LOCUS       NM_001108342            2519 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus 3-ketodihydrosphingosine reductase (Kdsr), mRNA.
ACCESSION   NM_001108342 XM_001064145 XM_341106
VERSION     NM_001108342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Boyden LM, Vincent NG, Zhou J, Hu R, Craiglow BG, Bayliss SJ,
            Rosman IS, Lucky AW, Diaz LA, Goldsmith LA, Paller AS, Lifton RP,
            Baserga SJ and Choate KA.
  TITLE     Mutations in KDSR Cause Recessive Progressive Symmetric
            Erythrokeratoderma
  JOURNAL   Am J Hum Genet 100 (6), 978-984 (2017)
   PUBMED   28575652
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Fukatsu K, Bannai H, Zhang S, Nakamura H, Inoue T and Mikoshiba K.
  TITLE     Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1
            is regulated by actin filaments and 4.1N in neuronal dendrites
  JOURNAL   J Biol Chem 279 (47), 48976-48982 (2004)
   PUBMED   15364918
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Kihara A and Igarashi Y.
  TITLE     FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an
            active site that faces the cytosolic side of the endoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 279 (47), 49243-49250 (2004)
   PUBMED   15328338
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Rimokh R, Gadoux M, Bertheas MF, Berger F, Garoscio M, Deleage G,
            Germain D and Magaud JP.
  TITLE     FVT-1, a novel human transcription unit affected by variant
            translocation t(2;18)(p11;q21) of follicular lymphoma
  JOURNAL   Blood 81 (1), 136-142 (1993)
   PUBMED   8417785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474000.1.
            
            On or before Oct 25, 2007 this sequence version replaced
            XM_001064145.1, XM_341106.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..2519
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /note="3-ketodihydrosphingosine reductase"
                     /db_xref="GeneID:360833"
                     /db_xref="RGD:1307775"
     exon            1..182
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1073
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /EC_number="1.1.1.102"
                     /note="follicular lymphoma variant translocation 1"
                     /codon_start=1
                     /product="3-ketodihydrosphingosine reductase"
                     /protein_id="NP_001101812.1"
                     /db_xref="GeneID:360833"
                     /db_xref="RGD:1307775"
                     /translation="MLLLAAAGLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGI
                     GKCIAIECYKQGAFITLVARNEDKLLQAKKEIEKYSINDKQVVLCISVDVSQDYNQVE
                     NVIKQAQEKLGPVDMLVNCAGTSKSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTM
                     KERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYPPD
                     TDTPGLAEENKTKPLETRLISETTAVCKPEQVAKQIVKDAIQGNFNSSIGSDGYMLSS
                     LTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDNIIRRCMVQKRKPEVGDKTA"
     exon            183..272
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..329
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..395
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..491
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..683
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..767
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..851
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..953
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2519
                     /gene="Kdsr"
                     /gene_synonym="Fvt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccctctcc cgcaaaccca aacactcccg gctgctggtg catgtgatct cccagtagac
       61 gctcgggcag agagatgttg ctgctggccg ccgccggcct cgtggccttc gtgctactcc
      121 tctacatggt gtcgccgctc atcagcccca agcccctcgc gctgcccggc gcgcacgtag
      181 tggtcacagg aggttccagt ggcatcggga agtgcattgc tattgagtgc tacaaacagg
      241 gagcgtttat aactctggtt gcacggaatg aggacaagct actgcaggcg aagaaagaga
      301 ttgaaaagta ctccattaac gacaaacagg tggtgctgtg tatctcagtt gatgtgtccc
      361 aagactataa ccaagtagag aatgtcataa agcaggcaca ggagaagctg ggtcctgtgg
      421 acatgctggt caactgtgca ggcacctcta agtcaggaaa gtttgaagaa cttgaagtta
      481 gtagttttga gaaattaatg agcataaatt acctgggcag cgtgtacccc agcagggcgg
      541 taatcaccac catgaaggag cgccgggtgg gcaggatcgt gtttgtgtcc tctcaggcag
      601 gacagctggg gctgtttggc ttcaccgcct actcttcatc caagtttgcc ataagaggat
      661 tggcagaagc tctgcaaatg gaggtgaagc cgtataatgt gtacgtcact gtggcctacc
      721 caccagacac tgacactccg gggctggcgg aggaaaacaa aacgaagccc ctggagaccc
      781 ggcttatctc agagaccaca gctgtttgca aaccagagca ggtggccaaa caaattgtca
      841 aggatgccat acaagggaat tttaatagtt ctattggctc agatgggtac atgctgtcct
      901 ccctgacctg tgggatggcc ccggtgactt ccatcactga aggactccag caggtggtca
      961 ccatgggcct tttccgaaca atcgctttgt tttaccttgg aagttttgat aatataattc
     1021 gccgctgcat ggtgcagaaa agaaagcctg aagtcggaga caaaactgcc taagtcttgc
     1081 cccttggacg aaagactgaa tccaatgatt tgtctggtgt gctgctaatg gagctcaagt
     1141 tttggcctgc agactcttgt gtcttgtttt tgaatgtgtg agattggacc ccatgctcct
     1201 cggaaatctg gctgcaaaca gagggacatg aagccatctc tacaacgtta ctgttaacac
     1261 tatgcaaata cggttttctg ggttttgcgg gtgatagtgt aagtactaac agcaggaaaa
     1321 cagggtaaag agcagaaggc agaatgctaa attcagcttt ccggttatat agccccatcc
     1381 tgcccatagc aatcaagaaa tgtactttgt ggcacataag aatttctgag gatttctttt
     1441 ggtttttggt tttaactttt catgaaagat ggtctgggtt tttatttgtc ttttttaatt
     1501 ttttgtattt tttcagtgta tgttattcaa ggtgtgtctt caggtagccc ctcatctgac
     1561 tctcagcacc tcttgctgtg cctgggactc gcttctgcta atgaagctgg tttctctctc
     1621 tttgatccca taaggctcga gggggatggg agagcagcac agaggaaggc aaggggtgag
     1681 tcctttgtga cagcaaatgg ggctttcttg tctccttaga ctgacgctta ccacgttctc
     1741 atttttattc agggggaaag acagcctcct tacgtgttat ctgaagagaa ataaaatctc
     1801 atagaagctt gaaagtttac agtttcttta gtagctatga tgacccgaag ttcacattcc
     1861 attccagctc agtttctagt gcttcttgac gctttctagt tctgctgatg ctaccttaat
     1921 atttttattt ttgtaaaaaa aaaagaaaga aaggaaggaa ggaaggagga agaaaaaaag
     1981 atggagacga gtgcaaatgt ttttgacctg actttttaaa ttaatccatg aattcattaa
     2041 aataaaaaac ttaaaagcat tacattctta ctctcagaga atacaacggg gctttaggga
     2101 aggcagctgg ttgtgtattt ttccgtctta ctgaaagacg gtcgattttg aagatgctca
     2161 ttttggaagt tgggtgttga gctgctctgt ctcccacact gactctgagc agtatctgca
     2221 gcacggtaag gagccctctg gcccttctcg ccctccacag cggcctgtgc gcgccatggg
     2281 tgagccagca atgcgcatgc gctgtgtgtt gcaggcctgc tgttccttgg atgagcctgc
     2341 tgcacatacc tctgatgagt ccagcctgat tccactcatc ctgtttgttg ttcccaggtt
     2401 gccacagttt ctatgtcctg gcgcgtttta ccctgtcctt cttgtataca aaatactaca
     2461 ctccagttca ttccatcgga aaaataccac tactttcaaa gaaaaacttt ttaactgtt
//
