LOCUS       NM_031855               1307 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ketohexokinase (Khk), mRNA.
ACCESSION   NM_031855 XM_346762
VERSION     NM_031855.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Miller,C.O., Yang,X., Lu,K., Cao,J., Herath,K., Rosahl,T.W.,
            Askew,R., Pavlovic,G., Zhou,G., Li,C. and Akiyama,T.E.
  TITLE     Ketohexokinase knockout mice, a model for essential fructosuria,
            exhibit altered fructose metabolism and are protected from
            diet-induced metabolic defects
  JOURNAL   Am J Physiol Endocrinol Metab 315 (3), E386-E393 (2018)
   PUBMED   29870677
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Lanaspa,M.A., Andres-Hernando,A., Orlicky,D.J., Cicerchi,C.,
            Jang,C., Li,N., Milagres,T., Kuwabara,M., Wempe,M.F.,
            Rabinowitz,J.D., Johnson,R.J. and Tolan,D.R.
  TITLE     Ketohexokinase C blockade ameliorates fructose-induced metabolic
            dysfunction in fructose-sensitive mice
  JOURNAL   J Clin Invest 128 (6), 2226-2238 (2018)
   PUBMED   29533924
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Kato,T., Iizuka,K., Takao,K., Horikawa,Y., Kitamura,T. and
            Takeda,J.
  TITLE     ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose
            Malabsorption
  JOURNAL   Nutrients 10 (3), 340 (2018)
   PUBMED   29534502
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Ishimoto,T., Lanaspa,M.A., Le,M.T., Garcia,G.E., Diggle,C.P.,
            Maclean,P.S., Jackman,M.R., Asipu,A., Roncal-Jimenez,C.A.,
            Kosugi,T., Rivard,C.J., Maruyama,S., Rodriguez-Iturbe,B.,
            Sanchez-Lozada,L.G., Bonthron,D.T., Sautin,Y.Y. and Johnson,R.J.
  TITLE     Opposing effects of fructokinase C and A isoforms on
            fructose-induced metabolic syndrome in mice
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4320-4325 (2012)
   PUBMED   22371574
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Vila,L., Rebollo,A., Adalsteisson,G.S., Alegret,M., Merlos,M.,
            Roglans,N. and Laguna,J.C.
  TITLE     Reduction of liver fructokinase expression and improved hepatic
            inflammation and metabolism in liquid fructose-fed rats after
            atorvastatin treatment
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 32-40 (2011)
   PUBMED   21122807
  REMARK    GeneRIF: Atorvastatin decreased the expression of fructokinase in
            livers of fructose-supplemented rats, reducing the metabolic burden
            on the liver that is imposed by continuous fructose ingestion.
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Hayward,B.E. and Bonthron,D.T.
  TITLE     Structure and alternative splicing of the ketohexokinase gene
  JOURNAL   Eur J Biochem 257 (1), 85-91 (1998)
   PUBMED   9799106
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Donaldson,I.A., Doyle,T.C. and Matas,N.
  TITLE     Expression of rat liver ketohexokinase in yeast results in fructose
            intolerance
  JOURNAL   Biochem J 291 (Pt 1) (Pt 1), 179-186 (1993)
   PUBMED   8471037
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Fukuda,H. and Iritani,N.
  TITLE     Effect of aging on changes in substrate and effector levels of
            rat-liver glycolytic and lipogenic enzymes during induction
  JOURNAL   Biochim Biophys Acta 795 (1), 79-84 (1984)
   PUBMED   6147160
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Shafrir,E. and Orevi,M.
  TITLE     Response of hepatic fructokinase to long-term sucrose diets and
            diabetes in spiny mice, albino mice and rats
  JOURNAL   Comp Biochem Physiol B 78 (2), 493-498 (1984)
   PUBMED   6088170
REFERENCE   10 (bases 1 to 1307)
  AUTHORS   Weiser,M.M., Quill,H. and Isselbacher,K.J.
  TITLE     Effects of diet on rat intestinal soluble hexokinase and
            fructokinase activities
  JOURNAL   Am J Physiol 221 (3), 844-849 (1971)
   PUBMED   5570341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078752.1.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by NM_031855.4.
            
            On Mar 1, 2007 this sequence version replaced NM_031855.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078752.1, FQ218346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1307
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /note="ketohexokinase"
                     /db_xref="GeneID:25659"
                     /db_xref="RGD:2966"
     exon            1..291
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1096
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /EC_number="2.7.1.3"
                     /note="hepatic fructokinase"
                     /codon_start=1
                     /product="ketohexokinase"
                     /protein_id="NP_114061.1"
                     /db_xref="GeneID:25659"
                     /db_xref="RGD:2966"
                     /translation="MEEKQILCVGLVVLDIINVVDKYPEEDTDRRCLSQRWQRGGNAS
                     NSCTVLSLLGARCAFMGSLAHGHVADFLVADFRRRGVDVSQVAWQSQGDTPCSCCIVN
                     NSNGSRTIILYDTNLPDVSAKDFEKVDLTRFKWIHIEGRNASEQVKMLQRIEQYNATQ
                     PLQQKVRVSVEIEKPREELFQLFGYGEVVFVSKDVAKHLGFRSAGEALKGLYSRVKKG
                     ATLICAWAEEGADALGPDGQLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSKGNSMQE
                     ALRFGCQVAGKKCGLQGFDGIV"
     exon            292..408
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            409..543
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            544..616
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            617..763
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            764..852
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1010
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1284
                     /gene="Khk"
                     /gene_synonym="KETHPRO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagagggt ctgccattgg ccggactagg taaccaaacc ctcgcaacag cagaaagcac
       61 cctgcgggag gagctccgca ggcagaggag gagccagggt agcccctgag aagttgggac
      121 acggtcctgc ggtagataag agacagagtc tagcaggaat cccctccgct tgcgggtagg
      181 aagcttgggg agcagcctca tggaagagaa gcagatcctg tgcgtggggc tggtggtgct
      241 ggacatcatc aatgtggtgg acaaataccc agaggaagac acggatcgca ggtgcctatc
      301 ccagagatgg cagcgtggag gcaacgcgtc caactcctgc actgtgcttt ccttgctcgg
      361 agcccgctgt gccttcatgg gctcgctggc ccatggccat gttgccgact tcctggtggc
      421 cgacttcagg cggaggggtg tggatgtgtc tcaagtggcc tggcagagcc agggagatac
      481 cccttgctcc tgctgcatcg tcaacaactc caatggctcc cgtaccatta ttctctacga
      541 cacgaacctg ccagatgtgt ctgctaagga ctttgagaag gtcgatctga cccggttcaa
      601 gtggatccac attgagggcc ggaatgcatc ggaacaggta aagatgctac agcggataga
      661 acagtacaat gccacgcagc ctctgcagca gaaggtccgg gtgtccgtgg agatagagaa
      721 gccccgagag gaactcttcc agctgttcgg ctatggagag gtggtgtttg tcagcaaaga
      781 tgtggccaag cacctggggt tccggtcagc aggggaggcc ctgaagggct tgtacagtcg
      841 tgtgaagaaa ggggctacgc tcatctgtgc ctgggctgag gagggagccg atgccctggg
      901 ccccgacggc cagctgctcc actcagatgc cttcccacca ccccgagtag tagacactct
      961 cggggctgga gacaccttca atgcctctgt catcttcagc ctctccaagg gaaacagcat
     1021 gcaggaggcc ctgagattcg ggtgccaggt ggctggcaag aagtgtggct tgcaggggtt
     1081 tgatggcatt gtgtgagaga tgagcggtgg gaggtagcag ctcgacacct cagaggctgg
     1141 caccactgcc tgccattgcc ttcttcattt catccagcct ggcgtctggc tgcccagttc
     1201 cctgggccag tgtaggctgt ggaacgggtc tttctgtctc ttctctgcag acacctggag
     1261 caaataaatc ttcccctgag ccaaaaaaaa aaaaaaaaaa aaaaaaa
//
