHSNVEDKEIERFQEILNCLFQNREGMRQEYLKVEMLLKENELKSSYHQQCHKQIEM
                     MCSEDKLEKATCRRDHRLEKLKSNRCVLEKKKEEMLKQFDENTNWLHRVESEMRLLGQ
                     NGDIPEGLNKDLHCHHLHLQNKDLKTQMGHMMTLAALQEQQHGQTEAVLNALLPVLRK
                     QYWRLKETGLSNAAFDSDFKDIEHLVERKKVVAWADQTAEHSNQSDVPGTSLLMTFPQ
                     LGPIQSIPCCSSMSDPSILKITPQRRTKRKLIPSPLKVKHTQKSALSERTQLNDSFSK
                     ELQPIVYTPEDSRRTVQDLSPPLARASSHSANGMNDNSLKALCRTESPLSRTECKEGL
                     YSTSAICDGIKSLKNNLPEPLPSSKSTLHRVESSSFPTKDSRSVSTSVPSYMAMTTAA
                     KRKWKFMSSTSDASLKSDESCGLAKRIRQDNSSVKLIRENRLRVGYKKTTNKTNSNML
                     RKFRRNTSKENVQ"
     exon            154..311
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            312..416
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            417..527
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            528..725
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            726..902
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            903..980
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1093
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1256
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1421
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1543
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1779
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2188
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2296
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2406
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..3001
                     /gene="Kif18a"
                     /gene_synonym="RGD1561740"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagacgcc ggggaaaacg accgacgtgc tgacgtcagc cgatcggcag ccaatgaaat
       61 ggatagctga ggaagctggc ttgggtttga atttgtggct gtgtttggag cgcctggaag
      121 ccaactcagc caagttgtcg cggtcacttc tagtatttgc atatggtgcc actggatctg
      181 ggaagactca cacaatgctg ggatcaactg ctgaacccgg ggtcatgtac ctaacaatgc
      241 tggacctttt caaatgcatg gatgaggtta aagacgagaa agagtgtagt actgcagtct
      301 cttatctgga ggtatataat gaacagattc gtgacctctt gacaaactca gggccacttg
      361 ctgtccggga agatgcccaa aaaggagtgg ttgttcaggg tcttactcta caccagccta
      421 aatcttcaga ggaaatattg cagctactag acaatggaaa caaaaacagg acgcagcatc
      481 ccactgacat gaatgctgcg tcttctcgtt ctcatgctgt tttccagatt tatttacgac
      541 aacaggacaa aacagcaagc atcaatcaaa atgtccatat agccaaaatg tcactcattg
      601 acctcgcagg atctgagcgg gccagtattt ctggtactaa agggacaaga tttgtagaag
      661 gcacaaatat taacaaatct cttctagctc ttgggaatgt catcaatgcc ttagcagata
      721 caaagagaag aaatcagcat attccttaca gaaatagtaa acttactcgt ttgctgaagg
      781 attctcttgg aggaaactgt caaactataa tgatagctgc tgttagtcct tcctctttat
      841 tctacgatga cacatataac actcttaagt acgcaaatcg tgccaaagac attaagtctt
      901 ctcagttgaa gagcaatgtt gtcaacctca gtagtcacat atcacagtat gtaaagatct
      961 gcaacatgca gaaggcagag attttaatgt tgaaagagaa actaaaggcc tatgaaggac
     1021 agaaagctct gactgacaga aatgactgtg ctaaattagt acattcaaac gtggaggaca
     1081 aagagattga aagatttcaa gaaattctga actgcttgtt ccagaatcga gaaggaatga
     1141 ggcaagaata tctgaaggta gaaatgttac ttaaagaaaa tgaactaaag tcatcctatc
     1201 atcaacagtg ccataagcaa atagaaatga tgtgttctga ggacaaattg gaaaaggcca
     1261 cttgcagacg agatcacaga cttgaaaagt tgaaaagcaa ccgctgtgtg ctagagaaaa
     1321 agaaagaaga gatgttgaaa cagtttgatg aaaatactaa ttggctacat cgagtggaaa
     1381 gtgaaatgcg actcttaggt caaaatggtg atattcccga gggactcaat aaagatcttc
     1441 attgtcacca tttacacctc caaaacaaag acctgaaaac acaaatggga cacatgatga
     1501 ctctggctgc tctccaggag cagcagcatg ggcagactga agcagtactg aatgctttgc
     1561 ttccagtcct aagaaaacag tattggagat tgaaagaaac cggcctgtca aacgctgctt
     1621 ttgattctga cttcaaagat attgaacatt tagtagagag aaaaaaggta gtggcttggg
     1681 ctgaccaaac tgctgaacat tcaaaccaaa gtgatgttcc tggtacttct cttcttatga
     1741 ccttcccaca gcttggacca attcagtcta ttccttgttg ctcatccatg agtgacccta
     1801 gcatacttaa gattactcca caaagaagaa ccaaaagaaa attaatacct tctccattga
     1861 aagtaaaaca tactcagaag tctgcactgt ctgaaaggac acagcttaat gattctttta
     1921 gcaaagaact tcagcctatt gtttacaccc cagaggacag cagaagaact gttcaggacc
     1981 tctctccacc cttagcaaga gcgtcctcac attctgcaaa tggaatgaat gataattccc
     2041 tgaaagcact gtgtagaaca gaatctcctc tcagcagaac cgagtgtaaa gagggtttgt
     2101 actctacatc tgctatatgt gatggtatca aaagcttgaa aaataatttg cctgaaccac
     2161 taccgagcag caaaagcact ttacacaggg tggagtcttc ctcatttcca acgaaggatt
     2221 ctaggtctgt atcaacaagt gtgccatcct acatggcgat gaccactgct gcaaagagga
     2281 agtggaaatt catgagttct acatcagatg cttcattaaa atctgatgaa agttgtggac
     2341 ttgccaaacg cattcgacag gataattcaa gtgttaagct catccgagaa aacagactga
     2401 gagtgggcta taaaaaaacc accaacaaaa caaattcaaa catgcttaga aaatttagaa
     2461 gaaacacttc aaaagaaaat gtacaataag aagaatcaat gtcctttgta tggtatttgt
     2521 ttcttcagaa atgtatttca agtctgtgaa aggagaccat ctaaaactgt ttgctcaaat
     2581 attttcagca gcaaaatgag acttttgtat ttaaaataaa tataaaatta caacagggta
     2641 tgtttcccat ttctcagata tttggtactc ttgaaaatct ctctaagtca ccatgatgcc
     2701 aatttacttg tactttacca gaacttgatt ggaacattgt agaaaaaata gaaaattaaa
     2761 ctgcccttat tattttcaaa aataaagaga ctttagaagt catagttatg gccaagatgt
     2821 tttggtcttc tgctgtgtgt caatatgttg gtatattcat acacgtgatt ttactttcta
     2881 aaattttggt gtaaaaatgt agatatatat ccataacatt gtaaatattg tttaaatact
     2941 caccataaat aatatggtaa tattttatta cttggtatat taaagatgta gattttaaat
     3001 a
//
