LOCUS       NM_001395096            4020 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus KH-type splicing regulatory protein (Khsrp),
            mRNA.
ACCESSION   NM_001395096 XM_006244292
VERSION     NM_001395096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Bikkavilli,R.K., Zerayesus,S.A., Van Scoyk,M., Wilson,L., Wu,P.Y.,
            Baskaran,A., Tang,K., Raheem,S., Samuelson,B.A., Reddy,N.M.,
            Reddy,S.P., Cool,C.D., Kosmider,B., Avasarala,S. and Winn,R.A.
  TITLE     K-homology splicing regulatory protein (KSRP) promotes
            post-transcriptional destabilization of Spry4 transcripts in
            non-small cell lung cancer
  JOURNAL   J Biol Chem 292 (18), 7423-7434 (2017)
   PUBMED   28275056
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Connerty,P., Bajan,S., Remenyi,J., Fuller-Pace,F.V. and
            Hutvagner,G.
  TITLE     The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the
            protein level of Ago2 in human cells
  JOURNAL   Biochim Biophys Acta 1859 (10), 1299-1305 (2016)
   PUBMED   27478153
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Jiang,H., Zhang,J., Du,Y., Jia,X., Yang,F., Si,S., Wang,L. and
            Hong,B.
  TITLE     microRNA-185 modulates low density lipoprotein receptor expression
            as a key posttranscriptional regulator
  JOURNAL   Atherosclerosis 243 (2), 523-532 (2015)
   PUBMED   26523989
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Zhu,X., Yao,L., Yang,X., Sun,H., Guo,A., Li,A. and Yang,H.
  TITLE     Spatiotemporal expression of KHSRP modulates Schwann cells and
            neuronal differentiation after sciatic nerve injury
  JOURNAL   Int J Biochem Cell Biol 48, 1-10 (2014)
   PUBMED   24368152
  REMARK    GeneRIF: Authors speculated that KHSRP was involved in SCs and
            neuronal differentiation by inducing beta-catenin mRNA decay.
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Bird,C.W., Gardiner,A.S., Bolognani,F., Tanner,D.C., Chen,C.Y.,
            Lin,W.J., Yoo,S., Twiss,J.L. and Perrone-Bizzozero,N.
  TITLE     KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth
            in embryonic hippocampal neurons
  JOURNAL   PLoS One 8 (11), e79255 (2013)
   PUBMED   24244461
  REMARK    GeneRIF: KSRP modulation of GAP-43 mRNA stability restricts axonal
            outgrowth in embryonic hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Kunde,S.A., Musante,L., Grimme,A., Fischer,U., Muller,E.,
            Wanker,E.E. and Kalscheuer,V.M.
  TITLE     The X-chromosome-linked intellectual disability protein PQBP1 is a
            component of neuronal RNA granules and regulates the appearance of
            stress granules
  JOURNAL   Hum Mol Genet 20 (24), 4916-4931 (2011)
   PUBMED   21933836
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Linker,K., Pautz,A., Fechir,M., Hubrich,T., Greeve,J. and
            Kleinert,H.
  TITLE     Involvement of KSRP in the post-transcriptional regulation of human
            iNOS expression-complex interplay of KSRP with TTP and HuR
  JOURNAL   Nucleic Acids Res 33 (15), 4813-4827 (2005)
   PUBMED   16126846
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Rehbein,M., Wege,K., Buck,F., Schweizer,M., Richter,D. and
            Kindler,S.
  TITLE     Molecular characterization of MARTA1, a protein interacting with
            the dendritic targeting element of MAP2 mRNAs
  JOURNAL   J Neurochem 82 (5), 1039-1046 (2002)
   PUBMED   12358751
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006244292.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.34376.1,
                                           SRR26643298.47586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000009.1  1959047-1959400     c
            355-451             JAXUCZ010000009.1  1956991-1957087     c
            452-490             JAXUCZ010000009.1  1956456-1956494     c
            491-530             JAXUCZ010000009.1  1956316-1956355     c
            531-580             JAXUCZ010000009.1  1955371-1955420     c
            581-652             JAXUCZ010000009.1  1955145-1955216     c
            653-710             JAXUCZ010000009.1  1954367-1954424     c
            711-885             JAXUCZ010000009.1  1954009-1954183     c
            886-984             JAXUCZ010000009.1  1953826-1953924     c
            985-1083            JAXUCZ010000009.1  1953498-1953596     c
            1084-1186           JAXUCZ010000009.1  1953308-1953410     c
            1187-1432           JAXUCZ010000009.1  1952770-1953015     c
            1433-1593           JAXUCZ010000009.1  1952534-1952694     c
            1594-1703           JAXUCZ010000009.1  1952349-1952458     c
            1704-1792           JAXUCZ010000009.1  1952031-1952119     c
            1793-1993           JAXUCZ010000009.1  1951744-1951944     c
            1994-2071           JAXUCZ010000009.1  1951590-1951667     c
            2072-4020           JAXUCZ010000009.1  1949557-1951505     c
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..4020
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /note="KH-type splicing regulatory protein"
                     /db_xref="GeneID:171137"
                     /db_xref="RGD:621828"
     exon            1..354
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2349
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /note="KSRP; FUSE-binding protein 2; MAP2 RNA trans-acting
                     protein 1; MAP2 RNA trans-acting protein MARTA1"
                     /codon_start=1
                     /product="far upstream element-binding protein 2"
                     /protein_id="NP_001382025.1"
                     /db_xref="GeneID:171137"
                     /db_xref="RGD:621828"
                     /translation="MSDYSTGGPPPGPPPPAGGGGGAAGAGGGPPPGPPGAGDRGGGG
                     PGGGGPGGGGASGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNNTP
                     DFGFGGQKRQLEDGDQPDSKKLASQGDSIGSQLGPIHPPPRTSMTEEYRVPDGMVGLI
                     IGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRG
                     GPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQ
                     NTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRVGGGIDVPVPRHS
                     VGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQ
                     SLRSGPPGPPGAPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKA
                     INQQTGAFVEISRQLPPNGDPNFKLFVIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPG
                     GPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPNKA
                     AAAATDPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWE
                     EYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEY
                     YRQQAAYYGQTPGPGGPQPPPTQQGQQQASGNCHPPPPPFSFQPPATVHPALVGSAGN
                     PFPCGVCP"
     exon            355..451
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..490
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..530
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..580
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..652
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..710
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..885
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..984
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1083
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1186
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1432
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1593
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1703
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1792
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1993
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2071
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..4020
                     /gene="Khsrp"
                     /gene_synonym="Marta1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgtgctcc gcggccgtgt ggagcgaggc cttgttcccg cgttgagccg ccgccgcctc
       61 ctcagcttga agcctccgcg ccaggcccgt ccccgccgca ccatgtcgga ctacagcacc
      121 ggaggtcccc cgcccggccc gccgcctccc gctggcggag gaggaggagc cgcgggtgcg
      181 ggaggaggcc ctccgccggg cccgccgggt gcgggagacc ggggcggcgg aggccctggc
      241 ggcggcggcc cgggtggagg aggcgcgtcc gggggccctt cgcagcctcc gggtggcggc
      301 ggtccgggga tacgcaagga cgccttcgcc gacgccgtgc agcgggcccg ccagattgca
      361 gccaaaatcg gaggtgatgc tgctaccacc gtgaataaca acactcctga tttcggtttt
      421 gggggccaaa agagacagct ggaagatgga gaccagccag acagcaagaa actggcttcc
      481 cagggagatt caattggttc tcagctggga cccatccatc ctccccccag gacctcaatg
      541 acagaagagt atagggttcc ggacggcatg gtgggcttga tcattggcag aggtggtgag
      601 cagataaaca aaatccagca ggactcaggc tgcaaagttc agatctcacc agatagtggc
      661 ggcctccctg agcgcagtgt gtccctgact ggagcaccag agtctgtcca aaaggcaaag
      721 atgatgctgg atgacattgt gtctcggggc cgtggaggcc ccccaggaca gttccatgac
      781 aacgccaacg ggggtcagaa tggcacagtg caggagatca tgatccctgc tggcaaggct
      841 ggcctggtca ttggcaaggg tggagagacc atcaagcagc tgcaggagcg ggctggggtg
      901 aagatgattt taattcagga cggctcccag aacacaaatg tggacaagcc gctgcggatt
      961 attggggacc catacaaagt acagcaagcc tgtgagatgg tgatggacat cctgcgagaa
     1021 cgtgaccagg gtggctttgg ggaccgcaat gaatacggat ctcgggttgg cggaggcatc
     1081 gatgtgcctg taccccggca ttcggttggt gtggtcattg gccggagtgg agagatgatc
     1141 aagaagatcc agaatgatgc tggtgtgcgc atccagttca agcaagatga cgggaccggc
     1201 cctgagaaga ttgctcacat catggggcct ccagatcggt gtgagcatgc agcccggatc
     1261 atcaatgacc tcctccagag tcttcggagt gggcccccag gtcctccagg ggcccctggc
     1321 atgccccctg gaggccgggg ccggggccga ggccaaggca actggggccc tcctggaggg
     1381 gagatgactt tctccattcc tacccataaa tgtgggctgg tcattggccg aggtggggag
     1441 aacgtgaagg ccattaacca gcagacaggc gcctttgtgg aaatatctcg gcagctgccg
     1501 cccaatggag accccaattt caagttattt gtcatccggg gctcacctca gcagattgac
     1561 catgcaaagc agctcattga ggagaagata gagggtcccc tctgcccagt tggaccaggc
     1621 cctgggggac caggccctgc tggacccatg gggcctttca accctggacc cttcaaccag
     1681 gggcctccag gggcaccacc acatgctggt ggtccccctc ctcaccagta cccgcctcag
     1741 ggctggggca atacctaccc ccagtggcaa ccacctgccc ctcatgaccc aaacaaagct
     1801 gcagcagcag ctacagaccc taatgctgcc tgggccgcct actactccca ctactaccag
     1861 caacccccag gccccgtgcc aggccctgcc ccagcccctg cagccccacc tgcgcaaggg
     1921 gagccccccc agcctccacc tactggccaa tcagactata ccaaggcttg ggaagagtat
     1981 tacaaaaaaa ttggccagca gccccagcag cctggggcgc ccccacagca ggattacacc
     2041 aaggcctggg aggagtacta caagaagcaa gcacaagtgg ccactggtgg gggtcctgga
     2101 gcaccccctg gctcccagcc tgactacagt gccgcctggg ctgagtatta cagacagcag
     2161 gctgcttact acggacagac cccaggccct ggtggcccac agccacctcc cacccagcag
     2221 ggacagcagc aggcaagtgg gaactgccac cctcctcctc ctcctttctc cttccaaccc
     2281 ccggccaccg tccatcctgc cttagtgggt agcgccggaa accctttccc ctgcggggtg
     2341 tgcccttgat gccagcctcg ggctcgtggc cagagtctcc cagagccccg cagccccgcc
     2401 gctgggaagc gctcgatggg tgcagaggct cactgaagag gcttctccgg tagccactgt
     2461 tggtgcgacg ttgtcgggtg ctgggggcac cggccgcaaa ggtggaactc tgaactgctg
     2521 gggtgtcccg ggtgggggca ggaagtgggg actgtgctgg gtaccatgcc ggttgctgaa
     2581 cccgctcgct caaaatctgg ccacttggga agaaaatgtc tatttttttt ccccgtctca
     2641 gcatcactat tttgggtttt gttctttttt attctttttt tttttttttt ttttttaagc
     2701 caccatcttt atatccccca tgttcaagta attgcgtgtt gcaggcggcc ctggctctgc
     2761 tgggatgtga ggggagccca ctgggccctc ctgtctggcg aggccacctc tggtgtgctt
     2821 gcctctgtgt cccggtcttg tctgtgaagt gggcatgacg atagttgcca ccttccaacc
     2881 tacctcacag gggtgttgtg gggacaccat ggtctgaatg ttgtgacgcc cagccgccgc
     2941 ctccctcctc tgtccccctc cctcctggca cttctcccgt gtgccctctt ccacacctct
     3001 ggcttctgct gcagactcct cctcctcttc ctcctccttt ctcctgtttc tccaccaagg
     3061 agcagtctga ctagtggagt ccccaagaca gacagtcaca gccccctgct tagcctgtgg
     3121 gggcttgggc tcggcctctt ggcccactgc ctggagtcgc agcctcttgt agccaggccg
     3181 ccctcctgcc atgaccattc ctgtctctcc ctctctgcag gcaactgaag caaatggata
     3241 tgaacttcat ctgtgaaaat attttttccc ttcatttttg ttccatttgg gggtttcttt
     3301 ttattggttt ctatatttga ttggtttggt gagagaacaa cggctgccta gggtgcaagg
     3361 atccccttca tgctgaggcg ccctctctca ttctgtgtgt ctcacatctt tttcctttcc
     3421 aaaatcggga tccttcatgt tgagccagcc ttagaaaata gcgagaattt aacctctgcc
     3481 aaaaaaaaag agaaaaaatg taaaaattaa atcacaaaga gcagaacaaa acctataaaa
     3541 tgatatatat atagaaatat ataaatcttt atcccccagc ctttgagccc accctctgag
     3601 ggaagtgatt cactatctcc ctattgtccg gggccctatt gtttttaaat aaacttttta
     3661 aaaggaaaga aagtcactct tgctatcttt tttttttttt ttttcggttt tttttttttc
     3721 tttttttttt tcttttagtt agagttggaa cattccttgg accaggtgtg ggtgtcacag
     3781 gcccctcctg tccctgccca tctctctctg tctctctctc tctctctctc tcttcccgcc
     3841 ccgctctccc ctggctcctc cctataccca ccccaacccc aggactggcc tggtacgttg
     3901 tcatctgttg aagatgagat aaactgagaa aaaaatgaga acaaaacaaa aaaattgtat
     3961 ggcagttttt actttttatc gctcgttttt aacttcacaa ataaatggta acaaaacctc
//
