LOCUS       NM_130405               2629 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus KH RNA binding domain containing, signal
            transduction associated 1 (Khdrbs1), mRNA.
ACCESSION   NM_130405
VERSION     NM_130405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Song,Z., Wei,D., Chen,Y., Chen,L., Bian,Y., Shen,Y., Chen,J. and
            Pan,Y.
  TITLE     Association of astragaloside IV-inhibited autophagy and
            mineralization in vascular smooth muscle cells with lncRNA H19 and
            DUSP5-mediated ERK signaling
  JOURNAL   Toxicol Appl Pharmacol 364, 45-54 (2019)
   PUBMED   30529164
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Goel,R.K., Paczkowska,M., Reimand,J., Napper,S. and Lukong,K.E.
  TITLE     Phosphoproteomics Analysis Identifies Novel Candidate Substrates of
            the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking
            C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites
            (SRMS)
  JOURNAL   Mol Cell Proteomics 17 (5), 925-947 (2018)
   PUBMED   29496907
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Chen,X., Liu,L., Qian,R., Liu,J., Yao,Y., Jiang,Z., Song,X., Ren,J.
            and Zhang,F.
  TITLE     Expression of Sam68 Associates with Neuronal Apoptosis and Reactive
            Astrocytes After Spinal Cord Injury
  JOURNAL   Cell Mol Neurobiol 37 (3), 487-498 (2017)
   PUBMED   27236696
  REMARK    GeneRIF: Sam68 might be illustrated in the apoptosis of neurons and
            proliferation of astrocytes after spinal cord injury.
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Chen,Q., Zhou,Y., Richards,A.M. and Wang,P.
  TITLE     Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced
            autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways
  JOURNAL   Biochem Biophys Res Commun 474 (1), 168-174 (2016)
   PUBMED   27105917
  REMARK    GeneRIF: In conclusion, miRNA-221 exerts cytoprotective effects in
            hypoxia-reoxygenation injury in association with alterations in
            autophagic cell injury. Mir-221 may constitute is a novel
            therapeutic target in the treatment of cardiac I/R injury.
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Chen,T., Damaj,B.B., Herrera,C., Lasko,P. and Richard,S.
  TITLE     Self-association of the single-KH-domain family members Sam68,
            GRP33, GLD-1, and Qk1: role of the KH domain
  JOURNAL   Mol Cell Biol 17 (10), 5707-5718 (1997)
   PUBMED   9315629
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Fusaki,N., Iwamatsu,A., Iwashima,M. and Fujisawa,Ji.
  TITLE     Interaction between Sam68 and Src family tyrosine kinases, Fyn and
            Lck, in T cell receptor signaling
  JOURNAL   J Biol Chem 272 (10), 6214-6219 (1997)
   PUBMED   9045636
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Richard,S., Yu,D., Blumer,K.J., Hausladen,D., Olszowy,M.W.,
            Connelly,P.A. and Shaw,A.S.
  TITLE     Association of p62, a multifunctional SH2- and SH3-domain-binding
            protein, with src family tyrosine kinases, Grb2, and phospholipase
            C gamma-1
  JOURNAL   Mol Cell Biol 15 (1), 186-197 (1995)
   PUBMED   7799925
REFERENCE   9  (bases 1 to 2629)
  AUTHORS   Wong,G., Muller,O., Clark,R., Conroy,L., Moran,M.F., Polakis,P. and
            McCormick,F.
  TITLE     Molecular cloning and nucleic acid binding properties of the
            GAP-associated tyrosine phosphoprotein p62
  JOURNAL   Cell 69 (3), 551-558 (1992)
   PUBMED   1374686
REFERENCE   10 (bases 1 to 2629)
  AUTHORS   Moran,M.F., Polakis,P., McCormick,F., Pawson,T. and Ellis,C.
  TITLE     Protein-tyrosine kinases regulate the phosphorylation, protein
            interactions, subcellular distribution, and activity of p21ras
            GTPase-activating protein
  JOURNAL   Mol Cell Biol 11 (4), 1804-1812 (1991)
   PUBMED   2005883
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_130405.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF305619.1, BC061987.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000005.1  147372989-147373448 c
            461-585             JAXUCZ010000005.1  147362161-147362285 c
            586-702             JAXUCZ010000005.1  147360062-147360178 c
            703-849             JAXUCZ010000005.1  147357429-147357575 c
            850-983             JAXUCZ010000005.1  147355889-147356022 c
            984-1185            JAXUCZ010000005.1  147354136-147354337 c
            1186-1253           JAXUCZ010000005.1  147353676-147353743 c
            1254-1312           JAXUCZ010000005.1  147352457-147352515 c
            1313-2629           JAXUCZ010000005.1  147347904-147349220 c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2629
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /note="KH RNA binding domain containing, signal
                     transduction associated 1"
                     /db_xref="GeneID:117268"
                     /db_xref="RGD:621459"
     exon            1..460
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1410
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /note="p68; src-associated in mitosis 68 kDa protein;
                     GAP-associated tyrosine phosphoprotein p62; KH domain
                     containing, RNA binding, signal transduction associated 1;
                     p21 Ras GTPase-activating protein-associated p62; src
                     associated in mitosis, 68 kDa; KH domain-containing,
                     RNA-binding, signal transduction-associated protein
                     1-like"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 1"
                     /protein_id="NP_569089.1"
                     /db_xref="GeneID:117268"
                     /db_xref="RGD:621459"
                     /translation="MQRRDDPAARLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRS
                     RGGGGGPRGGARASPATQPPPLLPPSNPGPDATVVGSAPTPLLPPSATAAAKMEPENK
                     YLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERV
                     LIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDP
                     KYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNG
                     VPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVP
                     PPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDSYAEQSYEGYEGYYSQSQG
                     ESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY"
     exon            461..585
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            586..702
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            703..849
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            850..983
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1185
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1253
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1312
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2629
                     /gene="Khdrbs1"
                     /gene_synonym="P62; Sam68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccaccccc gccaaccgcc gctcgggcct cagcgccgtc gcgtcgcttc ctcgctcgct
       61 cgccacacat cattcctgat gcagcgccgg gacgaccctg ccgcgcgcct cacccggtcc
      121 tcgggccgca gctgctccaa ggacccgtca ggtgcccacc cctcggtgcg tctgaccccg
      181 tctcggccgt cgccgcttcc tcaccggtcc cggggaggcg gaggtgggcc cagaggaggc
      241 gctcgggcct cgcccgctac gcagccgccg ccgctgctgc ctccctctaa tccgggtccc
      301 gacgcgactg tggtgggttc cgcgccgacc ccgctactgc ccccgtcagc cacagccgcg
      361 gccaagatgg agccggagaa taagtacctg cctgaactca tggctgagaa ggactcgctc
      421 gacccgtcct tcactcacgc catgcagctg ctgtccgtag aaattgagaa gattcagaag
      481 ggagagtcaa aaaaagatga cgaggagaat tatttggact tattttctca taagaacatg
      541 aagctgaaag agcgggtact gatccctgtc aagcagtatc caaagttcaa ttttgtgggg
      601 aagattcttg gaccacaagg aaatacaatc aaaagactcc aggaagagac tggtgcaaag
      661 atctctgtct tggggaaggg ttcgatgaga gacaaagcca aggaggaaga gttgcgcaag
      721 ggtggagacc ccaaatatgc ccatttaaat atggatctgc atgtcttcat tgaagtcttt
      781 ggacccccat gtgaagctta tgctcttatg gcccatgcta tggaagaagt caagaaattt
      841 ctagtaccag acatgatgga tgatatctgc caggagcagt ttctagaatt gtcctacttg
      901 aatggagttc ctgaaccctc tcgtggtcgt ggggtgtctg tgagaggacg aggagctgcc
      961 cctcctcctc cacctgttcc cagaggacgt ggtgttgggc cacctagagg ggctttggtt
     1021 cgtggaaccc cagtaagagg ctccatcacc agaggtgcca ctgtgactcg aggggtgcca
     1081 cccccaccta ctgtgagggg tgctccaaca ccgagagctc ggacagctgg tattcagaga
     1141 atacctttgc ctccaacacc tgcaccagaa acatacgaag attatggata tgatgattca
     1201 tatgcagaac agagctacga aggctatgaa ggctattaca gccagagtca aggggagtca
     1261 gagtattatg actatggaca tggggagctt caagattctt atgaagccta tggacaagat
     1321 gactggaatg ggaccaggcc atcactgaag gctcctccag ctaggccagt gaagggagca
     1381 tacagagagc acccatatgg acgttattaa aaacaaacag gaggggaaaa tatcagttat
     1441 gagcaaactt gttactgatt tcttgtatcc caggattcct gttgctttac ccacaacaga
     1501 caagtaattg tctaagtgtt tttctttgtg gtccctttct tttccccacc ttcctccatt
     1561 cttaactctg cattctggct tctgtatgta gtattttaaa atgagttaaa atagatttag
     1621 gaatatcgaa ttaatttttt aagtgtgtag atgctttttt tctttgttgt ttaaatataa
     1681 acagtgtacc ttttataata aaaaaaagtt gagttaaaaa aaaccacaaa catgttagtt
     1741 tcaaaagtgg cattgcttgc ttaaaggttc tgaagtaaag gcttgtcaac gttttcttag
     1801 ctttgatttg aggcaccccg taaagtcata gttgcagaat cccaaactag gctacatttc
     1861 aaaattcagg gctgcttaag ctgtaaaatc acaatgttaa cggcagtagg tgccaccatg
     1921 taaaagtgag ctcagatgtc tctaaaaaca tttcctttaa aagcacatgg cggttgaatc
     1981 ttaaggttaa attttaatat gaaagatcct catgaattaa atagttgatg caatttttaa
     2041 cgttaattga cttaaaacaa caacaaaatt aggtttgtaa aatgactttt tcattctgtg
     2101 ggttttgaaa tctagcccca gacatacagt gttgagagat acttagtggg gggggggttg
     2161 aataggttgc tggggaggga agctggccgc ctaaatggag tctgacagtt ctttttagcc
     2221 acagtctttt caataatagt actaataatc aaattttcag tatttaaaat gtcaagagta
     2281 ttttgtccat ctgagattct gcactccatg aaaaactcac ttggacactg gggccgaaag
     2341 ctgacgctgt tcattaagtt gaccattgtc agtttcgcac tgttgccacg gtagttaagt
     2401 atgtctcaac actagcatga cataaaaagg gacactgcag ctgaatgaga agagaatcaa
     2461 agtccacttt gtacataagt taaagtccta atggatttgt accgtcctcc cattttgttt
     2521 ttggaagatt aaatgctaca tgtgtaagtc tgcctaaata ggtagcttaa cctatgtcaa
     2581 aatgtctgca gcaagtttgt caataaagtt tagtcctttt ttaatcaaa
//
