LOCUS       NM_001108087            1972 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus keratocan (Kera), mRNA.
ACCESSION   NM_001108087 XM_001080530 XM_235082
VERSION     NM_001108087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Hayes AJ and Melrose J.
  TITLE     Immunolocalization of Keratan Sulfate in Rat Spinal Tissues Using
            the Keratanase Generated BKS-1(+) Neoepitope: Correlation of
            Expression Patterns with the Class II SLRPs, Lumican and Keratocan
  JOURNAL   Cells 9 (4), 826 (2020)
   PUBMED   32235499
  REMARK    GeneRIF: Immunolocalization of Keratan Sulfate in Rat Spinal
            Tissues Using the Keratanase Generated BKS-1(+) Neoepitope:
            Correlation of Expression Patterns with the Class II SLRPs, Lumican
            and Keratocan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Wentz-Hunter K, Cheng EL, Ueda J, Sugar J and Yue BY.
  TITLE     Keratocan expression is increased in the stroma of keratoconus
            corneas
  JOURNAL   Mol Med 7 (7), 470-477 (2001)
   PUBMED   11683372
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT,
            Krahe R, Kivela T, Kucherlapati R, Forsius H and de la Chapelle A.
  TITLE     Mutations in KERA, encoding keratocan, cause cornea plana
  JOURNAL   Nat Genet 25 (1), 91-95 (2000)
   PUBMED   10802664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235082.3, XM_001080530.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1972
                     /gene="Kera"
                     /note="keratocan"
                     /db_xref="GeneID:314771"
                     /db_xref="RGD:1305816"
     exon            1..170
                     /gene="Kera"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1067
                     /gene="Kera"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1234
                     /gene="Kera"
                     /codon_start=1
                     /product="keratocan precursor"
                     /protein_id="NP_001101557.1"
                     /db_xref="GeneID:314771"
                     /db_xref="RGD:1305816"
                     /translation="MATPTCLILWVLLIVDTVWTQSVRQAYEVQDPEEWDVHDDFYCP
                     RECFCPPSFPTALYCENRGLTEIPAIPSRIRYLYLENNLIETIPEKPFENATQLRWIN
                     LNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSSIPQ
                     GTFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ
                     LFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDAGLPSRGFDVSSILDLQLSHNQLT
                     NFPRINANLQHLHLDHNKIKNVNMSVICPSTLRAGQDAFLHGPQLSYLRLDGNEIKPP
                     IPMDLVACFKLLQAFII"
     exon            1068..1972
                     /gene="Kera"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacatcaaa acgtcttcat ggtgaccagt caccatacgt ttcatttttt tttcagattg
       61 gagattcaat agcatacagt caaaacattt tttcttttat cccccatcaa cttattttag
      121 ctaacttaag accagccaca ggactcaacg atatattcct ggaaagcaag gcactgcaat
      181 ggcaacccca acctgtttga tactctgggt gttactcata gtagacactg tgtggacaca
      241 gagtgtgagg caggcctatg aagtacagga cccagaggag tgggatgtcc atgatgactt
      301 ctactgtccc agagaatgct tctgtccacc gagtttccct actgccttat actgtgagaa
      361 cagaggtctc acagaaatcc ctgctatccc ttcaaggatc cggtacctgt acctggaaaa
      421 caacctgatt gaaacaatac cagagaagcc atttgagaat gccacccagc tgagatggat
      481 caatttaaac aagaacaaaa taaccaacta cgggattgag aagggggccc taagtcagct
      541 aaagaagctt cttttcctgt ttctagaaga caatgagcta gaggaggtac cttccccact
      601 gccaagaagt ttggaacaat tgcaattagc cagaaacaaa gtatccagca tccctcaggg
      661 gaccttcagt aatctggaaa acctgacact tcttgatctg caacataaca aactgttaga
      721 caatgccttt caaagagata ccttcaaggg gcttaagaat ctcatgcagc taaatatggc
      781 caagaatgcc ctaaggaaca tgcccccaag attaccagcc aacaccatgc aactttttct
      841 ggacaacaac tccattgaag ggatacctga gaattatttc aacgtgattc ctaaagtggc
      901 cttcctgagg ctcaaccaca acaagctatc agatgcaggt ctcccgtcga ggggttttga
      961 tgtgtcctcc attctagacc tccaactgtc tcacaaccag ctcacaaact ttccccgaat
     1021 caatgctaac ctacagcatc tacacctgga tcacaacaaa attaaaaatg tgaacatgtc
     1081 ggtaatatgt cccagcacac tgcgcgcagg acaggatgcc ttccttcacg gacctcaact
     1141 gagttacctg cgtctggatg ggaatgaaat caagccacca atcccgatgg atttagtggc
     1201 atgcttcaaa cttcttcagg ctttcatcat ataaaagcag cttcagagaa cccacaatgg
     1261 tttaagagta gatgtgtgtg gtatgagatt tgattgttac ttctaggtct aggtcataaa
     1321 ccacacttgc agttgttctt aaccaccgtt ttcatatgtg ctgcttgttt atgatcaagg
     1381 atgctcatca gtgacataca gggaccactt gcattagttt gctttcctct gattaacaaa
     1441 acagacacag agttgagaaa gttcctcaac tcaaagctat ttttgtctcc ttgcagctac
     1501 taatacccat ttttttcatt gtcacacatt caaaataatt tgcttgtatg tgaccaaatt
     1561 tcctaaattt ggtgtgctca tagtgtctac tctctataag caccacacac aatggagcag
     1621 caggagaaag ctctgaagaa tatgaaatat atgaaatatt cctgtctcat agttataagg
     1681 aacccactag tcaaatggtt cataaaaaga gaggttcata aaaagagaca tctagttatt
     1741 ggaataaaat gataaagcag gagacgctgg agtcccttag agttcaatga taattcagaa
     1801 gaaactggtg gttcgctatc ttttcttacg tatgtttcct tagatattat gcactatctc
     1861 cagtaactga atccctaaat tttccagtca ttataacaca gtttgcaaac tattcagctc
     1921 ttattttgat tatgattttg gagattttct aaataaaaaa tgaatgtttt ct
//
