LOCUS       NM_013062               5895 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kinase insert domain receptor (Kdr), mRNA.
ACCESSION   NM_013062
VERSION     NM_013062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5895)
  AUTHORS   Dai,Y.P. and Gao,X.Q.
  TITLE     Effects of silencing epididymal vascular endothelial growth factor
            (VEGF) expression on hyaluronidase (HYD) activity in arsenic
            poisoning rats through downregulating VEGF receptor 2 (VEGFR2)
  JOURNAL   Bioengineered 12 (1), 1351-1359 (2021)
   PUBMED   33904385
  REMARK    GeneRIF: Effects of silencing epididymal vascular endothelial
            growth factor (VEGF) expression on hyaluronidase (HYD) activity in
            arsenic poisoning rats through downregulating VEGF receptor 2
            (VEGFR2).
REFERENCE   2  (bases 1 to 5895)
  AUTHORS   Keil,V.C., Gielen,G.H., Pintea,B., Baumgarten,P., Datsi,A.,
            Hittatiya,K., Simon,M. and Hattingen,E.
  TITLE     DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess
            Angiogenesis: A Biopsy Study
  JOURNAL   Clin Neuroradiol 31 (4), 1049-1058 (2021)
   PUBMED   33900414
REFERENCE   3  (bases 1 to 5895)
  AUTHORS   Masaki,T., Okazawa,M., Asano,R., Inagaki,T., Ishibashi,T.,
            Yamagishi,A., Umeki-Mizushima,S., Nishimura,M., Manabe,Y.,
            Ishibashi-Ueda,H., Shirai,M., Tsuchimochi,H., Pearson,J.T.,
            Kumanogoh,A., Sakata,Y., Ogo,T., Kishimoto,T. and Nakaoka,Y.
  TITLE     Aryl hydrocarbon receptor is essential for the pathogenesis of
            pulmonary arterial hypertension
  JOURNAL   Proc Natl Acad Sci U S A 118 (11) (2021)
   PUBMED   33836606
REFERENCE   4  (bases 1 to 5895)
  AUTHORS   Gehmeyr,J., Maghnouj,A., Tjaden,J., Vorgerd,M., Hahn,S.,
            Matschke,V., Theis,V. and Theiss,C.
  TITLE     Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR
            via miRNA-204-5p
  JOURNAL   Int J Mol Sci 22 (4), 2173 (2021)
   PUBMED   33671638
  REMARK    GeneRIF: Disabling VEGF-Response of Purkinje Cells by
            Downregulation of KDR via miRNA-204-5p.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5895)
  AUTHORS   Bayraktar,B., Turkoz,D., Turkoz,A. and Karkucak,A.
  TITLE     Effects of Cerebral Ischemia on Levels of Vascular Endothelial
            Growth Factor (VEGF) and Its Soluble Receptors: A Possible Link to
            Angiogenesis in Arteriovenous Malformations
  JOURNAL   Turk Neurosurg 31 (6), 907-912 (2021)
   PUBMED   34169992
  REMARK    GeneRIF: Effects of Cerebral Ischemia on Levels of Vascular
            Endothelial Growth Factor (VEGF) and Its Soluble Receptors: A
            Possible Link to Angiogenesis in Arteriovenous Malformations.
REFERENCE   6  (bases 1 to 5895)
  AUTHORS   Shalaby,F., Rossant,J., Yamaguchi,T.P., Gertsenstein,M., Wu,X.F.,
            Breitman,M.L. and Schuh,A.C.
  TITLE     Failure of blood-island formation and vasculogenesis in
            Flk-1-deficient mice
  JOURNAL   Nature 376 (6535), 62-66 (1995)
   PUBMED   7596435
REFERENCE   7  (bases 1 to 5895)
  AUTHORS   Brown,L.F., Olbricht,S.M., Berse,B., Jackman,R.W., Matsueda,G.,
            Tognazzi,K.A., Manseau,E.J., Dvorak,H.F. and Van de Water,L.
  TITLE     Overexpression of vascular permeability factor (VPF/VEGF) and its
            endothelial cell receptors in delayed hypersensitivity skin
            reactions
  JOURNAL   J Immunol 154 (6), 2801-2807 (1995)
   PUBMED   7876550
REFERENCE   8  (bases 1 to 5895)
  AUTHORS   Millauer,B., Wizigmann-Voos,S., Schnurch,H., Martinez,R.,
            Moller,N.P., Risau,W. and Ullrich,A.
  TITLE     High affinity VEGF binding and developmental expression suggest
            Flk-1 as a major regulator of vasculogenesis and angiogenesis
  JOURNAL   Cell 72 (6), 835-846 (1993)
   PUBMED   7681362
REFERENCE   9  (bases 1 to 5895)
  AUTHORS   Terman,B.I., Dougher-Vermazen,M., Carrion,M.E., Dimitrov,D.,
            Armellino,D.C., Gospodarowicz,D. and Bohlen,P.
  TITLE     Identification of the KDR tyrosine kinase as a receptor for
            vascular endothelial cell growth factor
  JOURNAL   Biochem Biophys Res Commun 187 (3), 1579-1586 (1992)
   PUBMED   1417831
REFERENCE   10 (bases 1 to 5895)
  AUTHORS   Sarzani,R., Arnaldi,G., De Pirro,R., Moretti,P., Schiaffino,S. and
            Rappelli,A.
  TITLE     A novel endothelial tyrosine kinase cDNA homologous to
            platelet-derived growth factor receptor cDNA
  JOURNAL   Biochem Biophys Res Commun 186 (2), 706-714 (1992)
   PUBMED   1323289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM045206.1 and BC087029.1.
            
            On Nov 20, 2020 this sequence version replaced NM_013062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087029.1, U93306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                FM045206.1         1-29
            30-5895             BC087029.1         1-5866
FEATURES             Location/Qualifiers
     source          1..5895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..5895
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /note="kinase insert domain receptor"
                     /db_xref="GeneID:25589"
                     /db_xref="RGD:2965"
     exon            1..320
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..4285
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /EC_number="2.7.10.1"
                     /note="vascular endothelial growth factor receptor 2;
                     fetal liver kinase 1; protein-tyrosine kinase receptor
                     flk-1; FLK-1; FLK1 kinase insert domain receptor (VEGF
                     receptor 2); FLK1 kinase insert domain receptor (a type
                     III receptor tyrosine kinase) (VEGF receptor 2); kinase
                     insert domain protein receptor"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 2
                     precursor"
                     /protein_id="NP_037194.2"
                     /db_xref="GeneID:25589"
                     /db_xref="RGD:2965"
                     /translation="MESRALLAVALWFCVETRAASVGLPGDSLHPPKLSTQKDILTIL
                     ANTTLQITCRGQRDLDWLWPNTPRDSEERVLVTECGDSIFCKTLTVPRVVGNDTGAYK
                     CFYRDTDVSSIVYVYVQDHRSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVS
                     LCARYPEKRFVPDGNRISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLV
                     VGYRIYDVVLSPPHEIELSAGEKLVLNCTARTELNVGLDFSWQFPSSKHQHKKIVNRD
                     VKSLPGTVAKMFLSTLTIDSVTKSDQGEYTCTAYSGLMTKKNKTFVRVHTKPFIAFGS
                     GMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVSERD
                     AGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYAN
                     PPLHHIQWYWQLEEACSYRPSQTNPYTCKEWRHVKDFQGGNKIEVTKNQYALIEGKNK
                     TVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQPATQPTEQESVSLL
                     CTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTVFSNSTNDILIVA
                     FQNASLQDQGNYVCSAQDKKTKKRHCLVKQLVILERMAPMITGNLENQTTTIGETIEV
                     VCPTSGNPTPLITWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLG
                     CARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLLVIVLRTVKRANEGELKTGYL
                     SIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA
                     TCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF
                     CKFGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSG
                     FVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI
                     LLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFG
                     VLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQR
                     PAFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCMEEEEVC
                     DPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGMVLAS
                     EELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSDEA
                     GLLKLVDVAGHVDSGTTLRSSPV"
     exon            321..414
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..611
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..742
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..911
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1051
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1229
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1344
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1508
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1665
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1777
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1886
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2228
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2375
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2507
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2614
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2750
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2855
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2969
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3058
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3212
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3310
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3433
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3545
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3645
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3751
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3903
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4003
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4089
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..5895
                     /gene="Kdr"
                     /gene_synonym="Vegfr-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagagagt aggctgtgtc tccttagatc gcccggaacg ctactccgca cgactgaaag
       61 cccagattgt gtcctgcagc cgggataacc tggctgaccc gtgtccgccg acactgctgc
      121 agctgcggct ggagccaggg cgccggtgcc ctgcgctttc ccaggttttg cactgcagga
      181 gcgcgtaccg cttctgtgac ttctttgccg gccagggacc gagaaagcat ctgtgcccag
      241 cgcgaggtgc aggatggaga gcagggcgct gctagctgtc gctctgtggt tctgcgtgga
      301 gacccgagcc gcctctgtgg gtttgcctgg cgattccctc catccaccca agctcagcac
      361 acaaaaagac atacttacaa ttttggcaaa tacaaccctt cagattactt gcaggggaca
      421 gagggacctg gattggcttt ggcccaacac tccgcgtgac tctgaggaaa gggtgttggt
      481 gactgagtgt ggcgacagta tcttctgcaa gacactcaca gttcccagag tggttggaaa
      541 tgatactgga gcctacaagt gcttctatcg ggacaccgat gtctcctcca tcgtttatgt
      601 ctatgttcaa gatcacaggt caccattcat cgcctctgtc agtgacgagc atggcatcgt
      661 gtacatcact gagaacaaga acaaaactgt ggtgatccca tgccgagggt cgatttcaaa
      721 cctcaacgtg tcactttgtg ctaggtatcc agaaaagaga tttgttccgg atggaaacag
      781 aatttcctgg gacagcgaga aaggctttac tatccccagt tacatgatca gctatgccgg
      841 catggtcttc tgtgaggcaa agattaatga tgaaacgtat cagtctatca tgtacatagt
      901 tctggttgta ggatatagga tttatgatgt ggtcctgagc ccccctcatg aaattgagct
      961 atctgccgga gaaaagcttg tcttaaattg tacagcaaga acagagctca acgtggggct
     1021 tgatttcagc tggcaattcc cgtcctcaaa gcatcagcat aagaagattg taaaccggga
     1081 tgtgaaatcc cttcctggga ctgtggcaaa gatgtttttg agcaccttga ccatagacag
     1141 tgtgaccaag agtgaccaag gagaatacac ctgcacagcg tacagtggac tgatgaccaa
     1201 gaaaaataaa acatttgtcc gagttcatac aaaacctttt attgcttttg gtagcgggat
     1261 gaaatctttg gtggaagcca ctgtgggcag ccaagtccga atccctgtga agtatctcag
     1321 ttacccagct cctgatatca aatggtacag aaatggacga cccattgagt ccaattacac
     1381 aatgatcgtt ggtgatgaac tcaccatcat ggaagtgagt gaaagagatg cgggaaacta
     1441 cacggtcatc ctcaccaatc ccatttcaat ggagaaacag agccacatgg tctctctggt
     1501 tgtgaatgtt ccaccccaga tcggtgagaa agccttgatc tctcctatgg attcctacca
     1561 gtatggcacc atgcagacgc tgacatgcac agtctatgcc aaccctcccc tgcaccacat
     1621 ccaatggtac tggcagctag aagaagcatg ctcctacagg cccagccaaa caaacccata
     1681 tacttgtaaa gaatggagac acgtgaagga tttccagggg ggaaataaga tcgaagtcac
     1741 caaaaaccaa tatgccctaa ttgaaggaaa aaacaaaact gtaagtactc tggtcatcca
     1801 ggctgccaac gtgtccgcat tatacaaatg tgaagccatc aacaaagcag gacgaggaga
     1861 gagggtcatc tccttccatg tgatcagggg tcctgaaatt actgtccagc ctgctaccca
     1921 gccaaccgag caggagagtg tgtctctatt gtgcactgca gatagaaaca cgtttgagaa
     1981 cctcacgtgg tacaagcttg gctcacaggc aacatcggtc cacatgggcg aatcactcac
     2041 accagtttgc aagaacttgg acgctctttg gaaactgaat ggcaccgtgt tttctaacag
     2101 cacaaacgac atcttgattg tggcattcca gaatgcctcc ctgcaggacc aaggcaacta
     2161 tgtctgctct gctcaagaca agaagaccaa gaaaagacat tgcctagtca agcagctcgt
     2221 catcctagag cgcatggcac ccatgatcac tggaaatctg gagaatcaga caacaaccat
     2281 tggtgagacc atcgaagttg tttgtccaac atctggaaac cctacccccc tcattacatg
     2341 gttcaaagac aatgagaccc ttgtagaaga ttcaggcatt gtactaaaag acgggaaccg
     2401 gaacctaact atccgaaggg tgaggaagga agacgggggc ctctacacct gccaggcctg
     2461 caatgtcctt ggctgtgcaa gagcagagac actcttcata atagaaggtg cccaggaaaa
     2521 gaccaacttg gaagtcatta ttctcgtcgg cactgcagtg atcgccatgt tcttctggct
     2581 acttcttgtc attgttctac ggaccgttaa gcgggccaat gaaggggaac tgaagacagg
     2641 ctacttgtcc attgtcatgg atccagatga actgcccttg gatgagcgct gtgaacgctt
     2701 gccttatgat gccagcaagt gggagttccc cagggaccgg ctgaaactag gaaaacctct
     2761 tggccgtggt gcctttggcc aagtgattga ggcagatgcc tttggaatcg acaagacagc
     2821 gacttgcaaa acagtggctg tcaagatgtt gaaagaggga gcaacacaca gcgagcaccg
     2881 agccctcatg tccgaactca agatcctcat ccacattggc caccatctca atgtggtgaa
     2941 cctgctgggt gcctgcacga agcccggagg gcctctcatg gtgattgtag aattctgcaa
     3001 gtttggaaac ctatcaactt acttacgggg caagagaaat gaattcgtgc cctataagag
     3061 caaaggggca cgcttccgct ctgggaaaga ctatgttggg gagctctccg tagacctgaa
     3121 gcggcgcttg gacagcatca ccagcagtca gagctctgcc agctcaggtt ttgtggagga
     3181 gaaatccctc agtgacgtag aggaagaaga agcttctgaa gaactctaca aggacttcct
     3241 gaccttggag catctcatct gttacagctt ccaagtggct aagggcatgg agttcttggc
     3301 atcaaggaag tgtatccaca gggacctggc agcacgaaac attctcctat cggagaagaa
     3361 cgtggttaag atctgtgact ttggcttggc ccgggacatt tataaagacc cagattacgt
     3421 cagaaaagga gatgcccgac tccctttgaa gtggatggct ccggaaacaa tttttgacag
     3481 agtatacaca attcagagtg acgtgtggtc ttttggtgtt ttgctctggg aaatattttc
     3541 cttaggtgct tccccatatc ctggggtcaa gattgatgaa gaattttgta ggagattgaa
     3601 agaaggaacg agaatgcggg ctcctgacta caccacccca gaaatgtacc aaaccatgct
     3661 ggattgctgg catgaggacc ccaaccagag acccgcgttt tcagagttgg tggagcactt
     3721 gggaaatctc ctgcaagcaa atgctcagca ggatggcaaa gactatattg ttcttccaat
     3781 gtcagagaca ctgagcatgg aagaggattc tggactctcc ctgcctacct cacctgtttc
     3841 ctgtatggag gaagaggaag tgtgcgaccc caaattccat tatgacaaca cagcaggaat
     3901 cagtcattat ctgcagaaca gcaagcgaaa aagccggcca gtgagtgtaa aaacatttga
     3961 agatatccct ttggaggaac cagaagtaaa agtgattcca gatgacagcc agacagacag
     4021 tgggatggtc cttgcctcag aagagctgaa aactctggaa gacaggaaca aattatctcc
     4081 atcttttggt gggatgatgc ccagtaaaag cagggagtct gtggcctcgg aaggctccaa
     4141 ccagaccagc ggctaccagt ctgggtatca ctcagacgac acagatacca ccgtgtactc
     4201 cagcgacgag gcaggacttt taaagctggt ggatgttgca gggcacgttg actctgggac
     4261 cacactgcgc tcatctcctg tttaaaagga agtggccctg tcccgtcccc gcccccaact
     4321 cctggaaata actcgagagg tgctgcttag attttcaagt gttgttcttt ccaccactcg
     4381 gaagtagccg catttgattt tcatttcaga agagggacct cagacggcaa gaagcttgtc
     4441 ctcagggcat ttccagaaaa atgcccatga cccaagaatg tgttgactat actctctttt
     4501 ccattggttt aaaaatccta tatattgtgc cctgctgcgg gtctcactac cagttaaaac
     4561 aaaagacgtt caaacagcgg ctctatcctc caagaagtag ccatacccag gcaatggagc
     4621 cctctgtgaa actggataaa atgggcgatg ttagtgcttt gtgtgttggg atgggtgaga
     4681 tgtcccaggg ctgagtctac ctaaaaggct ttgtggagga tgtgggctat gagccaagtg
     4741 ttaagtgtga gatgtggact ggtaggaagg aaggagcaag ctcgctcaga gagcggttgg
     4801 agcctgcaga tgcattgtgc tggctgtggt ggaggtgagc atgtggcctg tcaggaaacg
     4861 ccaaggcggc tgtcggggtt tggttttgga aggttgcgtg ctcttcacgg ttgggctaca
     4921 ggcgagttcc ctgtgctgtt tcctactcct aatgagagtt ccttccggac tcttacgtgt
     4981 ctcctggcct agccccagga aggaaatgac gcagcttgct cctcatctcc caggctgtgc
     5041 cttaactcag aatactaaaa gagagggact ttggccgagg ctccgctcct tgtcatgctg
     5101 aagaactgtg agaacacaac agaaactcag ggtttctgct gggtggatac ccacttgtct
     5161 gccctggtgg cagtgtctga gggttttgtc aagtggcgac ggtaaaggct cagacaggat
     5221 gtatcccttt gttcttcctc taactccact tctgtcttgc cacacacccc cccctcccca
     5281 gtgctcagta ttttagcttt gtggccacgt gatggcagaa ggtcttaatt ggttggtttt
     5341 gctctccaga taaaatcact agtcagattt cgaaattact ttatagccaa ggtctgataa
     5401 catctactgt atcgtttaga atttaacata taaagctgtg tctactggtt tttttttttt
     5461 tgcccttggg catatgtttt tcaaaagaga aactactttt catttggtac catagcgtga
     5521 cgagcagggg ccaatgactg taaaacatgc tgtggcacat atatttatag tctgttatgt
     5581 ggaacaaatg taatatattg aaactttata ttatatataa ggaactttgt actatccgca
     5641 tttcgtatca gtattatgta gcacgacaga gactgtgagg tctgagcagc tggtggctca
     5701 ggacgttgag aaactcgaag gaatcctttc gtgaggatgc gcagctatcc ctacccatct
     5761 ctctcacctc aaacggagga gaaaggggaa tcagagataa tgtgagtgtg tccttgttct
     5821 ctgttcttag gaggaatgtt cttaccaact gttcatacgc tttataaacc aataaatgta
     5881 ttccgagtaa agaga
//
