LOCUS       NM_001191611            2259 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Kell metallo-endopeptidase (Kell blood group)
            (Kel), mRNA.
ACCESSION   NM_001191611 XM_216130
VERSION     NM_001191611.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Zhu,X., Cho,E.S., Sha,Q., Peng,J., Oksov,Y., Kam,S.Y., Ho,M.,
            Walker,R.H. and Lee,S.
  TITLE     Giant axon formation in mice lacking Kell, XK, or Kell and XK:
            animal models of McLeod neuroacanthocytosis syndrome
  JOURNAL   Am J Pathol 184 (3), 800-807 (2014)
   PUBMED   24405768
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Rivera,A., Kam,S.Y., Ho,M., Romero,J.R. and Lee,S.
  TITLE     Ablation of the Kell/Xk complex alters erythrocyte divalent cation
            homeostasis
  JOURNAL   Blood Cells Mol Dis 50 (2), 80-85 (2013)
   PUBMED   23122227
  REMARK    Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52]
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Zhu,X., Rivera,A., Golub,M.S., Peng,J., Sha,Q., Wu,X., Song,X.,
            Kumarathasan,P., Ho,M., Redman,C.M. and Lee,S.
  TITLE     Changes in red cell ion transport, reduced intratumoral
            neovascularization, and some mild motor function abnormalities
            accompany targeted disruption of the Mouse Kell gene (Kel)
  JOURNAL   Am J Hematol 84 (8), 492-498 (2009)
   PUBMED   19544475
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Claperon,A., Hattab,C., Armand,V., Trottier,S., Bertrand,O. and
            Ouimet,T.
  TITLE     The Kell and XK proteins of the Kell blood group are not
            co-expressed in the central nervous system
  JOURNAL   Brain Res 1147, 12-24 (2007)
   PUBMED   17379193
  REMARK    GeneRIF: Results demonstrate the lack of Kell expression in rodent
            neuronal cells. Kell expression is restricted to red blood cells in
            cerebral vessels.
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Claperon,A., Rose,C., Gane,P., Collec,E., Bertrand,O. and Ouimet,T.
  TITLE     The Kell protein of the common K2 phenotype is a catalytically
            active metalloprotease, whereas the rare Kell K1 antigen is
            inactive. Identification of novel substrates for the Kell protein
  JOURNAL   J Biol Chem 280 (22), 21272-21283 (2005)
   PUBMED   15769748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_216130.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.5953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000004.1  71551750-71551773   c
            25-166              JAXUCZ010000004.1  71551372-71551513   c
            167-343             JAXUCZ010000004.1  71550942-71551118   c
            344-468             JAXUCZ010000004.1  71550383-71550507   c
            469-615             JAXUCZ010000004.1  71549944-71550090   c
            616-678             JAXUCZ010000004.1  71547221-71547283   c
            679-867             JAXUCZ010000004.1  71546945-71547133   c
            868-1016            JAXUCZ010000004.1  71546368-71546516   c
            1017-1146           JAXUCZ010000004.1  71545473-71545602   c
            1147-1257           JAXUCZ010000004.1  71539070-71539180   c
            1258-1356           JAXUCZ010000004.1  71537879-71537977   c
            1357-1434           JAXUCZ010000004.1  71537616-71537693   c
            1435-1535           JAXUCZ010000004.1  71537138-71537238   c
            1536-1646           JAXUCZ010000004.1  71536883-71536993   c
            1647-1714           JAXUCZ010000004.1  71536666-71536733   c
            1715-1884           JAXUCZ010000004.1  71536296-71536465   c
            1885-1980           JAXUCZ010000004.1  71535886-71535981   c
            1981-2259           JAXUCZ010000004.1  71534882-71535160   c
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2259
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /note="Kell metallo-endopeptidase (Kell blood group)"
                     /db_xref="GeneID:297025"
                     /db_xref="RGD:1565470"
     CDS             1..2142
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /EC_number="3.4.24.11"
                     /note="Kell blood group, metallo-endopeptidase"
                     /codon_start=1
                     /product="kell blood group glycoprotein"
                     /protein_id="NP_001178540.1"
                     /db_xref="GeneID:297025"
                     /db_xref="RGD:1565470"
                     /translation="MGPPWSQERSPEESLSTEWSRQSTRARWVLLAVLLCGLLIGCSM
                     LWVYIFRNCGPWTCESPVCMELVNHYLASGNRSAAPCTDFFSFACEKANGTSNSFQAL
                     AEENKSRLWKLLEAPGSWHLESGEEKAFQFYNSCMDTDAIEASGTGPLVQIIKELGGW
                     NISGNWTFFDFNQNLRLLMSQYGHFPFFRAYLHPHPAPPHTPIIQIDQPEFDILLQQD
                     QEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQ
                     DKLFHVVTIDALQEMAPAIDWLSCLQAIFTPMSLSPSQTLQVHDLDYLRNMSQLVEEG
                     LLNHSEIIQSYMILGLVDTLSPALATKFQEARRELTQKLRKLKERPPLPAYPRWMKCV
                     EQTGSFFEPTLAALFVHEAFGPSIRSAAMELFAEIKDAVIVRLKKLSWISEETRKEAL
                     NKLTQLQVEMGAPKRALKTEMAKQEYSDIQLGPSFLQSFLSCVRSLQGRKVRSFLQPF
                     PYHRWQKSPWSVSAYYSVPDHVVVFPAGLLQPPFFHPGYPRAVNFGAVGSIMAHKLLH
                     IFFQFLLPGGCPACDTRALQEALLCLEHRYAAFPLPSMSSFNGSHTLLENAADIGGVA
                     IAFQAYRKRITERTGELTLPNQELSPYQLFFRSYAQVMCRELISQDPQDTHSPPRLRV
                     HGPLSNSPDFAKHFLCPSGSLLNPSTRCKLW"
     exon            1..24
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            25..166
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            167..343
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            344..468
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            469..615
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            616..678
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            679..867
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1016
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1146
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1257
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1356
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1434
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1535
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1646
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1714
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1884
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1980
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2259
                     /gene="Kel"
                     /gene_synonym="RGD1565470"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggacctc cctggagcca ggagagatct ccagaagaga gtctttccac tgaatggagc
       61 agacagtcga caagagccag atgggtgctg ctagctgtcc tgctttgtgg cctgctcatt
      121 ggttgttcta tgctttgggt ttacattttc cggaactgtg gtccttggac ctgtgagtca
      181 cctgtgtgta tggagctcgt gaaccattac ctggcttctg gaaacagaag tgcggccccc
      241 tgtactgact ttttcagctt tgcttgtgaa aaagccaatg ggaccagtaa ctctttccag
      301 gcacttgcag aagagaacaa gagccgactg tggaaactat tggaggcccc agggtcctgg
      361 catctagaat ctggagagga gaaagccttc caattttata actcctgcat ggacacagat
      421 gccattgaag cttcagggac tggtccactt gtacaaatta ttaaagagct tggaggctgg
      481 aatatttctg gcaattggac tttttttgac ttcaatcaaa atctgaggct tctgatgagt
      541 cagtatggcc acttcccatt cttccgagcc tatcttcatc ctcatccagc ccctccacat
      601 acgccaatca tccagataga ccagccggag tttgacattc ttctccagca agatcaggaa
      661 cagaaagtct atgctcagat cctacgggaa tatgtgacat acctgaaccg gttgggaact
      721 ttacttggga gtaacccaca ggaagcacaa caacatgcct cctggtccat cgtctttacc
      781 tcacggctgt tccagtttct gaggccacaa caacagcagc aggcacaaga caagctcttt
      841 cacgtggtta ctattgatgc ccttcaggaa atggccccag ccatcgactg gttatcctgt
      901 ttacaagcaa tattcacacc gatgtctttg agtccctccc agaccctcca agtccatgac
      961 ctagactact tgagaaacat gtcacagctg gtagaagaag ggctgctgaa tcacagtgag
     1021 ataatacaga gctacatgat ccttgggttg gtggataccc tttcaccagc actggccact
     1081 aaattccagg aggcacgcag agaactgact cagaaactac ggaaactgaa agaacgacca
     1141 cccctgccag cctaccctcg gtggatgaag tgtgtggaac agacgggatc cttctttgag
     1201 cctactctgg cagctctgtt tgttcatgaa gcctttggtc caagcattcg aagtgctgcc
     1261 atggaattat ttgctgagat aaaggatgct gtcatcgtac gcctcaagaa gctttcctgg
     1321 ataagtgagg agactcggaa agaggccttg aacaagctca cccaactgca ggtggagatg
     1381 ggggctccaa aacgggccct gaagactgag atggccaaac aagaatatag tgatatacaa
     1441 cttggtccca gtttccttca atctttccta agctgtgtac gatccctcca gggcagaaag
     1501 gttcggagtt tcttgcagcc ttttccctac cacagatggc agaaatctcc ctggagcgtc
     1561 agtgcctact attcagtacc tgaccatgtg gtggtcttcc ctgctggcct tctccaacct
     1621 ccattcttcc accctggcta ccccagagcc gtgaactttg gcgctgttgg cagcatcatg
     1681 gcccataaac tgttgcatat cttcttccaa ttcttacttc ctgggggctg cccagcctgc
     1741 gacacacgtg cactacaaga agcacttcta tgcctggagc atcgctatgc tgccttcccc
     1801 ttacccagca tgtcctcttt caatggttct cacacactcc tggaaaatgc tgcagacata
     1861 ggaggcgtag ccattgcatt tcaggcatat agaaagagga taacagagcg cactggagag
     1921 ttgactctgc ccaaccagga gctcagcccc tatcaactct tcttccgaag ctacgcccag
     1981 gtaatgtgta gggagctgat ctcacaagac cctcaggaca ctcacagtcc tccaaggctt
     2041 cgagtccatg ggcccctcag caattctcca gattttgcca aacattttct ttgtccaagt
     2101 ggttcccttc tgaatccctc tacccgctgc aagctctggt agcttggcta ccaaagagac
     2161 tgagatatac atggactcct tatgagccca tccttgaagt caaaataaat gtctctctcc
     2221 tttttgttcc caaaataaaa gtgtgtattt tccctttgc
//
