LOCUS       NM_001109287            3028 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus KICSTOR subunit 2 (Kics2), transcript variant 1,
            mRNA.
ACCESSION   NM_001109287 XM_001053387 XM_576234
VERSION     NM_001109287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and FM043012.1.
            
            On Sep 12, 2012 this sequence version replaced NM_001109287.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.27665.1,
                                           SRR26643429.26897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000007.1  59169703-59169965
            264-549             JAXUCZ010000007.1  59174985-59175270
            550-1678            JAXUCZ010000007.1  59180491-59181619
            1679-2272           FM043012.1         1-594
            2273-3028           JAXUCZ010000007.1  59182214-59182969
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3028
                     /gene="Kics2"
                     /gene_synonym="RGD1565498"
                     /note="KICSTOR subunit 2"
                     /db_xref="GeneID:500843"
                     /db_xref="RGD:1565498"
     exon            1..263
                     /gene="Kics2"
                     /gene_synonym="RGD1565498"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1366
                     /gene="Kics2"
                     /gene_synonym="RGD1565498"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0536 protein C12orf66 homolog; KICSTOR complex protein
                     C12orf66 homolog"
                     /codon_start=1
                     /product="KICSTOR subunit 2 isoform 1"
                     /protein_id="NP_001102757.2"
                     /db_xref="GeneID:500843"
                     /db_xref="RGD:1565498"
                     /translation="MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREAN
                     KSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDSVRTIYTSLHNELK
                     KVVAGRGAPGGTAPHVEELLPHLSEQLCFFVQARMEIADFYEKMYALSTQKFINTEEL
                     VSTLDTILKKYSSRFHHPILSPLESSFQLEVGVLSHLLKAQAQISEWKFLPSLVTLHN
                     AHTKLQSWGQTFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKTMLLAKFSFYFHEA
                     LSRQTTASEMKALTAKANPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPH
                     SYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRASDLNSLEKVVHFYDDKVQST
                     YFLTRPEPHFTIVVIFESKKSERDSHFISFLNELSLALKNPKVFASLKPGSKG"
     exon            264..549
                     /gene="Kics2"
                     /gene_synonym="RGD1565498"
                     /inference="alignment:Splign:2.1.0"
     exon            550..3028
                     /gene="Kics2"
                     /gene_synonym="RGD1565498"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgggtgg agctggcgcg caggtcgcat gggggagtct atcccactag ccgccccggt
       61 gccggtggaa caggcggtgc tggagacgtt cttctctcac ctgggtatct tctcttacga
      121 caaggccaag gacaatgtgg agaaggaacg agaggccaac aagagcgcgg ggggcagctg
      181 gctgtccctg ctggcggcct tggcgcacct ggccgcggcc gagaaggtct atcacagcct
      241 cacctacctg gggcagaaac tagggggaca gtccttcttc agcaggaaag actccgttcg
      301 caccatctac acgtccctac ataacgaact gaagaaggtg gtggccggcc gaggcgcccc
      361 gggtggaacg gctcctcacg tggaggagct tctcccccac ctgtcagagc agctctgttt
      421 ctttgttcag gcccggatgg agatcgcaga cttctacgag aagatgtacg ccctcagcac
      481 ccagaagttc atcaacactg aagagctggt cagcaccctg gacaccatcc tcaagaagta
      541 cagctctaga tttcaccacc ccatcctcag ccctctggag agcagtttcc agctggaagt
      601 gggcgtgctg agtcatctcc tcaaggccca ggctcagatc tccgagtgga agttcctccc
      661 ttcgctggtt accttgcaca atgctcacac gaagcttcag agctggggcc agacctttga
      721 gaagcagcgg gagaccaaga aacacctgtt tggggggcag tctcagaagg ctgtgcagcc
      781 cccacacctt ttcctttggc tgatgaaact caaaaccatg ctcttggcca agtttagctt
      841 ttacttccat gaggcgctga gccgacagac gactgcttca gaaatgaaag cactgactgc
      901 caaggcgaac ccggacctct ttggaaagat ctccagtttt atcaggaaat atgacgctgc
      961 caatgtgtcc ttaatttttg acaaccgggg ctcagagagc tttcagggtc atggctacca
     1021 ccatccacat tcctaccgag aggcccccaa gggagtggac cagtaccctg ccgtggtgtc
     1081 tctgcccagt gacaggcctg tcatgcactg gcccaatgtt atcatgatca tgacagaccg
     1141 agcatctgac ctgaacagct tggagaaagt ggtccacttc tatgatgaca aagtccagag
     1201 cacctacttc ctgacccgcc cggaacccca cttcaccatc gttgtcattt ttgagtcaaa
     1261 gaaatctgag agagactccc actttatttc cttcctcaac gagctctcac ttgcccttaa
     1321 gaaccccaaa gtgttcgcaa gtctgaagcc tggctccaaa ggttagcagg agcttggcca
     1381 aggcttccca agactggctg cgttgttctt agctgagcag tttgtggttt gtatttaggt
     1441 tagctcatgc tgctttcaga gctgagctaa agatggatcc tccctaatca tgttgcacag
     1501 ttcataagca attaggacca aggacggagt ctccaaagag tagtctagaa gaaccatggt
     1561 gactgctgca ccatggcata gcaaaggagt atcaacattt cctgatttcc ctgtatttca
     1621 tgtcaattga atatttattg gcctttcatt tacctttcca gatttgcttt tgttacactg
     1681 tgcccgatgc acttcctgtg cacttcccag catcctctct gtgtgtgtgt ccctgaggag
     1741 ctgcagggag aagacaccag atgggattgg ttgtagtttc ctcagcggtc gtactaacta
     1801 gttttataag ctaatctgat tagtattata gtgtaattag aatcttggtg agaaatttct
     1861 atcaggtggg agatgaccaa ttgatactgg tccttaaagc agtttaacca gccacaggtc
     1921 ctttcctggt gaccttcagc tccgtcccca ttagtcttca cctttaaagg gtttggtagt
     1981 agactgtccc aggtccaccc aagccattgt gttgggttgt cacctgctgg gggtcacttc
     2041 tctgcagcac agtttatttt tataaaaatc aaaacgacgg acttaatact ttgtgcttgc
     2101 tacacaaatc agttctgttc catggtcatc aggtgagtcc tgcagcacct ctggctgtgg
     2161 tttcttgcct tctggagatt aagttcagag tcagtactgg tcgagtttct cagcacaggc
     2221 taccctgtcc tttctcactg tgtgttcaca gggaagcaga cggaaggaaa ccaccaagaa
     2281 gaactgagct gcgactgctg ggtttgtccc ttggagctta tgtaaacatt acggtcagat
     2341 cagtgcttcc ctggagattg tatggagcca ttgtctggcg gggcgtccac agagcccctc
     2401 caagtgtggt tggtctacct gtgtaagagt ccgccgacca agttcctgca cctccccact
     2461 ttcacacaaa cttaagccag ttgtctttaa acagagggta gtgatttctc tgcagtttct
     2521 ccaggttcta cacaaatatg aacaaatttt ataatattga ccttgacatt aaaaaaattg
     2581 aaaacatttg gaattaaaaa ccaaaccatt tttcttcttt ttgtgttttg ctgagaaact
     2641 gaaaaataat ccttggtatg tgtttttgtg tttttcctga ctaaaaccac cattagcctt
     2701 aatgatgtgg ctcccaggca cctaaaagaa tataggcttt ggtagaccat ggagggatgt
     2761 atataaaaca tatataagtg tttattactt caaatggtca aatatataca tatttgaatt
     2821 gtatatttat ttttaaacat attttgagta atctaagagg tatttacaaa aaaacaggaa
     2881 gcagatgtga atgttaggaa aatctaaagg caacataaac tcttaagtcc ctatgcactg
     2941 tcagtatttg gaggaacctc aaagattggt actgtctctt taattgtttc ctaagctcct
     3001 caataaagtt ttatatatat tacatata
//
