LOCUS       NM_022249               1690 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus KH RNA binding domain containing, signal
            transduction associated 3 (Khdrbs3), mRNA.
ACCESSION   NM_022249
VERSION     NM_022249.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Iijima,T., Wu,K., Witte,H., Hanno-Iijima,Y., Glatter,T., Richard,S.
            and Scheiffele,P.
  TITLE     SAM68 regulates neuronal activity-dependent alternative splicing of
            neurexin-1
  JOURNAL   Cell 147 (7), 1601-1614 (2011)
   PUBMED   22196734
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Ray,D., Kazan,H., Chan,E.T., Pena Castillo,L., Chaudhry,S.,
            Talukder,S., Blencowe,B.J., Morris,Q. and Hughes,T.R.
  TITLE     Rapid and systematic analysis of the RNA recognition specificities
            of RNA-binding proteins
  JOURNAL   Nat Biotechnol 27 (7), 667-670 (2009)
   PUBMED   19561594
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Stoss,O., Novoyatleva,T., Gencheva,M., Olbrich,M., Benderska,N. and
            Stamm,S.
  TITLE     p59(fyn)-mediated phosphorylation regulates the activity of the
            tissue-specific splicing factor rSLM-1
  JOURNAL   Mol Cell Neurosci 27 (1), 8-21 (2004)
   PUBMED   15345239
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum Mol Genet 8 (6), 959-969 (1999)
   PUBMED   10332027
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022249.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152547.1, SRR22582424.863503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000007.1  102726843-102727050
            209-327             JAXUCZ010000007.1  102784937-102785055
            328-444             JAXUCZ010000007.1  102803428-102803544
            445-591             JAXUCZ010000007.1  102807631-102807777
            592-731             JAXUCZ010000007.1  102814753-102814892
            732-927             JAXUCZ010000007.1  102818841-102819036
            928-1010            JAXUCZ010000007.1  102840242-102840324
            1011-1069           JAXUCZ010000007.1  102874990-102875048
            1070-1690           JAXUCZ010000007.1  102876752-102877372
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1690
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /note="KH RNA binding domain containing, signal
                     transduction associated 3"
                     /db_xref="GeneID:64015"
                     /db_xref="RGD:620921"
     exon            1..208
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1161
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /note="SLM-2; rSLM-2; sam68-like mammalian protein 2;
                     etoile, Sam68-like protein SLM-2; KH domain containing,
                     RNA binding, signal transduction associated 3"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 3"
                     /protein_id="NP_071585.2"
                     /db_xref="GeneID:64015"
                     /db_xref="RGD:620921"
                     /translation="MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEAKDEEK
                     YIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGS
                     MRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN
                     DEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGV
                     PRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYS
                     TAYDDQSYDSYDNSYSTPAQSGADYYDYGHGLGEEAYDSYGQEDWTNSRHKAPSARTA
                     KGVYREQPYGRY"
     exon            209..327
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            328..444
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..591
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..731
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..927
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1010
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1069
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1690
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Slm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcttggcc gccgaggcgc ctggcggggt ccgcgccgcc gcgggcgggc ggctcgggct
       61 gcggggcggc tggcgcgcgc gcgcctcggg gcggagaagc gggcccggcg gccggcgagc
      121 atggaggaga agtacctgcc ggagctgatg gcggagaagg actctctgga cccctccttc
      181 acgcacgccc tgcgcttggt gaaccgagaa atagaaaagt ttcagaaggg agaagccaag
      241 gatgaagaga agtacattga tgtggtgata aacaagaaca tgaagctggg acagaaagtg
      301 ttgattcctg taaagcagtt tcccaagttc aactttgtgg ggaagctttt gggtccacgt
      361 ggcaattccc tgaagcgctt acaagaagaa acgttgacaa aaatgtccat ccttggcaaa
      421 ggttccatga gagacaaggc aaaggaggag gagctgagga aaagtggaga agcgaagtac
      481 tttcacctca atgacgacct gcacgtgctc attgaagtgt tcgcgccccc agcggaagct
      541 tatgcccgga tggggcatgc cttggaagag attaagaagt tcctgatccc tgactataat
      601 gatgaaatca ggcaagcaca gctccaggaa ttaacttatt tgaatggagg ttcagaaaat
      661 gcagatgtcc cagtggttcg agggaaatca actttgcgta cgagaggtgt aacgacacca
      721 gcaataacca ggggaagagg aggagtcaca gccaggcctg ttgcagttgg ggtaccacgt
      781 gggacaccga ctccccgagg agtcctttcc acccgagggc cagtgagccg gggaagagga
      841 cttctcactc ccagagcaag aggtgtcccc ccaactggat acagacctcc accgccaccc
      901 ccaacacagg agacctatgg agagtatgac tatgacgatg ggtacagtac agcatatgat
      961 gaccagagct acgactccta tgacaacagc tacagcaccc cagcacaaag cggagcggat
     1021 tactatgatt acgggcatgg actcggcgag gaggcttatg attcctatgg gcaagaggac
     1081 tggactaact caagacataa ggctccttcg gcgaggacag cgaagggcgt ctacagagag
     1141 cagccatatg gcagatactg actgtactgt ctgatgttgt gaaatagcca atctccaccg
     1201 tcctgtatac tgttcaaagt aattgttttc tatgaccaat ccctttttaa ataaatcaaa
     1261 atgcttaaaa tctgaacgga tggaacttaa agccactttg ttgaagcatc cacttggcag
     1321 ggagaagaag gacatgtaaa attttgttat ttgcagtctg tatatgaaag ctaggttatg
     1381 aaaaggaaaa aaaataactt tgattaacta gtgttaaaca aaaagatagg tttactaaat
     1441 atgttaatcc attctttaac ataagcctca cctttcattt taaaggtttc catagaattt
     1501 agttatttta tctttcagcc atatgctagt ttttttttct ttctttcttt ctttcttgcc
     1561 aacttgcgtg aaaagggagc caattacaag tgcagacaat gtggtttctt ttgtaactga
     1621 gtcctgaaat gttctgtagt gttaggcaaa gtctcctctt gcttgatact aaataaactt
     1681 ttgaaagaaa
//
